Aging Clinical Trials

120 studies are recruiting for aging in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Passive Heat Therapy for Lowering Systolic Blood Pressure and Improving Vascular Function in Mid-life and Older Adults

   This study aims to determine the effects of ~12 weeks of repeated hot water immersion ("heat therapy") vs. thermoneutral water immersion on blood pressure and vascular function in late middle-life to older (≥40 years) adults. The study also aims to determine the effects of ~12 weeks of heat therapy…

   Stage

   Not phased

   Ages

   40 and older

   Site

   University of Colorado Boulder, Boulder, Colorado

   Run by

   University of Colorado, Boulder

   See if you can join NCT05300971 on ClinicalTrials.gov

2. PET Imaging in the Baltimore Longitudinal Study of Aging (BLSA)

   Background: Some people experience cognitive decline as they age. That is, they lose memory, problem-solving, and other mental abilities. Amyloids are groups of proteins that develop in the brain and increase in number as people age. Researchers want to use imaging scans to track amyloids in people…

   Stage

   Not phased

   Ages

   55 to 110

   Site

   National Institute of Aging, Clinical Research Unit, Baltimore, Maryland

   Run by

   National Institute on Aging (NIA)

   See if you can join NCT07099053 on ClinicalTrials.gov

3. Precision Microbiota Interventions for Senoreduction Trial

   People with HIV who drink alcohol are at increased risk for accelerated aging biology, including increased immune senescence. This randomized, double-blind, crossover clinical trial evaluates two generally recognized as safe (GRAS) microbiota-targeted interventions on immune senescence biomarkers.

   Stage

   Phase 1

   Ages

   40 and older

   Site

   LSU Health, New Orleans, Louisiana

   Run by

   Louisiana State University Health Sciences Center in New Orleans

   See if you can join NCT07462767 on ClinicalTrials.gov

4. Using Nicotine to Reverse Age-related Auditory Processing Deficits

   The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse …

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Hearing and Speech Lab, Irvine, California

   Locations

   2 in total

   Run by

   University of California, Irvine

   See if you can join NCT04971954 on ClinicalTrials.gov

5. Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults

   This is a randomized, double-blind, placebo-controlled, two-arm crossover clinical trial evaluating the effects of nicotinamide mononucleotide (NMN) combined with trimethylglycine (TMG) supplementation, compared to NMN alone. The study will assess safety and efficacy in improving exercise tolerance…

   Stage

   Not phased

   Ages

   60 to 80

   Site

   Medical Office of Dr. Robert Huizenga MD, Beverly Hills, California

   Run by

   Scott Silveira

   See if you can join NCT07144527 on ClinicalTrials.gov

6. Walking Sensation Study

   The primary objective of this new line of research is to test whether augmenting sensory information from the legs, using Walkasins sensory neuroprosthesis, can enhance performance of a complex walking task in older adults with foot sensory impairment. The overarching hypothesis is that Walkasins w…

   Stage

   Not phased

   Ages

   65 to 95

   Site

   Clinical and Translational Research Building, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT06975423 on ClinicalTrials.gov

7. Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 2

   This study consists of three aims focused on examining the feasibility of adding the Geriatric Resources and Assessment for the Care of Elders (GRACE) model to structured Annual Wellness Visits (AWVs) to improve patient and caregiver outcomes and reduce hospitalizations in older adults with complex…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina

   Locations

   4 in total

   Run by

   Massachusetts General Hospital

   See if you can join NCT07166861 on ClinicalTrials.gov

8. Influence of Brain Oscillation-Dependent TMS on Motor Function

   Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands. But the effects of TMS are minor, and it doesn t work for everyone. Researchers w…

   Stage

   Not phased

   Ages

   18 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT03288220 on ClinicalTrials.gov

9. Metabolic and Functional Consequences of Aging in Health and Disease

   Considerable heterogeneity in the aging population has been observed. The exceptional longevity of individuals reaching 100 years old, so-called centenarians may be an example of life-long healthy aging, or added years may be spent in poor health with decreased physical and cognitive functioning. C…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Human Clinical Research Building, College Station, Texas

   Run by

   Texas A&M University

   See if you can join NCT05240885 on ClinicalTrials.gov

10. The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults

    To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.

