Chronic Pain Clinical Trials

125 studies are recruiting for chronic pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies now recruiting

1. Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure

   This project is a single-site, randomized controlled trial designed to investigate the impact of a 7-minute mindfulness intervention on pain among patients undergoing kyphoplasty or radiofrequency ablation.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tallahassee Orthopedic Clinic (TOC), Tallahassee, Florida

   Run by

   Florida State University

   See if you can join NCT06471075 on ClinicalTrials.gov

2. Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial

   The present study seeks to examine the implementation process of culturally tailoring screening and brief intervention for both chronic pain and opioid misuse/opioid use disorder in three American Indian and Alaska Native (AI/AN) serving clinics. The investigators also will assess staff perspective…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Clinic Site A (blinded pending tribal approval), Arcata, California

   Locations

   3 in total

   Run by

   University of New Mexico

   See if you can join NCT06565416 on ClinicalTrials.gov

3. ARPA-H Smart Band-Aid to Measure Chronic Pain in Women

   The goal of this clinical trial is to test whether a minimally invasive microneedle patch, called the A-Band (Smart Band-aid), worn on the arm (monitoring key biomarkers in interstitial fluid) and a commercial smartwatch can accurately correlate with self-reported pain in women with chronic pain. A…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Northwestern University Feinberg School of Medicine, Chicago, Illinois

   Locations

   2 in total

   Run by

   Northwestern University

   See if you can join NCT06994988 on ClinicalTrials.gov

4. QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing

   Quantitative Sensory Testing (QST) is a novel investigative technique used in other pain conditions to evaluate patterns of chronic pain, and in this study will be used to elucidate pain patterns in patients with Chronic Pancreatitis (CP). QST uses a specific series of standardized stimulations to …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins Medical Institutions, Baltimore, Maryland

   Locations

   2 in total

   Run by

   Anna Evans Phillips

   See if you can join NCT03434392 on ClinicalTrials.gov

5. Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

   Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable. The proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Indiana University Medical Center, Indianapolis, Indiana

   Locations

   3 in total

   Run by

   University of Pittsburgh

   See if you can join NCT04996628 on ClinicalTrials.gov

6. Patient Retrospective Outcomes (PRO)

   This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Lakeside Spine & Pain, Lake Havasu City, Arizona

   Locations

   144 in total

   Run by

   Boston Scientific Corporation

   See if you can join NCT01550575 on ClinicalTrials.gov

7. A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain

   The main purpose of this study is to test the safety and efficacy of study drug for the treatment of chronic low back pain (CLBP). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate the development of new treatments for chronic pain.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Synexus Clinical Research US, Inc., Phoenix, Arizona

   Locations

   37 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07641504 on ClinicalTrials.gov

8. A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

   The main purpose of this study is to test the safety and efficacy of study drug for the treatment of knee pain due to osteoarthritis (OA). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate the development of new treatments for chroni…

   Stage

   Phase 2

   Ages

   40 and older

   Site

   Central Research Associates, Birmingham, Alabama

   Locations

   37 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07641517 on ClinicalTrials.gov

9. The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain

   Spinal cord stimulation modulates the nervous system to effectively block pain signals originating from the back and legs. Spinal cord stimulation has been shown to improve chronic pain, improve quality of life, and reduce disability. Unfortunately, spinal cord stimulation has a high trial failure …

   Stage

   Not phased

   Ages

   22 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05741788 on ClinicalTrials.gov

10. Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer: A Randomized Clinical Trial

    The purpose of the study is to determine if an adapted mobile cognitive behavioral therapy (CBT) app (WebMAP Onc) is more effective than standard pain education in reducing chronic pain and improving daily functioning in adolescent survivors of pediatric cancer. This randomized study led by St. Jud…

    Stage

    Not phased

    Ages

    10 to 17

    Site

    St. Jude Children's Research Hospital, Memphis, Tennessee

    Run by

    St. Jude Children's Research Hospital

    See if you can join NCT07160621 on ClinicalTrials.gov

11. Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control

    Study to evaluate the effectiveness of time variant pulse (TVP)-SCS in patients with chronic pain using commercially approved Boston Scientific SCS Systems per local Instructions for use (IFU). In addition, to compile real-world clinical outcomes in subjects with chronic, intractable low back and/o…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Denver Back Pain Specialists, Greenwood, Colorado

    Locations

    7 in total

    Run by

    Boston Scientific Corporation

    See if you can join NCT07190807 on ClinicalTrials.gov

12. Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy

    The PERSIST study is being conducted within Medtronic's active post-market surveillance platform, the Product Surveillance Registry (PSR). The purpose of PERSIST is to generate long-term evidence for the Inceptiv™ Spinal Cord Stimulation therapy.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Center for Pain and Supportive Care, Phoenix, Arizona

    Locations

    6 in total

    Run by

    Medtronic

    See if you can join NCT07507422 on ClinicalTrials.gov

13. NonNarcotic Pain Control in Percutaneous Needle Tenotomy of Elbow

    This study is a double-blind, randomized controlled trial comparing the effectiveness of oral acetaminophen, diclofenac, and tramadol in reducing the consumption of narcotic doses (primary outcome) and minimizing patients' exposure to narcotics (secondary outcome) following an ultrasound-guided per…

