Breast Cancer Clinical Trials in Pittsburgh, Pennsylvania

25 studies are recruiting for breast cancer in Pittsburgh, Pennsylvania right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

Studies now recruiting

  1. Identifying Patterns in the Breath of Individuals With Breast Cancer

    Researchers will compare the breath profiles of women with breast cancer and those without to determine whether there are disease-specific patterns that can be leveraged to facilitate breast cancer detection. Women with mammogram-confirmed breast tissue density undergoing standard-of-care breast ca…

    Stage
    Not phased
    Ages
    40 to 74
    Site
    Weinstein Imaging Associates, Pittsburgh, Pennsylvania
    Locations
    5 in total
    Run by
    Breathe BioMedical Inc

    See if you can join NCT06512350 on ClinicalTrials.gov

  2. The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

    The Phase 2 monotherapy portion of this study is currently enrolling and will evaluate the efficacy and safety of PC14586 (INN rezatapopt) in participants with locally advanced or metastatic solid tumors harboring a TP53 Y220C mutation. The Phase 1 portion of the study will assess the safety, toler…

    Stage
    Phase 1
    Ages
    12 and older
    Site
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    Locations
    77 in total
    Run by
    PMV Pharmaceuticals, Inc

    See if you can join NCT04585750 on ClinicalTrials.gov

  3. A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

    The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Local Institution - 0014, Pittsburgh, Pennsylvania
    Locations
    65 in total
    Run by
    Bristol-Myers Squibb

    See if you can join NCT06618287 on ClinicalTrials.gov

  4. A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

    This research study is studying a new compound, AZD8205, as a possible treatment for advanced or metastatic solid tumours alone or in combination with anti-cancer agents

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Research Site, Pittsburgh, Pennsylvania
    Locations
    67 in total
    Run by
    AstraZeneca

    See if you can join NCT05123482 on ClinicalTrials.gov

  5. A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

    The purpose of this study is to assess the safety of GDC-4198 alone and in combination with giredestrant and also the efficacy of GDC-4198 + giredestrant versus abemaciclib + giredestrant in participants with locally advanced or metastatic ER+, HER2- breast cancer. The study consists of 2 phases: P…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    UPMC - Hillman Cancer Center, Pittsburgh, Pennsylvania
    Locations
    64 in total
    Run by
    Genentech, Inc.

    See if you can join NCT07100106 on ClinicalTrials.gov

  6. A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

    This study will evaluate the efficacy and safety of the combination of inavolisib plus a cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6i) and letrozole versus placebo plus a CDK4/6i and letrozole in the first-line setting in participants with endocrine-sensitive PIK3CA-mutated hormone receptor-p…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    UPMC Hillman Cancer Center - Magee-Women?s Hospital, Pittsburgh, Pennsylvania
    Locations
    241 in total
    Run by
    Hoffmann-La Roche

    See if you can join NCT06790693 on ClinicalTrials.gov

  7. Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

    This Phase III Trial will determine whether adjuvant chemotherapy (ACT) added to ovarian function suppression (OFS) plus endocrine therapy (ET) is superior to OFS plus ET in improving invasive breast cancer-free survival (IBCFS) among premenopausal, early- stage breast cancer (EBC) patients with es…

    Stage
    Phase 3
    Ages
    18 to 60
    Site
    Allegheny General Hospital, Pittsburgh, Pennsylvania
    Locations
    1261 in total
    Run by
    NRG Oncology

    See if you can join NCT05879926 on ClinicalTrials.gov

  8. A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

    Phase I Study of NT-175, an autologous T cell therapy product genetically engineered to express an HLA-A*02:01-restricted T cell receptor (TCR), targeting TP53 R175H mutant malignancies

    Stage
    Phase 1
    Ages
    18 and older
    Site
    Research Site, Pittsburgh, Pennsylvania
    Locations
    23 in total
    Run by
    AstraZeneca

    See if you can join NCT05877599 on ClinicalTrials.gov

  9. A Phase 1 Study of LNCB74 in Advanced Solid Tumors

    This is an open-label, phase 1, dose escalation and dose expansion study to determine safety and tolerability, and to determine the maximum tolerated dose and / or recommended phase 2 dose of LNCB74 in participants with advanced solid tumors.