    Stage

    Not phased

    Ages

    65 and older

    Site

    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Mayo Clinic

    See if you can join NCT06940037 on ClinicalTrials.gov

11. Role of Menopause in Thermoregulation

    The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group a…

    Stage

    Phase 4

    Ages

    42 to 64

    Site

    Noll Laboratory, University Park, Pennsylvania

    Run by

    Penn State University

    See if you can join NCT06798571 on ClinicalTrials.gov

12. Digital STEADI Efficacy

    The aging of the U.S. population, combined with health care workforce shortages and insufficient access to effective fall prevention and exercise programs, has contributed to a high burden of fall-related injuries in older adults, especially in those with Mild Cognitive Impairment (MCI), a precurso…

    Stage

    Phase 1

    Ages

    50 and older

    Site

    Emory University School of Medicine, Atlanta, Georgia

    Run by

    Friendi.fi Corporation

    See if you can join NCT07852650 on ClinicalTrials.gov

13. Sex Hormones and Aging

    This study investigates the influence of sex hormones and exercise on age-related neuromuscular decline in females. Specifically, the research aims to evaluate how hormonal variations impact both age-associated neuromuscular decline and the subsequent adaptations to exercise and resistance training…

    Stage

    Not phased

    Ages

    50 to 70

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07848438 on ClinicalTrials.gov

14. Neurobiological Mechanisms of Aging and Stress on Prospective Navigation

    Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress and altered regulation of the stress response. However, there are mar…

    Stage

    Not phased

    Ages

    65 to 80

    Site

    Center for Advance Brain Imaging, Atlanta, Georgia

    Run by

    Georgia Institute of Technology

    See if you can join NCT03896529 on ClinicalTrials.gov

15. Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging

    Much of human interaction is based on trust. Aging has been associated with deficits in trust-related decision making, likely further exacerbated in age-associated neurodegenerative disease (Alzheimer's disease/AD), possibly underlying the dramatically growing public health problem of elder fraud. …

    Stage

    Not phased

    Ages

    18 to 100

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT05457725 on ClinicalTrials.gov

16. The Role of the Locus Coeruleus in Age-related Distractibility

    A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these decli…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Virginia Polytechnic Institute and State University, Blacksburg, Virginia

    Run by

    Virginia Polytechnic Institute and State University

    See if you can join NCT05574634 on ClinicalTrials.gov

17. Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

    The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.

    Stage

    EARLY_Phase 1

    Ages

    18 to 70

    Site

    University of Missouri-Columbia, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT06417177 on ClinicalTrials.gov

18. Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

    To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.

    Stage

    EARLY_Phase 1

    Ages

    18 to 70

    Site

    University of Missouri, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT07674680 on ClinicalTrials.gov

19. C-Protein in Fatigue and Aging

    This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Oregon, Eugene, Oregon

    Run by

    University of Oregon

    See if you can join NCT05926219 on ClinicalTrials.gov

20. Targeting Aging With a Ketone Ester for Function in Frailty

    This study aims to find out if a food supplement that contains a naturally occurring substance, ketones, can help to improve strength and general wellness in adults at, or over the age of 65 years who are experiencing a slight decline in their physical function. Participation will involve a screeni…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Buck Institute for Research on Aging, Novato, California

    Locations

    3 in total

    Run by

    Buck Institute for Research on Aging

    See if you can join NCT06645847 on ClinicalTrials.gov

21. Longevity Metrics AI/ML Development Study

    This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy. Longevity Metrics collects a battery of clinical tests on each participant, in whole or in part, and follows every participant for life. The sit-to-rise tes…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07808619 on ClinicalTrials.gov

22. Heat Waves and the Elderly - Cooling Modalities

    The purpose of this study is to assess how well cooling modalities work in reducing cardiovascular stress of the elderly to heat wave conditions

    Stage

    Not phased

    Ages

    65 and older

    Site

    Texas Health Presbyterian Hospital Dallas, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05484739 on ClinicalTrials.gov

23. Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

    The goal of this clinical trial is to compare the Hospital Elder Life Program (HELP) with a family-augmented version of HELP (FAM-HELP), that includes family members and care partners, for the prevention of delirium in older patients during hospital admission. The main objectives of the trial are t…

    Stage

    Not phased

    Ages

    70 and older

    Site

    Saddleback Medical Center, Orange, California

    Locations

    7 in total

    Run by

    University of Michigan

    See if you can join NCT05929703 on ClinicalTrials.gov

24. 100-Year Human Aging Study

    The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo comprehensive multi-system health screening and longitudinal follow-up until…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07563777 on ClinicalTrials.gov

25. Human Observatory Study

    The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a con…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Longevity Metrics, Boulder, Colorado

    Run by

    Longevity Metrics, Inc.

    See if you can join NCT07646782 on ClinicalTrials.gov