Breast Cancer Clinical Trials

414 studies are recruiting for breast cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 15

1. Personalized Second Chance Breast Conservation (PSCBC): A Prospective Phase II Clinical Study

   The goal of the study is to investigate the feasibility of enabling a second chance for breast conservation in patients with in-breast recurrences after a previous lumpectomy and RT, investigators propose to test partial breast irradiation with the target volume encompassing the entire surgical bed…

   Stage

   Not phased

   Ages

   19 to 90

   Site

   New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York

   Locations

   3 in total

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT04371913 on ClinicalTrials.gov

2. Positron Emission Tomography (PET) Imaging With Zirconium-89 (89Zr)-Trastuzumab for Prediction of HER2 Targeted Therapy Effectiveness

   Our goal is to investigate the use of 89Zr-trastuzumab as a HER2 imaging agent to determine which patients are likely to respond to targeted HER2 agents as single agent therapy. We are proposing to perform a pilot study with goals of demonstrating the feasibility of imaging breast cancer patients w…

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   The Kirklin Clinic, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT03321045 on ClinicalTrials.gov

3. Project SOAR (Speaking Our African American Realities) Awakenings for Black American Women Diagnosed With Breast Cancer

   The goal of this clinical trial is to test an approach to promote well-being in Black American women diagnosed with breast cancer. The main questions it aims to answer are: * Can the Project SOAR (Speaking Our African American Realities) Awakenings online intervention improve depressive symptoms in…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UCLA, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT07208084 on ClinicalTrials.gov

4. [18F] F-GLN by PET/CT in Breast Cancer

   Patients with known or suspected primary or metastatic breast cancer with one lesion that is 1.0 cm in diameter or greater may be eligible for this study. Patients may participate in this study if they are at least 18 years of age. Up to 40 evaluable subjects will participate in a single imaging co…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   Abramson Cancer Center at Penn Medicine

   See if you can join NCT03863457 on ClinicalTrials.gov

5. Investigating the Metabolic Pathways in Hormone Receptor Positive/HER2 Negative Breast Cancer

   To analyze the metabolic activity of Hormone Receptor Positive (HR+)/Her 2 Negative (Her2-) Breast cancer.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

   Locations

   2 in total

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT05736367 on ClinicalTrials.gov

6. Feasibility of Symptom Management for Patients With Metastatic Breast Cancer to Increase Exercise

   This study will examine unmet exercise needs among patients with metastatic breast cancer (MBC) at UNC and assess whether participation in Get Real and Heel (GRH) can increase physical activity. The proposed research aims to improve multiple domains of well-being, quality of life, physical function…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Lineberger Comphrehensive Cancer Center at University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

   Run by

   UNC Lineberger Comprehensive Cancer Center

   See if you can join NCT07313306 on ClinicalTrials.gov

7. Neoadjuvant Therapy and Contrast-enhanced Mammography for Early Stage Breast Cancer

   The purpose of this study is to compare a special type of mammogram that uses a contrast agent called contrast-enhanced digital mammography with contrast-enhanced digital breast tomosynthesis (CEDM+CEDBT), with breast magnetic resonance imaging imaging (MRI) for predicting the effect of neoadjuvant…

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Stony Brook Breast Center, Stony Brook, New York

   Run by

   Alison Stopeck

   See if you can join NCT06220214 on ClinicalTrials.gov

8. Post-operative Radiotherapy Omission in Selected Patients With Early Breast Cancer Trial International VErsion (PROSPECTIVE)

   The PROSPECTIVE trial aims to find out if using the results of Magnetic Resonance Imaging (MRI) for early breast cancer can select people to not have radiotherapy and still have a low chance of the cancer coming back after surgery. The main question it aims to answer is: * Will cancer come back in …

   Stage

   Not phased

   Ages

   50 and older

   Site

   Mater Hospital, Sydney, North Sydney, New South Wales

   Locations

   9 in total

   Run by

   Breast Cancer Trials, Australia and New Zealand

   See if you can join NCT06445738 on ClinicalTrials.gov

9. Sample Collection for Ongoing Research and Product Evaluation Study

   The SCORE study is a prospective, multi-site clinical trial designed to collect blood and tissue samples, along with relevant clinical data, from participants diagnosed with various solid tumors. The collected specimens and information will be used to evaluate the clinical performance of Natera's m…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Natera, Inc., Austin, Texas

   Run by

   Natera, Inc.