    Stage
    Phase 1
    Ages
    18 and older
    Site
    UPMC, Pittsburgh, Pennsylvania
    Locations
    14 in total
    Run by
    NextCure, Inc.

    See if you can join NCT06774963 on ClinicalTrials.gov

  10. ATEMPT 2.0: Adjuvant T-DM1 vs TH

    This research study is studying how well newly diagnosed breast cancer that has tested positive for a protein called HER2 responds using one of two different combination of HER2-directed therapies as a treatment after surgery. The name of the study drugs involved are: * Trastuzumab-emtansine (T-DM1…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    University of Pittsburgh Medical Center Cancer UPMC- Magee Women's Hospital, Pittsburgh, Pennsylvania
    Locations
    53 in total
    Run by
    Dana-Farber Cancer Institute

    See if you can join NCT04893109 on ClinicalTrials.gov

  11. Biennial CEM in Women With a Personal History of Breast Cancer

    This is a prospective clinical trial that will examine if biennial contrast-enhanced mammography added to annual 3D mammography (tomosynthesis) substantially improves breast cancer detection with minimal increase in false-positives, in women with a personal history of breast cancer.

    Stage
    Not phased
    Ages
    30 to 79
    Site
    Magee-Womens Hospital, Pittsburgh, Pennsylvania
    Locations
    6 in total
    Run by
    Wendie Berg

    See if you can join NCT06105749 on ClinicalTrials.gov

  12. EXERT-BC Cardio: Cardio or Conditioning Training With Breast Cancer

    In this study, the investigators hypothesize that observed intense resistance training with conditioning elicits similar changes in body composition, muscle mass, and blood pressure as that with cardiovascular training (or cardio) for women treated with breast cancer.

    Stage
    Not phased
    Ages
    20 to 89
    Site
    AHN Allegheny General Hospital, Pittsburgh, Pennsylvania
    Run by
    Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

    See if you can join NCT07739563 on ClinicalTrials.gov

  13. Distance-Based Exercise to Preserve Function and Prevent Disability

    This clinical trial studies whether an exercise program can be successfully delivered to patients receiving treatment for cancer through virtual sessions and allow patients to exercise in their own home. Treatments for cancer can cause side effects such as fatigue and loss of strength. These side e…

    Stage
    Not phased
    Ages
    18 and older
    Site
    UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
    Locations
    18 in total
    Run by
    Alliance for Clinical Trials in Oncology

    See if you can join NCT07059884 on ClinicalTrials.gov

  14. E-Mindfulness Approaches for Living After Breast Cancer

    NRG-CC015 is a prospective, randomized phase III clinical trial to evaluate the efficacy of two distinct digital approaches for delivering a mindfulness-based intervention: a live, instructor-led version delivered over Zoom (MAPs LO), and an app-based, self-paced version (MAPs App). Participants wi…

    Stage
    Phase 3
    Ages
    18 to 50
    Site
    UPMC-Magee Womens Hospital, Pittsburgh, Pennsylvania
    Locations
    383 in total
    Run by
    NRG Oncology

    See if you can join NCT06748222 on ClinicalTrials.gov

  15. TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients

    This research is being done to assess whether an exercise intervention with protein intake support vs a health education and support program will make it easier for women age 65 or older who are receiving chemotherapy for breast cancer to receive all of their planned chemotherapy according to sched…

    Stage
    Not phased
    Ages
    65 and older
    Site
    University of Pittsburgh, Pittsburgh, Pennsylvania
    Locations
    4 in total
    Run by
    Dana-Farber Cancer Institute

    See if you can join NCT05535192 on ClinicalTrials.gov

  16. Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

    A Phase 1 Open-Label, First-in-human, Dose Escalation and Expansion Study to Determine the Safety, Tolerability, Dosimetry, Pharmacokinetics, and Preliminary Efficacy of 212Pb-DOTAM-GRPR1 in Adult Participants with Recurrent or Metastatic GRPR-expressing Tumors

    Stage
    Phase 1
    Ages
    18 and older
    Site
    University of Pittsburg Medical Center (UPCM), Pittsburgh, Pennsylvania
    Locations
    8 in total
    Run by
    Orano Med Theranostics, SAS

