Alcohol Use Disorder Clinical Trials

106 studies are recruiting for alcohol use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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1. Cerebellar Involvement in Alcohol Use Disorder (AUD)

   The goal of this observational and interventional study is to better understand the involvement of the cerebellum in the brain reward system in persons with alcohol use disorder (AUD). The main questions it aims to answer are: 1. What is the nature of cerebellar input to the ventral tegmental area …

   Stage

   Not phased

   Ages

   25 to 55

   Site

   Johns Hopkins University School of Medicine, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05732207 on ClinicalTrials.gov

2. Guanfacine for Alcohol Use Disorder (AUD)

   The investigators assess whether guanfacine extended release (GXR; 3mg/d) compared with placebo (PBO) will attenuate drinking and drinking-related factors in N=200 men and women with Alcohol Use Disorder (AUD) across 12-weeks.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   The Stark Neuroscience Building (Goodman Hall), Indianapolis, Indiana

   Locations

   2 in total

   Run by

   Indiana University

   See if you can join NCT06629259 on ClinicalTrials.gov

3. StuDy AimED at Increasing AlCohol AbsTinEnce

   The goal of this clinical trial is to test the feasibility \& acceptability of an integrated CM-PST intervention (in K99 phase) and preliminary efficacy (in R00 phase), vs. CM alone, to improve treatment efficacy and inform about neural mechanisms of treatment effects in young adults with Alcohol U…

   Stage

   Not phased

   Ages

   18 to 24

   Site

   University of Illinois at Chicago, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT05778734 on ClinicalTrials.gov

4. Implementation Facilitation Pilot for Alcohol Use Disorder (AUD) in Alcohol-associated Liver Disease (ALD)

   The goal of this project is to improve provision of integrated medications for alcohol use disorder (MAUD) with brief counseling for patients with alcohol use disorder (AUD) and alcohol-associated liver disease (ALD) in hepatology clinics. There are many benefits of AUD treatment among patients wit…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Yale School of Medicine/Yale-New Haven Health, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT07525258 on ClinicalTrials.gov

5. Enhancing Prospective Thinking in Early Recovery (HOME)

   The goal of this clinical trial is to use a novel virtual reality intervention to test for efficacy in reducing alcohol use and increasing abstinence, with concomitant increases in future self-identification, future time perspective, and delay-of-reward, in early recovering alcohol use disorder (AU…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   Indiana University School of Medicine - Goodman Hal, Indianapolis, Indiana

   Run by

   Indiana University

   See if you can join NCT06302413 on ClinicalTrials.gov

6. Brexpiprazole in Alcohol Use Disorder

   Few medications are currently Food \& Drug Administration (FDA)-approved for the treatment of Alcohol Use Disorder (AUD), and those that are have, on average, modest effects on drinking. "Precision medicine" research has explored whether patient-level variables, such as genetic variation, may ident…

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   University of Colorado Anschutz Medical Campus, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT04066192 on ClinicalTrials.gov

7. Motivation for IV Alcohol Self-Administration in Humans

   The goal of this translational study is to understand different reasons why people between the ages of 21 and 65 with alcohol use disorder are motivated to self-administer alcohol. The main questions it aims to answer are: * How does a person's desire for a reward affect their motivation to self-ad…

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   University of California, Los Angeles, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT06494891 on ClinicalTrials.gov

8. Human Laboratory Study of Apremilast for Alcohol Use Disorder

   Primary: The primary objective of this study is to compare the efficacy of two different maintenance doses of apremilast (tablets) in reducing alcohol craving among subjects with moderate to severe alcohol use disorder (AUD) after two weeks of daily dosing. Secondary: Secondary objectives include e…

   Stage

   Phase 2

   Ages

   21 and older

   Site

   University of California, Los Angeles, California

   Locations

   3 in total

   Run by

   National Institute on Alcohol Abuse and Alcoholism (NIAAA)

