Alzheimer Disease Clinical Trials in Boston, Massachusetts

13 studies are recruiting for alzheimer disease in Boston, Massachusetts right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease

   This study is to test LHP588 in persons who have mild to moderate Alzheimer's disease (AD) who have shown progressive mental decline in the last year and who have P. gingivalis (Pg) infection. P. gingivalis infection has been linked to the development of dementia. LHP588 is designed to target the P…

   Stage

   Phase 2

   Ages

   55 to 80

   Site

   Adams Clinical Boston, Boston, Massachusetts

   Locations

   38 in total

   Run by

   Lighthouse Pharmaceuticals, Inc.

   See if you can join NCT06847321 on ClinicalTrials.gov

2. A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

   The purpose of this study is to evaluate the safety and efficacy of KarXT in adult participants with mild to severe Alzheimer's Disease (AD) with moderate to severe psychosis related to AD.

   Stage

   Phase 3

   Ages

   55 to 90

   Site

   Tufts Medical Center - 800 Washington St - PPDS, Boston, Massachusetts

   Locations

   293 in total

   Run by

   Karuna Therapeutics, Inc., a Bristol Myers Squibb company

   See if you can join NCT06585787 on ClinicalTrials.gov

3. Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People at Risk for Alzheimer's Disease

   Alzheimer's disease (AD) is characterized by significant memory loss, toxic protein deposits (amyloid and tau) in the brain, and changes in the gamma frequency band on EEG. Gamma waves are important for memory, and in patients with AD, there are fewer gamma waves in the brain. The Tsai lab found th…

   Stage

   Not phased

   Ages

   55 to 90

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Massachusetts General Hospital

   See if you can join NCT05776641 on ClinicalTrials.gov

4. Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

   This early phase, open label, single arm clinical trial will determine the intraindividual safety, tolerability and effects of NPC1 (parthenolide and ipriflavone) on blood-based biomarkers of Alzheimer's disease (AD) pathology among adults with subjective cognitive decline, mild cognitive impairmen…

   Stage

   Phase 2

   Ages

   55 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07236190 on ClinicalTrials.gov

5. Trial-Ready Cohort-Down Syndrome (TRC-DS)

   The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 550 participants in total including co-enrolled in the Alzheimer Biomarkers Consortium - Down Syndrome (ABC-D…

   Stage

   Not phased

   Ages

   25 to 55

   Site

   Massachusetts General Hospital, Co-Enrolling through ABC-DS Only, Boston, Massachusetts

   Locations

   22 in total

   Run by

   University of Southern California

   See if you can join NCT04165109 on ClinicalTrials.gov

6. Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

   In this research study we want to learn more about the effects of non-invasive brain stimulation on memory and brain-network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation c…

   Stage

   EARLY_Phase 1

   Ages

   40 to 99

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06538311 on ClinicalTrials.gov

7. Cognitive Neurology Unit Clinical Registry

   A Prospective Comparative Study Of Monoclonal Antibodies For The Treatment Of Alzheimer's Disease

   Stage

   Not phased

   Ages

   50 to 95

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Run by

   Beth Israel Deaconess Medical Center

   See if you can join NCT05925621 on ClinicalTrials.gov

8. Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia

   This project aims to examine the efficacy of remote, caregiver-led tES/brain stimulation intervention targeted to improve memory, mobility, and executive functioning among older adults with mild cognitive impairment or mild dementia.

   Stage

   Not phased

   Ages

   55 and older

   Site

   Hinda and Arthur Marcus Institute for Aging Research, Boston, Massachusetts

   Run by

   Hebrew SeniorLife

   See if you can join NCT05661084 on ClinicalTrials.gov

9. Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0

   The goal of this pragmatic cluster randomized clinical trial is to compare management of suspected infection in nursing home residents with dementia The main questions it aims to answer whether residents with dementia in nursing homes randomized to use a multicomponent intervention to optimize susp…

   Stage

   Not phased

   Ages

   60 to 106

   Site

   Hebrew SeniorLife, Boston, Massachusetts

   Run by

   Hebrew SeniorLife

   See if you can join NCT05950607 on ClinicalTrials.gov

10. Assess Fibrin in Brains With AD/ADRD

    The goal of this project is to quantify brain fibrin content using 64Cu-FBP8-PET in the brains of subjects ranging from cognitively normal to clinically diagnosed with ADRD to evaluate potential regional differences.

    Stage

    Phase 1

    Ages

    55 to 90

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05336695 on ClinicalTrials.gov

11. Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation

    The investigators will evaluate the theory that Alzheimer's disease-related memory impairment derives from the inefficient orchestration of rhythmic activity at the level of large-scale cortical networks. The results as expected to elucidate AD-related pathophysiology and set groundwork for the dev…

    Stage

    Not phased

    Ages

    50 to 100

    Site

    677 Beacon St. Room 308, Boston, Massachusetts

    Run by

    Boston University Charles River Campus

    See if you can join NCT06094192 on ClinicalTrials.gov

12. Triage Survey for Neurology Research Eligibility

    TRIAGE-Neuro is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored neurology clinical trials.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Copley Clinical, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Adams Clinical

    See if you can join NCT06104852 on ClinicalTrials.gov

13. Gamma-Music Based Intervention for Mild Alzheimer's Disease

    The study will test and refine a novel brain-stimulation tool using gamma-frequency lights coupled with self-selected music for a gamma-music-based intervention for participants with mild Alzheimer's Disease. Results will yield a gamma-stimulation protocol that reliably influences brain activity (A…

    Stage

    Not phased

    Ages

    50 to 95

    Site

    Northeastern University, Boston, Massachusetts

    Run by

    Northeastern University

    See if you can join NCT05984524 on ClinicalTrials.gov