    See if you can join NCT05283330 on ClinicalTrials.gov

  17. Proteomics and Radiomics Research of Breast Cancer Markers in Tissue, Interstitial Fluid and Serum

    The current study is a case control study involving comparisons of tissue interstitial fluid from breast cancer and adjacent non-cancerous tissue as well as that from benign breast lesion and its adjacent non-diseased tissue for a distinguishable breast cancer profile. The purpose of this research …

    Stage
    Not phased
    Ages
    18 and older
    Site
    UPMC St. Margaret, Pittsburgh, Pennsylvania
    Run by
    University of Pittsburgh

    See if you can join NCT01042548 on ClinicalTrials.gov

  18. I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

    The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic res…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    University Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    Locations
    42 in total
    Run by
    QuantumLeap Healthcare Collaborative

    See if you can join NCT01042379 on ClinicalTrials.gov

  19. The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

    The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further technical development of the MR-Linac system with the ultimate purpos…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Allegheny Health Network, Pittsburgh, Pennsylvania
    Locations
    18 in total
    Run by
    UMC Utrecht

    See if you can join NCT04075305 on ClinicalTrials.gov

  20. EXERT-BCH Exercise Regimen to Improve Muscle Mass After Treatment of Breast Cancer

    The purpose of this research study is to evaluate the outcomes of two standard of care group exercise regimens to increase muscle mass in women who have been treated with breast cancer.

    Stage
    Not phased
    Ages
    20 to 89
    Site
    Allegheny General Hospital, Pittsburgh, Pennsylvania
    Run by
    Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

    See if you can join NCT06115486 on ClinicalTrials.gov

  21. Prospective Study of EXErcise Regimens After Treatment for Breast Cancer for Hypertrophy and Conditioning

    This study investigates the impact of four standard of care, monitored group exercise regimens (resistance training) on conditioning and hypertrophy in women previously treated for breast cancer. The study will compare two conditioning regimens (6-12-25 and 8x8) and two hypertrophy regimens (5/5/5 …

    Stage
    Not phased
    Ages
    20 to 89
    Site
    Allegheny General Hospital, Pittsburgh, Pennsylvania
    Run by
    Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

    See if you can join NCT07023887 on ClinicalTrials.gov

  22. Resistance Training and Post Workout Protein to Improve Body Composition During Neoadjuvant Chemotherapy for Breast Cancer

    In this study, the investigators hypothesize that a high dose of post-workout protein nutrition regimen focused on food quality and an observed exercise regimen utilizing high-load resistance training initiated during or after cancer treatment will improve body composition and functional capacity.

    Stage
    Not phased
    Ages
    20 to 89
    Site
    Allegheny General Hospital, Pittsburgh, Pennsylvania
    Run by
    Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

    See if you can join NCT06858449 on ClinicalTrials.gov

  23. Converting HR+ Breast Cancer Into an Individualized Vaccine

    Newly diagnosed post-menopausal women with clinical stage II-III, HR+HER2- breast cancer are eligible to a randomized trial, concurrently open at five US academic institutions. Patients receiving 4 months of standard neoadjuvant hormonal therapy with letrozole are randomly assigned to one of 4 arms…

    Stage
    Phase 2
    Ages
    18 to 90
    Site
    UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
    Locations
    8 in total
    Run by
    Weill Medical College of Cornell University

    See if you can join NCT03804944 on ClinicalTrials.gov

  24. EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

    The EXActDNA-003 study will prospectively enroll participants who are planning to undergo chemotherapy for high-risk, early breast cancer, who are willing to provide tissue and blood specimens for circulating tumor DNA (ctDNA) analysis. Participants will be followed for up to 5.5 years.

    Stage
    Not phased
    Ages
    18 and older
    Site
    UPMC Magee - Womens Hospital, Pittsburgh, Pennsylvania
    Locations
    58 in total
    Run by
    Exact Sciences Corporation

    See if you can join NCT06401421 on ClinicalTrials.gov

  25. MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

    The FLEX Registry will be implemented to operate as a large-scale, population based, prospective registry. All patients with stage I to III breast cancer who receive MammaPrint® and BluePrint testing on a primary breast tumor are eligible for entry into the FLEX Registry, which is intended to enabl…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Allegheny Health Network, Pittsburgh, Pennsylvania
    Locations
    134 in total
    Run by
    Agendia

    See if you can join NCT03053193 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.