   See if you can join NCT07318051 on ClinicalTrials.gov

10. Patient Care Outreach, Navigation, Technology and Support 2.0

    This is a feasibility study employing virtual patient navigation for underserved individuals who speak English, Chinese or Spanish and were diagnosed with breast cancer or cardiovascular disease to determine the extent of usability for a virtual patient navigation portal serving people in underserv…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Zuckerberg San Francisco General Hospital, San Francisco, California

    Locations

    2 in total

    Run by

    University of California, San Francisco

    See if you can join NCT06648278 on ClinicalTrials.gov

11. Gabapentin And Breast Surgery Decision Architecture Randomization Trial (GABS-DART) Protocol

    This study aims to assess whether gabapentin should be a standard component of peri-operative pain control in mastectomy patients at Memorial Sloan Kettering Cancer Center.

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT07308717 on ClinicalTrials.gov

12. Refining Local-Regional Therapy for IBC

    This Feasibility study is trying to determine: * If Lymphoscintigraphy (imaging of the lymphatic drainage patterns) is effective in demonstrating the drainage to the sentinel lymph nodes in patients with inflammatory breast cancer. * The likelihood of identifying the sentinel lymph nodes in the ope…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dana Farber Cancer Institute, Boston, Massachusetts

    Run by

    Dana-Farber Cancer Institute

    See if you can join NCT04636710 on ClinicalTrials.gov

13. THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation

    The study's purpose is to evaluate whether creatine supplementation can help breast cancer survivors respond quicker to exercise by improving strength, endurance, and body composition. We are seeking to compare information collected from healthy woman of the same age who have never had breast cance…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    The University of Texas Medical Branch, Galveston, Galveston, Texas

    Run by

    The University of Texas Medical Branch, Galveston

    See if you can join NCT06395506 on ClinicalTrials.gov

14. BRE-08 Phase II Study of CMC Regimen for Early Stage Breast Cancer

    This is a non-randomized, single arm phase 2 trial of oral CMC based on conversion of doses that would be delivered with conventional metronomic CMF chemotherapy.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Illinois, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT06085742 on ClinicalTrials.gov

15. De-convoluting Interactions Between Genes, the Cancer Environment, and the Immune System to Develop Therapies That Work for You

    This is a live biobank study for breast cancer (BC) patients where samples will be collected at inflection points in the course of the disease.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Brooklyn Methodist Hospital - NewYork Presbyterian, New York, New York

    Locations

    2 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05134779 on ClinicalTrials.gov

16. Navigator-Assisted Hypofractionation (NAVAH) on Radiation Therapy Completion in Breast Cancer and Prostate Cancer

    The purpose of this clinical trial is to evaluate radiation therapy (RT) completion rates among underrepresented cancer populations using qualitative measurements. Additionally, the study aims to assess the impact of patient navigators on supporting patients through their radiation care, as well as…

    Stage

    Not phased

    Ages

    18 and older

    Site

    OU Health Stephenson Cancer Center, Oklahoma City, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT07014618 on ClinicalTrials.gov

17. Definitive Radiation Therapy for Inoperable Breast Cancer

    The purpose of this study is to find out if adding radiation therapy to routine medications for breast cancer helps in reducing and preventing the cancer from getting worse. Patients with a locally advanced breast cancer who cannot, or do not want to, undergo surgery are eligible to participate. Pa…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Stony Brook University Cancer Center, Stony Brook, New York

