Alcohol Use Disorder Clinical Trials

104 studies are recruiting for alcohol use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder

   Background: Chronic heavy drinking can cause alcohol use disorder (AUD). AUD changes how the brain works. People with AUD may drink compulsively or feel like they cannot control their alcohol use. Acamprosate is an FDA-approved drug that reduces anxiety and craving in some, but not all, people with…

   Stage

   Phase 4

   Ages

   21 to 65

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute on Alcohol Abuse and Alcoholism (NIAAA)

   See if you can join NCT06269627 on ClinicalTrials.gov

2. Environment and Alcohol: A Pilot Study

   Background: Alcohol use disorder (AUD) is a chronic disease that causes more than 140,000 US deaths each year. AUD treatment often includes therapy and medication. Some people with AUD may also benefit from behavioral and lifestyle changes. Objective: To evaluate the effects of different activities…

   Stage

   Phase 1

   Ages

   21 to 100

   Site

   National Institute on Drug Abuse, Baltimore, Maryland

   Run by

   National Institute on Drug Abuse (NIDA)

   See if you can join NCT06860607 on ClinicalTrials.gov

3. Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

   Background: Phosphodiesterase-4B (PDE4B) is a protein in the brain that may play a role in several mental health disorders. Researchers want to know if drinking alcohol increases the binding of a radioactive tracer to PDE4B in the brain because of increased activity and/or amount of the protein. Th…

   Stage

   Phase 1

   Ages

   21 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT07027839 on ClinicalTrials.gov

4. Tdcs And cogNitive traininG cOmbined for AUD (TANGO)

   The overarching goal of this project is to expand the traditional expertise in non-invasive neuromodulation at the University of Minnesota towards developing novel paired-neuromodulation approaches using transcranial direct current stimulation (tDCS) for new treatments for alcohol use disorder (AUD…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05062369 on ClinicalTrials.gov

5. Developing a Novel Human Laboratory Paradigm for AUD Medication Screening

   The intent of the study is to develop two versions of the 'ability to resist' drinking model designed to screen Alcohol Use Disorder (AUD) medications.

   Stage

   Not phased

   Ages

   21 to 65

   Site

   Yale University, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06489782 on ClinicalTrials.gov

6. Phase 2 Study of Apremilast in Women and Men With Alcohol Use Disorder

   For this protocol, the investigators plan to collect data to evaluate apremilast (60mg/day) vs placebo in adults with Alcohol Use Disorders (AUD).

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   Yale University, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT07029529 on ClinicalTrials.gov

7. NIAAA Natural History Protocol

   Background: - About 17 million adults had an alcohol use disorder in 2012. Researchers want to follow people that have alcohol problems and want treatment, as well as those who do not want treatment and healthy volunteers. They also want to gather information on people with and without alcohol prob…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute on Alcohol Abuse and Alcoholism (NIAAA)

   See if you can join NCT02231840 on ClinicalTrials.gov

8. Peer Support for Liver Transplant Recipients With History of ALD

   Liver transplant (LT) recipients with a history of alcohol-related liver disease (ALD) may encounter various psychosocial and medical challenges during post-LT recovery, even beyond the initial post-transplant period. Effective and sustainable interventions will be crucial for improving patient out…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins University School of Medicine, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07397598 on ClinicalTrials.gov

9. PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder

   Background: People with alcohol use disorder (AUD) also often have bouts of depression called major depressive episodes (MDEs). People having MDEs have been found to have low levels of a protein called PDE4B in the brain. Researchers want to find out if people with AUD also have low levels of PDE4B…

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT06795581 on ClinicalTrials.gov

10. Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment and Reduction of Heavy Drinking in Individuals With of Alcohol Use Disorder (AUD)

    The study will compare alcohol use in two groups of subjects. One group will be assigned to the Deep TMS treatment and the other group will be assigned to the sham treatment. This is a prospective, 6-month, double blind, randomized, controlled, multi-center trial in outpatients recruited in both ac…

    Stage

    Not phased

    Ages

    18 to 86

    Site

    Alpha Neuron LLC, Tuscaloosa, Alabama

    Locations

    11 in total

    Run by

    Brainsway

    See if you can join NCT07216872 on ClinicalTrials.gov

11. Spironolactone in Alcohol Use Disorder (SAUD)

    Background: Alcohol use disorder (AUD) affects about 29.5 million people in the United States. Only 3 medicines have been approved by Food and Drug Administration to treat AUD. Researchers want to find better treatments for AUD. Animal studies found that a medicine called spironolactone, may decrea…

    Stage

    Phase 1

    Ages

    21 to 99

    Site

    National Institute on Drug Abuse, Baltimore, Maryland

    Run by

    National Institute on Drug Abuse (NIDA)

    See if you can join NCT05807139 on ClinicalTrials.gov

12. Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder

    This is a randomized, double-blind, crossover trial to evaluate the immediate effects of a nutritional ketone supplement, Kenotic compared to placebo on brain function and alcohol consumption in individuals with alcohol use disorder. Participants will complete 2 MRI scans, and 2 alcohol bar labs an…

    Stage

    Phase 2

    Ages

    21 to 65

    Site

    Center for Studies of Addiction, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06807918 on ClinicalTrials.gov

13. A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners

    The purpose of this study is to evaluate the efficacy of an adaptive web intervention (Partners Connect) on military spouse drinking behaviors (CPs) and service member help-seeking (SMs). The investigators want to identify for whom this intervention is most efficacious and on what drinking behavior…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Stanford University, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT05619185 on ClinicalTrials.gov

