Aging Clinical Trials

123 studies are recruiting for aging in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. Empagliflozin Reversal of Arterial StiffnEss in Aging

   Randomized placebo-controlled clinical trial in a cohort of males (n=40) and females (n=40), 60-80 years of age, with the hypothesis that SGLT2 inhibition with empagliflozin (10mg/day for 12 weeks) reduces aging-related arterial stiffening.

   Stage

   Phase 2

   Ages

   60 to 80

   Site

   University of Missouri, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT06506422 on ClinicalTrials.gov

2. Molecular Indicators of Systematic Fitness

   The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max/VO₂peak, and blood-based molecular measurements in adults. This is an observational study where research staff measures VO₂max/VO₂peak and collects fasted, resting blood samples on the sa…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VO Health, Inc., New Haven, Connecticut

   Run by

   VO Health, Inc.

   See if you can join NCT07393841 on ClinicalTrials.gov

3. Tennessee Alzheimer's Project

   The primary objective of the Vanderbilt Alzheimer's Disease Research Center (VADRC) is to provide local and national researchers with access to a well-characterized and diverse clinical cohort, including participant referrals, biosamples, clinical data, and neuroimaging data. The VADRC Clinical Cor…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT05372172 on ClinicalTrials.gov

4. Preliminary Testing of Cafe Move for Primary Prevention of Physical Frailty

   This project explores a novel means of health promotion and prevention of age-related physical frailty, which is designed to overcome barriers to access and promote autonomy in managing physical health.

   Stage

   Not phased

   Ages

   50 to 85

   Site

   University of Montana, Missoula, Montana

   Run by

   University of Montana

   See if you can join NCT05720507 on ClinicalTrials.gov

5. Identification of Critical Thermal Environments for Aged Adults

   This study evaluates critical environmental limits (temperature and humidity) above which older adults are unable to effectively thermoregulate. Participants will exercise in a series of different environmental conditions to identify combinations of temperature and humidity above which age-related …

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Noll Laboratory, University Park, Pennsylvania

   Run by

   Penn State University

   See if you can join NCT04284397 on ClinicalTrials.gov

6. Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 2

   This study consists of three aims focused on examining the feasibility of adding the Geriatric Resources and Assessment for the Care of Elders (GRACE) model to structured Annual Wellness Visits (AWVs) to improve patient and caregiver outcomes and reduce hospitalizations in older adults with complex…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina

   Locations

   4 in total

   Run by

   Massachusetts General Hospital

   See if you can join NCT07166861 on ClinicalTrials.gov

7. Mechanisms of Anabolic Resistance in Older Humans

   The purpose of this research is to understand how chronic inflammation affects muscle function and responses to exercise in older adults.

   Stage

   Not phased

   Ages

   21 to 85

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06617195 on ClinicalTrials.gov

8. Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise

   High blood pressure (BP) is the major modifiable risk factor for cardiovascular diseases (CVD) and related health conditions, particularly among postmenopausal (PM) women. In adults age ≥50 years this risk is primarily driven by above-normal systolic BP (SBP ≥120 mmHg), as diastolic BP plateaus, th…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Integrative Physiology of Aging Laboratory, Boulder, Colorado

   Run by

   University of Colorado, Boulder

   See if you can join NCT05000515 on ClinicalTrials.gov

9. Emotional Well-being and Measures of Healthy Aging

   This randomized control study is designed to understand the role of a positive psychology intervention (PARK: Positive Affect Regulation sKills) in biological aging and well-being. PARK provides a series of positive emotion skills in a self-guided online format, making the program accessible and co…

   Stage

   Not phased

   Ages

   40 to 70

   Site

   Potocsnak Human Longevity Lab, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT07334106 on ClinicalTrials.gov

10. Understanding Aided Speech Perception in Noise

    The overarching hypothesis to be evaluated using this protocol is that age-related hearing loss (ARHL) leads to shifts in the functional spatial boundaries between segregated and integrated auditory streams, and that hearing aid intervention that relies on directional processing schemes is most eff…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    USF Research Park BPB, 3802 Spectrum Boulevard, Suite 210C, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT06377215 on ClinicalTrials.gov

11. A Study of Dual-task Exercise Training to Prevent Falls Among Older Adults With Mild Cognitive Impairment

    To determine the efficacy of a dual-task tai ji quan training therapy in reducing the incidence of falls in older adults with mild cognitive impairment.

    Stage

    Not phased

    Ages

    65 to 95

    Site

    Oregon Research Institute, Springfield, Oregon

    Run by

    Oregon Research Institute

    See if you can join NCT05725668 on ClinicalTrials.gov

12. Pain and Split-belt Motor Learning in Older Adults

    The purpose of this research is to investigate the impact of acute pain, induced using an experimental pain paradigm of capsaicin paired with heat, on implicit locomotor learning and its retention in older adults.

    Stage

    Not phased

    Ages

    55 to 90

    Site

    Health Sciences Complex, Newark, Delaware

    Run by

    University of Delaware

    See if you can join NCT07054840 on ClinicalTrials.gov

13. Early Neurovascular Adaptations in Aging Women

    Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.

