Breast Cancer Clinical Trials

415 studies are recruiting for breast cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 10

1. Core Biopsies for Establishing a Breast Tumor Tissue Repository

   This research trial establishes a breast tumor tissue repository from core biopsies. Collecting breast tissue from core biopsies may allow doctors to learn more about the biology of breast cancer and to analyze proteins, genes, and other components of tumor cells. It may also allow doctors to condu…

   Stage

   Not phased

   Ages

   18 and older

   Site

   USC Norris Comprehensive Cancer Center, Los Angeles, California

   Run by

   University of Southern California

   See if you can join NCT02250352 on ClinicalTrials.gov

2. Brodalumab in the Treatment of Immune-Related Adverse Events

   The purpose of this study is to test the safety and effectiveness of using brodalumab in patients who develop side effects from cancer immune therapy. Immune-related side effects are due to activation of the immune system in patients who previously received immunotherapy and the goal of this study …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Brian Henick, MD

   See if you can join NCT06673329 on ClinicalTrials.gov

3. Global Cardio Oncology Registry

   G-COR is the first Global Prospective Cardio-Oncology Registry. It is a multinational, multicenter prospective observational cohort registry, with the goal of collecting clinical, laboratory, imaging, demographic, and socioeconomic data to identify risk factors associated with increased incidence o…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cleveland Clinic Florida, Weston, Florida

   Run by

   The Cleveland Clinic

   See if you can join NCT05598879 on ClinicalTrials.gov

4. A Study of Language Interpretation Solutions for People With Breast Cancer

   The study will be conducted in 2 overlapping phases. In Phase 1, there will be a 3-arm randomized controlled trial of Remote Simultaneous Medical Interpreting/RSMI (Arm 1), versus Remote Consecutive Medical Interpreting/RCMI (Arm 2) and versus Remote Consecutive Video Medical Interpreting/RCVI (Arm…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Basking Ridge (Consent Only), Basking Ridge, New Jersey

   Locations

   8 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT06721065 on ClinicalTrials.gov

5. IKS014 in Advanced Solid Tumors That Express HER2

   This study will evaluate the recommended dose for further clinical development, safety, tolerability, anti-tumor activity, immunogenicity, pharmacokinetics and pharmacodynamics of IKS014, a HER2 targeting antibody-drug conjugate, in patients with advanced solid tumors.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Hoag Memorial Hospital Presbyterian, Newport Beach, California

   Locations

   13 in total

   Run by

   Iksuda Therapeutics Ltd.

   See if you can join NCT05872295 on ClinicalTrials.gov

6. Impact of Ketogenic Diet on Tumor Microenvironment in Patients With Breast Cancer

   This study is testing the effects of a ketogenic diet on patients with early stage breast cancer. Participants will keep to a ketogenic diet for 3 weeks prior to surgery.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mays Cancer Center, UT Health San Antonio, San Antonio, Texas

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT07574671 on ClinicalTrials.gov

7. Proteomics and Radiomics Research of Breast Cancer Markers in Tissue, Interstitial Fluid and Serum

   The current study is a case control study involving comparisons of tissue interstitial fluid from breast cancer and adjacent non-cancerous tissue as well as that from benign breast lesion and its adjacent non-diseased tissue for a distinguishable breast cancer profile. The purpose of this research …

   Stage

   Not phased

   Ages

   18 and older

   Site

   UPMC St. Margaret, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT01042548 on ClinicalTrials.gov

8. Lymphedema Surveillance Study

   This study is being done to find out how many women develop lymphedema after an axillary lymph node dissection. The investigators also want to look for reasons why some women get lymphedema and others don't. Specifically, the investigators want to do tests on the breast tissue that is removed at th…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Basking Ridge (Consent only), Basking Ridge, New Jersey

   Locations

   7 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT02743858 on ClinicalTrials.gov

9. COOL-IT-PRO: Cryoablation of Breast Cancer in Non-surgical Patients

   This is a subject registry study of patients who undergo cryoablation for their breast cancer after being determined not to be surgical candidates. Data collected as part of this registry will be used to assess the safety of percutaneous ultrasound-guided cryoablation in this population as well as …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT05972343 on ClinicalTrials.gov

10. I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

    The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic res…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    42 in total

    Run by

    QuantumLeap Healthcare Collaborative

    See if you can join NCT01042379 on ClinicalTrials.gov

11. Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial

    This research is to evaluate the effectiveness of Talazoparib as a potential treatment for metastatic breast cancer with a BRCA 1 or BRCA 2 mutation.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    UCSF Medical Center-Mission Bay/Benioff Children's Hospital, San Francisco, California

    Locations

    7 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT03990896 on ClinicalTrials.gov

12. IMPACT Trial: Intervention to iMProve AdherenCe Equitably

    To determine the efficacy of a multicomponent adherence intervention among participants with early-stage breast cancer on endocrine therapy and at least one oral cardiovascular disease (CVD) medication on adherence to endocrine therapy and to CVD medication at 24 weeks assessed by self-report using…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Columbia University Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT05496829 on ClinicalTrials.gov

13. Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

    This study is designed to characterize the safety, tolerability, and anti-tumor activity of MDX2001 in patients with advanced solid tumors.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Sarah Cannon Research Institute, Denver, Colorado

    Locations

    6 in total

    Run by

    ModeX Therapeutics, An OPKO Health Company

    See if you can join NCT06239194 on ClinicalTrials.gov

14. Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

    This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise program (MEM+EX) in addressing cancer-related cognitive impairment (CRCI) and underlying CRCI biomar…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill, North Carolina