14. AAT for Alcohol Use Disorder in Veterans

    The proposed study will test a novel treatment for alcohol use disorders (AUD) to determine if it helps Veterans reduce their hazardous drinking and recover from alcohol-related functional impairments across social, occupational, and domestic domains. To do so, the investigators will evaluate clini…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    VA San Diego Healthcare System, San Diego, CA, San Diego, California

    Run by

    VA Office of Research and Development

    See if you can join NCT05372029 on ClinicalTrials.gov

15. Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)

    Background: Alcohol use disorder (AUD) is the most common substance use disorder in the world. Long-term AUD can affect a person s sense of taste and smell. This natural history study will compare alcohol drinking behaviors and measures of taste and smell in people with and without AUD. Objective: …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute on Alcohol Abuse and Alcoholism (NIAAA)

    See if you can join NCT05677321 on ClinicalTrials.gov

16. Hepatic Lipid Metabolism-Alcohol Use Disorder

    Patients with hepatic steatosis due to alcohol will be offered liver biopsies when they enter a detoxification program. The first biopsy will occur in the first week of admission and the second in the fourth week when the steatosis has resolved. The hepatic transcriptome will be compared,

    Stage

    Not phased

    Ages

    18 to 100

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    See if you can join NCT07191561 on ClinicalTrials.gov

17. A Study of Brenipatide in Participants With Alcohol Use Disorder

    The purpose of this study is to see if brenipatide when compared to a placebo works and is safe for participants with Alcohol Use Disorder (AUD) and hazardous alcohol use. Participation in this study will last approximately 56 weeks.

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    North Star Medical Research, Middleburg Heights, Ohio

    Locations

    116 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07219953 on ClinicalTrials.gov

18. A Study of Brenipatide in Participants With Moderate-to-Severe Alcohol Use Disorder

    The purpose of this study is to see if brenipatide when compared to a placebo works and is safe for participants with moderate-to-severe Alcohol Use Disorder (AUD). Participation in this study will last approximately 56 weeks.

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    Maryland Treatment Centers - Avery Road Treatment Center, Rockville, Maryland

    Locations

    117 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT07219966 on ClinicalTrials.gov

19. Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder

    The goal of this clinical trial is to identify sex-specific biomarkers that confer greater susceptibility for Alcohol Use Disorder (AUD) and differentiate how treatment response varies by sex in people with Alcohol Use Disorder. The main questions it aims to answer are: * How does trauma affect emo…

    Stage

    Phase 4

    Ages

    18 to 60

    Site

    VA Portland Health Care System, Portland, Oregon

    Run by

    Milky Kohno

    See if you can join NCT06426303 on ClinicalTrials.gov

20. Cannabis' Impact on Alcohol Consumption

    This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which participants choose either to drink or receive monetary reinforcement f…

    Stage

    Phase 2

    Ages

    21 to 50

    Site

    Brown University, Providence, Rhode Island

    Run by

    Brown University

    See if you can join NCT05389930 on ClinicalTrials.gov

21. Intranasal Insulin for Treatment of Alcohol Use Disorder

    This is a randomized controlled trial (RCT), within-subject, crossover, double-blind, placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD) (N=40, 50% female) randomized to IN insulin or placebo. In a bar laboratory setting, randomized participants will receive a s…

    Stage

    Phase 1

    Ages

    21 and older

    Site

    Brown University, Providence, Rhode Island

    Run by

    Brown University

    See if you can join NCT05988632 on ClinicalTrials.gov

22. tAN for Substance Use Disorder

    The study will involve a 5-day tAN treatment to attenuate alcohol withdrawal syndrome (AWS) and alter resting state functional connectivity (RSFC) between OFC and striatum in patients with alcohol use disorder (AUD). Enrolled participants will wear the tAN device on-site (at The Menninger Clinic) f…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    The Menninger Clinic, Houston, Texas

    Run by

    Spark Biomedical, Inc.

    See if you can join NCT07281261 on ClinicalTrials.gov

23. Orexin Receptor Antagonism for the Treatment of Alcohol Use Disorder and Stress-Related Drinking

    The goal of this clinical trial is to learn if, how, and for whom suvorexant (SUV) works to treat alcohol use disorder (AUD). The main questions it aims to answer are: * Is SUV effective for AUD? * Does SUV dampen stress reactivity? * Can the researchers develop a biomarker for SUV treatment respon…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Ohio State University, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT07214207 on ClinicalTrials.gov

24. Cessation or Reduction of Alcohol Consumption in Veterans: A Randomized Controlled Trial for Alcohol Use Disorder (CRAVE)

    This clinical trial aims to test the effectiveness and safety of semaglutide, a GLP-1 receptor agonist, in treating moderate to severe alcohol use disorder (AUD) in Veterans. Participants who qualify will be randomly assigned to receive either semaglutide injections or placebo injections over a 24-…

    Stage

    Phase 3

    Ages

    18 to 80

    Site

    VA Long Beach Healthcare System, Long Beach, CA, Long Beach, California

    Locations

    19 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT07218354 on ClinicalTrials.gov

25. The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration

    Oral disulfiram (Antabuse®) has been shown to improve image-forming vision in animal models with retinal degeneration due to its ability to decrease Retinoic Acid synthesis and consequently reduce hyperactivity in the inner retina. The investigator will aim to evaluate the impact of oral disulfiram…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT06319872 on ClinicalTrials.gov