Type 2 Diabetes Clinical Trials

95 studies are recruiting for type 2 diabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Polypill for Prevention of Cardiomyopathy

   This study will investigate the utility of a polypill-based strategy for patients with type 2 diabetes mellitus and high risk of heart failure (HF), as assessed via the WATCH-DM risk score. Polypill therapy will consist of empagliflozin 12.5 mg, losartan 25, 50 or 100 mg, and finerenone 10 mg daily…

   Stage

   Phase 1

   Ages

   18 to 100

   Site

   UT Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT06143566 on ClinicalTrials.gov

2. Using Continuous Glucose Monitoring to Quantify the Effects of NOURISH's Culturally Modified Meals on Asian Americans With Type 2 Diabetes

   The investigators are hoping to determine whether tailoring the diet of someone with type 2 diabetes to their ethnic group while following American Diabetes Association guidelines can make a significant difference in their blood sugar controls. Participants will be required to wear a Continuous Glu…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Stanford University, Stanford, California

   Run by

   Stanford University

   See if you can join NCT06836479 on ClinicalTrials.gov

3. Outcomes of Physiologic Insulin Resensitization (PIR) in Patients With Chronic Kidney Disease and Type 2 Diabetes Mellitus

   The purpose of this research is to evaluate outcomes of physiologic insulin re-sensitization (PIR) in patients with Chronic Kidney Disease (CKD) and Type 2 Diabetes Mellitus (T2DM).

   Stage

   Not phased

   Ages

   18 and older

   Site

   Arizona Kidney Disease and Hypertension Center, Phoenix, Arizona

   Locations

   2 in total

   Run by

   Well Cell Global

   See if you can join NCT07187479 on ClinicalTrials.gov

4. Time-restricted Eating for Patients With Type 2 Diabetes

   This is a single-arm pragmatic clinical trial of time-restricted eating in patients with type 2 diabetes. Patients will be recruited from the University of Kentucky Barnstable Brown Diabetes Center. Subjects will participate in a 10-hour time-restricted eating intervention for 1-year.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Kentucky Barnstable Brown Diabetes Center, Lexington, Kentucky

   Run by

   Justin (Matt) Thomas

   See if you can join NCT07318207 on ClinicalTrials.gov

5. SALUD-M: Acceptance Based Coping Skills for Hispanic/Latinx Military Patients With Type 2 Diabetes

   People of Hispanic or Latino/a/x ("H/L") ethnicity, including US military servicemembers, Veterans, and their families, experience a higher prevalence of type 2 diabetes and more challenges managing diabetes than non-Hispanic White populations. Uncontrolled diabetes is linked with lower quality of …

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Brooke Army Medical Center, San Antonio, Texas

   Run by

   Baylor College of Medicine

   See if you can join NCT07674628 on ClinicalTrials.gov

6. SGLTi, Hepatic Glucose Production and Ketogenesis

   In this study, we will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) and type 1 diabetes (T1D), and that the increases in ketone production an…

   Stage

   Phase 1

   Ages

   30 to 75

   Site

   Texas Diabetes Institute/UH, San Antonio, Texas

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT05960656 on ClinicalTrials.gov

7. SGLT2i, Hepatic Glucose Production, and SNS

   In this study, PI will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) that the increases in ketone production and lipolysis can be prevented by…

   Stage

   EARLY_Phase 1

   Ages

   30 to 75

   Site

   Texas Diabetes Institute/UH, San Antonio, Texas

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT07053293 on ClinicalTrials.gov

8. SGLT2i, Ketoacidosis, Volume Contraction, and Insulinopenia

   To examine the 2-HIT hypothesis that the SGLT2i-induced stimulation of EGP, lipolysis, and ketone production requires the combination of volume depletion plus insulinopenia in T2D individuals.

   Stage

   Phase 1

   Ages

   30 to 75

   Site

   Texas Diabetes Institute/UH, San Antonio, Texas

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT07053306 on ClinicalTrials.gov

9. SGLT2i, Pioglitazone, and Ketone Production in T2D

   To examine whether the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T2D individuals can be blocked by pioglitazone (which has direct hepatic and adipose tissue effects).

