Aging Clinical Trials

123 studies are recruiting for aging in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Neurobiological Mechanisms of Aging and Stress on Prospective Navigation

   Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress and altered regulation of the stress response. However, there are mar…

   Stage

   Not phased

   Ages

   65 to 80

   Site

   Center for Advance Brain Imaging, Atlanta, Georgia

   Run by

   Georgia Institute of Technology

   See if you can join NCT03896529 on ClinicalTrials.gov

2. SMART Exercise for PAD

   Supervised exercise therapy (SET), consisting of treadmill exercise conducted three times weekly at a center while supervised by healthcare personnel, is first line therapy for people disabled by lower extremity peripheral artery disease (PAD). However, travelling three times/week to a center for S…

   Stage

   Phase 3

   Ages

   50 and older

   Site

   Northwestern University Feinberg School of Medicine, Chicago, Illinois

   Locations

   3 in total

   Run by

   Northwestern University

   See if you can join NCT06032065 on ClinicalTrials.gov

3. Fisetin to Reduce Senescence and Mobility Impairment in PAD

   The investigators propose a pilot randomized trial to gather preliminary data to test the hypothesis that Fisetin will reduce abundance of senescent cells in blood, skeletal muscle, and both subcutaneous and inter muscular adipose tissue and improve 6-minute walk distance in 34 people with peripher…

   Stage

   Phase 2

   Ages

   50 and older

   Site

   Northwestern University Feinberg School of Medicine, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT06399809 on ClinicalTrials.gov

4. ENhancing Exercise With LIGHT to Improve Functioning in PAD

   The ENLIGHTEN PAD Trial will collect preliminary data to test whether daily 660 nm light treatment of the lower extremities immediately before home-based walking exercise sessions improves six-minute walk distance at 4-month follow-up, compared to sham light, in people with lower extremity peripher…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Northwestern University, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT06399900 on ClinicalTrials.gov

5. Improving PCP Advance Care Planning for People With ADRD

   This study will test the Dementia Advance Care Planning (AD ACP) Toolkit intervention to usual care in facilitating goals of care (GOC) discussions between People Living with Dementia (PLwD) and primary care team members over an 18-month period. The primary outcome is to assess the frequency and qu…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   University of North Carolina, Chapel Hill, Chapel Hill, North Carolina

   Run by

   University of Pittsburgh

   See if you can join NCT06565169 on ClinicalTrials.gov

6. Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce

   This project will compare two training models of an evidence-based online dementia care training program for direct care staff in assisted living to a waitlist control: 1) essentiALZ training and 2) essentiALZ training + Project ECHO. It will examine the extent to which each model is implemented an…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT06239688 on ClinicalTrials.gov

7. Arterial Stiffness and Blood Pressure

   Hypertension is a common and treatable disorder that remains the leading preventable cause of heart disease. Blood pressure treatment relies mainly on upper arm blood pressure readings and ignores blood vessel physiology and underlying individual genetic information. Older Veterans with hypertensio…

   Stage

   Not phased

   Ages

   60 and older

   Site

   William S. Middleton Memorial Veterans Hospital, Madison, WI, Madison, Wisconsin

   Locations

   3 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT06495710 on ClinicalTrials.gov

8. Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging

   Much of human interaction is based on trust. Aging has been associated with deficits in trust-related decision making, likely further exacerbated in age-associated neurodegenerative disease (Alzheimer's disease/AD), possibly underlying the dramatically growing public health problem of elder fraud. …

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT05457725 on ClinicalTrials.gov

9. The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses

   This study focuses on the role of neutrophils in shaping the adaptive immune response to the anti-pneumococcal vaccine Prevnar-13 in young and elderly adults.

   Stage

   Phase 4

   Ages

   21 and older

   Site

   University at Buffalo, Buffalo, New York

   Run by

   State University of New York at Buffalo

   See if you can join NCT06128915 on ClinicalTrials.gov

10. The Effect of NAD Supplementation on Brain Vascular Health in Aging

    Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.

    Stage

    Phase 4

    Ages

    60 to 85

    Site

    University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT05483465 on ClinicalTrials.gov

11. BID WM Digital Intervention in Aging

    The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are: 1. Does engagement in with a digital intervention improve working memory? 2. Does engagement in with a digital intervention improve inhibito…

    Stage

    Not phased

    Ages

    60 to 85

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06918704 on ClinicalTrials.gov

12. Pain in Aging Former Athletes, Master's Athletes, and Nonathletes

    The goal of this clinical trial is to determine how male and female former athletes experience pain and respond to moderate-intensity exercise (strength versus aerobic) compared with both current master's athletes and nonathletes. The main questions this study aims to address are: 1. How do former …

    Stage

    Not phased

    Ages

    35 to 65

    Site

    Marquette University, Milwaukee, Wisconsin

    Run by

    Marquette University

    See if you can join NCT07502742 on ClinicalTrials.gov

13. Skeletal Muscle Aging and Responsiveness in Aged People With MS

    The purposes of this study are to: 1) compare baseline muscle and cardiovascular health in older individuals (>60 years old) diagnosed with MS to age-matched people without MS, 2) determine muscle and whole body changes to an exercise training program, 3) determine if the muscle in a more affected …

