Alcohol Use Disorder Clinical Trials

106 studies are recruiting for alcohol use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies, page 4

1. A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT

   Substance Use Disorders continue to increase across the United States with significant adverse effects resulting in more than $700 billion annually (NIDA, 2017) with high co-occurring rates of IPV. The negative consequences are devastating to families and society. This team has developed a digital,…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Strong Recovery - Part Of Strong Memorial Hospital, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT05943171 on ClinicalTrials.gov

2. Naltrexone in AUD Reward Drinkers

   This study is a phase IV, two-arm, randomized, double-blind, placebo-controlled study to assess whether individuals identified as primarily reward drinkers are significantly more likely to reduce heavy drinking if they receive XR-NTX than a matching placebo injection. Study subjects will receive mo…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   University of Pennsylvania Center for Studies of Addiction, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT05028062 on ClinicalTrials.gov

3. Acute Alcohol Response In Bipolar Disorder: a Longitudinal Alcohol Administration/fMRI Study

   Alcohol use disorders (AUDs) affect up to 60% of individuals with bipolar disorder during their lifetime and is associated with worse illness outcomes, yet few studies have been performed to clarify the causes of this comorbidity. Understanding biological risk factors that associate with and predic…

   Stage

   Not phased

   Ages

   21 to 26

   Site

   University of Texas at Austin, Austin, Texas

   Run by

   University of Texas at Austin

   See if you can join NCT05838274 on ClinicalTrials.gov

4. Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity

   This project is designed to determine if a computer-delivered cognitive-behavioral treatment can improve the otherwise poor alcohol use disorder treatment outcomes for individuals with a co-occurring anxiety disorder. In the past, the investigators showed that this treatment does improve outcomes f…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Lodging Plus Program, Fairview Hospital, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05117255 on ClinicalTrials.gov

5. Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related Drinking

   The goal of this clinical trial is to learn if, how, and for whom suvorexant (SUV) works to treat alcohol use disorder (AUD). The main questions it aims to answer are: * Is SUV effective for AUD? * Does SUV dampen stress reactivity? * Can the researchers develop a biomarker for SUV treatment respon…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   Ohio State University, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT07214207 on ClinicalTrials.gov

6. Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial

   This study will collect data that measures the effects of a psychedelic intervention on patients struggling with alcohol use disorder (AUD). The study design will be a double blind, randomized, active-comparator trial with two study arms. Subjects randomized to Arm 1 (n=40) will receive individual …

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   University of Iowa Health Care, Iowa City, Iowa

   Run by

   University of Iowa

   See if you can join NCT06405607 on ClinicalTrials.gov

7. LGG Supplementation in Patients With AUD and ALD

   To test the efficacy of 6-month LGG compared to placebo in treating Alcoholic Use Disorder (AUD) and liver injury in Alcoholic Hepatitis (AH). And to evaluate the effects of LGG treatment compared to placebo on therapeutic-mechanistic markers of the gut-brain axis and pro-inflammatory activity in p…

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   University of Louisville Hospital, Louisville, Kentucky

   Run by

   University of Louisville

   See if you can join NCT05178069 on ClinicalTrials.gov

8. Tirzepatide for Alcohol Use Disorder

   The objective of this Phase 2 randomized controlled trial is to evaluate the effects of weekly tirzepatide (vs. placebo) on alcohol consumption and cardiometabolic outcomes in adults with alcohol use disorder and overweight or obesity.

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   Keck School of Medicine, University of Southern California, Los Angeles, California

   Run by

   University of Southern California

   See if you can join NCT06994338 on ClinicalTrials.gov

9. Tdcs And cogNitive traininG cOmbined for AUD (TANGO)

   The overarching goal of this project is to expand the traditional expertise in non-invasive neuromodulation at the University of Minnesota towards developing novel paired-neuromodulation approaches using transcranial direct current stimulation (tDCS) for new treatments for alcohol use disorder (AUD…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05062369 on ClinicalTrials.gov

10. A Combined Neurofeedback-TMS Intervention for Alcohol Use Disorder

    The goal of this clinical study is to test the effectiveness of a supplemental fMRI neurofeedback and/or TMS intervention in individuals seeking treatment for Alcohol Use Disorder. After an initial visit, participants will come in once a week for four (4) weeks for an intervention session, which ma…

    Stage

    Not phased

    Ages

    19 to 65

    Site

    Auburn University, Auburn, Alabama

    Run by

    Auburn University

    See if you can join NCT05621538 on ClinicalTrials.gov

11. Emergency Medicine Peer Outreach Worker Engagement for Recovery

    This is an observational, prospective case-control study evaluating the effects of an emergency department community health worker-peer recovery specialist program (PCHW), the Substance Misuse Assistance Response Team (SMART). Aims of this study are to 1) understand participant experiences working …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rhode Island Hospital, Providence, Rhode Island

    Run by

    University of California, Los Angeles

    See if you can join NCT06320015 on ClinicalTrials.gov

12. Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder

    The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with moderate to severe alcohol use disorder at the Hospital of the University of Pennsylvania, Cedar Deto…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Center for Studies of Addiction, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06559995 on ClinicalTrials.gov

13. Intranasal Insulin for Treatment of Alcohol Use Disorder

    This is a randomized controlled trial (RCT), within-subject, crossover, double-blind, placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD) (N=40, 50% female) randomized to IN insulin or placebo. In a bar laboratory setting, randomized participants will receive a s…

    Stage

    Phase 1

    Ages

    21 and older

    Site

    Brown University, Providence, Rhode Island

    Run by

    Brown University

    See if you can join NCT05988632 on ClinicalTrials.gov

14. A Peer Recovery Coaching Intervention for Hospitalized Alcohol Use Disorder Patients

    The project objective is to rigorously evaluate the effectiveness of a peer recovery coaching intervention (called RC-Link) in patients hospitalized with medical complications from alcohol use on recovery outcomes guided by the new NIAAA definition of recovery, examine mechanisms of heavy drinking …

