Type 2 Diabetes Clinical Trials

101 studies are recruiting for type 2 diabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH

   The goal of this research study is to evaluate the pathophysiologic mechanisms by which genetic variation impacts response to an FDA-approved medication commonly used to treat type 2 diabetes called oral semaglutide (Rybelsus) and to characterize the physiological response to a mixed meal tolerance…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06003153 on ClinicalTrials.gov

2. Virtual Diabetes Care for Adults With Type 2 Diabetes on Medicaid and Insulin Therapy

   This 12-month pilot tests a nurse-led, app-based intervention to improve diabetes self-management for Medicaid patients. It includes MyChart messaging to give education, phone help on problem-solving with clinicians, and using a diabetes app to track data. The study aims to enhance self-management …

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Rutgers Health Family Medicine at Monument Square, New Brunswick, New Jersey

   Locations

   2 in total

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT06814184 on ClinicalTrials.gov

3. Exercise and Intranasal Insulin in Type 2 Diabetes

   About 6.5 million adults in the United States who are 65 or older have dementia. While the exact cause of dementia is not known, it may be due to changes in the brain. Further, risk may be higher when the brain does not respond to insulin. Indeed, brain insulin resistance has emerged as a pathologi…

   Stage

   Phase 2

   Ages

   55 to 80

   Site

   Robert Wood Johnson University Hospital Clinical Research Center, New Brunswick, New Jersey

   Locations

   4 in total

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT07675499 on ClinicalTrials.gov

4. Sleep and Glycemic Control in Type 2 Diabetes Adolescents

   The primary objective is to determine the cross-sectional relationship between sleep duration (as measured by 14 days of actigraphy) and glycemic control in an adolescent Type 2 Diabetes (T2DM) cohort (age 12-20y, n=67). A secondary objective is to determine if a loss-framed incentive for achieving…

   Stage

   Not phased

   Ages

   12 to 20

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT04213547 on ClinicalTrials.gov

5. Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes

   This observational study aims to collect detailed metabolic and physiologic data from adults with insulin-dependent type 2 diabetes mellitus following consumption of a mixed meal tolerance test. Participants will undergo frequent blood sampling over a 4-hour period after consuming a standardized li…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Illinois Institute of Technology, Chicago, Illinois

   Run by

   Clinical Nutrition Research Center, Illinois Institute of Technology

   See if you can join NCT07650682 on ClinicalTrials.gov

6. THC Effects on Glucose in Type 2 Diabetes

   This study will examine the effects THC has on Glucose Metabolism and Endothelial Functioning in participants with Type 2 Diabetes. The participants will complete blood tests and tests to measure energy expenditure, CVD risks, and glucose metabolism. These tests will be performed prior to start of …

   Stage

   Phase 1

   Ages

   21 to 70

   Site

   UC San Diego Altman Clinical & Translational Research Institute, La Jolla, California

   Run by

   University of California, San Diego

   See if you can join NCT05322213 on ClinicalTrials.gov

7. Mechanism of SGLT2 Inhibition in the Kidney

   The goal of this open-label, non-randomized clinical trial is to determine what effects, if any, an FDA-approved drug class known as SGLT2 inhibitors (Canagliflozin or INVOKANA) has any protective effects on kidney function in Type 2 diabetes. We are looking for participants 18-80 years of age, who…

   Stage

   Phase 4

   Ages

   18 to 80

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT06291155 on ClinicalTrials.gov

8. Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery

   The goal of this randomized controlled trial is to compare the efficacy and safety of the iLet Bionic Pancreas (BP) System in adults with insulin-treated diabetes (type 1 diabetes or type 2 diabetes) compared to standard of care when ordered by primary care providers. The main question it aims to a…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   University of Colorado Anschutz Medical Campus, Aurora, Colorado

   Locations

   2 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT07011147 on ClinicalTrials.gov

9. Nutrition+: Effect of a High-Protein Diabetes Formula on Body Composition in Type 2 Diabetes Patients Treated With Incretin Mimetics

   A randomized clinical study to assess the efficacy of a high-protein diabetes specific formula (HPDSF) on lean muscle mass in overweight and obese patients with type 2 diabetes who are initiating treatment with incretin-mimetic drugs.

