Alzheimer Disease Clinical Trials

135 studies are recruiting for alzheimer disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Beta Amyloid PET Imaging for Alzheimer Disease With [18F]-Fluselenamyl

   The purpose of this research study is to determine the safety of a radiotracer 18F-Fluselenamyl using positron emission tomography (PET) imaging.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT06439992 on ClinicalTrials.gov

2. F 18 T807 Tau PET Imaging of Alzheimer's Disease

   A single-center, open-label baseline controlled imaging study designed to assess whether brain tau fibril uptake of flortaucipir as measured by PET correlates with cognitive status of individuals with and without brain tau fibrils.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Tammie L. S. Benzinger, MD, PhD

   See if you can join NCT02414347 on ClinicalTrials.gov

3. Neuroimaging in Healthy Aging and Senile Dementia (HASD_IND)

   To identify factors that signal the transition from asymptomatic (preclinical) to symptomatic Alzheimer disease (AD).

   Stage

   Not phased

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Tammie L. S. Benzinger, MD, PhD

   See if you can join NCT04579120 on ClinicalTrials.gov

4. Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

   This early phase, open label, single arm clinical trial will determine the intraindividual safety, tolerability and effects of NPC1 (parthenolide and ipriflavone) on blood-based biomarkers of Alzheimer's disease (AD) pathology among adults with subjective cognitive decline, mild cognitive impairmen…

   Stage

   Phase 2

   Ages

   55 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07236190 on ClinicalTrials.gov

5. A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)

   The main purpose of this study is to evaluate the safety and tolerability of the study drug known as LY4006895. Part A will administer a single-ascending dose in healthy participants or Part B will administer multiple-ascending doses in participants with early symptomatic Alzheimer's Disease (AD). …

   Stage

   Phase 1

   Ages

   45 to 85

   Site

   Collaborative Neuroscience Network - CNS, Los Alamitos, California

   Locations

   13 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT06657768 on ClinicalTrials.gov

6. Human Mesenchymal Stem Cells (hMSC) in Behavioral Problems Due to Alzheimer's Disease.

   The purpose of this research study is to test if adding one infusion of mesenchymal stem cells to the current treatment with antipsychotic medication may help control behavioral problems in people with a diagnosis of moderate to severe Alzheimer's disease.

   Stage

   Phase 2

   Ages

   55 to 90

   Site

   University of Miami Department of Neurology, Miami, Florida

   Run by

   Bernard (Barry) Baumel

   See if you can join NCT06781333 on ClinicalTrials.gov

7. TREAD: Time Restricted Eating Intervention for Alzheimer's Disease

   The goal of this clinical trial is to learn if restricting the time of eating to allow for prolonged fasting at night may reduce sleep disturbances, cognitive decay, and pathology in patients diagnosed with Mild Cognitive Impairment (MCI) or early to moderate Alzheimer's disease (AD). It will also …

   Stage

   Phase 1

   Ages

   60 and older

   Site

   Shiley Marcos Alzheimer's Disease Center, San Diego, California

   Run by

   University of California, San Diego

   See if you can join NCT06548191 on ClinicalTrials.gov

8. [18F]PI-2620 Phase 3 Histopathological Study

   This study is an open-label, multi-center, non-randomized pivotal Phase 3 study to assess the efficacy and safety of PET imaging with [18F]PI-2620 for detection of tau deposition in subjects with Alzheimer's disease (AD) and controls during lifetime when compared to histopathology obtained after de…

   Stage

   Phase 3

   Ages

   50 and older

   Site

   Barrow Neurological Institute, Phoenix, Arizona

   Locations

   25 in total

   Run by

   Lantheus Biosciences Ltd.

   See if you can join NCT05641688 on ClinicalTrials.gov

9. Clinical Trial on Agitation in Alzheimer's Dementia

   The purpose of this study is to assess the efficacy of the oral medication IGC-AD1, a THC-based (Delta-9-Tetrahydrocannabinol) formulation administered twice a day on Agitation in patients with mild to severe dementia from Alzheimer's.

   Stage

   Phase 2

   Ages

   60 and older

   Site

   ClinCloud, LLC, Melbourne, Florida

   Locations

   31 in total

   Run by

   IGC Pharma, LLC

   See if you can join NCT05543681 on ClinicalTrials.gov

10. Trial-Ready Cohort-Down Syndrome (TRC-DS)

    The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 550 participants in total including co-enrolled in the Alzheimer Biomarkers Consortium - Down Syndrome (ABC-D…

    Stage

    Not phased

    Ages

    25 to 55

    Site

    Barrow Neurological Institute, Phoenix, Arizona

    Locations

    22 in total

    Run by

    University of Southern California

    See if you can join NCT04165109 on ClinicalTrials.gov

11. Late Onset Alzheimer's Disease

    The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to…

    Stage

    Not phased

    Ages

    55 and older

    Site

    University of Washington, Washington D.C., District of Columbia

    Locations

    12 in total

    Run by

    Columbia University

    See if you can join NCT05010603 on ClinicalTrials.gov

12. Tele-Savvy for Latino Caregivers

    Latino caregivers of individuals with Alzheimer's disease and related dementias experience high levels of stress burden and depressive symptoms and are underrepresented in caregiver intervention research. Tele Savvy is an evidence based caregiver education program that focuses on developing caregiv…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rochester School of Nursing, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT07290387 on ClinicalTrials.gov

