Alcohol Use Disorder Clinical Trials

106 studies are recruiting for alcohol use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder

   Background: People with alcohol use disorder (AUD) also often have bouts of depression called major depressive episodes (MDEs). People having MDEs have been found to have low levels of a protein called PDE4B in the brain. Researchers want to find out if people with AUD also have low levels of PDE4B…

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT06795581 on ClinicalTrials.gov

2. Environment and Alcohol: A Pilot Study

   Background: Alcohol use disorder (AUD) is a chronic disease that causes more than 140,000 US deaths each year. AUD treatment often includes therapy and medication. Some people with AUD may also benefit from behavioral and lifestyle changes. Objective: To evaluate the effects of different activities…

   Stage

   Phase 1

   Ages

   21 to 100

   Site

   National Institute on Drug Abuse, Baltimore, Maryland

   Run by

   National Institute on Drug Abuse (NIDA)

   See if you can join NCT06860607 on ClinicalTrials.gov

3. Hepatic Lipid Metabolism-Alcohol Use Disorder

   Patients with hepatic steatosis due to alcohol will be offered liver biopsies when they enter a detoxification program. The first biopsy will occur in the first week of admission and the second in the fourth week when the steatosis has resolved. The hepatic transcriptome will be compared,

   Stage

   Not phased

   Ages

   18 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT07191561 on ClinicalTrials.gov

4. The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration

   Oral disulfiram (Antabuse®) has been shown to improve image-forming vision in animal models with retinal degeneration due to its ability to decrease Retinoic Acid synthesis and consequently reduce hyperactivity in the inner retina. The investigator will aim to evaluate the impact of oral disulfiram…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT06319872 on ClinicalTrials.gov

5. PT150 Drug for Use in Alcohol Use Disorder

   The goal of this study is to learn if PT150 can reduce the behavioral and physical effects of stress, alcohol, and alcohol use in people with alcohol use disorder.

   Stage

   Phase 1

   Ages

   21 to 55

   Site

   University of Kentucky, Lexington, Kentucky

   Run by

   Pop Test Oncology LLC

   See if you can join NCT06712602 on ClinicalTrials.gov

6. Cannabidiol and Alcohol Use Disorder Phenotypes

   The goal of this study is to learn how CBD affects drinking in people who drink alcohol regularly. Researchers want to see if CBD can help people drink less and reduce problems related to alcohol use.

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   University of Colorado School of Medicine- Anschutz Medical Campus, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07279558 on ClinicalTrials.gov

7. Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)

   Background: Alcohol use disorder (AUD) is the most common substance use disorder in the world. Long-term AUD can affect a person s sense of taste and smell. This natural history study will compare alcohol drinking behaviors and measures of taste and smell in people with and without AUD. Objective: …

   Stage

   Not phased

   Ages

   18 to 65

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute on Alcohol Abuse and Alcoholism (NIAAA)

   See if you can join NCT05677321 on ClinicalTrials.gov

8. Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder

   This study aims to examine the effects of Low-Intensity Focused Ultrasound (LIFU) on brain activity in patients with alcohol use disorder.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT06518785 on ClinicalTrials.gov

9. Cessation or Reduction of Alcohol Consumption in Veterans: A Randomized Controlled Trial for Alcohol Use Disorder (CRAVE)

   This clinical trial aims to test the effectiveness and safety of semaglutide, a GLP-1 receptor agonist, in treating moderate to severe alcohol use disorder (AUD) in Veterans. Participants who qualify will be randomly assigned to receive either semaglutide injections or placebo injections over a 24-…

   Stage

   Phase 3

   Ages

   18 to 80

   Site

   VA Long Beach Healthcare System, Long Beach, CA, Long Beach, California

   Locations

   19 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT07218354 on ClinicalTrials.gov

10. Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder

    The primary objective of this multimodal positron emission tomography (PET) study is to use PET brain imaging to measure both MOR (Mu-Opioid receptors) and KOR (kappa-opioid receptors) in participants with alcohol use disorder (AUD) and to quantify the relationships between MOR and KOR, separately …

    Stage

    EARLY_Phase 1

    Ages

    21 to 70

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT05957159 on ClinicalTrials.gov

11. Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment and Reduction of Heavy Drinking in Individuals With of Alcohol Use Disorder (AUD)

    The study will compare alcohol use in two groups of subjects. One group will be assigned to the Deep TMS treatment and the other group will be assigned to the sham treatment. This is a prospective, 6-month, double blind, randomized, controlled, multi-center trial in outpatients recruited in both ac…

    Stage

    Not phased

    Ages

    18 to 86

    Site

    Alpha Neuron LLC, Tuscaloosa, Alabama

    Locations

    10 in total

    Run by

    Brainsway

    See if you can join NCT07216872 on ClinicalTrials.gov

12. Role of Phosphatidylethanol in Predicting Perioperative Outcomes of Admitted Patients at UHCMC

    This study aims to see if there's a link between a substance called phosphatidylethanol (PEth) and how patients who have surgery at University Hospitals do after surgery. PEth levels reflect the amount of alcohol use by someone over the past few weeks. This study is checking PEth levels on all pati…

    Stage

    Not phased

    Ages

    21 to 79

    Site

    University Hospital, Cleveland, Ohio

    Run by

    University Hospitals Cleveland Medical Center

    See if you can join NCT06864819 on ClinicalTrials.gov

13. A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder

    The purpose of this study is to see if brenipatide when compared to a placebo works and is safe for participants with moderate-to-severe Alcohol Use Disorder (AUD). Participation in this study will last approximately 56 weeks.

