Alcohol Use Disorder Clinical Trials

104 studies are recruiting for alcohol use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. PT150 Drug for Use in Alcohol Use Disorder

   The goal of this study is to learn if PT150 can reduce the behavioral and physical effects of stress, alcohol, and alcohol use in people with alcohol use disorder.

   Stage

   Phase 1

   Ages

   21 to 55

   Site

   University of Kentucky, Lexington, Kentucky

   Run by

   Pop Test Oncology LLC

   See if you can join NCT06712602 on ClinicalTrials.gov

2. Cannabidiol and Alcohol Use Disorder Phenotypes

   The goal of this study is to learn how CBD affects drinking in people who drink alcohol regularly. Researchers want to see if CBD can help people drink less and reduce problems related to alcohol use.

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   University of Colorado School of Medicine- Anschutz Medical Campus, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07279558 on ClinicalTrials.gov

3. Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder

   This study aims to examine the effects of Low-Intensity Focused Ultrasound (LIFU) on brain activity in patients with alcohol use disorder.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT06518785 on ClinicalTrials.gov

4. Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder

   The primary objective of this multimodal positron emission tomography (PET) study is to use PET brain imaging to measure both MOR (Mu-Opioid receptors) and KOR (kappa-opioid receptors) in participants with alcohol use disorder (AUD) and to quantify the relationships between MOR and KOR, separately …

   Stage

   EARLY_Phase 1

   Ages

   21 to 70

   Site

   Yale University, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT05957159 on ClinicalTrials.gov

5. Role of Phosphatidylethanol in Predicting Perioperative Outcomes of Admitted Patients at UHCMC

   This study aims to see if there's a link between a substance called phosphatidylethanol (PEth) and how patients who have surgery at University Hospitals do after surgery. PEth levels reflect the amount of alcohol use by someone over the past few weeks. This study is checking PEth levels on all pati…

   Stage

   Not phased

   Ages

   21 to 79

   Site

   University Hospital, Cleveland, Ohio

   Run by

   University Hospitals Cleveland Medical Center

   See if you can join NCT06864819 on ClinicalTrials.gov

6. Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUD

   This is a double-blind, randomized, placebo-controlled Phase 2 mechanistic clinical trial designed to evaluate the therapeutic neural mechanisms of psilocybin in patients with alcohol use disorder (AUD), and to determine whether further studies are warranted to study the relationship of any such ef…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT06349083 on ClinicalTrials.gov

7. Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat

   The overall objective of this study it to use Positron Emission Tomography (PET) brain imaging and a radiotracer that measures the epigenetic marker Histone Deacetylase 6 (HDAC6) to examine HDAC6 expression in people with Post-Traumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), or concurr…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Yale University, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06371404 on ClinicalTrials.gov

8. The Impact of Heavy Alcohol Use on Saliva and Oral Health

   Background: People with alcohol use disorder (AUD) have a higher rate of dental and gum disease. Poor oral health can increase the risk of other diseases, such as diabetes and stroke. Researchers want to learn more about how to identify developing inflammation in the mouth. They also want to know h…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institutes of Health Clinical Center (CC)

   See if you can join NCT06684483 on ClinicalTrials.gov

9. Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

   Background: People who will participate in research studies need to undergo proper screening, evaluation, and assessment (SEA). SEA helps keep those who participate in studies safe. It also helps ensure accurate study results. The National Institute on Drug Abuse (NIDA) Intramural Research Program …

   Stage

   Not phased

   Ages

   18 to 99

   Site

   National Institute on Drug Abuse, Baltimore, Maryland

   Run by

   National Institute on Drug Abuse (NIDA)

   See if you can join NCT06552741 on ClinicalTrials.gov

10. Drinking, Acetate, and Stress

    The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the body's chemistry. Specifically, the investigators will be studying relationships of drinking and a stress hormone called cortisol. The investigators believe that results w…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    The Anlyan Center, 300 Cedar St., New Haven, Connecticut

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT06584448 on ClinicalTrials.gov

11. Tirzepatide in MetALD

    Background: People with alcohol use disorder (AUD) often develop metabolic alcohol-associated liver disease (MetALD). MetALD is a term for the heart, liver, obesity, and other issues that can accompany AUD. MetALD can be fatal. An approved weight management drug (Tirzepatide) may be able to help pe…

    Stage

    Phase 2

    Ages

    21 to 100

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    See if you can join NCT07046819 on ClinicalTrials.gov

12. Effects of Ketogenic Diet on Alcohol Intoxication

    The research study is being conducted to better understand the effects of ketosis on brain functioning and the acute effects of alcohol. Participants will be asked to undergo ~4 weeks of ketogenic diet intervention. The study involves three lab visits: Lab 1 before starting the diet, Lab 2 after ab…

    Stage

    Not phased

    Ages

    21 to 50

    Site

    Center for Studies of Addiction, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT07602270 on ClinicalTrials.gov

13. Implementation of Mobile-based Programs for Alcohol Cessation in Treatment of Alcohol-associated Liver Disease

    This protocol describes a randomized controlled trial testing the effectiveness and implementability of the CHESS Health Connections smartphone application among patients with alcohol-associated liver disease (ALD) at two medical centers in Michigan and Wisconsin, in two types of clinics: general h…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Henry Ford + Michigan State University Health Center, Lansing, Michigan

