Chronic Pain Clinical Trials

124 studies are recruiting for chronic pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain

   Spinal cord stimulation modulates the nervous system to effectively block pain signals originating from the back and legs. Spinal cord stimulation has been shown to improve chronic pain, improve quality of life, and reduce disability. Unfortunately, spinal cord stimulation has a high trial failure …

   Stage

   Not phased

   Ages

   22 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05741788 on ClinicalTrials.gov

2. Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer: A Randomized Clinical Trial

   The purpose of the study is to determine if an adapted mobile cognitive behavioral therapy (CBT) app (WebMAP Onc) is more effective than standard pain education in reducing chronic pain and improving daily functioning in adolescent survivors of pediatric cancer. This randomized study led by St. Jud…

   Stage

   Not phased

   Ages

   10 to 17

   Site

   St. Jude Children's Research Hospital, Memphis, Tennessee

   Run by

   St. Jude Children's Research Hospital

   See if you can join NCT07160621 on ClinicalTrials.gov

3. Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy

   The PERSIST study is being conducted within Medtronic's active post-market surveillance platform, the Product Surveillance Registry (PSR). The purpose of PERSIST is to generate long-term evidence for the Inceptiv™ Spinal Cord Stimulation therapy.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Center for Pain and Supportive Care, Phoenix, Arizona

   Locations

   6 in total

   Run by

   Medtronic

   See if you can join NCT07507422 on ClinicalTrials.gov

4. NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow

   This study is a double-blind, randomized controlled trial comparing the effectiveness of oral acetaminophen, diclofenac, and tramadol in reducing the consumption of narcotic doses (primary outcome) and minimizing patients' exposure to narcotics (secondary outcome) following an ultrasound-guided per…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   The Cleveland Clinic Florida, Coral Springs, Florida

   Locations

   2 in total

   Run by

   The Cleveland Clinic

   See if you can join NCT06373978 on ClinicalTrials.gov

5. Group Music Therapy for Chronic Pain Management in Active Duty Service Members

   This randomized controlled trial will evaluate the effectiveness of an 8-week group music therapy intervention for active duty service members with chronic pain. Participants will be randomized to either a group music therapy intervention plus standard care or standard care alone. Outcomes will be …

   Stage

   Phase 2

   Ages

   18 to 64

   Site

   Joint Base Elmendorf-Richardson (JBER), Anchorage, Alaska

   Run by

   Henry M. Jackson Foundation for the Advancement of Military Medicine

   See if you can join NCT07755540 on ClinicalTrials.gov

6. RCT of a Weighted Blanket to Reduce Pain in Veterans With Chronic Pain

   Chronic pain is a major health concern for returning Veterans and is associated with decreases in quality of life. In addition, chronic pain is often accompanied by significant disturbance in sleep. Sensory interventions may offer effective, low-cost complementary tools for chronic pain and sleep d…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA San Diego Healthcare System, San Diego, CA, San Diego, California

   Locations

   2 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT05963607 on ClinicalTrials.gov

7. Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study

   The goal of this clinical trial is to pilot a randomized controlled trial comparing an adaptation of mindfulness-based cognitive therapy to the health enhancement program for chronic pain and depression. The main questions it aims to answer in a later fully powered randomized controlled trial are: …

   Stage

   Not phased

   Ages

   50 to 120

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07118722 on ClinicalTrials.gov

8. Prospective Assessment of Integrative Therapies for Neuromusculoskeletal Pain (PAIN)

   With vast numbers of active-duty members restricted from their specific duties or deemed unfit for deployment because of low back pain, both the mission of the Department of Defense and overall military workflow can be significantly impacted. More than restriction from duty or being barred from dep…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mike O'Callaghan Military Medical Center, Nellis Air Force Base, Nevada

   Run by

   David Moss

   See if you can join NCT07094282 on ClinicalTrials.gov

9. Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

   To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Yale New Haven Health Old Saybrook Medical Center, Old Saybrook, Connecticut

   Run by

   Yale University

   See if you can join NCT07639060 on ClinicalTrials.gov

10. From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects

    This is a multicenter prospective study of patients who currently have stably implanted spinal cord simulators. Patients will be randomly assigned to turn on or off their spinal cord stimulators for two week intervals up to six weeks after enrollment, and on the final day of study participation, fo…

    Stage

    Phase 2

    Ages

    18 to 80

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT05661903 on ClinicalTrials.gov

11. VETERANS AFFAIRS AUGUSTA

    Chronic pain is a prevalent and debilitating condition among Veterans, often accompanied by depression, anxiety, sleep disturbances, and social isolation. Despite the availability of behavioral interventions many Veterans-particularly those with high in-person healthcare utilization-face barriers t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Augusta Health Care System, Augusta, Georgia

    Run by

    Companion IQ, Inc

    See if you can join NCT07776600 on ClinicalTrials.gov

12. Video Intervention for Older Adults With Chronic Pain

    Chronic musculoskeletal (MSK) pain, which includes spinal pain, osteoarthritis, and fibromyalgia, is a common and costly problem for older adults and is associated with decreased quality of life. In this project, investigators propose to create Reclaim Your Day (RYD), which will consist of 6, 30-mi…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Butler Hospital, Providence, Rhode Island

