Breast Cancer Clinical Trials

414 studies are recruiting for breast cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 14

1. GammaPod Dose Escalation Radiation for Early Stage Breast Cancer

   The GammaPod machine was made by Xcision Medical Systems and is already FDA cleared to deliver focused radiation within the breast. Unlike current radiation machines, the GammaPod was designed specifically for treating breast cancer. The GammaPod can pinpoint radiation to the tumor bed in the breas…

   Stage

   Not phased

   Ages

   45 and older

   Site

   UMMC, Baltimore, Maryland

   Locations

   4 in total

   Run by

   University of Maryland, Baltimore

   See if you can join NCT04234386 on ClinicalTrials.gov

2. Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

   Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes. This project is translational and has the potential to lead to future translational research opportunities, including interventional trials in which therapeutic escala…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT04354064 on ClinicalTrials.gov

3. A Study of Radiation Therapy With Pembrolizumab and Olaparib or Other Radiosensitizers in Women Who Have Triple-Negative or Hormone-Receptor Positive/Her2 Negative Breast Cancer

   The purpose of this study is to find out whether adding pembrolizumab, with or without olaparib, to standard radiation therapy is a safe and effective treatment for metastatic breast cancer, , and to see whether the study treatment is better than, the same as, or worse than the usual approach (radi…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

   Locations

   7 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT04683679 on ClinicalTrials.gov

4. Pharmacokinetics and Safety of Epidiferphane and Taxanes in Breast Cancer Patients

   Patients with breast cancer are commonly treated with taxane chemotherapy. Some very common side effects of taxanes, such as anemia and peripheral neuropathy, are often as not well addressed during treatment, resulting in dose reductions, dose delays and early discontinuation (collectively called r…

   Stage

   Phase 1

   Ages

   18 to 99

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT05074290 on ClinicalTrials.gov

5. Phase 1/2 Dose Finding, Safety and PK Study in Advanced Refractory Solid Tumors

   This is a multicenter, open-label FIH, Phase 1a (dose escalation), Phase 1b (dose expansion) and Phase 2 study in patients with advanced metastatic solid tumors refractory to standard treatment.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California

   Locations

   7 in total

   Run by

   MBrace Therapeutics

   See if you can join NCT07145255 on ClinicalTrials.gov

6. A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

   Phase 1 dose escalation and expansion study of CLSP-1025, a first-in-class HLA-A*02:01 specific T cell engager (TCE) targeting solid tumors that harbor the p53 R175H mutation.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   HonorHealth Research Institute, Scottsdale, Arizona

   Locations

   21 in total

   Run by

   Clasp Therapeutics, Inc.

   See if you can join NCT06778863 on ClinicalTrials.gov

7. Bortezomib Followed by Pembrolizumab and Cisplatin in metTNBC

   The hypothesis of this pilot trial is that administration of bortezomib will inhibit NHEJ in metastatic TNBC leading at the time of disease progression to metastases that are HR-deficient and sensitive to pembrolizumab and cisplatin therapy. The trial will include in depth analysis of the patients'…

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Baylor University Medical Center, Baylor Charles A Sammons Cancer Center, Dallas, Texas

   Run by

   Baylor Research Institute

   See if you can join NCT04265872 on ClinicalTrials.gov

8. Tirzepatide Weight Loss for MRD+ Early Breast Cancer

   This trial aims to asses if tirzepatide-induced weight loss will lead to metabolic and hormonal changes in hormone receptor-positive (HR+), human epidermal growth factor receptor-negative (HER2-), node-positive (N+) high risk early breast cancer patients with obesity or overweight, inhibiting the g…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Baylor University Medical Center, Baylor Charles A Sammons Cancer Center, Dallas, Texas

   Run by

   Baylor Research Institute

   See if you can join NCT06517212 on ClinicalTrials.gov

9. Evaluating the Use of a Medication 'Switch' vs Guideline-directed Interventions for Relieving Side Effects of Aromatase Inhibitors Among Breast Cancer Patients

   Researchers have learned that about 50% of women do not finish the standard 5-year breast cancer treatment with an aromatase inhibitor. An aromatase inhibitor is hormone therapy that lowers the chance of breast cancer coming back (recurring) after surgery by blocking an enzyme in fat tissue called …

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Dartmouth Cancer Center, Lebanon, New Hampshire

   Run by

   Dartmouth-Hitchcock Medical Center

   See if you can join NCT07071038 on ClinicalTrials.gov

10. Feasibility Study for the SIRA-1000, SIRA® RFA Electrosurgical Device as an Adjunct to Breast Conserving Surgery

    This study aims to assess the safety and clinical accuracy of the SIRA-1000, SIRA® RFA Electrosurgical Device in ablating margins post-lumpectomy in patients undergoing breast conserving surgery for breast cancer. Radiofrequency ablation, or RFA, uses radio waves to create heat, that in turn, cause…

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of Texas Medical Branch at Galveston, TX, Galveston, Texas

    Run by

    Innoblative Designs, Inc.