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Joslin Diabetes Center, Boston, Massachusetts

   Run by

   Joslin Diabetes Center

   See if you can join NCT07271043 on ClinicalTrials.gov

10. A Phase 1, Multiple Ascending Dose Study to Evaluate HMS1005 in Participants With Type 2 Diabetes

    The study is to assess the safety, pharmacokinetics, and pharmacodynamic profile of HMS1005 in patient with diabetes

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Clinical Pharmacology of Miami, Miami, Florida

    Run by

    Hua Medicine Limited

    See if you can join NCT07568678 on ClinicalTrials.gov

11. Exercise and Protein Efficiency in T2D

    In this randomized controlled trial, 30 older adults (aged> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program. They will undergo pre- and post-testing that includes body composition measures; oral glucose tolerance testing; cardiovascular fitnes…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Freer Hall - University of Illinois, Urbana, Illinois

    Run by

    University of Illinois at Urbana-Champaign

    See if you can join NCT07477067 on ClinicalTrials.gov

12. Pilot-Testing Strategies to Improve Outcomes for Youth With Type 2 Diabetes by Addressing Health-Related Social Needs

    The goal of this clinical trial is to pilot test different strategies to address health related social needs (HRSN) experienced by adolescent and young adult patients with type 2 diabetes and their families. The main questions it aims to answer are: * How feasible are the strategies? * How acceptab…

    Stage

    Not phased

    Ages

    13 and older

    Site

    UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT07216118 on ClinicalTrials.gov

13. HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes

    Blood sugar levels are controlled by insulin, a hormone made by cells in the pancreas. After a meal, carbohydrates are broken down into glucose which is absorbed from the intestine into the blood leading to a rise in glucose (blood sugar) which triggers the secretion of insulin. Insulin binds to ce…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Alliance Clinical Canoga Park (Hope Clinical Research), Canoga Park, California

    Locations

    25 in total

    Run by

    Housey Healthcare ULC

    See if you can join NCT07546929 on ClinicalTrials.gov

14. Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide

    This study is to investigate how adipocyte (fat cell) function and fat distribution differ between individuals with normal-weight type 2 diabetes (NWD), those with overweight type 2 diabetes (OWD), and normal-weight controls without diabetes (NWC). The study will assess whether adipocyte-directed t…

    Stage

    Phase 4

    Ages

    30 to 70

    Site

    Stanford University, Palo Alto, California

    Locations

    2 in total

    Run by

    Stanford University

    See if you can join NCT06657209 on ClinicalTrials.gov

15. Treating Early Type 2 Diabetes by Reducing Postprandial Glucose Excursions: A Paradigm Shift in Lifestyle Modification

    A Randomized Control Trial (RCT) with 1:1 randomization of adults newly diagnosed with type 2 diabetes (T2D) to Routine Care (RC) and RC + Glycemic Excursion Minimization (RC+GEM); a program that provides RC in addition to continuous glucose monitors (CGM) within a structured, self-directed, and pe…

    Stage

    Not phased

    Ages

    30 to 80

    Site

    University of Colorado Department of Family Medicine, Aurora, Colorado

    Locations

    2 in total

    Run by

    Chiara Fabris, PhD

    See if you can join NCT05766735 on ClinicalTrials.gov

16. Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function

    This study is being done to evaluate how a ketone ester (KE) supplement affects heart function and health in people with diabetes compared to a placebo supplement (made with standard food ingredients that do not contain ketone esters).

