Alcohol Use Disorder Clinical Trials

106 studies are recruiting for alcohol use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Effects of Ketogenic Diet on Alcohol Intoxication

   The research study is being conducted to better understand the effects of ketosis on brain functioning and the acute effects of alcohol. Participants will be asked to undergo ~4 weeks of ketogenic diet intervention. The study involves three lab visits: Lab 1 before starting the diet, Lab 2 after ab…

   Stage

   Not phased

   Ages

   21 to 50

   Site

   Center for Studies of Addiction, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT07602270 on ClinicalTrials.gov

2. Spironolactone in Alcohol Use Disorder (SAUD)

   Background: Alcohol use disorder (AUD) affects about 29.5 million people in the United States. Only 3 medicines have been approved by Food and Drug Administration to treat AUD. Researchers want to find better treatments for AUD. Animal studies found that a medicine called spironolactone, may decrea…

   Stage

   Phase 1

   Ages

   21 to 99

   Site

   National Institute on Drug Abuse, Baltimore, Maryland

   Run by

   National Institute on Drug Abuse (NIDA)

   See if you can join NCT05807139 on ClinicalTrials.gov

3. Implementation of Mobile-based Programs for Alcohol Cessation in Treatment of Alcohol-associated Liver Disease

   This protocol describes a randomized controlled trial testing the effectiveness and implementability of the CHESS Health Connections smartphone application among patients with alcohol-associated liver disease (ALD) at two medical centers in Michigan and Wisconsin, in two types of clinics: general h…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Henry Ford + Michigan State University Health Center, Lansing, Michigan

   Locations

   3 in total

   Run by

   University of Wisconsin, Madison

   See if you can join NCT06305624 on ClinicalTrials.gov

4. Understanding Pathways to Wellness and Recovery in Detroit - Digital Recovery Support Services

   The goal of this clinical trial is to learn if digital recovery support services (such as smartphone app) help to support alcohol recovery. We focus on a community of Black and African American people with alcohol use disorder (AUD) who receive in-person recovery support services from a recovery co…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Detroit Recovery Project, Detroit, Michigan

   Run by

   Brandeis University

   See if you can join NCT07724275 on ClinicalTrials.gov

5. Emergency Department-Initiated Medications for Alcohol Use Disorder

   The proposed study will be the first randomized clinical trial to evaluate a comprehensive Emergency Department (ED)-based intervention for moderate to severe Alcohol Use Disorder (AUD) combining Screening, Brief Intervention and Referral to Treatment (SBIRT) with ED-initiated medications for treat…

   Stage

   Phase 3

   Ages

   18 to 80

   Site

   Yale New Haven Hospital, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT05827159 on ClinicalTrials.gov

6. Supporting Adolescent Alcohol Treatment With Computer-Based ('Path180') Skills Training

   This 8-week clinical trial will test a computer-based skills training program called Path180 with 112 adolescents aged 13 to 19 who are receiving mental health counseling or outpatient substance use treatment. Participants will be randomly assigned to either standard treatment (treatment as usual) …

   Stage

   Not phased

   Ages

   13 to 19

   Site

   Brown University Center for Alcohol and Addiction Studies, Providence, Rhode Island

   Run by

   Brown University

   See if you can join NCT07713251 on ClinicalTrials.gov

7. Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

   "Gold-standard" medications for opioid use disorder (MOUD) treatment combines FDA-approved medications, primarily methadone and buprenorphine, with behavioral therapies to provide "whole-patient" treatment. Prior to the pandemic, methadone and buprenorphine were subject to greater federal regulatio…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Medical Center, Boston, Massachusetts

   Run by

   Boston University

   See if you can join NCT07232641 on ClinicalTrials.gov

8. Behavioral and Functional Task Development, Implementation, and Testing

   Background: - Scientists know that alcohol use disorders affect brain structure. They want to know more about the effects of alcohol use disorders on a person s behavior. They want to develop tasks that can be done inside a scanner that can help them better understand these effects in later studies…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute on Alcohol Abuse and Alcoholism (NIAAA)

   See if you can join NCT02108054 on ClinicalTrials.gov

9. Optimizing Smart Technology for Addiction Recovery

   The goal of this study is to develop a machine-learning guided recovery messaging system. The main question it aims to answer is can messages be used to: * help people to improve their health * make changes in people's lives to address alcohol and substance use Participants will: * complete surveys…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Wisconsin, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT07573540 on ClinicalTrials.gov

10. Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)

    The goal of the project is to evaluate whether donepezil + cognitive remediation therapy is superior to placebo in reducing heavy drinking in patients with alcohol use disorder in a double-blind, placebo-controlled trial.

    Stage

    Phase 2

    Ages

    18 to 80

    Site

    VA Connecticut Healthcare System, West Haven, Connecticut

    Run by

    VA Connecticut Healthcare System

    See if you can join NCT05042102 on ClinicalTrials.gov

11. An Effectiveness Trial of the PrEP for WINGS Study

    (Effectiveness Aim 1) To test the comparative effectiveness of PreP for WINGS versus PrEP alone on primary outcomes of increasing PrEP initiation measured by self-report/medical records, recent adherence and longer-term adherence by self-report/medical records over the 6-month follow-up; and second…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Columbia Community Partnership for Health, New York, New York

    Run by

    Columbia University

    See if you can join NCT06853314 on ClinicalTrials.gov

12. Alcohol Use Disorder and Cannabidiol

    This is a double-blind, placebo-controlled, parallel group study designed to assess the efficacy of full spectrum CBD and broad spectrum CBD, compared to a placebo control (PC), to reduce drinking in participants with alcohol use disorder. If eligible for the study, subjects will be randomized to r…

