Aging Clinical Trials

123 studies are recruiting for aging in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Motivating Activity Through Text Communications - Helping Adults Increase Movement

   The goal of this clinical trial is to compare the effect of different types of text messages on physical activity levels of middle-aged and older adults and to determine whether these messages are effective in adults age 40 and older who are engaging in less than 90 minutes per week of moderate or …

   Stage

   Not phased

   Ages

   40 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT07593677 on ClinicalTrials.gov

2. Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and MCI

   The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in an aging population.

   Stage

   Not phased

   Ages

   60 and older

   Site

   Kessler Foundation, East Hanover, New Jersey

   Run by

   Kessler Foundation

   See if you can join NCT06269939 on ClinicalTrials.gov

3. Strength and Pain-Coping Through Resilience and Knowledge

   Older adults who are 50 years of age and older with depressive symptoms, pain and difficulty with mobility will participate in the SPARK intervention study that includes 8 nurse visits in participants' homes to help participants with participants' pain and mood.

   Stage

   Not phased

   Ages

   50 and older

   Site

   Johns Hopkins School of Nursing, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07228520 on ClinicalTrials.gov

4. Memory Enhancement in Aging With Optimal Dosing

   This project optimizes high-resolution transcranial Alternating Current Stimulation (tACS) to improve memory in healthy older adults, advancing drug-free approaches for Alzheimer's disease and related dementia (ADRD). We test stimulation schedules and develop an adaptive, brain-guided tACS system t…

   Stage

   Not phased

   Ages

   65 and older

   Site

   111 Cummington Mall, Boston, Massachusetts

   Run by

   Boston University Charles River Campus

   See if you can join NCT07461584 on ClinicalTrials.gov

5. Post-market Cosmetic Evaluation of Ariessence™ Pure PDGF+ Following Ablative Laser

   ariessence is intended to be used as a viscous, leave-on solution designed for topical application to the face. It is intended to be used following non-medical cosmetic procedures, performed by licensed healthcare professionals to enhance comfort and maintain skin hydration. This study is designed …

   Stage

   Not phased

   Ages

   40 to 70

   Site

   Laser & Skin Surgery Medical Group, Sacramento, California

   Locations

   2 in total

   Run by

   Lynch Regenerative Medicine

   See if you can join NCT07718347 on ClinicalTrials.gov

6. Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia

   This study is following up on previous studies that have demonstrated that geriatric subjects respond different to ultraviolet B (UVB) light than young subjects. The treatment of geriatric skin with dermal rejuvenation therapies (dermabrasion, fractionated laser resurfacing) restores the appropriat…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Dayton VA Medical Center, Dayton, Ohio

   Run by

   Wright State University

   See if you can join NCT03906253 on ClinicalTrials.gov

7. The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

   The purpose of this study is to determine if the Fractionated Laser Resurfacing (FLR) procedure can protect one forearm/wrist from precancerous actinic keratosis (AKs) as well as prevent skin cancer in older subjects with active AKs. This study builds on a similar study ongoing at the Dayton Vetera…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Wright State Physicians, Fairborn, Ohio

   Run by

   Wright State University

   See if you can join NCT06428721 on ClinicalTrials.gov

8. Restructuring the Alpha-Gamma Code in Aging Vision

   Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and personalized complex-waveform HD-tACS to (1) quantify aging effects on phase-amplitude coupling, (2) drive PAC into a preferred "gamma-at-alpha-tr…

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   111 Cummington Mall, Boston University, Boston, Massachusetts

   Run by

   Boston University Charles River Campus

   See if you can join NCT07208318 on ClinicalTrials.gov

9. The Role of Sirolimus in Preventing Functional Decline in Older Adults

   Aging is associated with progressive impairment of tissue and organ function, resulting in increased susceptibility to chronic disease, frailty and disability. Currently there are limited treatment options to alter this inevitable process. The proposed work has the potential to identify a new thera…

   Stage

   Phase 2

   Ages

   65 to 80

   Site

   UT Southwestern Medical Center, Dallas, Texas

   Run by

   Irina Timofte

   See if you can join NCT05237687 on ClinicalTrials.gov

10. MTOR Inhibitors in Older Adults

    Over the past decades, healthcare systems face significant challenges to meet the needs of an aging population due to progressive debility, functional decline and chronic diseases development. While there is a growing appreciation of the potential impact of mTOR inhibitors on slowing aging processe…

    Stage

    Phase 1

    Ages

    65 to 80

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06727305 on ClinicalTrials.gov

11. Role of Menopause in Thermoregulation

    The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group a…

    Stage

    Phase 4

    Ages

    42 to 64

    Site

    Noll Laboratory, University Park, Pennsylvania

    Run by

    Penn State University

    See if you can join NCT06798571 on ClinicalTrials.gov

12. Testing Effectiveness of a Stochastic Noise Stimulator to Immediately Improve Balance and Gait

    The goal of this intervention study is to determine if a new electronic stimulation device, similar to a TENS can improve balance and make walking easier in older individuals with reduced balance function. The main question aims to answer the following: Can using the device improve walking speed in…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Massachusetts Eye and Ear Infirmary

