Aging Clinical Trials

123 studies are recruiting for aging in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging

   Background: Some people experience cognitive decline as they age. That is, they lose memory, problem-solving, and other mental abilities. Amyloids are groups of proteins that develop in the brain and increase in number as people age. Researchers want to use imaging scans to track amyloids in people…

   Stage

   Not phased

   Ages

   55 to 110

   Site

   National Institute of Aging, Clinical Research Unit, Baltimore, Maryland

   Run by

   National Institute on Aging (NIA)

   See if you can join NCT07099053 on ClinicalTrials.gov

2. The Role of the Locus Coeruleus in Age-related Distractibility

   A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these decli…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Virginia Polytechnic Institute and State University, Blacksburg, Virginia

   Run by

   Virginia Polytechnic Institute and State University

   See if you can join NCT05574634 on ClinicalTrials.gov

3. Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

   The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.

   Stage

   EARLY_Phase 1

   Ages

   18 to 70

   Site

   University of Missouri-Columbia, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT06417177 on ClinicalTrials.gov

4. Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

   To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.

   Stage

   EARLY_Phase 1

   Ages

   18 to 70

   Site

   University of Missouri, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT07674680 on ClinicalTrials.gov

5. C-Protein in Fatigue and Aging

   This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of Oregon, Eugene, Oregon

   Run by

   University of Oregon

   See if you can join NCT05926219 on ClinicalTrials.gov

6. Targeting Aging With a Ketone Ester for Function in Frailty

   This study aims to find out if a food supplement that contains a naturally occurring substance, ketones, can help to improve strength and general wellness in adults at, or over the age of 65 years who are experiencing a slight decline in their physical function. Participation will involve a screeni…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Buck Institute for Research on Aging, Novato, California

   Locations

   3 in total

   Run by

   Buck Institute for Research on Aging

   See if you can join NCT06645847 on ClinicalTrials.gov

7. Longevity Metrics AI/ML Development Study

   This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy. Longevity Metrics collects a battery of clinical tests on each participant, in whole or in part, and follows every participant for life. The sit-to-rise tes…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   Longevity Metrics, Inc.

   See if you can join NCT07808619 on ClinicalTrials.gov

8. Heat Waves and the Elderly - Cooling Modalities

   The purpose of this study is to assess how well cooling modalities work in reducing cardiovascular stress of the elderly to heat wave conditions

   Stage

   Not phased

   Ages

   65 and older

   Site

   Texas Health Presbyterian Hospital Dallas, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT05484739 on ClinicalTrials.gov

9. Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

   The goal of this clinical trial is to compare the Hospital Elder Life Program (HELP) with a family-augmented version of HELP (FAM-HELP), that includes family members and care partners, for the prevention of delirium in older patients during hospital admission. The main objectives of the trial are t…

   Stage

   Not phased

   Ages

   70 and older

   Site

   Saddleback Medical Center, Orange, California

   Locations

   7 in total

   Run by

   University of Michigan

   See if you can join NCT05929703 on ClinicalTrials.gov

10. 100-Year Human Aging Study

    The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo comprehensive multi-system health screening and longitudinal follow-up until…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07563777 on ClinicalTrials.gov

11. Human Observatory Study

    The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a con…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07646782 on ClinicalTrials.gov

12. Health Ahead Comparative Effectiveness Study

    The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening system deployable in any environment, including the most isolated and r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    William Brandenburg, MD

    See if you can join NCT07669168 on ClinicalTrials.gov

13. Effects of Obesity in the Aged

    The overall objective of this application is to investigate the effects of obesity on lung function, exercise tolerance, and DOE in older obese adults as compared with older adults without obesity, using a novel probe for mechanically unloading the thorax at rest and during exercise. The investigat…

    Stage

    Not phased

    Ages

    65 to 75

    Site

    Institute for Exercise and Environmental Medicine, UT Southwestern and Texas Health Resources, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05028309 on ClinicalTrials.gov

14. Baltimore Longitudinal Study of Aging

    Background: - The Baltimore Longitudinal Study of Aging (BLSA) is a clinical research program on human aging that began in 1958. Volunteers of different ages join the study when they are healthy, and have follow-up visits for life. Visits last for multiple days. Participants are evaluated for many …

    Stage

    Not phased

    Ages

    20 to 120

    Site

    National Institute of Aging, Clinical Research Unit, Baltimore, Maryland

    Run by

    National Institute on Aging (NIA)