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT06727773 on ClinicalTrials.gov

15. A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

    The purpose of this study is to learn about the safety and effects of the study medicine PF-07248144 when given along with fulvestrant for the possible treatment of HR-positive, HER2-negative advanced or metastatic breast cancer. HR-positive breast cancer cells have proteins on their surface called…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Ironwood Cancer & Research Centers, Chandler, Arizona

    Locations

    202 in total

    Run by

    Pfizer

    See if you can join NCT07062965 on ClinicalTrials.gov

16. Trial of Neoadjuvant THP vs TCHP for HER2-Amplified/Positive Breast Cancer

    This is a randomized phase II study to evaluate the pathological complete response (pCR) rate with two neoadjuvant regimens (Docetaxel+Carboplatin+Herceptin/Perjeta and Docetaxel+Herceptin/Perjeta) in HER2 amplified/positive early breast cancer.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    The University of Kansas Cancer Center (KUCC), Fairway, Kansas

    Locations

    8 in total

    Run by

    University of Kansas Medical Center

    See if you can join NCT07220135 on ClinicalTrials.gov

17. Window Study of Intratumoral Mitazalimab in Breast Cancer (WINIT-BC)

    The goal of this clinical trial is to study the safety, feasibility, histologic and immunological effects of Mitazalimab, a CD40 agonistic antibody, when administered either alone or in combination with PD-1 inhibition prior to surgical resection. The investigator hypothesizes that preoperative adm…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Jennifer Zhang

    See if you can join NCT07319195 on ClinicalTrials.gov

18. Randomized Feasibility Trial for Mesh in Pre-Pectoral Reconstruction

    Surgical mesh products, particularly acellular dermal matrices (ADM), are now used by the majority of plastic surgeons to assist with the nearly 100,000 prosthetic breast reconstruction procedures in the United States, despite never being approved by Food and Drug Administration (FDA) for this indi…

    Stage

    Not phased

    Ages

    22 to 75

    Site

    University of California Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT05190978 on ClinicalTrials.gov

19. Axelopran for Advanced Cancer in Patients Receiving Opioids

    The primary objective of this single arm, open label, phase II trial is to determine if axelopran use impacts cancer control in patients with advanced cancers of the lung, breast, pancreas, and prostate. The primary study period for assessing the primary aim is through day 43 (6 weeks). The main qu…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    HealthPartners Frauenshuh Cancer Research Center, Saint Louis Park, Minnesota

    Locations

    2 in total

    Run by

    HealthPartners Institute

    See if you can join NCT07354919 on ClinicalTrials.gov

20. Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

    The purpose of this study is to determine if a combination of two drugs sacituzumab govitecan and atezolizumab works as a treatment for residual cancer in the breast or lymph nodes and have circulating tumor DNA in the blood. This research study involves the following investigational drugs: * Sacit…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California San Francisco, San Francisco, California

    Locations

    7 in total

    Run by

    Dana-Farber Cancer Institute

    See if you can join NCT04434040 on ClinicalTrials.gov

21. Feasibility and Acceptibility of a Multi-site Trial of Time Restircted Eating During Chemotheraply for Breast Cancer.

    This study is being done to better understand how time restricted eating (eating all food in an 8 hour window) can help a person receiving chemotherapy treatment for breast cancer, stages I-IV. The aim is to find out if time restricted is feasible and acceptable to individuals starting chemotherapy…

    Stage

    Not phased

    Ages

    25 to 99

    Site

    Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois

    Locations

    2 in total

    Run by

    University of Illinois at Chicago

    See if you can join NCT07387445 on ClinicalTrials.gov

22. VS-6766+Abema+Fulv in Met HR+/HER- BC

    This research is being done to evaluate the safety and effectiveness of a drug currently known as VS-6766 in combination with the drugs abemaciclib and fulvestrant in HR+/HER2-negative breast cancer. The names of the study drugs involved in this study are: * VS-6766 * Abemaciclib * Fulvestrant

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Adrienne G. Waks

    See if you can join NCT05608252 on ClinicalTrials.gov

23. Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

    This research study involves testing the safety and efficacy of an investigational intervention for patients with triple-negative breast cancer (TNBC) that has spread, or metastasized, to other parts the body and is PD-L1-negative. The names of the study interventions involved in this study are: * …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Stamford Hospital, Stamford, Connecticut

    Locations

    15 in total

    Run by

    Dana-Farber Cancer Institute

    See if you can join NCT04468061 on ClinicalTrials.gov

24. Exercise in Metastatic Breast Cancer: EMBody

    The purpose of this study is to study exercise in a novel population with indolent MBC (no progression on current therapy in prior 12 months and not receiving cytotoxic chemotherapy). The study team hypothesizes that delivering virtual, supervised, progressive intensity aerobic and resistance train…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Indiana University Melvin & Bren Simon Cancer Center, Indianapolis, Indiana

    Locations

    6 in total

    Run by

    Indiana University

    See if you can join NCT05468034 on ClinicalTrials.gov

25. Preoperative Chemotherapy, Pembrolizumab and Low or High Dose RADiation in an Expansion Cohort of Node(+), Triple Negative Breast Cancer

    This is a prospective radiation dose-finding, phase 2 expansion study of the Triple Negative (TN) cohort of the multicenter randomized study P-RAD (A Randomized Study of Preoperative Chemotherapy, Pembrolizumab and No, Low or High Dose RADiation in Node-Positive, HER2-Negative Breast Cancer; NCT044…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of North Carolina, Chapel Hill, North Carolina

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT07276880 on ClinicalTrials.gov