    See if you can join NCT06688578 on ClinicalTrials.gov

13. Gait Adaptation Study

    This pilot study proposes a clinical trial to target treatment of sensorimotor and cognitive deficits in persons with Multiple Sclerosis (pwMS). The proposal has the potential to promote neuroplasticity and induce re-normalization in brain to muscle (cortico-muscular) connectivity (BMC) and within …

    Stage

    EARLY_Phase 1

    Ages

    18 to 80

    Site

    Stanley Bergen Building, Newark, New Jersey

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT07660601 on ClinicalTrials.gov

14. Older Age and Generalization

    The goal of this clinical is to learn how the brain supports different kinds of memory decisions in healthy young and older adults. The main question it seeks to answer is: Do older adults make memory decisions by integrating across experiences? Young (aged 18-30 years) and older (aged 65-80 years)…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Wisconsin-Milwaukee, Milwaukee, Wisconsin

    Run by

    Caitlin Bowman

    See if you can join NCT07440017 on ClinicalTrials.gov

15. Spinal Networks of Balance Learning and Retention in Older Adults

    Age-related balance and walking issues increase fall risks, leading to injuries, higher healthcare costs, reduced quality of life, and increased morbidity/mortality rates. Preserving functional ability is a crucial public health priority, with the potential to reduce healthcare costs and enhance ol…

    Stage

    Not phased

    Ages

    65 to 95

    Site

    Malcom Randall VA Medical Center Brain Rehabilitation Research Center, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT06517043 on ClinicalTrials.gov

16. Walking Sensation Study

    The primary objective of this new line of research is to test whether augmenting sensory information from the legs, using Walkasins sensory neuroprosthesis, can enhance performance of a complex walking task in older adults with foot sensory impairment. The overarching hypothesis is that Walkasins w…

    Stage

    Not phased

    Ages

    65 to 95

    Site

    Clinical and Translational Research Building, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT06975423 on ClinicalTrials.gov

17. Effect of Gerofit Exercise on Cognition in Older Veterans

    Over 50% of the Veterans enrolled for VA health care are over the age of 65. Dementia prevalence increases with age, and with the increase in the population of people ages 65 and older, the total number of people with dementia is also increasing. Older Veterans often have comorbid PTSD, major depre…

    Stage

    Not phased

    Ages

    65 and older

    Site

    VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles, California

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT06107842 on ClinicalTrials.gov

18. Reducing Blood Pressure in Mid-life Adult Binge Drinkers

    This study has two phases: Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers. Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular fu…

    Stage

    Not phased

    Ages

    50 to 64

    Site

    University of Texas at Arlington, Arlington, Texas

    Run by

    The University of Texas at Arlington

    See if you can join NCT05522075 on ClinicalTrials.gov

19. RESTOR: PK/PD mTORi Inhibition in Older Adults

    As people get older, there are changes in their cells and tissues that may affect their ability to function. This can lead to increased death and age-associated disorders, like heart disease, cancer, and Alzheimer's disease. Studies in animal models have been able to identify drugs that slow the ag…

    Stage

    EARLY_Phase 1

    Ages

    65 to 90

    Site

    The University of Texas Health Science Center at San Antonio, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT06658093 on ClinicalTrials.gov

20. Rapalog Pharmacology (RAP PAC) Study

    The objective of RAP PAC is to identify safe and effective weekly dose(s) for the mTOR inhibitors sirolimus and everolimus that intervene on the underlying fundamental biology of aging. Participants who are 55-89 years old that are free of overt chronic diseases will be assigned to either 6 weeks o…

    Stage

    Phase 1

    Ages

    55 to 89

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT05949658 on ClinicalTrials.gov

21. Mode of Exercise and Bone Biomarkers in Older Veterans

    Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise b…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado

    Run by

    VA Office of Research and Development

    See if you can join NCT05266976 on ClinicalTrials.gov

22. Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV

    People with HIV experience earlier impairments in physical function compared to people in the general population. They also exhibit an earlier presentation and more rapid development of frailty, a multisystemic syndrome of aging characterized by reduced activity, fatigue, slowness, weakness, and we…

    Stage

    Phase 2

    Ages

    50 to 80

    Site

    University of Colorado - Anschutz Medical Campus, Aurora, Colorado

    Locations

    2 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT06554717 on ClinicalTrials.gov

23. SickleFit Exercise and Nutrition Study

    To goal of this study is to pilot the SickleFit exercise and nutrition intervention in adults with sickle cell disease in a randomized control trial

    Stage

    Not phased

    Ages

    35 and older

    Site

    Duke University, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT07442851 on ClinicalTrials.gov

24. Adipose Tissue Blood Flow in Aging Humans

    The goal of this basic science clinical trial is to understand whether adipose tissue blood flow changes between younger and older healthy adults. The main question[s] it aims to answer are: * Is basal and nutrient responsive adipose tissue blood flow (ATBF) different between younger and older adul…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Mayo Clinic Minnesota, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06096532 on ClinicalTrials.gov

25. Arlington Aging Study

    The goal of this observational study is to learn about the mechanisms causing functional decline with age, using magnetic resonance imaging, exercise science, integrative physiology, neuroscience, and remote monitoring. Specific aims include: Aim 1: Advance knowledge of the biology of aging and its…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    University of Texas Arlington, Arlington, Texas

    Run by

    The University of Texas at Arlington

    See if you can join NCT06857877 on ClinicalTrials.gov