    Run by

    Alexander Stessin

    See if you can join NCT07122713 on ClinicalTrials.gov

18. Combined Immunotherapies in Metastatic ER+ Breast Cancer

    Women with Hormone Receptor (HR)+ Human Epidermal growth factor Receptor (HER)2- metastatic breast cancer are eligible to a randomized trial. Patients receiving standard first line therapy for metastatic HR+ Breast cancer(BC) (letrozole+palbociclib) are randomly assigned to also receive Stereotacti…

    Stage

    Phase 2

    Ages

    18 to 90

    Site

    Weill Cornell Medicine, New York, New York

    Locations

    3 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT04563507 on ClinicalTrials.gov

19. Trial of Neratinib Plus Capecitabine in Subjects With HER2-Negative Metastatic Breast Cancer With Brain Metastases and Abnormally Active HER2 Signaling

    The purpose of this research is to look at the safety and effectiveness of a HER2-targeted therapy neratinib when given with capecitabine, a chemotherapy, for breast cancer patients with brain metastases whose tumors were HER2-negative by standard tests but showed abnormal HER2 activity based on th…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Rochester, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT04965064 on ClinicalTrials.gov

20. A Study of MT-4561 in Patients With Various Advanced Solid Tumors

    This is a First In Human (FIH), multicenter, open-label, Phase I/II study to evaluate safety, tolerability, Pharmacokinetics (PK), pharmacodynamics, and efficacy of MT-4561 in patients with advanced solid tumors. This study will be conducted in 3 parts. Part 1 is aimed at evaluating safety, tolerab…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Southern California, Los Angeles, California

    Locations

    6 in total

    Run by

    Tanabe Pharma America, Inc.

    See if you can join NCT06943521 on ClinicalTrials.gov

21. 5 vs. 9-day Course of Whole Breast Radiotherapy With Boost for Early-stage Breast Cancer

    The goal of this study is to evaluate 5 days vs. 9 days of whole breast radiation.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT06961955 on ClinicalTrials.gov

22. Sacituzumab Govitecan and Zimberelimab w/SRS in the Management of Metastatic Triple Negative Breast Cancer With Brain Metastases

    This is a Phase I/II Study to determine the safety and efficacy of Sacituzumab Govitecan and Zimberelimab with stereotactic radiation (SRS) in participants with metastatic triple negative breast cancer with brain metastases, compared to treatment with Sacituzumab Govitecan alone.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Moffitt Cancer Center, Tampa, Florida

    Run by

    H. Lee Moffitt Cancer Center and Research Institute

    See if you can join NCT06238921 on ClinicalTrials.gov

23. Prospective Breast Cancer Biospecimen Collection

    Tissue will be procured during a standard of care procedure the patient will already be scheduled to undergo. A one time blood draw will be performed at this time and an optional rectal swab for biome analysis may occur. Follow Up will only consist of chart review to determine date of recurrence, m…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania

    Run by

    Thomas Jefferson University

    See if you can join NCT04074720 on ClinicalTrials.gov

24. SAVE Trial: SAfe Opioid Use Video Education

    The study will assess the efficacy of a standardized postoperative patient-centered intervention designed to educate patients on the opioid epidemic, the judicious use of opioids, and the proper disposal of opioids. This trial is a single-institution, randomized controlled trial comparing total pos…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Utah Huntsman Cancer Institute, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT07044583 on ClinicalTrials.gov

25. BREAST Choice Decision Tool R21 - AIM2

    Breast reconstruction is a critical component of breast cancer treatment because it restores quality of life and body image after mastectomy. However, Spanish-speaking Latina women are significantly less likely to undergo reconstruction (13.5% vs. 41% for non-Latina White or highly acculturated Lat…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of North Carolina, Chapel Hill, North Carolina

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT06817226 on ClinicalTrials.gov