Type 2 Diabetes Clinical Trials

95 studies are recruiting for type 2 diabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Pilot-Testing Strategies to Improve Outcomes for Youth With Type 2 Diabetes by Addressing Health-Related Social Needs

   The goal of this clinical trial is to pilot test different strategies to address health related social needs (HRSN) experienced by adolescent and young adult patients with type 2 diabetes and their families. The main questions it aims to answer are: * How feasible are the strategies? * How acceptab…

   Stage

   Not phased

   Ages

   13 and older

   Site

   UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT07216118 on ClinicalTrials.gov

2. HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes

   Blood sugar levels are controlled by insulin, a hormone made by cells in the pancreas. After a meal, carbohydrates are broken down into glucose which is absorbed from the intestine into the blood leading to a rise in glucose (blood sugar) which triggers the secretion of insulin. Insulin binds to ce…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Alliance Clinical Canoga Park (Hope Clinical Research), Canoga Park, California

   Locations

   25 in total

   Run by

   Housey Healthcare ULC

   See if you can join NCT07546929 on ClinicalTrials.gov

3. Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide

   This study is to investigate how adipocyte (fat cell) function and fat distribution differ between individuals with normal-weight type 2 diabetes (NWD), those with overweight type 2 diabetes (OWD), and normal-weight controls without diabetes (NWC). The study will assess whether adipocyte-directed t…

   Stage

   Phase 4

   Ages

   30 to 70

   Site

   Stanford University, Palo Alto, California

   Locations

   2 in total

   Run by

   Stanford University

   See if you can join NCT06657209 on ClinicalTrials.gov

4. Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes

   It is not known whether a new diabetes drug, semaglutide, is an effective treatment for type 2 diabetes for persons with spinal cord injury (SCI), a population at higher risk for this condition. Therefore, this study looks at the effect of semaglutide on glucose levels in the body and other informa…

   Stage

   Phase 4

   Ages

   18 to 70

   Site

   University Health - Texas Diabetic Institute, San Antonio, Texas

   Locations

   2 in total

   Run by

   Marzieh Salehi

   See if you can join NCT06706284 on ClinicalTrials.gov

5. Treating Early Type 2 Diabetes by Reducing Postprandial Glucose Excursions: A Paradigm Shift in Lifestyle Modification

   A Randomized Control Trial (RCT) with 1:1 randomization of adults newly diagnosed with type 2 diabetes (T2D) to Routine Care (RC) and RC + Glycemic Excursion Minimization (RC+GEM); a program that provides RC in addition to continuous glucose monitors (CGM) within a structured, self-directed, and pe…

   Stage

   Not phased

   Ages

   30 to 80

   Site

   University of Colorado Department of Family Medicine, Aurora, Colorado

   Locations

   2 in total

   Run by

   Chiara Fabris, PhD

   See if you can join NCT05766735 on ClinicalTrials.gov

6. Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function

   This study is being done to evaluate how a ketone ester (KE) supplement affects heart function and health in people with diabetes compared to a placebo supplement (made with standard food ingredients that do not contain ketone esters).

   Stage

   Not phased

   Ages

   18 to 80

   Site

   The Ross Heart Hospital, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT06078683 on ClinicalTrials.gov

7. The Food for Health Study

   The project, called Food for Health (F4H), will study a new Produce Prescription Program (PPP) designed for rural Native American older adults. The study is based in the Confederated Salish and Kootenai Tribes (CSKT) of the Flathead Indian Reservation in Montana. In this community, many older adult…

   Stage

   Not phased

   Ages

   55 and older

   Site

   Arlee Health Center, Arlee, Montana

   Run by

   University of Montana

   See if you can join NCT07254689 on ClinicalTrials.gov

8. Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes

   The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal…

   Stage

   Not phased

   Ages

   30 to 55

   Site

   University of Colorado, Aurora, Colorado

   Locations

   2 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT04791371 on ClinicalTrials.gov

9. IH, Brain Health, and T2D

   The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).

   Stage

   Not phased

   Ages

   60 to 85

   Site

   University of Iowa, Iowa City, Iowa

   Run by

   Darren P Casey

   See if you can join NCT07173543 on ClinicalTrials.gov

10. Diabetes Body Project 2

    The purpose of this study is to test the feasibility and effectiveness of an eating disorder prevention program specifically targeted for women with type 2 diabetes (T2D) called the Diabetes Body Project 2 (DBP2). The Diabetes Body Project 2 (DBP2) will be adapted from the Diabetes Body Project, wh…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    Joslin Diabetes Center, Boston, Massachusetts

    Run by

    Joslin Diabetes Center

    See if you can join NCT07468188 on ClinicalTrials.gov

11. Implementing an Effective Diabetes Intervention Among Low-Income Immigrants

    The goal of this IDEAL project is to examine the effectiveness and implementation process of the video-based Diabetes Self-Management Education and Support (DSMES) + community health worker (CHW) (hereafter: "IDEAL") intervention compared with a wait-list control group (hereafter: "CONTROL") to imp…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06319703 on ClinicalTrials.gov

12. PILI 'Āina Household

    Native Hawaiians' traditional lifestyles and diets ensured the mutual health and well-being of the land and its inhabitants, which stand in stark contrast to the disproportionately high prevalence of diet-related, cardiometabolic diseases they experience today. In this project, the investigators wi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kula no nā Po'e Hawai'i, Honolulu, Hawaii

    Locations

    2 in total

    Run by

    University of Hawaii

    See if you can join NCT06526273 on ClinicalTrials.gov

13. 'Ai Pono Cooking Demonstrations

    Native Hawaiians' traditional lifestyles and diets ensured the mutual health and well-being of the land and its inhabitants, which stand in stark contrast to the disproportionately high prevalence of diet-related, cardiometabolic diseases they experience today. In this project, the investigators wi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kula no na Poe Hawaii, Honolulu, Hawaii

