Aging Clinical Trials

123 studies are recruiting for aging in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 5

1. The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults

   To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.

   Stage

   Not phased

   Ages

   65 and older

   Site

   Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Mayo Clinic

   See if you can join NCT06940037 on ClinicalTrials.gov

2. Optimizing Strength Training in Older Adults

   The objective of the current study is to determine whether lifting lighter loads close to failure improves strength training adaptations and function in older adults. The main questions it aims to answer are: 1. The effect of light loads on physical function 2. The effect of light loads on muscle m…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Exercise & Aging Lab, Queens College, Flushing, New York

   Run by

   Queens College, The City University of New York

   See if you can join NCT06812143 on ClinicalTrials.gov

3. Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation

   The goal of this randomized, controlled trial is to evaluate the effectiveness of alternative therapies (metformin alone, with rapamycin, and with low-dose naltrexone) in maintaining weight loss in patients weaning off GLP-1 medications. The main questions it aims to answer are: * Whether the combi…

   Stage

   Phase 2

   Ages

   40 to 85

   Site

   AgelessRx, Chicago, Illinois

   Run by

   AgelessRx

   See if you can join NCT07092618 on ClinicalTrials.gov

4. Apple Health Study

   The Apple Health Study aims to build a diverse and inclusive group of participants to help researchers advance our understanding of how signals and information collected from apps and devices relate to health and may be used to predict, detect, monitor, and manage changes in health. To enroll, US r…

   Stage

   Not phased

   Ages

   18 and older

   Site

   MCRA, Washington D.C., District of Columbia

   Locations

   2 in total

   Run by

   Apple Inc.

   See if you can join NCT06958523 on ClinicalTrials.gov

5. Multimodal Musical Stimulation for Healthy Neurocognitive Aging

   This is a Stage I randomized, sham-controlled trial on the effects of multimodal musical stimulation on working memory in aging. Neurologically healthy older and younger adults will be tested on working memory and electroencephalography in the first randomized controlled trial of music as a form of…

   Stage

   Not phased

   Ages

   18 to 95

   Site

   Northeastern University, Boston, Massachusetts

   Run by

   Northeastern University

   See if you can join NCT06229093 on ClinicalTrials.gov

6. Heterogeneity of Vascular Adaptations to Exercise With Aging in Women and Men

   The goal of the proposed study is to understand the reasons for the variability in aerobic exercise (AE) training benefits on the vasculature in middle-age and older (MA/O) adults, including differences between men and women. To achieve this goal, a mechanistic randomized controlled (RCT) will be c…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Colorado Anschutz Medical Center, Clinical Translational Research Center and Exercise Research Laboratory, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT06912984 on ClinicalTrials.gov

7. Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities

   The aim of this study is to design a sleep and mindfulness intervention to improve sleep, quality of life, and cognitive function among older adults.

   Stage

   Not phased

   Ages

   55 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Brigham and Women's Hospital

   See if you can join NCT06989619 on ClinicalTrials.gov

8. Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

   The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed computerized cognitive tests. These tests are designed to permit the early detection of individuals at risk of age-related cognitive declin…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Neurobehavioral Systems, Inc., Berkeley, California

   Run by

   Neurobehavioral Systems, Inc.

   See if you can join NCT04800588 on ClinicalTrials.gov

9. Inspiratory Muscle Strength Training in Chronic Kidney Disease

   More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control <130/80 mmHg, leading to high risk of cardiovascular diseases and end-stage kidney disease. A stepwise combination of lifestyle modifications and drug thera…

   Stage

   Not phased

   Ages

   50 and older

   Site

   University of Colorado - Anschutz Medical Campus, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT04911491 on ClinicalTrials.gov

10. Passive Heat Therapy for Lowering Systolic Blood Pressure and Improving Vascular Function in Mid-life and Older Adults

    This study aims to determine the effects of ~12 weeks of repeated hot water immersion ("heat therapy") vs. thermoneutral water immersion on blood pressure and vascular function in late middle-life to older (≥40 years) adults. The study also aims to determine the effects of ~12 weeks of heat therapy…

    Stage

    Not phased

    Ages

    40 and older

    Site

    University of Colorado Boulder, Boulder, Colorado

    Run by

    University of Colorado, Boulder

    See if you can join NCT05300971 on ClinicalTrials.gov

11. Speech Perception and High Cognitive Demand

    With advancing age, adults experience increasing speech understanding difficulties in challenging situations. Currently, speech-in-noise difficulties are rehabilitated by providing hearing aids. For older normal-hearing adults, however, hearing devices do not provide much benefit since these adults…

    Stage

    Not phased

    Ages

    65 to 85

    Site

    Department of Hearing and Speech Sciences, College Park, Maryland

    Locations

    2 in total

    Run by

    University of Maryland, College Park

    See if you can join NCT04997577 on ClinicalTrials.gov

12. Glucose Variability and Cognition in Prediabetes

    This study examines the association of variability in glucose values over a 10-day period with cognitive function and functional status among individuals with prediabetes, aged 50 or older.