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    Headlands Research - Scottsdale, Scottsdale, Arizona

    Locations

    118 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07219966 on ClinicalTrials.gov

14. Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder

    Background: Chronic heavy drinking can cause alcohol use disorder (AUD). AUD changes how the brain works. People with AUD may drink compulsively or feel like they cannot control their alcohol use. Acamprosate is an FDA-approved drug that reduces anxiety and craving in some, but not all, people with…

    Stage

    Phase 4

    Ages

    21 to 65

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    See if you can join NCT06269627 on ClinicalTrials.gov

15. Neurobehavioral Mechanisms of Psilocybin-assisted Treatment for AUD

    This is a double-blind, randomized, placebo-controlled Phase 2 mechanistic clinical trial designed to evaluate the therapeutic neural mechanisms of psilocybin in patients with alcohol use disorder (AUD), and to determine whether further studies are warranted to study the relationship of any such ef…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06349083 on ClinicalTrials.gov

16. Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat

    The overall objective of this study it to use Positron Emission Tomography (PET) brain imaging and a radiotracer that measures the epigenetic marker Histone Deacetylase 6 (HDAC6) to examine HDAC6 expression in people with Post-Traumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), or concurr…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06371404 on ClinicalTrials.gov

17. NIAAA Natural History Protocol

    Background: - About 17 million adults had an alcohol use disorder in 2012. Researchers want to follow people that have alcohol problems and want treatment, as well as those who do not want treatment and healthy volunteers. They also want to gather information on people with and without alcohol prob…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    See if you can join NCT02231840 on ClinicalTrials.gov

18. The Impact of Heavy Alcohol Use on Saliva and Oral Health

    Background: People with alcohol use disorder (AUD) have a higher rate of dental and gum disease. Poor oral health can increase the risk of other diseases, such as diabetes and stroke. Researchers want to learn more about how to identify developing inflammation in the mouth. They also want to know h…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institutes of Health Clinical Center (CC)

    See if you can join NCT06684483 on ClinicalTrials.gov

19. Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

    Background: People who will participate in research studies need to undergo proper screening, evaluation, and assessment (SEA). SEA helps keep those who participate in studies safe. It also helps ensure accurate study results. The National Institute on Drug Abuse (NIDA) Intramural Research Program …

    Stage

    Not phased

    Ages

    18 to 99

    Site

    National Institute on Drug Abuse, Baltimore, Maryland

    Run by

    National Institute on Drug Abuse (NIDA)

    See if you can join NCT06552741 on ClinicalTrials.gov

20. A Study of Brenipatide in Participants With Alcohol Use Disorder

    The purpose of this study is to see if brenipatide when compared to a placebo works and is safe for participants with Alcohol Use Disorder (AUD) and hazardous alcohol use. Participation in this study will last approximately 56 weeks.

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    Headlands Research - Scottsdale, Scottsdale, Arizona

    Locations

    116 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07219953 on ClinicalTrials.gov

21. AAT for Alcohol Use Disorder in Veterans

    The proposed study will test a novel treatment for alcohol use disorders (AUD) to determine if it helps Veterans reduce their hazardous drinking and recover from alcohol-related functional impairments across social, occupational, and domestic domains. To do so, the investigators will evaluate clini…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    VA San Diego Healthcare System, San Diego, CA, San Diego, California

    Run by

    VA Office of Research and Development

    See if you can join NCT05372029 on ClinicalTrials.gov

22. Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

    Background: Phosphodiesterase-4B (PDE4B) is a protein in the brain that may play a role in several mental health disorders. Researchers want to know if drinking alcohol increases the binding of a radioactive tracer to PDE4B in the brain because of increased activity and/or amount of the protein. Th…

    Stage

    Phase 1

    Ages

    21 to 70

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Mental Health (NIMH)

    See if you can join NCT07027839 on ClinicalTrials.gov

23. Drinking, Acetate, and Stress

    The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the body's chemistry. Specifically, the investigators will be studying relationships of drinking and a stress hormone called cortisol. The investigators believe that results w…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    The Anlyan Center, 300 Cedar St., New Haven, Connecticut

    Locations

    2 in total

    Run by

    Yale University

    See if you can join NCT06584448 on ClinicalTrials.gov

24. Tirzepatide in MetALD

    Background: People with alcohol use disorder (AUD) often develop metabolic alcohol-associated liver disease (MetALD). MetALD is a term for the heart, liver, obesity, and other issues that can accompany AUD. MetALD can be fatal. An approved weight management drug (Tirzepatide) may be able to help pe…

    Stage

    Phase 2

    Ages

    21 to 100

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    See if you can join NCT07046819 on ClinicalTrials.gov

25. Mobile Platform for Optimizing Wellness and Engagement in Recovery

    This pilot study addresses the urgent public health crisis of co-occurring opioid and alcohol use disorders (OUD-AUD), leading causes of mortality in the United States, by testing a scalable digital contingency management (CM) treatment among Medicaid beneficiaries. The study aims to evaluate the f…

    Stage

    Not phased

    Ages

    19 to 63

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07178990 on ClinicalTrials.gov