    Locations

    2 in total

    Run by

    University of Hawaii

    See if you can join NCT06526650 on ClinicalTrials.gov

14. NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study

    A pragmatic, randomized clinical trial to evaluate the effect of a heart failure (HF) risk assessment and prevention strategy incorporating HF clinical risk scores (WATCH-DM) with cardiac biomarker (NT-proBNP) paired with a clinical decision support tool to implement an intensive prevention strateg…

    Stage

    Not phased

    Ages

    Any age

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06593327 on ClinicalTrials.gov

15. Food and Fitness With Medicine (FFWM)

    Food and Fitness with Medicine (FFWM) is a 24-week randomized controlled trial (RCT) enrolling 200 post-menopausal women (PMW) with stage 2 cardio-kidney metabolic (CKM) syndrome and type-2 diabetes (T2D) within 6 weeks of initiating glucagon-like peptide-1 receptor agonist (GLP-1RAs) to: 1. Examin…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Martha Morehouse, Columbus, Ohio

    Locations

    4 in total

    Run by

    Ohio State University

    See if you can join NCT07027995 on ClinicalTrials.gov

16. Assessing the Efficacy of Targeted Home Visits in the Management of Chronic Conditions

    The purpose of study is to evaluate whether home visit programs are an effective method for HTN and T2DM management as compared to standard of care clinic visits.

    Stage

    Not phased

    Ages

    18 to 60

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05168605 on ClinicalTrials.gov

17. Type 2 Continuous Glucose Monitoring Academy

    The goal of this clinical trial is to evaluate the Impact of Continuous Glucose Monitoring Academy Education Curriculum Versus Standard Care on Glycemic Outcomes for Youth With Type 2 Diabetes (T2D): * The first aim is to determine how feasible it is to adapt the Continuous Glucose Monitoring Acade…

    Stage

    Not phased

    Ages

    8 to 21

    Site

    Children's Hospital Los Angeles, Los Angeles, California

    Run by

    Children's Hospital Los Angeles

    See if you can join NCT06516640 on ClinicalTrials.gov

18. Ultrasound Effects on Glycemic Control in T2DM

    This is an open label, exploratory pilot study that will assess the effects of dual site focused pulsed ultrasound treatment on glycemic parameters in subjects with T2DM.

    Stage

    Not phased

    Ages

    21 to 75

    Site

    Yale-New Haven Hospital, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT05354947 on ClinicalTrials.gov

19. Extracellular Vesicles, Insulin Action, and Exercise

    Extracellular vesicles (EVs) play a role in obesity-induced insulin resistance and likely impact the development of cardiovascular disease. However, little is known on how EVs affect vascular insulin action in people. The purpose of this study is to understand how EVs play a role in type 2 diabetes…

    Stage

    Not phased

    Ages

    30 to 80

    Site

    Institute for Food, Nutrition, and Health, New Brunswick, New Jersey

    Locations

    3 in total

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT06546085 on ClinicalTrials.gov

20. Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes

    This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not de…

    Stage

    EARLY_Phase 1

    Ages

    18 to 80

    Site

    University of Texas Health Science Center at San Antonio, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT06108076 on ClinicalTrials.gov

21. Mobile Health Dietary Intervention for Stroke Survivors With Prediabetes or Type 2 Diabetes

    Objectives: This study aims to test whether a mobile app called PortionSize Ed can help adults who have had a recent stroke and also have prediabetes or type 2 diabetes improve their diet. Specifically, we want to see if the app can help people follow a Mediterranean-style diet, which may lower the…

    Stage

    Not phased

    Ages

    30 to 65

    Site

    University of Hawaii Cancer Center, Honolulu, Hawaii

    Run by

    University of Hawaii

    See if you can join NCT07120334 on ClinicalTrials.gov

22. Precision Dosing of Metformin in Youth With T2D

    The purpose of this study to compare the typically prescribed dose of metformin (1000mg twice a day) with a higher dose of metformin (1350mg twice a day).

    Stage

    EARLY_Phase 1

    Ages

    10 to 21

    Site

    UCSF Benioff Children's Hospital Oakland, Pediatric Diabetes Clinic, Oakland, California

    Locations

    2 in total

    Run by

    University of California, San Francisco

    See if you can join NCT06120881 on ClinicalTrials.gov

23. High Fructose Diet, the Gut Microbiome, and Metabolic Health

    Americans commonly consume excess amounts of dietary fructose. Added fructose has been shown to have an adverse impact on metabolic health, including increased insulin resistance and type 2 diabetes (T2D) risk. However, the mechanisms that link dietary fructose and metabolic health are poorly under…

    Stage

    Not phased

    Ages

    25 to 45

    Site

    Mount Sinai Morningside, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06329544 on ClinicalTrials.gov

24. A Low-Carb Approach to Treat Type 2 Diabetes in Pediatric Patients

    The purpose of this project is to test the effect of a low carb diet compared to standard carb diet among adolescents with T2D over a 24-week period.

    Stage

    Not phased

    Ages

    12 to 18

    Site

    University of Alabama at Birmingham/ Children's of Alabama, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06902077 on ClinicalTrials.gov

25. Continuous Glucose Monitors (CGMs) for All: Studying the Impact of Expanding CGM Access

    This non-blinded, non-randomized pre-post study will examine the impact of providing CGM sensors free of charge to adult patients of Fair Haven Community Health Care with poorly controlled type 2 diabetes on glycemic control and quality of life.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Fair Haven Community Health Care (FHCHC), New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06658067 on ClinicalTrials.gov