    Stage

    Not phased

    Ages

    50 and older

    Site

    Baltimore VA Geriatric Research Education and Clinical Center (GRECC), Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT04201600 on ClinicalTrials.gov

13. The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults

    The goal of this study is to determine the impact of pre-diabetes and type 2 diabetes on muscle atrophy during a period of bed rest and recovery of muscle mass, strength, and physical function following bed rest.

    Stage

    Not phased

    Ages

    60 to 80

    Site

    Translational Research Institute for Metabolism and Diabetes, Orlando, Florida

    Run by

    AdventHealth Translational Research Institute

    See if you can join NCT03761446 on ClinicalTrials.gov

14. Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

    Aging is the primary risk factor for cardiovascular diseases (CVD), the number one cause of death in developed societies. Systolic blood pressure (SBP) increase with age and is a key intermediary factor linking aging to increased CVD risk. The primary mechanisms underlying the age-associated increa…

    Stage

    Phase 2

    Ages

    50 and older

    Site

    Integrative Physiology of Aging Laboratory, Boulder, Colorado

    Run by

    Douglas Seals

    See if you can join NCT03821623 on ClinicalTrials.gov

15. Breaking Sitting with High-intensity Interval Training for Brain Health

    This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in cognitively normal older adults. This trial will test the feasibility of HIIT br…

    Stage

    Not phased

    Ages

    40 to 75

    Site

    University of Illinois at Urbana-Champaign, Urbana, Illinois

    Run by

    University of Illinois at Urbana-Champaign

    See if you can join NCT06243016 on ClinicalTrials.gov

16. Gene Expression Changes In Young and Geriatric Skin

    This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to …

    Stage

    EARLY_Phase 1

    Ages

    21 and older

    Site

    Wright State Physicians, Fairborn, Ohio

    Run by

    Wright State University

    See if you can join NCT03932162 on ClinicalTrials.gov

17. Mindfulness for Cognition in Early-stage Alzheimer's Disease

    The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1. How does mindfulness impact thinking and memory? 2. How does mindfulness influence brain function and struct…

    Stage

    Not phased

    Ages

    50 to 100

    Site

    VA Boston Healthcare System - Jamaica Plain Campus, Boston, Massachusetts

    Run by

    VA Boston Healthcare System

    See if you can join NCT06792877 on ClinicalTrials.gov

18. The Lake Nona Life Project

    The Lake Nona Life Project aims to examine the health and wellness of participants over the course of multiple years, focusing on the links between health and wellness, longevity, quality of life, and human performance.

    Stage

    Not phased

    Ages

    18 to 110

    Site

    Lake Nona Institute, Orlando, Florida

    Run by

    University of Central Florida

    See if you can join NCT02533804 on ClinicalTrials.gov

19. Molecular Optimization Via Exercise (MOVE)

    This study is to investigate characteristics of muscle, blood, and urine samples from older adults (ages 65-80) who are either sedentary or athletes performing at an elite level for their age. This observational study will include bio-specimen collection, as well as physical and cognitive function …

    Stage

    Not phased

    Ages

    65 to 80

    Site

    Buck Institute for Research on Aging, Novato, California

    Run by

    Buck Institute for Research on Aging

    See if you can join NCT06540287 on ClinicalTrials.gov

20. Western Diet on Cardiometabolic and Immune Function

    This study will implement a Western Diet (WD) to understand cardiometabolic and immune function in middle-aged adults (50- 64 years old). Vascular health, intestinal permeability, and T-cell function will be examined before, during, and after the WD. The WD is a 10-day diet and will consist of 25% …

    Stage

    Not phased

    Ages

    50 to 64

    Site

    University of Delaware, Newark, Delaware

    Run by

    University of Delaware

    See if you can join NCT06528977 on ClinicalTrials.gov

21. Cardiometabolic Consequences of the Loss of Ovarian Function

    The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease. The purpose of this research is to study how the decrease in estrogen at menopause changes artery health an…

    Stage

    Phase 4

    Ages

    20 to 45

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06264882 on ClinicalTrials.gov

22. Bioenergetic Effects of Aging and Menopause (BEAM)

    The menopause transition is associated with increased risk for weight gain and a shift toward storing fat in the belly region, which may increase risk for cardiovascular disease and diabetes. The study will determine whether the stress hormone cortisol contributes to this shift.

    Stage

    Phase 4

    Ages

    40 to 65

    Site

    University of Colorado - Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT04043520 on ClinicalTrials.gov

23. DC Longitudinal Study on Aging and Specimen Bank

    The Georgetown University Memory Disorders Program, part of the Department of Neurology, is conducting pilot studies of the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment and other neurodegenerative diseases. Further, this study is assessing longitudinal …

    Stage

    Not phased

    Ages

    45 and older

    Site

    Georgetown University Memory Disorders Program, Washington D.C., District of Columbia

    Run by

    Georgetown University

    See if you can join NCT03702907 on ClinicalTrials.gov