Breast Cancer Clinical Trials

414 studies are recruiting for breast cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 12

1. Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial

   This research is to evaluate the effectiveness of Talazoparib as a potential treatment for metastatic breast cancer with a BRCA 1 or BRCA 2 mutation.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   UCSF Medical Center-Mission Bay/Benioff Children's Hospital, San Francisco, California

   Locations

   7 in total

   Run by

   Massachusetts General Hospital

   See if you can join NCT03990896 on ClinicalTrials.gov

2. IMPACT Trial: Intervention to iMProve AdherenCe Equitably

   To determine the efficacy of a multicomponent adherence intervention among participants with early-stage breast cancer on endocrine therapy and at least one oral cardiovascular disease (CVD) medication on adherence to endocrine therapy and to CVD medication at 24 weeks assessed by self-report using…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Columbia University Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT05496829 on ClinicalTrials.gov

3. Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

   This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise program (MEM+EX) in addressing cancer-related cognitive impairment (CRCI) and underlying CRCI biomar…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill, North Carolina

   Run by

   UNC Lineberger Comprehensive Cancer Center

   See if you can join NCT06727773 on ClinicalTrials.gov

4. Trial of Neoadjuvant THP vs TCHP for HER2-Amplified/Positive Breast Cancer

   This is a randomized phase II study to evaluate the pathological complete response (pCR) rate with two neoadjuvant regimens (Docetaxel+Carboplatin+Herceptin/Perjeta and Docetaxel+Herceptin/Perjeta) in HER2 amplified/positive early breast cancer.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   The University of Kansas Cancer Center (KUCC), Fairway, Kansas

   Locations

   8 in total

   Run by

   University of Kansas Medical Center

   See if you can join NCT07220135 on ClinicalTrials.gov

5. Window Study of Intratumoral Mitazalimab in Breast Cancer (WINIT-BC)

   The goal of this clinical trial is to study the safety, feasibility, histologic and immunological effects of Mitazalimab, a CD40 agonistic antibody, when administered either alone or in combination with PD-1 inhibition prior to surgical resection. The investigator hypothesizes that preoperative adm…

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   Jennifer Zhang

   See if you can join NCT07319195 on ClinicalTrials.gov

6. Randomized Feasibility Trial for Mesh in Pre-Pectoral Reconstruction

   Surgical mesh products, particularly acellular dermal matrices (ADM), are now used by the majority of plastic surgeons to assist with the nearly 100,000 prosthetic breast reconstruction procedures in the United States, despite never being approved by Food and Drug Administration (FDA) for this indi…

   Stage

   Not phased

   Ages

   22 to 75

   Site

   University of California Los Angeles, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT05190978 on ClinicalTrials.gov

7. Axelopran for Advanced Cancer in Patients Receiving Opioids

   The primary objective of this single arm, open label, phase II trial is to determine if axelopran use impacts cancer control in patients with advanced cancers of the lung, breast, pancreas, and prostate. The primary study period for assessing the primary aim is through day 43 (6 weeks). The main qu…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   HealthPartners Frauenshuh Cancer Research Center, Saint Louis Park, Minnesota

   Locations

   2 in total

   Run by

   HealthPartners Institute

   See if you can join NCT07354919 on ClinicalTrials.gov

8. Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

   The purpose of this study is to determine if a combination of two drugs sacituzumab govitecan and atezolizumab works as a treatment for residual cancer in the breast or lymph nodes and have circulating tumor DNA in the blood. This research study involves the following investigational drugs: * Sacit…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of California San Francisco, San Francisco, California

   Locations

   7 in total

   Run by

   Dana-Farber Cancer Institute

   See if you can join NCT04434040 on ClinicalTrials.gov

9. Feasibility and Acceptibility of a Multi-site Trial of Time Restircted Eating During Chemotheraply for Breast Cancer.

   This study is being done to better understand how time restricted eating (eating all food in an 8 hour window) can help a person receiving chemotherapy treatment for breast cancer, stages I-IV. The aim is to find out if time restricted is feasible and acceptable to individuals starting chemotherapy…

   Stage

   Not phased

   Ages

   25 to 99

   Site

   Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois

   Locations

   2 in total

   Run by

   University of Illinois at Chicago

   See if you can join NCT07387445 on ClinicalTrials.gov

10. VS-6766+Abema+Fulv in Met HR+/HER- BC

    This research is being done to evaluate the safety and effectiveness of a drug currently known as VS-6766 in combination with the drugs abemaciclib and fulvestrant in HR+/HER2-negative breast cancer. The names of the study drugs involved in this study are: * VS-6766 * Abemaciclib * Fulvestrant

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Adrienne G. Waks

    See if you can join NCT05608252 on ClinicalTrials.gov

11. Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

    This research study involves testing the safety and efficacy of an investigational intervention for patients with triple-negative breast cancer (TNBC) that has spread, or metastasized, to other parts the body and is PD-L1-negative. The names of the study interventions involved in this study are: * …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Stamford Hospital, Stamford, Connecticut

    Locations

    15 in total

    Run by

    Dana-Farber Cancer Institute

    See if you can join NCT04468061 on ClinicalTrials.gov

12. Exercise in Metastatic Breast Cancer: EMBody

    The purpose of this study is to study exercise in a novel population with indolent MBC (no progression on current therapy in prior 12 months and not receiving cytotoxic chemotherapy). The study team hypothesizes that delivering virtual, supervised, progressive intensity aerobic and resistance train…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Indiana University Melvin & Bren Simon Cancer Center, Indianapolis, Indiana