    Stage

    EARLY_Phase 1

    Ages

    18 to 70

    Site

    University of Missouri-Columbia, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT06520982 on ClinicalTrials.gov

14. Ultrasound for Healthy Aging

    The investigators will study the effects of an ultrasound bath device that uses low-frequency ultrasound on the healthy aging. Participants will have before and after ultrasound assessments of muscle and thinking skills, aging related to the immune system, and body make-up. The group that is assign…

    Stage

    Not phased

    Ages

    70 and older

    Site

    University of Texas Health Science Center at San Antonio, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT07168525 on ClinicalTrials.gov

15. Cognitive Vitality Pilot Study

    This study's purpose is to evaluate the effects of a dietary supplement on cognitive function and psychological well-being in community-dwelling older adults aged 55+. The study involves taking a commercially available dietary supplement daily for 45 days. A 45-minute assessment will be conducted a…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Community, West Palm Beach, Florida

    Run by

    Arizona State University

    See if you can join NCT07208279 on ClinicalTrials.gov

16. Aging, Beta Blockers, and Thermoregulatory Responses

    This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.

    Stage

    Phase 4

    Ages

    65 and older

    Site

    IEEM Texas Health Presbyterian Hospital Dallas, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06582680 on ClinicalTrials.gov

17. Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults

    Participants in this study will undergo a series of non-invasive tests and activities designed to understand how a single dose of psilocybin might influence cognition and emotional well-being in healthy older adults. After providing written informed consent, eligible participants, aged between 60 a…

    Stage

    Phase 1

    Ages

    60 to 85

    Site

    University of California, Berkeley, Berkeley, California

    Run by

    University of California, Berkeley

    See if you can join NCT06367738 on ClinicalTrials.gov

18. Technical Development of Multi-Parametric Renocerebral MRI

    The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests.

    Stage

    Not phased

    Ages

    21 to 80

    Site

    Center for Magnetic Resonance Research, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT02831335 on ClinicalTrials.gov

19. bpMedManage: Digital Technology to Support Adherence to Hypertension Medications

    The purpose of the bpMedManage study is to rigorously test the efficacy of a smartphone technology to help improve high blood pressure medication adherence among older adults with mild cognitive impairment (MCI) in a 16-week randomized controlled trial. A total of 100 older adults will be recruited…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of Arizona, Tucson, Arizona

    Locations

    2 in total

    Run by

    University of Arizona

    See if you can join NCT06307574 on ClinicalTrials.gov

20. Metabolic and Functional Consequences of Aging in Health and Disease

    Considerable heterogeneity in the aging population has been observed. The exceptional longevity of individuals reaching 100 years old, so-called centenarians may be an example of life-long healthy aging, or added years may be spent in poor health with decreased physical and cognitive functioning. C…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Human Clinical Research Building, College Station, Texas

    Run by

    Texas A&M University

    See if you can join NCT05240885 on ClinicalTrials.gov

21. Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty

    Patients experience dramatic quadriceps strength loss after total knee replacement, which contributes to persistent weakness and reduced long-term function after surgery. Neuromuscular electrical stimulation (NMES) reduces quadriceps weakness and improves patient function after knee replacement, bu…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UCHealth, Aurora, Colorado

    Locations

    3 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT06953375 on ClinicalTrials.gov

22. Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals

    The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of exercise. Participants will come in for 3 study visits and get home-bas…

    Stage

    Phase 2

    Ages

    65 to 85

    Site

    Froedtert Hospital, Wauwatosa, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT05808686 on ClinicalTrials.gov

23. Angiotensin-(1-7) Cardiovascular Effects in Aging

    Aging is an independent risk factor for developing hypertension and cardiovascular disease; however, the mechanisms underlying age-related cardiovascular disease remain poorly understood. One hallmark of aging is an increase in sympathetic nervous system activity, which can decrease the number and/…

    Stage

    EARLY_Phase 1

    Ages

    65 to 80

    Site

    Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania

    Run by

    Milton S. Hershey Medical Center

    See if you can join NCT05301192 on ClinicalTrials.gov

24. Fatty Acid Modulation of Brain Function in Older Adults

    In this crossover study, the investigtors will administer two experimental diets in a random order for one week, and each experimental diet will be preceded by a one-week, low fat control diet for a total four-week study period. The goal is to study how the fatty acid content of the diet affects br…

    Stage

    Not phased

    Ages

    65 to 75

    Site

    University of Vermont, Burlington, Vermont

    Run by

    University of Vermont

    See if you can join NCT06192407 on ClinicalTrials.gov

25. Dehydration, Rehydration, and Impact on Physiology

    Our goal is to determine whether hydration status influences inflammation, and overall physiological performance in adults aged 45-65. Aim 1: The effects of 4-day mild dehydration followed by 4-day rehydration (defined as approximately 2-3% body mass loss) on H2O2, upstream inflammatory signal (NFk…

    Stage

    Not phased

    Ages

    45 to 65

    Site

    Texas Tech University, Lubbock, Texas

    Run by

    Texas Tech University

    See if you can join NCT07084675 on ClinicalTrials.gov