Chronic Pain Clinical Trials

124 studies are recruiting for chronic pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Chromatic Retinal Stimulation to Reduce Chronic Pain and Pain Sensitivity

   Participants with chronic pain conditions including chronic low back pain and fibromyalgia may benefit from light stimuli presented to the retina to reduce chronic pain severity and pain sensitivity. Participants will be recruited into this study and will be presented with one of three uniform ligh…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University Of North Carolina, Chapel Hill, North Carolina

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT05956067 on ClinicalTrials.gov

2. Sana Device for Post-Treatment Lyme Disease Syndrome Chronic Pain

   This study will investigate the effectiveness of the Sana Pain Reliever (Sana PR) at reducing chronic pain. The Sana PR is a device comprised of one main component (Mask with Earbuds) and two ancillary components (Charger and Headband). The device is worn over the eyes (with earbuds in ears). The d…

   Stage

   Not phased

   Ages

   18 and older

   Site

   The Cohen Center for Recovery from Complex Chronic Illnesses (CoRE), New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT06655844 on ClinicalTrials.gov

3. Reducing Chronic Pain Following Cesarean Delivery

   This pilot study will evaluate the feasibility and acceptability of delivering Empowered Relief (ER), a single-session pain relief skills class, to postpartum women with ongoing pain and/or pain interference following cesarean delivery. Participants will receive ER in addition to standard postpartu…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Stanford Medicine Children's Health - Specialty Services, Welch Road, Palo Alto, California

   Run by

   Stanford University

   See if you can join NCT07799883 on ClinicalTrials.gov

4. Focused Ultrasound Stimulation for the Treatment of Chronic Pain

   ATTN201 is a non-invasive focused ultrasound neurostimulation device that delivers offline MRI-guided non-invasive focused ultrasound to target brain areas. A cranial MRI is obtained before starting treatment while subjects wear a MR-compatible fiducial laced version of the wearable to co-register …

   Stage

   Not phased

   Ages

   22 to 80

   Site

   Attune Neurosciences, Inc., San Francisco, California

   Locations

   2 in total

   Run by

   Attune Neurosciences Inc

   See if you can join NCT07801443 on ClinicalTrials.gov

5. A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain

   This Phase 2 study will evaluate whether multiple doses of cebranopadol suppress opioid withdrawal signs and symptoms compared with placebo in adults with chronic pain who are physically dependent on prescribed opioids. Participants whose physical dependence is confirmed will be assigned by chance …

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   001127, North Canton, Ohio

   Locations

   2 in total

   Run by

   Adneuris Therapeutics, Inc.

   See if you can join NCT07874620 on ClinicalTrials.gov

6. Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance

   The goal of this clinical trial is to examine the effects of duloxetine on walking ability and physical activity in patients with knee osteoarthritis. Researchers will compare duloxetine to a placebo (a look-alike substance that contains no drug) to see if duloxetine works to improve walking abilit…

   Stage

   Phase 4

   Ages

   45 to 80

   Site

   University of Pittsburgh - Center for Innovation in Pain Care (Research), Pittsburgh, Pennsylvania

   Run by

   Benedict Alter

   See if you can join NCT07759336 on ClinicalTrials.gov

7. Cannabidiol in Opioid Use Disorder and Chronic Pain With Buprenorphine

   This is a randomized, placebo-controlled, crossover human laboratory study investigating the dose-dependent safety and acute effects of Cannabidiol (CBD) on measures of pain and opioid craving in outpatients with opioid use disorder (OUD) receiving medication-assisted treatment with buprenorphine. …

   Stage

   EARLY_Phase 1

   Ages

   18 to 70

   Site

   Department of Veterans Affairs Hospital, West Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT07886606 on ClinicalTrials.gov

8. Overlapping Pain Trajectory Study

   The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1. If spatial and temporal filtering of nociceptive information is disrupted in youth with COP…

   Stage

   Not phased

   Ages

   10 to 19

   Site

   Cincinnati Children's Hospital, Cincinnati, Ohio

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT05752396 on ClinicalTrials.gov

9. Biopsychosocial Risk Influences on the Development and Generation of Early-Onset Chronic Pain

   The purpose of the study is to discover the underlying subtypes of chronic musculoskeletal pain (muscle and joint pain) in youth. Specifically, the researchers are looking for different profiles of brain and immune system signals that affect how the body feels pain, and how these pain profiles are …

   Stage

   Not phased

   Ages

   14 to 26

   Site

   Cincinnati Children's Hospital, Cincinnati, Ohio

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT07602595 on ClinicalTrials.gov

10. Culturally Adapted Pain Management for Indigenous Peoples

    The proposed study involves a randomized feasibility pilot trial of a culturally adapted psychological intervention for chronic pain for American Indian/Alaska Native (AI/AN) individuals receiving care for pain at the Portland Area Indian Health Service - Yakama Service Unit. The study will provide…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Portland Area Indian Health Services - Yakama Service Unit, Yakima, Washington

    Run by

    University of California, San Diego

    See if you can join NCT07524751 on ClinicalTrials.gov

11. EPPIC: Easing Pelvic Pain Interventions Clinical Research Program

    The EPPIC (Easing Pelvic Pain Interventions Clinical Research Program) study evaluates an ultra-brief, 4 session cognitive behavioral pain treatment transdiagnostic in design for urologic chronic pain syndrome (UCPPS) with clinical and practical advantages over existing behavioral therapies whose l…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University at Buffalo (the only clinical site where treatment is delivered), Buffalo, New York