    Locations

    6 in total

    Run by

    Indiana University

    See if you can join NCT05468034 on ClinicalTrials.gov

13. Preoperative Chemotherapy, Pembrolizumab and Low or High Dose RADiation in an Expansion Cohort of Node(+), Triple Negative Breast Cancer

    This is a prospective radiation dose-finding, phase 2 expansion study of the Triple Negative (TN) cohort of the multicenter randomized study P-RAD (A Randomized Study of Preoperative Chemotherapy, Pembrolizumab and No, Low or High Dose RADiation in Node-Positive, HER2-Negative Breast Cancer; NCT044…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of North Carolina, Chapel Hill, North Carolina

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT07276880 on ClinicalTrials.gov

14. A Pilot Trial of "Just ASK™" to Increase Discussions About Breast Cancer Clinical Trials

    The goal of this study is to conduct a pilot stepped-wedge cluster randomized controlled trial (RCT) of the "Just ASK™" training and implementation to increase provider discussions of cancer clinical trials (CCTs) with patients with breast cancer. The main research questions the study aims to answe…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Princeton Medical Center, Plainsboro, New Jersey

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT07040891 on ClinicalTrials.gov

15. PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease

    This is a Phase II, interventional, prospective, single-arm, multi-center study that will enroll patients with stage II/III triple negative breast cancer (TNBC) who have residual cancer burden (RCB) II/III after conventional neoadjuvant chemo-immunotherapy followed by surgery. Technological advance…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT07069595 on ClinicalTrials.gov

16. Individualizing Approaches to Surveillance Mammography in Older Breast Cancer Survivors - The I-MAMMO Study

    This study evaluates the effectiveness of a Shared Decision-Making (SDM) toolkit designed to support older breast cancer survivors aged 80 and above in making informed decisions about continuing surveillance mammography.

    Stage

    Phase 2

    Ages

    80 and older

    Site

    Dana-Farber Cancer Institute, Boston, Massachusetts

    Run by

    Dana-Farber Cancer Institute

    See if you can join NCT07123649 on ClinicalTrials.gov

17. Novel Body Composition Measurements in Association With Outcomes of Breast Reconstruction Reconstruction

    This study compares measurements of body composition to outcomes of breast reconstruction.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07546331 on ClinicalTrials.gov

18. Reinvigorating TNBC Response to Immunotherapy With Combination Myeloid Inhibition and Radiation

    This is an open-label prospective, single institution, Phase II study of pembrolizumab in combination with radiation therapy and CSF-1R inhibition in patients with high-risk TNBC. The primary objective is to assess the pathologic complete response (pCR) rate where pCR is defined as the absence of i…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Stephen Shiao

    See if you can join NCT05491226 on ClinicalTrials.gov

19. Quantitative MRI Assessment of Breast Cancer Therapy Response

    The goal of this observational study is to investigate and validate multi-parametric magnetic resonance imaging (MRI) modalities for assessment of breast cancer response to neoadjuvant chemotherapy in a multi-site and multi-MRI scanner platform setting. This study is conducted at Oregon Health \& S…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Iowa, Iowa City, Iowa

    Locations

    4 in total

    Run by

    Corewell Health East

    See if you can join NCT05704062 on ClinicalTrials.gov

20. Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer

    This is an open label multicenter, Phase IB/II Study of Abemaciclib in Combination with Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer

    Stage

    Phase 1

    Ages

    18 to 90

    Site

    Mount Sinai Beth Israel, New York, New York

    Locations

    3 in total

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT05095207 on ClinicalTrials.gov

21. Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors

    The goal of this clinical research trial is to study the use of differing investigational doses and scheduling for Proton Therapy for tumors previously treated with radiation therapy. Generally, when patients are first treated for cancer with radiation therapy, they are treated with traditional pho…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The New York Proton Center, New York, New York

    Run by

    The New York Proton Center

    See if you can join NCT05313191 on ClinicalTrials.gov

22. NeoTAILOR: ABiomarker-directed Approach to Guide Neoadjuvant Therapy for Patients With Stage II/III ER-positive, HER2-negative Breast Cancer

    This study aims to utilize a novel biomarker-driven approach to guide neoadjuvant treatment selection. It is the hypothesis that this will improve clinical response for postmenopausal women with clinical stage II/III ER-positive, HER2-negative breast cancer and identify those who may not require ne…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05837455 on ClinicalTrials.gov

23. Artificial Intelligence and Machine Learning to Guide CDK4/6 Inhibitor Rechallenge in Breast Cancer.

    The goal of this clinical trial is to learn if an artificial intelligence model will be able to select patients with advanced breast cancer who may respond to a second cyclin-dependent kinase 4/6 (CDK4/6) inhibitor after they have progressed on the first CDK4/6 inhibitor. Patients for this study ne…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California, San Diego, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT07227233 on ClinicalTrials.gov

24. SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers

    Investigators aim to conduct a type 1 hybrid effectiveness-implementation surgeon-level cluster randomized clinical trial (RCT) of a multi-level intervention, a shared decision making training for surgeons plus patient decision aid vs. usual care (UC), at 7 large health systems across the U.S. to l…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Locations

    11 in total

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06896474 on ClinicalTrials.gov

25. Phase I Study of SYS6043 in Patients With Advanced/Metastatic Solid Tumors

    The goal of this clinical trial is to learn if investigational drug called SYS6043 works in adults with advanced or metastatic solid tumors that have spread or cannot be treated with standard therapies. The main goals of the study are to understand how safe SYS6043 is, what side effects it may caus…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    BRCR Global, Plantation, Florida

    Locations

    5 in total

    Run by

    Conjupro Biotherapeutics, Inc.

    See if you can join NCT07424547 on ClinicalTrials.gov