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    The Cleveland Clinic Florida, Coral Springs, Florida

    Locations

    2 in total

    Run by

    The Cleveland Clinic

    See if you can join NCT06373978 on ClinicalTrials.gov

14. Group Music Therapy for Chronic Pain Management in Active Duty Service Members

    This randomized controlled trial will evaluate the effectiveness of an 8-week group music therapy intervention for active duty service members with chronic pain. Participants will be randomized to either a group music therapy intervention plus standard care or standard care alone. Outcomes will be …

    Stage

    Phase 2

    Ages

    18 to 64

    Site

    Joint Base Elmendorf-Richardson (JBER), Anchorage, Alaska

    Run by

    Henry M. Jackson Foundation for the Advancement of Military Medicine

    See if you can join NCT07755540 on ClinicalTrials.gov

15. RCT of a Weighted Blanket to Reduce Pain in Veterans With Chronic Pain

    Chronic pain is a major health concern for returning Veterans and is associated with decreases in quality of life. In addition, chronic pain is often accompanied by significant disturbance in sleep. Sensory interventions may offer effective, low-cost complementary tools for chronic pain and sleep d…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA San Diego Healthcare System, San Diego, CA, San Diego, California

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT05963607 on ClinicalTrials.gov

16. Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study

    The goal of this clinical trial is to pilot a randomized controlled trial comparing an adaptation of mindfulness-based cognitive therapy to the health enhancement program for chronic pain and depression. The main questions it aims to answer in a later fully powered randomized controlled trial are: …

    Stage

    Not phased

    Ages

    50 to 120

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07118722 on ClinicalTrials.gov

17. Prospective Assessment of Integrative Therapies for Neuromusculoskeletal Pain (PAIN)

    With vast numbers of active-duty members restricted from their specific duties or deemed unfit for deployment because of low back pain, both the mission of the Department of Defense and overall military workflow can be significantly impacted. More than restriction from duty or being barred from dep…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mike O'Callaghan Military Medical Center, Nellis Air Force Base, Nevada

    Run by

    David Moss

    See if you can join NCT07094282 on ClinicalTrials.gov

18. Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

    To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Yale New Haven Health Old Saybrook Medical Center, Old Saybrook, Connecticut

    Run by

    Yale University

    See if you can join NCT07639060 on ClinicalTrials.gov

19. From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects

    This is a multicenter prospective study of patients who currently have stably implanted spinal cord simulators. Patients will be randomly assigned to turn on or off their spinal cord stimulators for two week intervals up to six weeks after enrollment, and on the final day of study participation, fo…

    Stage

    Phase 2

    Ages

    18 to 80

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT05661903 on ClinicalTrials.gov

20. VETERANS AFFAIRS AUGUSTA

    Chronic pain is a prevalent and debilitating condition among Veterans, often accompanied by depression, anxiety, sleep disturbances, and social isolation. Despite the availability of behavioral interventions many Veterans-particularly those with high in-person healthcare utilization-face barriers t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Augusta Health Care System, Augusta, Georgia

    Run by

    Companion IQ, Inc

    See if you can join NCT07776600 on ClinicalTrials.gov

21. Video Intervention for Older Adults With Chronic Pain

    Chronic musculoskeletal (MSK) pain, which includes spinal pain, osteoarthritis, and fibromyalgia, is a common and costly problem for older adults and is associated with decreased quality of life. In this project, investigators propose to create Reclaim Your Day (RYD), which will consist of 6, 30-mi…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Butler Hospital, Providence, Rhode Island

    Run by

    Butler Hospital

    See if you can join NCT07404618 on ClinicalTrials.gov

22. Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome

    The purpose of this study is to assess the effects of tDCS in combination with TUS for the treatment of pain in subjects with Carpal Tunnel Syndrome. The investigators hypothesize that there will be a decrease in pain levels with active stimulation, when compared to sham stimulation.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Spaulding Rehabilitation Network Research Institute, Charlestown, Massachusetts

    Run by

    Spaulding Rehabilitation Hospital

    See if you can join NCT04206215 on ClinicalTrials.gov

23. Pain Management Teams Using Whole Health to Optimize Function and Safety in Veterans: The TEAMWORK Trial

    The focus of this study is to determine whether adding Whole Health Coaching (WHC) improves pain care among adults with chronic pain and who are currently working with a pain management team (PMT) at the VA.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama

    Locations

    5 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT07149870 on ClinicalTrials.gov

24. Pain and Major Depressive Disorder

    This study will examine the effects of brain stimulation on pain symptoms associated with Major depressive disorder. This study will enroll 54 Subjects. Study subjects will be asked to complete surveys about their mood and well-being, 2 blood draws, 2 MRIs, 3 electroencephalograms, and receive 30 t…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    UCLA Semel Institute, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT04556890 on ClinicalTrials.gov

25. POP SINGER Randomized Clinical Trial

    Conduct a feasibility randomized controlled trial (N = 130, 65 per group) comparing the POPSINGER music therapy (MT) intervention to yoga.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University Hospitals, Cleveland, Ohio

    Run by

    University Hospitals Cleveland Medical Center

    See if you can join NCT07756541 on ClinicalTrials.gov