    See if you can join NCT00233272 on ClinicalTrials.gov

15. Influence of Brain Oscillation-Dependent TMS on Motor Function

    Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands. But the effects of TMS are minor, and it doesn t work for everyone. Researchers w…

    Stage

    Not phased

    Ages

    18 to 120

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT03288220 on ClinicalTrials.gov

16. Examining the Effects of Theta Burst TMS on Brain Connectivity and Balance Ability in Older Adults With Balance Problems

    The goal of this study is to learn if manipulating the brain using magnets works to treat balance impairment, a major cause of falls, in older adults with balance problems. The technique to manipulate the brain using magnets is known as transcranial magnetic stimulation or TMS. The main questions t…

    Stage

    EARLY_Phase 1

    Ages

    65 and older

    Site

    The Center for Neuromotor and Biomechanics Research at the University of Houston, Houston, Texas

    Run by

    Weinberg Medical Physics LLC

    See if you can join NCT06779188 on ClinicalTrials.gov

17. Identifying Challenges to Healthy Aging in Persons With Human Immunodeficiency Virus (HIV) Age 50 and Older

    The primary objective of this study is to identify and characterize frailty and pre-frailty in persons age 50 and older living with human immunodeficiency virus (HIV) followed by the Atrium Health Wake Forest Baptist Infectious Diseases Specialty Clinics (IDSC).

    Stage

    Not phased

    Ages

    50 and older

    Site

    Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT05858034 on ClinicalTrials.gov

18. Enhancing Attention and Wellbeing Using Digital Therapeutics

    The goals of the proposed research are to first determine the minimal and/or optimal dose of a digital intervention required for cognitive enhancement, and then to examine the impact of several potential moderators of treatment effects (i.e., cognitive decline, AD polygenic hazard score, cardiovasc…

    Stage

    Not phased

    Ages

    60 to 99

    Site

    University of California San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06397469 on ClinicalTrials.gov

19. Ketone Ester And Salt (KEAS) in Older Adults

    Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs blood pressure control by affecting systemic blood vessels and the kidneys. These changes contribute to excess salt consumpti…

    Stage

    Not phased

    Ages

    50 to 85

    Site

    School of Public Health, Bloomington, Indiana

    Run by

    Indiana University

    See if you can join NCT06868719 on ClinicalTrials.gov

20. Artificial Intelligence-Based Health Assessment From Face Photographs - Healthy Volunteer Study

    The investigators aim to examine how FaceAge estimates (a measure of biological age based on facial features) change across different time points and identify factors that may influence these changes. This will help the investigators understand the consistency and reliability of the FaceAge algorit…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT07719049 on ClinicalTrials.gov

21. The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults

    The goal of this clinical trial is to test the effects of MitoQ supplementation in older adults and frail older adults with physical dysfunction and/or cognitive dysfunction. The main question[s] it aims to answer are: * To compare vascular function, oxidative stress levels, and physical and cognit…

    Stage

    Phase 2

    Ages

    65 to 80

    Site

    UConn Health, Farmington, Connecticut

    Run by

    UConn Health

    See if you can join NCT06027554 on ClinicalTrials.gov

22. Using Nicotine to Reverse Age-related Auditory Processing Deficits

    The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse …

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Hearing and Speech Lab, Irvine, California

    Run by

    University of California, Irvine

    See if you can join NCT04971954 on ClinicalTrials.gov

23. Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)

    Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but …

    Stage

    Not phased

    Ages

    60 and older

    Site

    Florida Institute for Human and Machine Cognition, Pensacola, Florida

    Locations

    2 in total

    Run by

    Florida Institute for Human and Machine Cognition

    See if you can join NCT06507189 on ClinicalTrials.gov

24. Optimization of a Behavioral Intervention to Increase Physical Activity in Older Adults Living With HIV

    The goal of this clinical trial is to examine 3 interventions designed to increase physical activity in older adults with HIV. We will examine 3 potential components of an intervention package: physical activity coaching, cognitive behavioral therapy targeted toward common barriers to physical acti…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Hennepin Healthcare Research Institute, Minneapolis, Minnesota

    Locations

    2 in total

    Run by

    Butler Hospital

    See if you can join NCT05752500 on ClinicalTrials.gov

25. Neural Control of Gait & Navigation in ADRD

    Brain network segregation, or independent functioning, declines with age and is associated with slower walking speed. Here, the investigators will determine the extent to which brain vestibular network segregation can be altered with bilateral vestibular cortical transcranial direct current stimula…

    Stage

    Not phased

    Ages

    65 to 89

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT06501820 on ClinicalTrials.gov