Alzheimer Disease Clinical Trials

135 studies are recruiting for alzheimer disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. Cognitive Neurology Unit Clinical Registry

   A Prospective Comparative Study Of Monoclonal Antibodies For The Treatment Of Alzheimer's Disease

   Stage

   Not phased

   Ages

   50 to 95

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Run by

   Beth Israel Deaconess Medical Center

   See if you can join NCT05925621 on ClinicalTrials.gov

2. Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol

   The goal of this clinical trial is to evaluate an investigational ultralow dose Positron Emission Tomography (PET) imaging technique for Alzheimer's disease, mild cognitive impairment, other forms of dementia detection and monitoring. The main question it aims to answer is: Can the investigators op…

   Stage

   Phase 2

   Ages

   18 to 120

   Site

   Nuclear Imaging Institute, Englewood, New Jersey

   Run by

   Akiva Mintz

   See if you can join NCT07012993 on ClinicalTrials.gov

3. Tau Networks in Psychotic Alzheimer's Disease

   This research project aims to understand the brain mechanisms behind the manifestation of psychotic symptoms in Alzheimer´s disease (AD), and nature of the unique relationship with tau pathology. Amongst the cognitive manifestations of psychosis are impairments related to frontal circuits (social c…

   Stage

   Not phased

   Ages

   65 to 85

   Site

   The Feinstein Institutes for Medical Research, Manhasset, New York

   Run by

   Northwell Health

   See if you can join NCT05847192 on ClinicalTrials.gov

4. Selective PET Imaging of Astrocytes and Microglia in Alzheimer's Disease

   Inflammation occurs in many brain diseases including Alzheimer's disease. In Alzheimer's disease, an abnormal protein called amyloid starts accumulating decades before the start of forgetfulness. However, scientists have reported that inflammation but not amyloid is linked to forgetfulness and the …

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Houston Methodist Research Institute, Houston, Texas

   Run by

   The Methodist Hospital Research Institute

   See if you can join NCT05582200 on ClinicalTrials.gov

5. Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy

   Alzheimer's disease (AD) is characterized by significant memory loss, toxic protein deposits amyloid and tau) in the brain, and changes in the gamma frequency band on EEG. The investigator's lab found that boosting gamma waves in AD mouse models using light and sound stimulation at 40Hz not only re…

   Stage

   Not phased

   Ages

   65 to 100

   Site

   Massachusetts Institute of Technology, Cambridge, Massachusetts

   Run by

   Massachusetts Institute of Technology

   See if you can join NCT05655195 on ClinicalTrials.gov

6. Connect-Home: Alzheimer's Disease and Related Dementias

   This study is a parallel arm, cluster randomized trial (CRT) to test the efficacy of Connect-Home ADRD, a transitional care intervention focusing on Skilled Nursing Facility (SNF) patients with Alzheimer's disease and dementias and their caregivers during transitions from SNFs to home, assisted, li…

   Stage

   Not phased

   Ages

   19 and older

   Site

   University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT06840587 on ClinicalTrials.gov

7. Early-Stage Partner in Care Living Alone Plus

   EPICLA+ (Early-Stage Partners in Care Living Alone Plus) is a research project designed to assist people with early-stage memory loss who live alone in the community by providing early-stage related education and skill-training sessions, held via Zoom, designed to reduce stress, enhance well-being,…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Arizona State University, Phoenix, Arizona

   Run by

   Arizona State University

   See if you can join NCT06962111 on ClinicalTrials.gov

8. Brain Effects of Gamma Frequency Sensory Stimulation (40Hz Light, Sound and Other Devices)

   Despite the huge healthcare and economic impact of AD, there is still no disease modifying therapeutics available. In fact, the available therapeutics show low efficacy at best in the treatment of cognitive impairment in dementia. Development of a non-invasive medical device that is effective in sl…