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Greenville Memorial Hospital, Greenville, South Carolina

    Locations

    2 in total

    Run by

    Clemson University

    See if you can join NCT06479681 on ClinicalTrials.gov

15. Trial of a Culturally Informed Brief Intervention to Reduce Alcohol Related Health Disparities and Treatment Inequities Among Latinxs

    This Stage II Randomized Efficacy Trial will compare the effectiveness of a theoretically informed and culturally responsive brief motivational intervention to a non-adapted brief intervention among non-treatment seeking Latinxs admitted for medical treatment of an injury who engage in at risk drin…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University Medical Center of El Paso, El Paso, Texas

    Run by

    University of Texas, El Paso

    See if you can join NCT05800899 on ClinicalTrials.gov

16. Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder

    Alcohol Use Disorders are currently positioned as the third leading cause of preventable death in the United States, constituting a humanitarian crisis with substantial financial burden on society and medical facilities. While several pharmacological interventions exist, 60% of individuals who seek…

    Stage

    Not phased

    Ages

    25 to 75

    Site

    VA Palo Alto Health Care System, Palo Alto, California

    Run by

    VA Palo Alto Health Care System

    See if you can join NCT06415721 on ClinicalTrials.gov

17. Amplification of Positivity for Alcohol Use

    The proposed study consists of two phases. During Phase 1, the investigators will recruit a small sample of participants to complete a psychosocial intervention termed Amplification of Positivity (AMP) for individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder (A…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Laureate Institute for Brain Research, Tulsa, Oklahoma

    Run by

    Laureate Institute for Brain Research, Inc.

    See if you can join NCT06030154 on ClinicalTrials.gov

18. Electronic Harm Reduction Treatment for Alcohol

    The goal of this project is to transform a successful, face-to-face harm-reduction treatment (HaRT-A) into a digital format, creating eHaRT-A. This new platform is specifically designed for people who have experienced homelessness and an alcohol use disorder (AUD), living within the framework of pe…

    Stage

    Phase 3

    Ages

    21 and older

    Site

    Downtown Emergency Service Center, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06702007 on ClinicalTrials.gov

19. Evaluating a One-Year Version of the Parent-Child Assistance Program

    The proposed project seeks to achieve three objectives that will, collectively, evaluate the effectiveness of a one-year version of the Parent-Child Assistance Program (PCAP-1) -a model for a home visitation and case management program for parents who used substances. First, the proposed project ai…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Remote Worker, Enid, Oklahoma

    Locations

    2 in total

    Run by

    University of Oklahoma

    See if you can join NCT06163651 on ClinicalTrials.gov

20. rTMS as Add on Treatment for Substance Use Disorders

    This pilot study is designed to test feasibility and superiority of rTMS types and target locations for the optimal rTMS intervention for individuals seeking treatment for Alcohol Use Disorder (AUD) or Opioid Use Disorder (OUD). The critical questions this study seeks to answer are: which rTMS type…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Hartford Healthcare, Hartford, Connecticut

    Run by

    Yale University

    See if you can join NCT06963476 on ClinicalTrials.gov

21. Virtual Incentive Treatment for Alcohol

    The overall objective of this program of research is to utilize phosphatidylethanol (PEth), a blood-based biomarker that can detect alcohol use for up to 28 days to deliver a feasible telehealth-based 26-week CM intervention. This study will test a telehealth PEth-based CM model in a sample of adul…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Washington State University, Spokane, Washington

    Run by

    Washington State University

    See if you can join NCT06265506 on ClinicalTrials.gov

22. A Pilot Study of Non-invasive Brain Stimulation to Boost the Efficacy of Psychotherapy in a Community Sample of People Who Drink Alcohol

    The goal of this small (n=75) proof-of-concept randomized clinical trial is to test the effects of transcranial alternating current stimulation (tACS) during motivational interviewing (MI) sessions with participants who drink at above the low-risk level. Participants will be randomized to receive e…

    Stage

    Phase 2

    Ages

    21 to 60

    Site

    The Mind Research Network, Albuquerque, New Mexico

    Run by

    The Mind Research Network

    See if you can join NCT04770025 on ClinicalTrials.gov

23. Systematic Implementation of Patient-centered Care for Alcohol Use Trial: Beyond Referral to Treatment

    The Systematic Implementation of Patient-centered Care for Alcohol Use Trial is a pragmatic, cluster-randomized, effectiveness-implementation trial testing two interventions in Kaiser Permanente Washington to systematically implement shared decision-making with primary care patients with symptoms d…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kaiser Permanente Washington, Seattle, Washington

    Run by

    Kaiser Permanente

    See if you can join NCT06318026 on ClinicalTrials.gov

24. Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD

    This is a double-blind, 2-group randomized controlled trial evaluating the effects of topiramate versus placebo in patients with comorbid PTSD and moderate-to-severe AUD. This trial will provide one of the first rigorous tests of whether the effects of topiramate in AUD generalize to patients with …

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    New York University School of Medicine, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT03667846 on ClinicalTrials.gov

25. TRAC-ER Intervention to Reduce Risky Alcohol Use and HIV Risk

    Ecological momentary interventions (EMI), which use phones to deliver messages to reduce alcohol use and related risk behaviors during or prior to drinking events, can help to address triggers in real-time. GPS tracking can determine when individuals visit places they have previously reported drink…

    Stage

    Not phased

    Ages

    18 to 35

    Site

    Yale University, New Haven, Connecticut

    Locations

    2 in total

    Run by

    University of Kentucky

    See if you can join NCT05576350 on ClinicalTrials.gov