    Run by

    Butler Hospital

    See if you can join NCT07404618 on ClinicalTrials.gov

13. Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome

    The purpose of this study is to assess the effects of tDCS in combination with TUS for the treatment of pain in subjects with Carpal Tunnel Syndrome. The investigators hypothesize that there will be a decrease in pain levels with active stimulation, when compared to sham stimulation.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Spaulding Rehabilitation Network Research Institute, Charlestown, Massachusetts

    Run by

    Spaulding Rehabilitation Hospital

    See if you can join NCT04206215 on ClinicalTrials.gov

14. Pain Management Teams Using Whole Health to Optimize Function and Safety in Veterans: The TEAMWORK Trial

    The focus of this study is to determine whether adding Whole Health Coaching (WHC) improves pain care among adults with chronic pain and who are currently working with a pain management team (PMT) at the VA.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama

    Locations

    5 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT07149870 on ClinicalTrials.gov

15. Pain and Major Depressive Disorder

    This study will examine the effects of brain stimulation on pain symptoms associated with Major depressive disorder. This study will enroll 54 Subjects. Study subjects will be asked to complete surveys about their mood and well-being, 2 blood draws, 2 MRIs, 3 electroencephalograms, and receive 30 t…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    UCLA Semel Institute, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT04556890 on ClinicalTrials.gov

16. POP SINGER Randomized Clinical Trial

    Conduct a feasibility randomized controlled trial (N = 130, 65 per group) comparing the POPSINGER music therapy (MT) intervention to yoga.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University Hospitals, Cleveland, Ohio

    Run by

    University Hospitals Cleveland Medical Center

    See if you can join NCT07756541 on ClinicalTrials.gov

17. A Community Health Worker-Led Program for Chronic Pain and Loneliness in Older Adults

    The goal of this clinical trial is to test a new community health worker-delivered program (Strengthening COnnections to Overcome Pain, or SCOOP) that teaches strategies for managing chronic pain and loneliness to older adults living in rural areas. The main questions it aims to answer are: 1. Does…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT06671925 on ClinicalTrials.gov

18. Integrating Nonpharmacologic Strategies for Pain With Inclusion, Respect, and Equity

    INSPIRE creates a trilingual mobile app and telehealth coaching program to promote non-pharmacologic strategies for pain management with Black, Chinese, and Latinx communities in the San Francisco Bay Area. Years 1-2 will develop the app and test it with a brief single arm pilot starting in Nov 202…

    Stage

    Not phased

    Ages

    18 and older

    Site

    San Francisco General Hospital, San Francisco, California

    Locations

    2 in total

    Run by

    University of California, San Francisco

    See if you can join NCT06183281 on ClinicalTrials.gov

19. Mindfulness Texting for Medication Adherence and Chronic Pain Management

    The goal of this clinical trial is to examine the effects of reminder and mindfulness text messages based on integrated Acceptance and Commitment Therapy and Mindfulness Based Relapse Prevention (ACT+MBRP) on medication adherence and managing craving, pain, mindfulness, and withdrawal symptoms in p…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of New Mexico, Albuquerque, New Mexico

    Run by

    University of New Mexico

    See if you can join NCT07711795 on ClinicalTrials.gov

20. Combined THC and CBD for OUD and Chronic Pain

    The primary objective of this phase 2 study is to investigate the therapeutic potential of orally administered combined delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in relieving both pain and cue-induced opioid craving in people with co-occurring opioid use disorder (OUD) and chronic pa…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Connecticut Mental Health Center, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06544291 on ClinicalTrials.gov

21. Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain

    This project is a single-site, three-arm, randomized controlled trial investigating whether different length audio-recorded mindfulness practices differentially decrease pain among patients in a waiting room awaiting orthopedic care.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tallahassee Orthopedic Clinic, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT07562412 on ClinicalTrials.gov

22. Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline

    The investigators aim to conduct a randomized controlled trial to compare two symptom-management programs for Black older adults with early cognitive decline (self-reported confirmed by testing) and chronic pain. The programs are Mindfulness-Based Cognitive Therapy with Walking (MBCT+w) and Active …

    Stage

    Not phased

    Ages

    50 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06246929 on ClinicalTrials.gov

23. Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain

    The purpose of this research study is to test whether Brief Behavioral Treatment for Insomnia (BBTI) delivered over the phone or Brief Mindfulness Training (BMT) delivered over the phone is better able to improve the symptoms of insomnia, reduce chronic pain, and slow the pace of biological aging i…

    Stage

    Not phased

    Ages

    25 to 65

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT07270406 on ClinicalTrials.gov

24. Assessing the Efficacy of an Acceptance-Based Digital Intervention for Veterans With Chronic Pain

    Pain has been identified as among the most frequent presenting medical complaints, in particular within primary care for Veterans. There are few areas of daily living and functioning that pain intensity does not impact, with reported pain intensity related to difficulties in social situations and c…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas, Texas

    Locations

    3 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT06058624 on ClinicalTrials.gov

25. Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy

    The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam d…

    Stage

    Not phased

    Ages

    8 and older

    Site

    F.M. Kirby Center, Baltimore, Maryland

    Locations

    4 in total

    Run by

    Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

    See if you can join NCT05197946 on ClinicalTrials.gov