   Stage

   Phase 2

   Ages

   18 to 100

   Site

   MIT, Cambridge, Massachusetts

   Run by

   Massachusetts Institute of Technology

   See if you can join NCT07496918 on ClinicalTrials.gov

9. Brain Outcomes With Lifestyle Change in Down Syndrome

   The goal of this study is to determine if weight loss or changes in dietary intake can help prevent of delay adults with Down syndrome from developing Alzheimer's Disease Adults with Down syndrome without dementia will be randomized to either a weight loss group or a general health education contro…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   University of Kansas Medical Center, Kansas City, Kansas

   Run by

   University of Kansas Medical Center

   See if you can join NCT05985486 on ClinicalTrials.gov

10. Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's

    The goal of this clinical trial is to test the effectiveness of a computerized anxiety sensitivity treatment (CAST) compared to a health education control (HEC) in older adults with mild cognitive impairment (MCI) or mild Alzheimer's Disease and related dementias (ADRD) and their care partners. The…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Anxiety and Behavioral Health Clinic, Tallahassee, Florida

    Locations

    3 in total

    Run by

    Florida State University

    See if you can join NCT05748613 on ClinicalTrials.gov

11. Nicotinic Acid for the Treatment of Alzheimer's Disease

    Increased dietary intake of niacin is correlated with reduced risk of Alzheimer's Disease and age-associated cognitive decline. The goal of this study is to collect data on the penetration of commercially available, FDA approved, extended-release niacin into the spinal fluid. One dose of 500 mg nic…

    Stage

    Phase 1

    Ages

    60 to 85

    Site

    IU Health Neuroscience Center, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT06582706 on ClinicalTrials.gov

12. Repurposing Siponimod for Alzheimer's Disease

    Collaboration with multiple sclerosis (MS) specialty colleagues led us to formulate the central hypothesis that Siponimod could lower the rate of brain atrophy in Alzheimer's disease (AD) subjects. To test our central hypothesis, we will carry out an 18-month Phase II, double-blind, randomized, two…

    Stage

    Phase 2

    Ages

    50 to 85

    Site

    St. Joseph's Hospital and Medical Center, Phoenix, Arizona

    Run by

    St. Joseph's Hospital and Medical Center, Phoenix

    See if you can join NCT06639282 on ClinicalTrials.gov

13. Exercise to Improve Brain Health in Older African Americans

    The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans. Specifically, the main question[s] it aims to answer are: * What is the effect of a Cardio-Dance Fitness (CDF) vs. a Strength, Flexibility, and Bala…

    Stage

    Phase 2

    Ages

    60 and older

    Site

    Rutgers, The State University of New Jersey - Newark campus, Newark, New Jersey

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT05597124 on ClinicalTrials.gov

14. Comparing Structured Retrieval Practice and Reading-Based Education for Dementia Caregivers

    Caring for a person living with dementia can be stressful, and many family caregivers report limited access to effective educational resources for managing dementia-related behaviors and caregiver stress. This study will evaluate a learning-based educational intervention called structured retrieval…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Virginia Wesleyan University, Virginia Beach, Virginia

    Run by

    Virginia Wesleyan University

    See if you can join NCT07413406 on ClinicalTrials.gov

15. Evaluating the Efficacy of the Pain Identification and Communication Toolkit

    This study will evaluate the Pain Identification and Communication Toolkit (PICT), a multicomponent intervention for caregivers of people with Alzheimer's disease and related dementias (ADRD). PICT provides training in observational pain assessment and coaching in effective pain communication techn…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT06168604 on ClinicalTrials.gov

16. Advancing Alzheimer's Care: Home-based tDCS for Affective Symptoms

    Participants will be asked to participate in this research study of a device that creates transcranial direct current stimulation (tDCS). The researchers hope to learn if 30 minute sessions of transcranial direct current stimulation (tDCS) improve such a mood or feelings in people with Alzheimer's …

    Stage

    Not phased

    Ages

    60 to 85

    Site

    University of Texas Health Science Center at San Antonio, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT06801639 on ClinicalTrials.gov

17. ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults

    This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults with mild cognitive impairment and APOE4 genotype. By targeting the e…

    Stage

    Phase 2

    Ages

    60 and older

    Site

    Rutgers - Institute for Health, New Brunswick, New Jersey

    Run by

    Michal Schnaider Beeri, Ph.D.