   See if you can join NCT07325266 on ClinicalTrials.gov

9. A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners

   The purpose of this study is to evaluate the efficacy of an adaptive web intervention (Partners Connect) on military spouse drinking behaviors (CPs) and service member help-seeking (SMs). The investigators want to identify for whom this intervention is most efficacious and on what drinking behavior…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Stanford University, Palo Alto, California

   Run by

   Stanford University

   See if you can join NCT05619185 on ClinicalTrials.gov

10. Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

    The goal of this clinical trial is to test the efficacy of a novel integrative cognitive-behavioral intervention in patients with posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Specific Aim 1: Examine the efficacy of CPT-RP, as compared to RP alone, in reducing alcohol frequen…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Locations

    2 in total

    Run by

    Texas A&M University

    See if you can join NCT05959434 on ClinicalTrials.gov

11. Study of NTX-2001 on Alcohol Consumption in Alcohol Use Disorder

    The primary goal of this Phase 1b clinical trial is to evaluate the effects of a novel TAAR1 receptor partial agonist (NTX-2001) in adults with Alcohol Use Disorder (AUD). The main questions this trial aims to answer are: * Does NTX-2001 affect alcohol consumption in adults with AUD? * Is NTX-2001 …

    Stage

    Phase 1

    Ages

    21 to 60

    Site

    Yale University School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut

    Run by

    Newleos Therapeutics, Inc.

    See if you can join NCT07520292 on ClinicalTrials.gov

12. Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship

    Intimate partner violence (IPV) is a serious public health problem that results in significant health and economic burdens including mortality, morbidity, and poor treatment outcomes. A well-developed field of research suggests that alcohol misuse and posttraumatic stress disorder (PTSD) can lead t…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05786157 on ClinicalTrials.gov

13. MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience

    The purpose of this study is to develop transcranial magnetic stimulation (TMS), specifically TMS at a frequency known as theta burst stimulation (TBS), to see how it affects the brain and changes the brain's response to alcohol-related pictures. TMS and TBS are stimulation techniques that use magn…

    Stage

    Not phased

    Ages

    21 to 65

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT04998916 on ClinicalTrials.gov

14. A First in Human Study of CMND-100 in Healthy and Alcohol Use Disorder (AUD) Subjects

    The primary objective of this study is to find the tolerable dose and characterize the safety and pharmacokinetics/ pharmacodynamics (PK/PD) of single and repeated dose of CMND-100 in Healthy Volunteers (HV) and Subjects with Alcohol Use Disorder (AUD). The secondary objective of this study is to p…

    Stage

    Phase 1

    Ages

    18 to 60

    Site

    Connecticut Mental Health Center, New Haven, Connecticut

    Locations

    4 in total

    Run by

    Clearmind Medicine Inc.

    See if you can join NCT05913752 on ClinicalTrials.gov

15. Virtual Reality (VR) NATURE - Alcohol Use Disorder (AUD)

    This pilot randomized clinical trial will evaluate the feasibility, acceptability, and preliminary effectiveness of immersive Virtual Reality (VR) nature intervention among adults with at least moderate depression symptoms enrolled in an intensive outpatient Program (IOP) for Alcohol Use Disorder (…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07413458 on ClinicalTrials.gov

16. Non-invasive Vagal Nerve Stimulation as Novel Treatment to Improve Functional Outcomes in Veterans With Alcohol Use Disorder

    Alcohol use disorder (AUD) is a major health concern amongst Veterans as it causes functional impairments and decreased quality of life. Current AUD treatments show limited effectiveness in reducing withdrawal-related psychological and physical distress, which drives the urge to drink to relieve th…

    Stage

    Not phased

    Ages

    21 to 65

    Site

    VA San Diego Healthcare System, San Diego, CA, San Diego, California

    Run by

    VA Office of Research and Development

    See if you can join NCT06399653 on ClinicalTrials.gov

17. Integrated Treatment for Enhancing Growth in Recovery During Adolescence

    This is a Phase II parallel group randomized controlled trial with 294 adolescents (age: 14-21 years) with alcohol and other drug [AOD] use disorder (hereafter substance use disorder), that compares two different active psychosocial interventions designed to address adolescent substance use disorde…

