Breast Cancer Clinical Trials

414 studies are recruiting for breast cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 13

1. Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients

   Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients

   Stage

   Not phased

   Ages

   18 and older

   Site

   Ohio State University Comprehensive Cancer Center, Columbus, Ohio

   Run by

   Ohio State University Comprehensive Cancer Center

   See if you can join NCT04022616 on ClinicalTrials.gov

2. Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

   Incyclix Bio (Incyclix) is developing INX-315 as an oral, small molecule inhibitor of cyclin dependent kinase 2 (CDK2) for the treatment of human cancers. This first-in-human study is designed to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary antitumor activity of INX-315 …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Florida Cancer Specialists, Orlando, Florida

   Locations

   18 in total

   Run by

   Incyclix Bio

   See if you can join NCT05735080 on ClinicalTrials.gov

3. Personalized Dendritic Cell Vaccine Pilot for High Risk TNBC After Neoadjuvant Therapy

   This is a pilot protocol to evaluate the safety, feasibility, and immunogenicity of a personalized breast cancer vaccine based utilizing whole exome sequencing data of a patient's residual breast tumor following neoadjuvant chemotherapy.

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Moffitt Cancer Center, Tampa, Florida

   Run by

   H. Lee Moffitt Cancer Center and Research Institute

   See if you can join NCT06435351 on ClinicalTrials.gov

4. Breast Cancer Implementation Science Study With Educational Intervention

   A study uniquely focused on system-based practice change, measuring the impact of educational interventions on both patients and clinicians for the recognition and management of treatment-related adverse effects for HER2+/HER2 low breast cancer patients on or about to start on HER2 targeted antibod…

   Stage

   Not phased

   Ages

   18 and older

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT06927895 on ClinicalTrials.gov

5. A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

   This is a two-part, open-label, multicenter, dose escalation and dose expansion study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and anti- tumor activity of ETX-19477, a novel reversible small molecule inhibitor of PARG.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Mayo Clinic, Phoenix, Arizona

   Locations

   14 in total

   Run by

   858 Therapeutics, Inc.

   See if you can join NCT06395519 on ClinicalTrials.gov

6. Study of Tucatinib and Doxil in Participants With Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Metastatic Breast Cancer

   This clinical trial is evaluating tucatinib in combination with Doxil in participants with human epidermal growth factor 2 positive (HER2+) locally advanced or metastatic breast cancer. The main goals of this study are to: * Learn how well the combination of tucatinib and Doxil works * Learn more a…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Maryland Oncology Hematology, Columbia, Maryland

   Locations

   8 in total

   Run by

   SCRI Development Innovations, LLC

   See if you can join NCT05748834 on ClinicalTrials.gov

7. Microbiome and Association With Implant Infections

   The most common tissue expander-related infections are from Staphylococcus and Pseudomonas species. In addition, from breast tissue microbiome studies, Staphylococcus and Pseudomonas show variable abundance across samples. The investigator hypothesizes that participants undergoing mastectomy with h…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT05020574 on ClinicalTrials.gov

8. Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

   This phase I trial studies the side effects and best dose of modified immune cells (IL13Ralpha2 CAR T cells) after a chemotherapy conditioning regimen for the treatment of patients with stage IIIC or IV melanoma or solid tumors that have spread to other places in the body (metastatic). The study ag…

   Stage

   Phase 1

   Ages

   18 to 75

   Site

   City of Hope, Duarte, California

   Locations

   3 in total

   Run by

   Anusha Kalbasi

   See if you can join NCT04119024 on ClinicalTrials.gov

9. Feasibility Evaluation of the Muse Magnetic Resonance Guided Focused Ultrasound System

   This is an open-label, single arm, single center, non-randomized feasibility study of the Muse MRgFUS System in subjects with breast cancer. Subjects will undergo partial ablation of half (≤50%) of one of their tumors (if multifocal or multicentric disease) followed by surgical resection per standa…

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Huntsman Cancer Institute at University of Utah, Salt Lake City, Utah

   Run by

   University of Utah

   See if you can join NCT05291507 on ClinicalTrials.gov

10. EXploring Inflammation and Social deTerminants Study in Breast Cancer Patients

    This is a pilot trial to assess how measures of inflammation are correlated with Social Determinants of Health (SDoH) in breast cancer patients. Expected duration of subject participation is one single time point. The patients will fill out questionnaires and provide a plasma sample.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania

    Run by

    Thomas Jefferson University

    See if you can join NCT07478016 on ClinicalTrials.gov

11. PAS 1ml Magtrace® for Sentinel Lymph Node Biopsy in Breast Cancer Patients

    The purpose of this study is to provide prospective evidence in the US population of the frequency of skin discoloration and Sentinel Lymph Node detection rate in patients who have recevied Magtrace for Sentinel Lymph Node Biopsy (SLNB) and to evaluate the impact that skin discoloration has on pati…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UNC, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

    Locations

    2 in total

    Run by

    Endomagnetics Ltd.