    See if you can join NCT07392723 on ClinicalTrials.gov

18. Tennessee Alzheimer's Project

    The primary objective of the Vanderbilt Alzheimer's Disease Research Center (VADRC) is to provide local and national researchers with access to a well-characterized and diverse clinical cohort, including participant referrals, biosamples, clinical data, and neuroimaging data. The VADRC Clinical Cor…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05372172 on ClinicalTrials.gov

19. Perturbation Training Reduces Falls in People With Alzheimer's Disease (AD)

    This study will examine the overall capacity of people with Alzheimer's disease learning fall-resistant skills from perturbation training.

    Stage

    Not phased

    Ages

    65 to 90

    Site

    Reminiscent, Valdosta, Georgia

    Run by

    Georgia State University

    See if you can join NCT05205980 on ClinicalTrials.gov

20. A Study of Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer's Disease

    The purpose of this research study is to investigate how the brain, memory, thinking, and motor behavior change both in individuals with movement and/or cognitive disorders, as well as healthy individuals. Researchers will look at measurements of memory, thinking, brain wave and muscle activity, da…

    Stage

    Not phased

    Ages

    50 to 95

    Site

    Mayo Clinic Arizona, Scottsdale, Arizona

    Run by

    Mayo Clinic

    See if you can join NCT06057909 on ClinicalTrials.gov

21. Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease

    The goal of this clinical trial is to learn about how genetics and the response to stress predicts cognitive decline in individuals with mild cognitive impairment. The main question[s] it aims to answer are: * Does the hormone response to acute stress predict the degree of cognitive impairment foll…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05795634 on ClinicalTrials.gov

22. A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK

    This study will assess if drug (NIO752) reduces production of a protein, tau, by the brain. Normally tau maintains the internal skeleton of nerve cells. In Alzheimer's disease (AD) it builds up in the brain, causing damage. Abnormal tau proteins cling to each other forming 'tangles' inside nerve ce…

    Stage

    Phase 1

    Ages

    21 to 80

    Site

    Washington University in St. Louis, St Louis, Missouri

    Locations

    2 in total

    Run by

    University College, London

    See if you can join NCT06372821 on ClinicalTrials.gov

23. Biomarker Exploration in Aging, Cognition and Neurodegeneration

    The purpose of this research study is to understand the factors that underlie changes in thinking and memory with increasing age. The investigators will test the usefulness of MRI, PET, and cognitive testing in detecting subtle changes in the brain that precede cognitive decline. An addendum to thi…

    Stage

    Phase 3

    Ages

    60 and older

    Site

    University of California, Irvine, Irvine, California

    Run by

    University of California, Irvine

    See if you can join NCT03860857 on ClinicalTrials.gov

24. Bumetanide in Patients With Alzheimer's Disease

    This study aims to investigate bumetanide in patients with biologically confirmed Alzheimer's disease (AD). Bumetanide is a potent diuretic administered orally and is FDA approved for the treatment of edema and hypertension. Repurposing bumetanide as a medication for AD has been proposed based on d…

    Stage

    Phase 2

    Ages

    50 to 85

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT06052163 on ClinicalTrials.gov

25. Vestibular Therapy in Alzheimer's Disease

    Nearly 2 out of 3 patients with Alzheimer's disease (AD) experience problems with balance and mobility, which places such patients at increased risk of falling. The vestibular (inner ear balance) system plays an important role in balance stability, and vestibular therapy (VT) is well-known to impro…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Johns Hopkins University School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT03799991 on ClinicalTrials.gov