    See if you can join NCT07206121 on ClinicalTrials.gov

11. Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

    This study is a first in human Phase 1 study that involves patients with a type of cancer called HER2 (Human Epidermal Growth Factor Receptor 2) positive cancer. This study asks patients to volunteer to take part in a research study investigating the safety and efficacy of using special immune cell…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Baylor St. Luke's Medical Center, Houston, Texas

    Run by

    Baylor College of Medicine

    See if you can join NCT03740256 on ClinicalTrials.gov

12. A Study of Revaree Plus in People With Breast Cancer

    The purpose of this study is to find out whether Revaree Plus is effective at improving vaginal health for people who are having symptoms of vaginal dryness during breast cancer treatment.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Basking Ridge (Consent Only), Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT07042581 on ClinicalTrials.gov

13. Improving Care for Rural Patients With Solid Tumors

    This study will assess if the CARES (Cancer Advocacy, Resources, Education and Support) intervention improves time to start of treatment after diagnosis and time to treatment completion for solid tumors (ex: lung, head, neck, thyroid, cervical, breast, bladder, colon, and rectal cancers) in rural p…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    University of Colorado Hospital, Aurora, Colorado

    Locations

    14 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT04916990 on ClinicalTrials.gov

14. CTNNA1 Familial Expansion Study

    The goal of the CAFÉ Study is to determine the cancer risks associated with germline CTNNA1 loss-of-function variants.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT05126290 on ClinicalTrials.gov

15. Exercise to ReGain Stamina and Energy (The EXERGISE Study)

    About 20%-70% of breast cancer survivors experience fatigue after cancer therapy. Because epidemiologic evidence shows that old age is a risk factor for fatigue in adults with cancer history, older breast cancer survivors suffer from even more fatigue than younger survivors. The purpose of this stu…

    Stage

    Not phased

    Ages

    60 to 105

    Site

    Institute on Aging; University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT05684367 on ClinicalTrials.gov

16. Telehealth Exercise Program Evaluating Fatigue and Physical Function in Rural Cancer Survivors

    This study investigates the efficacy of a telehealth exercise program designed specifically for rural cancer survivors with cancer-related fatigue (CRF). Small dried blood samples and measures of physical function will be collected throughout the program. The main questions it aims to answer are: *…

    Stage

    Phase 2

    Ages

    18 to 89

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Locations

    2 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT07001241 on ClinicalTrials.gov

17. The MIND-BC Study: MIND Diet for Breast Cancer Cognition

    This fully, powered efficacy RCT, the MIND diet for Breast Cancer Cognition (MIND-BC), will evaluate the MIND diet in a rigorous, highly controlled academic cancer center. We will recruit breast cancer survivors reporting CRCI with a MIND diet score < 8, based on a previously devised 14-item diet q…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Moffitt Cancer Center, Tampa, Florida

    Run by

    H. Lee Moffitt Cancer Center and Research Institute

    See if you can join NCT07018986 on ClinicalTrials.gov

18. Nutrition Awareness Among Women With Non-Metastatic Breast Cancer

    This study explores perspectives of women with non-metastatic breast cancer regarding their willingness and ability to make dietary changes pertaining to foods/food products that may pose a risk to their cancer prognosis and survival. This is a single-group study conducted entirely online. All stud…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UNC Cancer Hospital, Chapel Hill, North Carolina

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT07389967 on ClinicalTrials.gov

19. EXERT-BCH Exercise Regimen to Improve Muscle Mass After Treatment of Breast Cancer

    The purpose of this research study is to evaluate the outcomes of two standard of care group exercise regimens to increase muscle mass in women who have been treated with breast cancer.

    Stage

    Not phased

    Ages

    20 to 89

    Site

    Allegheny General Hospital, Pittsburgh, Pennsylvania

    Run by

    Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

    See if you can join NCT06115486 on ClinicalTrials.gov

20. Resistance Training and Post Workout Protein to Improve Body Composition During Neoadjuvant Chemotherapy for Breast Cancer

    In this study, the investigators hypothesize that a high dose of post-workout protein nutrition regimen focused on food quality and an observed exercise regimen utilizing high-load resistance training initiated during or after cancer treatment will improve body composition and functional capacity.

    Stage

    Not phased

    Ages

    20 to 89

    Site

    Allegheny General Hospital, Pittsburgh, Pennsylvania

    Run by

    Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

    See if you can join NCT06858449 on ClinicalTrials.gov

21. Efficacy of OneMark Device in Identifying Breast Cancer for Surgery and Surveillance

    The goal of this research is to study a localization device for breast cancer called OneMark. This device will be studied in breast cancer surgery and during surveillance in patients being monitored for breast cancer. The main questions the study aims to answer are: Can surgeons visualize the OneMa…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Diego, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT07087691 on ClinicalTrials.gov

22. Harnessing Analysis RNA Expression and Molecular Subtype to Optimize Novel TherapY MBCA

    The HARMONY trial is an interventional trial enrolling metastatic breast cancer (MBC). Current treatment of breast cancer uses clinical subtype information (e.g. hormone receptor-positive (HR+)) to help guide treatment options. Breast cancer can also be characterized by molecular subtype, but it is…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

    Locations

    2 in total

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT03769415 on ClinicalTrials.gov

23. The Immune System's Response to Young Women's Breast Cancer

    This study plans to learn more about the immune system's response to breast cancer in young women.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Colorado Denver, Aurora, Colorado

    Locations

    5 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT01503190 on ClinicalTrials.gov

24. Converting HR+ Breast Cancer Into an Individualized Vaccine

    Newly diagnosed post-menopausal women with clinical stage II-III, HR+HER2- breast cancer are eligible to a randomized trial, concurrently open at five US academic institutions. Patients receiving 4 months of standard neoadjuvant hormonal therapy with letrozole are randomly assigned to one of 4 arms…

    Stage

    Phase 2

    Ages

    18 to 90

    Site

    New York Presbyterian Hospital - Queens, New York, New York

    Locations

    8 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT03804944 on ClinicalTrials.gov

25. Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors

    The purpose of this study is to determine the effectiveness of a digital health program called AYA STEPS, which is designed to help adolescent and young adult (AYA) cancer survivors manage symptoms and engage in recommended follow-up care.

    Stage

    Not phased

    Ages

    18 to 39

    Site

    Duke Cancer Institute, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06371768 on ClinicalTrials.gov