    Stage

    Not phased

    Ages

    60 and older

    Site

    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma

    Run by

    Oklahoma Medical Research Foundation

    See if you can join NCT07500727 on ClinicalTrials.gov

14. Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging

    The goal of this behavioral clinical trial is to learn how to increase physical activity in mid-life adults. Specifically, can guided imagery that includes creating mental pictures increase excitement about working out. Participants will be asked to complete testing at the beginning of the study, f…

    Stage

    Not phased

    Ages

    45 to 65

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT06123182 on ClinicalTrials.gov

15. Tirzepatide to Slow Biological Aging

    This pilot clinical study aims to investigate the potential effects of tirzepatide on biological aging in older adults. In this novel study, 90 adults aged 55-70 years with an indication for tirzepatide weight-loss therapy will be randomized to receive either tirzepatide 2.5 mg subcutaneously (SC) …

    Stage

    Phase 2

    Ages

    55 to 70

    Site

    University of Texas Medical Branch, Galveston, Texas

    Run by

    The University of Texas Medical Branch, Galveston

    See if you can join NCT07220473 on ClinicalTrials.gov

16. Synbiotic to Attenuate Resorption of the Skeleton

    This randomized, double blind, placebo controlled clinical trial will test the efficacy of a probiotic/prebiotic combination ("synbiotic") on the skeleton in older women.

    Stage

    Not phased

    Ages

    60 and older

    Site

    Hebrew SeniorLife, Roslindale, Massachusetts

    Run by

    Hebrew SeniorLife

    See if you can join NCT06389539 on ClinicalTrials.gov

17. IH, Brain Health, and T2D

    The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).

    Stage

    Not phased

    Ages

    60 to 85

    Site

    University of Iowa, Iowa City, Iowa

    Run by

    Darren P Casey

    See if you can join NCT07173543 on ClinicalTrials.gov

18. The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers

    The goal of this pilot study is to explore a combination of two interventions: (1) a behavioral alcohol-reduction intervention using motivational interviewing, and (2) a blinded probiotic microbiome or placebo intervention. The study examines whether these interventions improve cognitive and neurop…

    Stage

    Not phased

    Ages

    65 to 84

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT07415707 on ClinicalTrials.gov

19. Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health

    Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability. Quantifying function in former athletes with and without a prior injury …

    Stage

    Not phased

    Ages

    18 to 64

    Site

    Marquette University, Milwaukee, Wisconsin

    Run by

    Marquette University

    See if you can join NCT05344001 on ClinicalTrials.gov

20. Cognitive Remediation

    The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in some older adults following a viral infection. The main questions it aim…

    Stage

    Not phased

    Ages

    60 and older

    Site

    UConn Health, Farmington, Connecticut

    Run by

    Cutter Lindbergh

    See if you can join NCT07171450 on ClinicalTrials.gov

21. Exercise to Improve Brain Health in Older African Americans

    The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans. Specifically, the main question[s] it aims to answer are: * What is the effect of a Cardio-Dance Fitness (CDF) vs. a Strength, Flexibility, and Bala…

    Stage

    Phase 2

    Ages

    60 and older

    Site

    Rutgers, The State University of New Jersey - Newark campus, Newark, New Jersey

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT05597124 on ClinicalTrials.gov

22. Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults

    This is a randomized, double-blind, placebo-controlled, two-arm crossover clinical trial evaluating the effects of a patented age-reversal therapy, EGA®, compared to conventional nicotinamide mononucleotide (NMN) supplementation. The study will assess safety and efficacy in improving exercise toler…

    Stage

    Not phased

    Ages

    60 to 80

    Site

    Medical Office of Dr. Robert Huizenga MD, Beverly Hills, California

    Run by

    Scott Silveira

    See if you can join NCT07144527 on ClinicalTrials.gov

23. Fiber and Calcium Absorption in Older Men

    Osteoporotic fractures are a major but underrecognized problem in men. There is growing evidence that low dietary fiber intake is a modifiable risk factor for age-related bone loss in men. Preclinical and human studies in adolescents and postmenopausal women suggest that dietary fiber intake influe…

    Stage

    Phase 2

    Ages

    60 and older

    Site

    San Francisco VA Medical Center, San Francisco, CA, San Francisco, California

    Run by

    VA Office of Research and Development

    See if you can join NCT06519877 on ClinicalTrials.gov

24. Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults

    During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on motoneuronal activation in healthy adults, which typically decreases with age. The investigators will also test whether WB-EMS Exercise will improve measures…

    Stage

    Not phased

    Ages

    18 and older

    Site

    NextGen Precision Health Building, Clinical and Translational Science Unit, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT06689618 on ClinicalTrials.gov

25. Tau PET in Imaging and Cognition: Healthy Adults From 55-90

    The investigators aim to use the new PET radioligand, 18F-MK-6240, to detect tau pathology in cognitive healthy and mild cognitive impairment (MCI) elders. The investigators will then examine the interactions between differential tau burden and performance on cognitive tasks, functional magnetic re…

    Stage

    Not phased

    Ages

    55 to 90

    Site

    Columbia University Medical Center, New York, New York

    Run by

    Yaakov Stern

    See if you can join NCT03372317 on ClinicalTrials.gov