Breast Cancer Clinical Trials

415 studies are recruiting for breast cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 11

1. A Pilot Trial of "Just ASK™" to Increase Discussions About Breast Cancer Clinical Trials

   The goal of this study is to conduct a pilot stepped-wedge cluster randomized controlled trial (RCT) of the "Just ASK™" training and implementation to increase provider discussions of cancer clinical trials (CCTs) with patients with breast cancer. The main research questions the study aims to answe…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Princeton Medical Center, Plainsboro, New Jersey

   Run by

   Abramson Cancer Center at Penn Medicine

   See if you can join NCT07040891 on ClinicalTrials.gov

2. PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease

   This is a Phase II, interventional, prospective, single-arm, multi-center study that will enroll patients with stage II/III triple negative breast cancer (TNBC) who have residual cancer burden (RCB) II/III after conventional neoadjuvant chemo-immunotherapy followed by surgery. Technological advance…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

   Run by

   UNC Lineberger Comprehensive Cancer Center

   See if you can join NCT07069595 on ClinicalTrials.gov

3. Individualizing Approaches to Surveillance Mammography in Older Breast Cancer Survivors - The I-MAMMO Study

   This study evaluates the effectiveness of a Shared Decision-Making (SDM) toolkit designed to support older breast cancer survivors aged 80 and above in making informed decisions about continuing surveillance mammography.

   Stage

   Phase 2

   Ages

   80 and older

   Site

   Dana-Farber Cancer Institute, Boston, Massachusetts

   Run by

   Dana-Farber Cancer Institute

   See if you can join NCT07123649 on ClinicalTrials.gov

4. Novel Body Composition Measurements in Association With Outcomes of Breast Reconstruction Reconstruction

   This study compares measurements of body composition to outcomes of breast reconstruction.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT07546331 on ClinicalTrials.gov

5. Reinvigorating TNBC Response to Immunotherapy With Combination Myeloid Inhibition and Radiation

   This is an open-label prospective, single institution, Phase II study of pembrolizumab in combination with radiation therapy and CSF-1R inhibition in patients with high-risk TNBC. The primary objective is to assess the pathologic complete response (pCR) rate where pCR is defined as the absence of i…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Cedars-Sinai Medical Center, Los Angeles, California

   Run by

   Stephen Shiao

   See if you can join NCT05491226 on ClinicalTrials.gov

6. Quantitative MRI Assessment of Breast Cancer Therapy Response

   The goal of this observational study is to investigate and validate multi-parametric magnetic resonance imaging (MRI) modalities for assessment of breast cancer response to neoadjuvant chemotherapy in a multi-site and multi-MRI scanner platform setting. This study is conducted at Oregon Health \& S…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Iowa, Iowa City, Iowa

   Locations

   4 in total

   Run by

   Corewell Health East

   See if you can join NCT05704062 on ClinicalTrials.gov

7. ARTIDIS Nanomechanical Generated Measurements for Early Breast Lesions

   This prospective, blinded, single-arm study aims to test the performance of nanomechanical phenotype in predicting tumor type, tumor aggressiveness, and neoadjuvant treatment response compared to the gold standard of histopathological assessment. The study involves patients with suspicious breast l…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Texas Southwestern Medical Center, Dallas, Texas

   Locations

   5 in total

   Run by

   ARTIDIS AG

   See if you can join NCT06085833 on ClinicalTrials.gov

8. Factors Associated With Breast Cancer Risks and Outcomes

   The purpose of this study is to learn more about risks and outcomes of breast cancer in people with different backgrounds. Tissue and blood will be collected from participants for research purposes. Participants will complete questionnaires during their standard medical care. The study will not pro…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Cancer Center Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

   Locations

   7 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT07294703 on ClinicalTrials.gov

9. Comparative Performance of Molecular Breast Imaging (MBI) to Magnetic Resonance Imaging (MRI) of the Breast in Identifying and Excluding Breast Carcinoma in Women at High Risk for Breast Cancer

   To evaluate the diagnostic performance of Tc99m sestamibi (MBI) compared to breast MRI in women who are at high risk for developing breast cancer. To assess the relationship of tumor size, histologic subtype and location of lesion and how it affects lesion conspicuity and sensitivity in MBI detecte…

   Stage

   Not phased

   Ages

   18 and older

   Site

   M D Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT05042687 on ClinicalTrials.gov

10. Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer

    This is an open label multicenter, Phase IB/II Study of Abemaciclib in Combination with Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer

    Stage

    Phase 1

    Ages

    18 to 90

    Site

    Mount Sinai Beth Israel, New York, New York

    Locations

    3 in total

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT05095207 on ClinicalTrials.gov

11. Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors

    The goal of this clinical research trial is to study the use of differing investigational doses and scheduling for Proton Therapy for tumors previously treated with radiation therapy. Generally, when patients are first treated for cancer with radiation therapy, they are treated with traditional pho…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The New York Proton Center, New York, New York

    Run by

    The New York Proton Center

    See if you can join NCT05313191 on ClinicalTrials.gov

12. NeoTAILOR: ABiomarker-directed Approach to Guide Neoadjuvant Therapy for Patients With Stage II/III ER-positive, HER2-negative Breast Cancer

    This study aims to utilize a novel biomarker-driven approach to guide neoadjuvant treatment selection. It is the hypothesis that this will improve clinical response for postmenopausal women with clinical stage II/III ER-positive, HER2-negative breast cancer and identify those who may not require ne…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05837455 on ClinicalTrials.gov

13. Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

    This clinical trial will assess the safety and early efficacy of Hydroxychloroquine or Avelumab, with or without Palbociclib, in early-stage ER+ breast cancer patients who are found to harbor disseminated tumor cells (DTCs) in the bone marrow after definitive surgery and standard adjuvant therapy.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Georgetown University, Washington D.C., District of Columbia

    Locations

    7 in total

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT04841148 on ClinicalTrials.gov

14. Artificial Intelligence and Machine Learning to Guide CDK4/6 Inhibitor Rechallenge in Breast Cancer.

    The goal of this clinical trial is to learn if an artificial intelligence model will be able to select patients with advanced breast cancer who may respond to a second cyclin-dependent kinase 4/6 (CDK4/6) inhibitor after they have progressed on the first CDK4/6 inhibitor. Patients for this study ne…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California, San Diego, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT07227233 on ClinicalTrials.gov

15. SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers

    Investigators aim to conduct a type 1 hybrid effectiveness-implementation surgeon-level cluster randomized clinical trial (RCT) of a multi-level intervention, a shared decision making training for surgeons plus patient decision aid vs. usual care (UC), at 7 large health systems across the U.S. to l…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Locations

    11 in total

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06896474 on ClinicalTrials.gov

16. Phase I Study of SYS6043 in Patients With Advanced/Metastatic Solid Tumors

    The goal of this clinical trial is to learn if investigational drug called SYS6043 works in adults with advanced or metastatic solid tumors that have spread or cannot be treated with standard therapies. The main goals of the study are to understand how safe SYS6043 is, what side effects it may caus…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    BRCR Global, Plantation, Florida

    Locations

    5 in total

    Run by

    Conjupro Biotherapeutics, Inc.

    See if you can join NCT07424547 on ClinicalTrials.gov

17. Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients

    Myeloid-Derived Suppressor Cell Function in Breast Cancer Patients

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ohio State University Comprehensive Cancer Center, Columbus, Ohio

    Run by

    Ohio State University Comprehensive Cancer Center

    See if you can join NCT04022616 on ClinicalTrials.gov

18. Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

    Incyclix Bio (Incyclix) is developing INX-315 as an oral, small molecule inhibitor of cyclin dependent kinase 2 (CDK2) for the treatment of human cancers. This first-in-human study is designed to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary antitumor activity of INX-315 …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Florida Cancer Specialists, Orlando, Florida

    Locations

    18 in total

    Run by

    Incyclix Bio

    See if you can join NCT05735080 on ClinicalTrials.gov

19. Personalized Dendritic Cell Vaccine Pilot for High Risk TNBC After Neoadjuvant Therapy

    This is a pilot protocol to evaluate the safety, feasibility, and immunogenicity of a personalized breast cancer vaccine based utilizing whole exome sequencing data of a patient's residual breast tumor following neoadjuvant chemotherapy.

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Moffitt Cancer Center, Tampa, Florida

    Run by

    H. Lee Moffitt Cancer Center and Research Institute

    See if you can join NCT06435351 on ClinicalTrials.gov

20. Breast Cancer Implementation Science Study With Educational Intervention

    A study uniquely focused on system-based practice change, measuring the impact of educational interventions on both patients and clinicians for the recognition and management of treatment-related adverse effects for HER2+/HER2 low breast cancer patients on or about to start on HER2 targeted antibod…

    Stage

    Not phased

    Ages

    18 and older

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06927895 on ClinicalTrials.gov

21. Avera Cancer Sequencing and Analytics Protocol (ASAP)

    The purpose of this study is to characterize the breadth of molecular features present in participants receiving care within a large, integrated, community-based healthcare system. Through comprehensive genomic profiling, investigators aim to identify the underlying genomic drivers of premalignant …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Avera Cancer Institute - Marshall, Marshall, Minnesota

    Locations

    6 in total

    Run by

    Avera McKennan Hospital & University Health Center

    See if you can join NCT05142033 on ClinicalTrials.gov

22. A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

    This is a two-part, open-label, multicenter, dose escalation and dose expansion study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and anti- tumor activity of ETX-19477, a novel reversible small molecule inhibitor of PARG.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Mayo Clinic, Phoenix, Arizona

    Locations

    14 in total

    Run by

    858 Therapeutics, Inc.

    See if you can join NCT06395519 on ClinicalTrials.gov

23. Safety and Feasibility of Robotic SP Nipple Sparing Mastectomy

    This is a single arm, single-center, prospective clinical trial designed to track the peri, post-operative and oncologic outcomes when utilizing the da-Vinci single port (SP) robotic platform to perform robotic nipple sparing mastectomy (rNSM) and immediate breast reconstruction with tissue expande…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    UT Southwestern, Dallas, Texas

    Run by

    Deborah Farr, MD

    See if you can join NCT05245812 on ClinicalTrials.gov

24. Study of Tucatinib and Doxil in Participants With Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Metastatic Breast Cancer

    This clinical trial is evaluating tucatinib in combination with Doxil in participants with human epidermal growth factor 2 positive (HER2+) locally advanced or metastatic breast cancer. The main goals of this study are to: * Learn how well the combination of tucatinib and Doxil works * Learn more a…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Maryland Oncology Hematology, Columbia, Maryland

    Locations

    8 in total

    Run by

    SCRI Development Innovations, LLC

    See if you can join NCT05748834 on ClinicalTrials.gov

25. Microbiome and Association With Implant Infections

    The most common tissue expander-related infections are from Staphylococcus and Pseudomonas species. In addition, from breast tissue microbiome studies, Staphylococcus and Pseudomonas show variable abundance across samples. The investigator hypothesizes that participants undergoing mastectomy with h…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT05020574 on ClinicalTrials.gov