    Stage

    Not phased

    Ages

    18 to 80

    Site

    The Ross Heart Hospital, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06078683 on ClinicalTrials.gov

17. The Food for Health Study

    The project, called Food for Health (F4H), will study a new Produce Prescription Program (PPP) designed for rural Native American older adults. The study is based in the Confederated Salish and Kootenai Tribes (CSKT) of the Flathead Indian Reservation in Montana. In this community, many older adult…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Arlee Health Center, Arlee, Montana

    Run by

    University of Montana

    See if you can join NCT07254689 on ClinicalTrials.gov

18. Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes

    The goal of this two-site grant proposal is to determine the role of the decreased insulin-mediated muscle perfusion found in type 2 diabetes in contributing to the development of cardiac and skeletal muscle dysfunction and subsequent functional exercise impairment. In addition, it is also our goal…

    Stage

    Not phased

    Ages

    30 to 55

    Site

    University of Colorado, Aurora, Colorado

    Locations

    2 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT04791371 on ClinicalTrials.gov

19. IH, Brain Health, and T2D

    The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).

    Stage

    Not phased

    Ages

    60 to 85

    Site

    University of Iowa, Iowa City, Iowa

    Run by

    Darren P Casey

    See if you can join NCT07173543 on ClinicalTrials.gov

20. Diabetes Body Project 2

    The purpose of this study is to test the feasibility and effectiveness of an eating disorder prevention program specifically targeted for women with type 2 diabetes (T2D) called the Diabetes Body Project 2 (DBP2). The Diabetes Body Project 2 (DBP2) will be adapted from the Diabetes Body Project, wh…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    Joslin Diabetes Center, Boston, Massachusetts

    Run by

    Joslin Diabetes Center

    See if you can join NCT07468188 on ClinicalTrials.gov

21. Implementing an Effective Diabetes Intervention Among Low-Income Immigrants

    The goal of this IDEAL project is to examine the effectiveness and implementation process of the video-based Diabetes Self-Management Education and Support (DSMES) + community health worker (CHW) (hereafter: "IDEAL") intervention compared with a wait-list control group (hereafter: "CONTROL") to imp…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06319703 on ClinicalTrials.gov

22. PILI 'Āina Household

    Native Hawaiians' traditional lifestyles and diets ensured the mutual health and well-being of the land and its inhabitants, which stand in stark contrast to the disproportionately high prevalence of diet-related, cardiometabolic diseases they experience today. In this project, the investigators wi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kula no nā Po'e Hawai'i, Honolulu, Hawaii

    Locations

    2 in total

    Run by

    University of Hawaii

    See if you can join NCT06526273 on ClinicalTrials.gov

23. 'Ai Pono Cooking Demonstrations

    Native Hawaiians' traditional lifestyles and diets ensured the mutual health and well-being of the land and its inhabitants, which stand in stark contrast to the disproportionately high prevalence of diet-related, cardiometabolic diseases they experience today. In this project, the investigators wi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kula no na Poe Hawaii, Honolulu, Hawaii

    Locations

    2 in total

    Run by

    University of Hawaii

    See if you can join NCT06526650 on ClinicalTrials.gov

24. Food and Fitness With Medicine (FFWM)

    Food and Fitness with Medicine (FFWM) is a 24-week randomized controlled trial (RCT) enrolling 200 post-menopausal women (PMW) with stage 2 cardio-kidney metabolic (CKM) syndrome and type-2 diabetes (T2D) within 6 weeks of initiating glucagon-like peptide-1 receptor agonist (GLP-1RAs) to: 1. Examin…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Martha Morehouse, Columbus, Ohio

    Locations

    4 in total

    Run by

    Ohio State University

    See if you can join NCT07027995 on ClinicalTrials.gov

25. Assessing the Efficacy of Targeted Home Visits in the Management of Chronic Conditions

    The purpose of study is to evaluate whether home visit programs are an effective method for HTN and T2DM management as compared to standard of care clinic visits.

    Stage

    Not phased

    Ages

    18 to 60

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05168605 on ClinicalTrials.gov