    See if you can join NCT06610539 on ClinicalTrials.gov

12. Feasibility Study of CBCT for IGRT in Cancer Patients

    Cone beam computed tomography (CBCT) is an imaging technology that is incorporated into many modern radiation therapy systems. The quality of conventional CBCT is good enough to align patients for their daily radiation therapy but CBCT images have poor contrast and are susceptible to imaging artefa…

    Stage

    Not phased

    Ages

    18 and older

    Site

    James Outpatient Center, Columbus, Ohio

    Locations

    4 in total

    Run by

    Varian, a Siemens Healthineers Company

    See if you can join NCT06681233 on ClinicalTrials.gov

13. Empowering Vulnerable and Resilient Latinas to Obtain Breast Cancer Care

    The investigator and study staff will identify, recruit and randomize Latina participants with elevated genetic and Social Determinants of Heath (SDH) risks. Within 1 week of enrollment, all Latina Aim 1 participants in both study arms will engage in three 30-minute, individual, phone-based session…

    Stage

    Not phased

    Ages

    30 and older

    Site

    University of Illinois, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT05483283 on ClinicalTrials.gov

14. Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients

    Hot flashes present a considerable problem for many breast cancer patients; these symptoms may be intensified by hormonal therapies, such as aromatase inhibitors or tamoxifen. This study examines the value of solifenacin (a muscarinic acetylcholine receptor antagonist) in reducing hot flashes, comp…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas

    Run by

    University of Arkansas

    See if you can join NCT01530373 on ClinicalTrials.gov

15. The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

    The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further technical development of the MR-Linac system with the ultimate purpos…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Allegheny Health Network, Pittsburgh, Pennsylvania

    Locations

    18 in total

    Run by

    UMC Utrecht

    See if you can join NCT04075305 on ClinicalTrials.gov

16. Longitudinal Sexual and Reproductive Health Study of Women With Breast Cancer and Lymphoma

    The purpose of this study is to see how cancer treatment affects sexual and reproductive function. The patient will also be asked to participate in blood draws to see if and how cancer treatment affects the ovaries and the ability to have children (fertility). These blood draws are optional and the…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT01788839 on ClinicalTrials.gov

17. Tart Cherry Juice as a Dietary Supplement for the Prevention of Paclitaxel-Induced Neuropathy

    This is a single institution phase II randomized study evaluating the potential benefits of a supplement, tart cherry juice at high- versus low-doses, to prevent taxane induced peripheral neuropathy in breast and ovarian cancer patients undergoing paclitaxel chemotherapy. Eligible participants enro…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California Davis Comprehensive Cancer Center, Sacramento, California

    Run by

    University of California, Davis

    See if you can join NCT06268665 on ClinicalTrials.gov

18. Reiki Breast Surgery QOL Project for Women Undergoing Breast Surgery

    This pilot study will examine the impact of pre-operative Medical Reiki© on the psychosocial well-being and recovery of underserved women undergoing breast cancer surgery.

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Montefiore Medical Center, The Bronx, New York

    Run by

    Albert Einstein College of Medicine

    See if you can join NCT06524895 on ClinicalTrials.gov

19. Development of Patient Derived Xenografts (PDX) in Patients With Breast Cancer

    Breast cancer patients who undergo neoadjuvant systemic therapy and have residual breast cancer identified at the time of surgery exhibit a high (>50%) risk of future life-threatening recurrences and death.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT04703244 on ClinicalTrials.gov

20. Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

    This is a phase II single-arm, Phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining efficacy of riluzole in preventing cognitive dysfunction in subjects with cancer, who are receiving chemotherapy.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, California

    Run by

    University of California, Irvine

    See if you can join NCT07447050 on ClinicalTrials.gov

21. A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors

    This study is a Phase 1/2, first-in-human, open-label, clinical trial to assess the safety, tolerability, pharmacokinetics and preliminary efficacy of HMBD-501 in patients with advanced-stage, relapsed and/or refractory human epidermal growth factor receptor 3 (HER3)-expressing solid tumors. The st…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Research Site, La Jolla, California

    Locations

    7 in total

    Run by

    Hummingbird Bioscience

    See if you can join NCT06956690 on ClinicalTrials.gov

22. Cryoablation vs Lumpectomy in T1 Breast Cancers

    This trial studies the efficacy and safety of cryoablation in patients with low risk, early stage breast cancer. Cryoablation is a method of killing a tumor by freezing it. The standard approach for patients with this kind of cancer is a lumpectomy. This study will review the safety of the cryoabla…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05505643 on ClinicalTrials.gov

23. FES BPET-DBT in Newly Diagnosed Breast Cancer

    Patients with newly diagnosed primary estrogen-receptor (ER) positive breast cancer, with at least one breast lesion that is 1.0 cm in diameter or greater, may be eligible for this study. Patients may participate in this study if they are at least 18 years of age. Up to 20 evaluable subjects will p…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT05659797 on ClinicalTrials.gov

24. Safe and Explainable AI

    While current AI technology is suitable for automating some repetitive clinical tasks, technical challenges remain in solving critical and gainful problems in the domains of patient and disease management. The proposed research seeks to address issues in medical AI, such as integrating medical know…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT06694181 on ClinicalTrials.gov

25. The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer

    The investigators propose a randomized controlled clinical trial in 250 women with a history of early stage breast cancer who are overweight or obese with insomnia to test whether a brief, cognitive-behavioral intervention for insomnia (CBT-I) prior to behavioral weight loss (CBT-I+BWL) is superior…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Sibley Memorial Hospital, Washington D.C., District of Columbia

    Locations

    4 in total

    Run by

    Johns Hopkins University

    See if you can join NCT05780814 on ClinicalTrials.gov