    Stage

    Not phased

    Ages

    14 to 21

    Site

    UConn Health, Farmington, Connecticut

    Locations

    2 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT06395467 on ClinicalTrials.gov

18. Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep to Reward- and Stress-Related Brain Function

    This research will use biobehavioral approaches to generate understanding about the linkages between stressful life events, sleep duration and timing, and alcohol use in young adults, with a long-term aim of developing effective preventative interventions for alcohol use disorders.

    Stage

    Not phased

    Ages

    18 to 24

    Site

    Oregon Sleep Lab, Eugene, Oregon

    Run by

    University of Oregon

    See if you can join NCT05684094 on ClinicalTrials.gov

19. Piloting a Deaf Accessible Pre-Treatment for AUD

    This pilot study will evaluate the feasibility, acceptability, and preliminary efficacy of an adaptation of Motivational Enhancement Therapy (MET) titled "DeafMET", intended for Deaf adults with high-risk alcohol use. In this single intervention cycle, 10 Deaf participants will receive the DeafMET …

    Stage

    Not phased

    Ages

    18 and older

    Site

    UMass Chan, Shrewsbury, Massachusetts

    Run by

    University of Massachusetts, Worcester

    See if you can join NCT07269119 on ClinicalTrials.gov

20. Alcohol Research in HIV: Relapse Prevention

    3-arm type 1 pilot implementation-efficacy trial for people with alcohol use disorders to examine the preliminary effectiveness and feasibility of an adapted 2-session, computerized and person delivered relapse prevention intervention.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05163301 on ClinicalTrials.gov

21. Anxiety During Abstinence in AUD

    The goal of this study is to better understand the underlying neurobiological basis of anxiety that emerges during abstinence in patients with alcohol use disorder (AUD). The main questions it aims to answer are: 1. To characterize anxiety itself as well as anxiety related-neurobiological circuitry…

    Stage

    EARLY_Phase 1

    Ages

    21 to 55

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT06793488 on ClinicalTrials.gov

22. Ketone Ester Intervention in Alcohol Use Disorder

    The purpose of this research is to study how a nutritional ketone ester may effect brain function and alcohol consumption in regular alcohol users. The study will see how the brain responds, once after drinking the ketone ester and once after drinking a "placebo", which will look and taste the same…

    Stage

    Phase 2

    Ages

    21 to 65

    Site

    University of Pennsylvania Center for Studies of Addiction, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT04616781 on ClinicalTrials.gov

23. Brief Family Involved Treatment Telehealth

    Improving alcohol use disorder (AUD) treatment among Veterans is a national public health problem. The rate of AUD among Veterans is twice that of civilians, with up to 50% of Veterans having AUD. Family-based AUD programs are rarely undertaken in busy treatment clinics, and Veterans with problem d…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05674409 on ClinicalTrials.gov

24. Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for Alcohol Use Disorder (AUD)

    This study is testing a new treatment called IR-TMS (image-guided, robot navigated transcranial magnetic stimulation) to see if it can help people who drink too much alcohol to reduce the amount they drink. Participants will be placed into one of three groups, each receiving a slightly different ve…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Be Well Institute, University of Texas Health Science Center - Department of Psychiatry & Behavioral Sciences, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT06648642 on ClinicalTrials.gov

25. Pregnenolone for the Treatment of Alcohol Use Disorder

    This Phase 2 randomized cotrolled trial (RCT) will assess the safety and efficacy of pregnenolone (PREG; 300 mg/day, b.i.d dosing) vs. placebo (PBO) over a 12 week treatment period, and at 1-month post-treatment follow-up in individuals with Alcohol Use Disorder (AUD).

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    The Yale Stress Center: Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT05781009 on ClinicalTrials.gov