Chronic Pain Clinical Trials

125 studies are recruiting for chronic pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. A Community Health Worker-Led Program for Chronic Pain and Loneliness in Older Adults

   The goal of this clinical trial is to test a new community health worker-delivered program (Strengthening COnnections to Overcome Pain, or SCOOP) that teaches strategies for managing chronic pain and loneliness to older adults living in rural areas. The main questions it aims to answer are: 1. Does…

   Stage

   Not phased

   Ages

   60 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT06671925 on ClinicalTrials.gov

2. Integrating Nonpharmacologic Strategies for Pain With Inclusion, Respect, and Equity

   INSPIRE creates a trilingual mobile app and telehealth coaching program to promote non-pharmacologic strategies for pain management with Black, Chinese, and Latinx communities in the San Francisco Bay Area. Years 1-2 will develop the app and test it with a brief single arm pilot starting in Nov 202…

   Stage

   Not phased

   Ages

   18 and older

   Site

   San Francisco General Hospital, San Francisco, California

   Locations

   2 in total

   Run by

   University of California, San Francisco

   See if you can join NCT06183281 on ClinicalTrials.gov

3. Mindfulness Texting for Medication Adherence and Chronic Pain Management

   The goal of this clinical trial is to examine the effects of reminder and mindfulness text messages based on integrated Acceptance and Commitment Therapy and Mindfulness Based Relapse Prevention (ACT+MBRP) on medication adherence and managing craving, pain, mindfulness, and withdrawal symptoms in p…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of New Mexico, Albuquerque, New Mexico

   Run by

   University of New Mexico

   See if you can join NCT07711795 on ClinicalTrials.gov

4. Combined THC and CBD for OUD and Chronic Pain

   The primary objective of this phase 2 study is to investigate the therapeutic potential of orally administered combined delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in relieving both pain and cue-induced opioid craving in people with co-occurring opioid use disorder (OUD) and chronic pa…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   Connecticut Mental Health Center, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06544291 on ClinicalTrials.gov

5. Examining Racial and Socioeconomic Differences in Chronic Low Back Pain

   The purpose of this research study is to gain a better understanding of how people's racial background and socioeconomic status (e.g., income, education, and employment) impact their experiences of chronic low back pain (cLBP).

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT05991440 on ClinicalTrials.gov

6. Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain

   This project is a single-site, three-arm, randomized controlled trial investigating whether different length audio-recorded mindfulness practices differentially decrease pain among patients in a waiting room awaiting orthopedic care.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tallahassee Orthopedic Clinic, Tallahassee, Florida

   Run by

   Florida State University

   See if you can join NCT07562412 on ClinicalTrials.gov

7. Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline

   The investigators aim to conduct a randomized controlled trial to compare two symptom-management programs for Black older adults with early cognitive decline (self-reported confirmed by testing) and chronic pain. The programs are Mindfulness-Based Cognitive Therapy with Walking (MBCT+w) and Active …

   Stage

   Not phased

   Ages

   50 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06246929 on ClinicalTrials.gov

8. Healthy Behaviors for Insomnia Prevention in People With HIV and Ongoing Pain

   The purpose of this research study is to test whether Brief Behavioral Treatment for Insomnia (BBTI) delivered over the phone or Brief Mindfulness Training (BMT) delivered over the phone is better able to improve the symptoms of insomnia, reduce chronic pain, and slow the pace of biological aging i…

   Stage

   Not phased

   Ages

   25 to 65

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT07270406 on ClinicalTrials.gov

9. Assessing the Efficacy of an Acceptance-Based Digital Intervention for Veterans With Chronic Pain

   Pain has been identified as among the most frequent presenting medical complaints, in particular within primary care for Veterans. There are few areas of daily living and functioning that pain intensity does not impact, with reported pain intensity related to difficulties in social situations and c…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas, Texas

   Locations

   3 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT06058624 on ClinicalTrials.gov

10. Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy

    The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam d…

    Stage

    Not phased

    Ages

    8 and older

    Site

    F.M. Kirby Center, Baltimore, Maryland

    Locations

    4 in total

    Run by

    Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

    See if you can join NCT05197946 on ClinicalTrials.gov

11. Improving Sleep in Veterans With the Polytrauma Clinical Triad

    The "polytrauma clinical triad" (PCT), a highly disabling constellation of factors, is defined by the coexistence of traumatic brain injury, post-traumatic stress disorder, and chronic pain. Veterans with the PCT are medically complex, often refractory to conventional therapies, and suffer from add…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    VA Portland Health Care System, Portland, OR, Portland, Oregon

    Run by

    VA Office of Research and Development

    See if you can join NCT06477796 on ClinicalTrials.gov

12. Real-World Efficacy of Evoke® Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy in Chronic Pain Patients (ULTRA).

    This observational, prospective data collection is designed to evaluate the efficacy of CL-SCS therapy in real-world patients suffering from chronic pain.