    Stage

    Phase 2

    Ages

    21 and older

    Site

    University of Colorado Anschutz, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT05613608 on ClinicalTrials.gov

13. Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH

    Given the severe consequences of alcohol relapse following liver transplantation for alcoholic hepatitis (AH-LT), it is critical to accurately identify alcohol use and implement alcohol interventions early in the post-transplant period to optimize patient outcomes. The proposed randomized clinical …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins University School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT03845205 on ClinicalTrials.gov

14. Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment

    This study will help determine the feasibility and acceptability of a brief opioid-informed alcohol intervention in patients receiving prescribed buprenorphine for opioid use who are currently drinking alcohol. It will also provide initial information on whether the intervention improves outcomes r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Notre Dame, Notre Dame, Indiana

    Run by

    University of Notre Dame

    See if you can join NCT07342504 on ClinicalTrials.gov

15. Suvorexant and Alcohol

    This research will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for alcohol, as well as other alcohol-associated maladaptive behaviors in people with Alcohol Use Disorder. This study will also provide basic science …

    Stage

    EARLY_Phase 1

    Ages

    21 to 55

    Site

    Psychopharmacology of Addiction Laboratory, Lexington, Kentucky

    Run by

    William Stoops

    See if you can join NCT06326684 on ClinicalTrials.gov

16. Phase 2 Study of Apremilast in Women and Men With Alcohol Use Disorder

    For this protocol, the investigators plan to collect data to evaluate apremilast (60mg/day) vs placebo in adults with Alcohol Use Disorders (AUD).

    Stage

    Phase 2

    Ages

    21 to 65

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT07029529 on ClinicalTrials.gov

17. Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection

    Alcohol use disorder (AUD) has been associated with high prevalence of inflammation-associated co-morbidities in people living with HIV even those receiving effective antiretroviral therapy (ART). Our preliminary data support a model in which the combined insult of AUD and HIV on the gut, specifica…

    Stage

    Not phased

    Ages

    45 to 75

    Site

    Ali Keshavarzian, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT06139224 on ClinicalTrials.gov

18. Imaging CRF X NOP Interactions in Alcohol Use Disorder

    This positron emission tomography imaging study uses [C-11]NOP-1A and hydrocortisone to image stress-modulating proteins in heavy drinking alcohol use disorder (AUD) subjects and healthy controls (HC). It will also characterize the role of these stress-regulating proteins in a relapse to alcohol.

    Stage

    EARLY_Phase 1

    Ages

    18 to 55

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    Rajesh Narendran

    See if you can join NCT07612631 on ClinicalTrials.gov

19. MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder

    The study investigators are conducting the first randomized placebo-controlled trial of MDMA-assisted therapy with a comorbid sample of military Veterans with a co-occurring diagnosis of Alcohol Use Disorder (AUD) and Post-Traumatic Stress Disorder (PTSD). This novel experimental treatment package …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT07118839 on ClinicalTrials.gov

20. tAN for Substance Use Disorder

    The study will involve a 5-day tAN treatment to attenuate alcohol withdrawal syndrome (AWS) and alter resting state functional connectivity (RSFC) between OFC and striatum in patients with alcohol use disorder (AUD). Enrolled participants will wear the tAN device on-site (at The Menninger Clinic) f…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    The Menninger Clinic, Houston, Texas

    Run by

    Spark Biomedical, Inc.

    See if you can join NCT07281261 on ClinicalTrials.gov

21. TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)

    The study aims to explore the potential of Transcranial Magnetic Stimulation (TMS), particularly Theta Burst Stimulation (TBS), as an adjunctive treatment to enhance recovery outcomes (consumption and craving; withdrawal symptoms; mental, physical, sleep, and cognitive health; engagement with thera…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Another Chance Drug & Alcohol Rehab Center of Portland, Portland, Oregon

    Run by

    Washington State University

    See if you can join NCT07171359 on ClinicalTrials.gov

22. Neural and Hormonal Influences on Sex Differences in Risk for AUD

    The sex gap in alcohol consumption is closing rapidly, due to alarming increases among women. From 2002-2013, Alcohol Use Disorder (AUD) increased 84% for women, compared to 35% for men. As such, there is an urgent need to determine the factors underlying sex differences in risk for AUD. Current ad…

    Stage

    Not phased

    Ages

    21 to 26

    Site

    The Ohio State University, Columbus, Ohio

    Run by

    Jessica Weafer

    See if you can join NCT04929288 on ClinicalTrials.gov

23. Impulsivity Domains and Subjective Response

    Findings from this project will determine the relationship between two vulnerability factors for Alcohol Use Disorder (AUD) in young adults: impulsivity and subjective response to alcohol. The results will identify badly needed, novel targets for prevention and treatment efforts to simultaneously r…

    Stage

    EARLY_Phase 1

    Ages

    21 to 25

    Site

    Northeastern University, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Jessica Weafer

    See if you can join NCT05929677 on ClinicalTrials.gov

24. Developing a Novel Human Laboratory Paradigm for AUD Medication Screening

    The intent of the study is to develop two versions of the 'ability to resist' drinking model designed to screen Alcohol Use Disorder (AUD) medications.

    Stage

    Not phased

    Ages

    21 to 65

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06489782 on ClinicalTrials.gov

25. Sex Differences in the Response to Abstinence From Alcohol.

    In laboratory animals, repeated cycles of abstinence from and return to alcohol drinking can lead to changes in alcohol intake. In a study of the effect of abstinence on drinking in humans, the investigators found evidence that abstinence affects drinking differently in women compared to men. In th…

    Stage

    Phase 1

    Ages

    21 to 35

    Site

    University Hospital, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT03827460 on ClinicalTrials.gov