    Locations

    3 in total

    Run by

    State University of New York at Buffalo

    See if you can join NCT05127616 on ClinicalTrials.gov

12. Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control

    Study to evaluate the effectiveness of time variant pulse (TVP)-SCS in patients with chronic pain using commercially approved Boston Scientific SCS Systems per local Instructions for use (IFU). In addition, to compile real-world clinical outcomes in subjects with chronic, intractable low back and/o…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Denver Back Pain Specialists, Greenwood, Colorado

    Locations

    7 in total

    Run by

    Boston Scientific Corporation

    See if you can join NCT07190807 on ClinicalTrials.gov

13. Patient Retrospective Outcomes (PRO)

    This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Lakeside Spine & Pain, Lake Havasu City, Arizona

    Locations

    145 in total

    Run by

    Boston Scientific Corporation

    See if you can join NCT01550575 on ClinicalTrials.gov

14. Tai Chi Intervention for Geriatric Pain Syndrome

    Accumulating evidence supports that more pain, whether measured by number of pain sites or pain severity, is associated with poorer cognitive function and mobility, and fall risk in older persons. Tai Chi which holistically integrates physical and cognitive functions offers the possibility not only…

    Stage

    Not phased

    Ages

    65 and older

    Site

    HELP Study Office and Lab, Boston, Massachusetts

    Run by

    University of Massachusetts, Boston

    See if you can join NCT03705598 on ClinicalTrials.gov

15. Insula Neuromodulation for Chronic Neuropathic Pain

    This study will comprehensively investigate the insula as a brain target for neuromodulation to treat chronic neuropathic pain.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Virginia, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT05404581 on ClinicalTrials.gov

16. Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain

    This protocol aims to test whether an infusion of allogeneic bone marrow-derived mesenchymal stromal cells (BM-MSCs) can reduce pain associated with chronic pancreatitis (CP) and explore potential mechanisms of MSC action.

    Stage

    EARLY_Phase 1

    Ages

    18 to 75

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06205342 on ClinicalTrials.gov

17. Scrambler Therapy in Chronic Pancreatitis

    The investigators will enroll adults with chronic pancreatitis who have persistent abdominal pain not relieved by standard treatments. This study will test the feasibility and effectiveness of Scrambler Therapy, a non-invasive FDA-cleared device that delivers "non-pain" electrical signals through t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins Green Spring Station, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT07174609 on ClinicalTrials.gov

18. Remote Monitoring Using a Digital Platform

    A single site, proof-of-concept prospective behavioral interventional study testing remote monitoring among people living with chronic pain. The study is a single arm study. The duration of the study will be 12-18 months, enrolling 100 and following up to six months post enrollment/ baseline. A con…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Hackensack University Medical Center, Hackensack, New Jersey

    Locations

    2 in total

    Run by

    Hackensack Meridian Health

    See if you can join NCT07837102 on ClinicalTrials.gov

19. Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure

    This project is a single-site, randomized controlled trial designed to investigate the impact of a 7-minute mindfulness intervention on pain among patients undergoing kyphoplasty or radiofrequency ablation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tallahassee Orthopedic Clinic (TOC), Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT06471075 on ClinicalTrials.gov

20. Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial

    The present study seeks to examine the implementation process of culturally tailoring screening and brief intervention for both chronic pain and opioid misuse/opioid use disorder in three American Indian and Alaska Native (AI/AN) serving clinics. The investigators also will assess staff perspective…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Clinic Site A (blinded pending tribal approval), Arcata, California

    Locations

    3 in total

    Run by

    University of New Mexico

    See if you can join NCT06565416 on ClinicalTrials.gov

21. ARPA-H Smart Band-Aid to Measure Chronic Pain in Women

    The goal of this clinical trial is to test whether a minimally invasive microneedle patch, called the A-Band (Smart Band-aid), worn on the arm (monitoring key biomarkers in interstitial fluid) and a commercial smartwatch can accurately correlate with self-reported pain in women with chronic pain. A…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northwestern University Feinberg School of Medicine, Chicago, Illinois

    Locations

    2 in total

    Run by

    Northwestern University

    See if you can join NCT06994988 on ClinicalTrials.gov

22. QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing

    Quantitative Sensory Testing (QST) is a novel investigative technique used in other pain conditions to evaluate patterns of chronic pain, and in this study will be used to elucidate pain patterns in patients with Chronic Pancreatitis (CP). QST uses a specific series of standardized stimulations to …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins Medical Institutions, Baltimore, Maryland

    Locations

    2 in total

    Run by

    Anna Evans Phillips

    See if you can join NCT03434392 on ClinicalTrials.gov

23. Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

    Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable. The proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Indiana University Medical Center, Indianapolis, Indiana

    Locations

    3 in total

    Run by

    University of Pittsburgh

    See if you can join NCT04996628 on ClinicalTrials.gov

24. A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain

    The main purpose of this study is to test the safety and efficacy of study drug for the treatment of chronic low back pain (CLBP). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate the development of new treatments for chronic pain.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Synexus Clinical Research US, Inc., Phoenix, Arizona

    Locations

    37 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07641504 on ClinicalTrials.gov

25. A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

    The main purpose of this study is to test the safety and efficacy of study drug for the treatment of knee pain due to osteoarthritis (OA). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate the development of new treatments for chroni…

    Stage

    Phase 2

    Ages

    40 and older

    Site

    Central Research Associates, Birmingham, Alabama

    Locations

    37 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07641517 on ClinicalTrials.gov