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Spine and Nerve Center of Saint Francis Hospital, Charleston, West Virginia

    Run by

    Saint Francis Hospital

    See if you can join NCT06246526 on ClinicalTrials.gov

13. Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma

    The purpose of this single-arm trial is to determine the feasibility of emotional awareness and expression therapy (EAET) for individuals with persistent pain following orthopedic trauma. As part of this study, participants will be asked to attend weekly EAET treatment sessions and complete assessm…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05989230 on ClinicalTrials.gov

14. Placebo Impacts Sleep and Pain Modulation in Chronic Pain

    The goal of this free-choice parallel design clinical trial is to examine the potential beneficial effects of using open-label placebo (OLP) in improving chronic pain related outcomes and sleep quality in people with temporomandibular disorders. This study will enroll a cohort of participants with …

    Stage

    Not phased

    Ages

    18 to 88

    Site

    University of Maryland Baltimore School of Nursing, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT06225817 on ClinicalTrials.gov

15. Weighted Blanket Use for Adults With Chronic Pain

    Chronic pain is a common condition that can affect sleep, daily functioning, and overall quality of life. Many individuals living with chronic pain seek non-medication approaches to help manage their symptoms. Weighted blankets are commonly used to promote relaxation and comfort during sleep, but t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    National University of Natural Medicine, Portland, Oregon

    Run by

    National University of Natural Medicine

    See if you can join NCT07498491 on ClinicalTrials.gov

16. Integrated PTSD and Chronic Pain Treatment

    Posttraumatic stress disorder (PTSD) occurs in approximately 7% of adults in the general population. PTSD greatly impacts quality of life and often co-occurs with other conditions such as chronic pain. Individuals with co-morbid PTSD and chronic pain demonstrate higher PTSD symptoms and pain (as we…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT07225049 on ClinicalTrials.gov

17. Group-based Integrative Pain Management in Primary Care Safety Net Clinics

    Socioeconomically disadvantaged populations have a high prevalence of chronic pain, exacerbated by social isolation, intersectional stigma, and disparities in pain assessment and treatment options. Effective interventions using a multilevel, biopsychosocial approach are needed to decrease the unequ…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tom Waddell Urban Health Clinic, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06327542 on ClinicalTrials.gov

18. Culturally Adapted Pain Management for Indigenous Peoples

    The proposed study involves a randomized feasibility pilot trial of a culturally adapted psychological intervention for chronic pain for American Indian/Alaska Native (AI/AN) individuals receiving care for pain at the Portland Area Indian Health Service - Yakama Service Unit. The study will provide…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Portland Area Indian Health Services - Yakama Service Unit, Yakima, Washington

    Run by

    University of California, San Diego

    See if you can join NCT07524751 on ClinicalTrials.gov

19. Equipping Patients Using Interventions for Pain and Depression

    This project is part of the NIH Helping to End Addiction Long-term (HEAL) initiative (https://heal.nih.gov/). This randomized controlled trial (RCT) is phase 2 of a two-phase, 5-year project with the overarching goal of testing a decision aid (DA)/coaching intervention, tailored to Black patients w…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Eskenazi Health Primary Care, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT06500780 on ClinicalTrials.gov

20. The PROACTIVE Study for Black Elders

    Chronic musculoskeletal pain (CMP), while a leading cause of physical disablement, is a neglected national health disparity issue in Black communities. The purpose of this study is to test a novel culturally congruent pain self-management intervention. A total of 120 persons aged 50-92, self-identi…

    Stage

    Not phased

    Ages

    50 to 92

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT06512727 on ClinicalTrials.gov

21. Mechanisms of Mindfulness Meditation and Self-Hypnosis for Pain in Older Adults With Chronic Pain

    The goal of this study is to better understand how two common psychological treatments for pain work in the brain of older adults living with chronic pain. This study will: 1. evaluate fMRI of adults receiving psychological treatments for chronic pain to determine how these interventions work withi…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of Washington, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06957743 on ClinicalTrials.gov

22. Neuroimaging of Opioid Phase (OPAL)

    The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT05905419 on ClinicalTrials.gov

23. MIVetsCan: Can-Coach Trial (Phase 2)

    The goal of the MIVetsCan Can-Coach Trial is to test four coaching sessions to help Veterans with chronic pain use their own cannabis products more effectively to manage pain and related symptoms.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06283862 on ClinicalTrials.gov

24. Developing an Opioid Taper Intervention Before Total Joint Arthroplasty

    The goal of this clinical trial is to develop an pharmacist-led preoperative opioid taper intervention for patients undergoing total knee or hip replacement who are on chronic opioids before their surgery. The main questions it aims to answer are: * Is the intervention feasible and acceptable to pa…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UAB Hospital-Highlands, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05788016 on ClinicalTrials.gov

25. The PROmoting Pain Self-Management (PROs) Trial: Holistic Pain Care in the Military Health System

    The goal of this study is to improve pain care in the MHS by identifying effective, whole-person, non-pharmacologic interventions for persons with chronic musculoskeletal pain. The investigators will evaluate two promising, evidence-based holistic health interventions and compare them to usual care.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Desmond Doss Health Clinic, Schofield Barracks, Hawaii

    Locations

    5 in total

    Run by

    Brooke Army Medical Center

    See if you can join NCT06940986 on ClinicalTrials.gov