    Locations

    3 in total

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06305624 on ClinicalTrials.gov

14. Understanding Pathways to Wellness and Recovery in Detroit - Digital Recovery Support Services

    The goal of this clinical trial is to learn if digital recovery support services (such as smartphone app) help to support alcohol recovery. We focus on a community of Black and African American people with alcohol use disorder (AUD) who receive in-person recovery support services from a recovery co…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Detroit Recovery Project, Detroit, Michigan

    Run by

    Brandeis University

    See if you can join NCT07724275 on ClinicalTrials.gov

15. Emergency Department-Initiated Medications for Alcohol Use Disorder

    The proposed study will be the first randomized clinical trial to evaluate a comprehensive Emergency Department (ED)-based intervention for moderate to severe Alcohol Use Disorder (AUD) combining Screening, Brief Intervention and Referral to Treatment (SBIRT) with ED-initiated medications for treat…

    Stage

    Phase 3

    Ages

    18 to 80

    Site

    Yale New Haven Hospital, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT05827159 on ClinicalTrials.gov

16. Supporting Adolescent Alcohol Treatment With Computer-Based ('Path180') Skills Training

    This 8-week clinical trial will test a computer-based skills training program called Path180 with 112 adolescents aged 13 to 19 who are receiving mental health counseling or outpatient substance use treatment. Participants will be randomly assigned to either standard treatment (treatment as usual) …

    Stage

    Not phased

    Ages

    13 to 19

    Site

    Brown University Center for Alcohol and Addiction Studies, Providence, Rhode Island

    Run by

    Brown University

    See if you can join NCT07713251 on ClinicalTrials.gov

17. Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

    "Gold-standard" medications for opioid use disorder (MOUD) treatment combines FDA-approved medications, primarily methadone and buprenorphine, with behavioral therapies to provide "whole-patient" treatment. Prior to the pandemic, methadone and buprenorphine were subject to greater federal regulatio…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Medical Center, Boston, Massachusetts

    Run by

    Boston University

    See if you can join NCT07232641 on ClinicalTrials.gov

18. Optimizing Smart Technology for Addiction Recovery

    The goal of this study is to develop a machine-learning guided recovery messaging system. The main question it aims to answer is can messages be used to: * help people to improve their health * make changes in people's lives to address alcohol and substance use Participants will: * complete surveys…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT07573540 on ClinicalTrials.gov

19. Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)

    The goal of the project is to evaluate whether donepezil + cognitive remediation therapy is superior to placebo in reducing heavy drinking in patients with alcohol use disorder in a double-blind, placebo-controlled trial.

    Stage

    Phase 2

    Ages

    18 to 80

    Site

    VA Connecticut Healthcare System, West Haven, Connecticut

    Run by

    VA Connecticut Healthcare System

    See if you can join NCT05042102 on ClinicalTrials.gov

20. An Effectiveness Trial of the PrEP for WINGS Study

    (Effectiveness Aim 1) To test the comparative effectiveness of PreP for WINGS versus PrEP alone on primary outcomes of increasing PrEP initiation measured by self-report/medical records, recent adherence and longer-term adherence by self-report/medical records over the 6-month follow-up; and second…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Columbia Community Partnership for Health, New York, New York

    Run by

    Columbia University

    See if you can join NCT06853314 on ClinicalTrials.gov

21. Alcohol Use Disorder and Cannabidiol

    This is a double-blind, placebo-controlled, parallel group study designed to assess the efficacy of full spectrum CBD and broad spectrum CBD, compared to a placebo control (PC), to reduce drinking in participants with alcohol use disorder. If eligible for the study, subjects will be randomized to r…

    Stage

    Phase 2

    Ages

    21 and older

    Site

    University of Colorado Anschutz, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT05613608 on ClinicalTrials.gov

22. Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH

    Given the severe consequences of alcohol relapse following liver transplantation for alcoholic hepatitis (AH-LT), it is critical to accurately identify alcohol use and implement alcohol interventions early in the post-transplant period to optimize patient outcomes. The proposed randomized clinical …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins University School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT03845205 on ClinicalTrials.gov

23. Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment

    This study will help determine the feasibility and acceptability of a brief opioid-informed alcohol intervention in patients receiving prescribed buprenorphine for opioid use who are currently drinking alcohol. It will also provide initial information on whether the intervention improves outcomes r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Notre Dame, Notre Dame, Indiana

    Run by

    University of Notre Dame

    See if you can join NCT07342504 on ClinicalTrials.gov

24. Suvorexant and Alcohol

    This research will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for alcohol, as well as other alcohol-associated maladaptive behaviors in people with Alcohol Use Disorder. This study will also provide basic science …

    Stage

    EARLY_Phase 1

    Ages

    21 to 55

    Site

    Psychopharmacology of Addiction Laboratory, Lexington, Kentucky

    Run by

    William Stoops

    See if you can join NCT06326684 on ClinicalTrials.gov

25. Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection

    Alcohol use disorder (AUD) has been associated with high prevalence of inflammation-associated co-morbidities in people living with HIV even those receiving effective antiretroviral therapy (ART). Our preliminary data support a model in which the combined insult of AUD and HIV on the gut, specifica…

    Stage

    Not phased

    Ages

    45 to 75

    Site

    Ali Keshavarzian, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT06139224 on ClinicalTrials.gov