13. Cardiac-Control Affecting Learning Through Mindfulness (CALM)

    Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily mindfulness practice with heart rate biofeedbac…

    Stage

    Not phased

    Ages

    50 to 70

    Site

    University of Southern California, Los Angeles, California

    Run by

    University of Southern California

    See if you can join NCT06410157 on ClinicalTrials.gov

14. Alzheimer"s Imaging Biomarkers in Obesity

    High body fat at midlife, as evidenced by overweight or obese body mass index (BMI), is increasingly understood as a risk factor for Alzheimer's disease. However, the underlying processes and mechanisms that may underlie this risk remains unknown. With this project, the Investigator proposes to cre…

    Stage

    Not phased

    Ages

    40 to 60

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Cyrus A Raji

    See if you can join NCT05077579 on ClinicalTrials.gov

15. Swallowing Impairments in Adults With and Without Alzheimer's Disease

    This research study is investigating whether people with Alzheimer's disease (AD) experience more changes to swallowing than their healthy age-matched peers. The prevalence of swallowing impairments in moderate-severe AD is high (85-93%), yet little is known about how swallow function evolves throu…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT06678100 on ClinicalTrials.gov

16. Novel Brain Stimulation Treatment for Neuropsychiatric Symptoms in Alzheimer's Disease

    The goal of this pilot study is to test a combination of two non-invasive brain stimulation methods, called iTBS (intermittent theta burst stimulation) and tDCS (transcranial direct current stimulation), in people with Alzheimer's Disease (AD) and related dementias (ADRD). This study will also expl…

    Stage

    Not phased

    Ages

    65 to 85

    Site

    Michael E. DeBakey VA Medical Center, Houston, Texas

    Run by

    Baylor College of Medicine

    See if you can join NCT06835283 on ClinicalTrials.gov

17. Aβ Dynamics in LLMD

    This study will examine the biological factors that may modulate the relationship between depression and the development of Alzheimer's disease (AD). Since the direction of causation between depression and the biological factors associated with AD is unknown, the only way to understand cause and as…

    Stage

    Phase 4

    Ages

    60 and older

    Site

    NYU Langone Health, New York, New York

    Locations

    2 in total

    Run by

    NYU Langone Health

    See if you can join NCT05004987 on ClinicalTrials.gov

18. Music Therapy for Patients With Alzheimer's Disease

    This study is designed to assess the feasibility that individualized reminiscence-based virtual music therapy sessions can enhance autobiographical memory, mood, and cognition in patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD). 60 patients with MCI or …

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05151562 on ClinicalTrials.gov

19. Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

    In this research study we want to learn more about the effects of non-invasive brain stimulation on memory and brain-network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation c…

    Stage

    EARLY_Phase 1

    Ages

    40 to 99

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06538311 on ClinicalTrials.gov

20. A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses

    The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitne…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Arizona State University, Phoenix, Arizona

    Run by

    Arizona State University

    See if you can join NCT05877196 on ClinicalTrials.gov

21. Phase II Trial to Evaluate Safety and Efficacy of GM-CSF/Sargramostim in Alzheimer's Disease

    A medicine that is FDA-approved for bone marrow stimulation (called sargramostim) will be tested for its safety and efficacy in individuals with mild-to-moderate Alzheimer's disease over a six month treatment period.

    Stage

    Phase 2

    Ages

    60 to 85

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT04902703 on ClinicalTrials.gov

22. Inspiring Seniors Towards Exercise Promotion to Protect Cognition

    The goal of this clinical trial is to test the benefits of beat-accented music stimulation (BMS) for behavioral changes of physical activity (PA) in older adults with subjective memory complaints. Specific Aims are to determine (1) whether BMS beneficially influences PA behaviors and psychological …

    Stage

    Not phased

    Ages

    65 and older

    Site

    Emory University, Atlanta, Georgia

    Locations

    2 in total

    Run by

    Emory University

    See if you can join NCT06496425 on ClinicalTrials.gov

23. Palliative Care Education in Assisted Living for Dementia Care Providers (PCEAL-DCP)

    The palliative care education in assisted living for dementia care providers (PCEAL-DCP) is a 4-week intervention (once a week for 1.5 hours, a total of 6 hours) for licensed nurses, administrators and dementia care coordinators to improve quality of dementia care outcomes

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of South Florida, Tampa, Florida

    Locations

    2 in total

    Run by

    University of South Florida

    See if you can join NCT06722352 on ClinicalTrials.gov

24. Combating Alzheimer's Through Sleep and Exercise

    The purpose of this research is to see how sleep and exercise affects dementia risk over time.

    Stage

    Not phased

    Ages

    45 to 80

    Site

    University of Miami Hospitals, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT04855630 on ClinicalTrials.gov

25. Improving PCP Advance Care Planning for People With ADRD

    This study will test the Dementia Advance Care Planning (AD ACP) Toolkit intervention to usual care in facilitating goals of care (GOC) discussions between People Living with Dementia (PLwD) and primary care team members over an 18-month period. The primary outcome is to assess the frequency and qu…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    University of North Carolina, Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of Pittsburgh

    See if you can join NCT06565169 on ClinicalTrials.gov