   Stage

   Phase 1

   Ages

   30 to 75

   Site

   Texas Diabetes Institute/UH, San Antonio, Texas

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT07053319 on ClinicalTrials.gov

10. Individualized Diabetes Education Assisted by CGM (IDEA-CGM)

    This project will compare medical nutrition therapy personalized by continuous glucose monitor (CGM) feedback to control interventions in participants with type 2 diabetes mellitus (T2DM).

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06784375 on ClinicalTrials.gov

11. Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

    This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced …

    Stage

    Not phased

    Ages

    14 to 18

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06007404 on ClinicalTrials.gov

12. GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH

    The goal of this research study is to evaluate the pathophysiologic mechanisms by which genetic variation impacts response to an FDA-approved medication commonly used to treat type 2 diabetes called oral semaglutide (Rybelsus) and to characterize the physiological response to a mixed meal tolerance…

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06003153 on ClinicalTrials.gov

13. ACCESS 2: AI for pediatriC diabetiC Eye examS Study 2

    The purpose of this study is to determine if use of a nonmydriatic fundus camera using autonomous artificial intelligence software at the point of care increases the proportion of underserved youth with diabetes screened for diabetic retinopathy, and to determine the diagnostic accuracy of the auto…

    Stage

    Not phased

    Ages

    8 to 21

    Site

    Johns Hopkins Pediatric Diabetes Center, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05463289 on ClinicalTrials.gov

14. Virtual Diabetes Care for Adults With Type 2 Diabetes on Medicaid and Insulin Therapy

    This 12-month pilot tests a nurse-led, app-based intervention to improve diabetes self-management for Medicaid patients. It includes MyChart messaging to give education, phone help on problem-solving with clinicians, and using a diabetes app to track data. The study aims to enhance self-management …

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Rutgers Health Family Medicine at Monument Square, New Brunswick, New Jersey

    Locations

    2 in total

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT06814184 on ClinicalTrials.gov

15. Exercise and Intranasal Insulin in Type 2 Diabetes

    About 6.5 million adults in the United States who are 65 or older have dementia. While the exact cause of dementia is not known, it may be due to changes in the brain. Further, risk may be higher when the brain does not respond to insulin. Indeed, brain insulin resistance has emerged as a pathologi…

    Stage

    Phase 2

    Ages

    55 to 80

    Site

    Robert Wood Johnson University Hospital Clinical Research Center, New Brunswick, New Jersey

    Locations

    4 in total

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT07675499 on ClinicalTrials.gov

16. Sleep and Glycemic Control in Type 2 Diabetes Adolescents

    The primary objective is to determine the cross-sectional relationship between sleep duration (as measured by 14 days of actigraphy) and glycemic control in an adolescent Type 2 Diabetes (T2DM) cohort (age 12-20y, n=67). A secondary objective is to determine if a loss-framed incentive for achieving…

    Stage

    Not phased

    Ages

    12 to 20

    Site

    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

    Run by

    Children's Hospital of Philadelphia

    See if you can join NCT04213547 on ClinicalTrials.gov

17. Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes

    This observational study aims to collect detailed metabolic and physiologic data from adults with insulin-dependent type 2 diabetes mellitus following consumption of a mixed meal tolerance test. Participants will undergo frequent blood sampling over a 4-hour period after consuming a standardized li…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Illinois Institute of Technology, Chicago, Illinois

    Run by

    Clinical Nutrition Research Center, Illinois Institute of Technology

    See if you can join NCT07650682 on ClinicalTrials.gov

18. THC Effects on Glucose in Type 2 Diabetes

    This study will examine the effects THC has on Glucose Metabolism and Endothelial Functioning in participants with Type 2 Diabetes. The participants will complete blood tests and tests to measure energy expenditure, CVD risks, and glucose metabolism. These tests will be performed prior to start of …

    Stage

    Phase 1

    Ages

    21 to 70

    Site

    UC San Diego Altman Clinical & Translational Research Institute, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT05322213 on ClinicalTrials.gov

19. Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy

    This is a phase 2 randomized, double-blind, placebo-controlled trial assessing the efficacy and safety of icovamenib in participants with Type 2 Diabetes (T2D) not achieving glycemic targets despite Ozempic-based therapy.

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    Central Research Associates, LLC dba Flourish Research, Birmingham, Alabama

    Locations

    17 in total

    Run by

    Biomea Fusion Inc.

    See if you can join NCT07502508 on ClinicalTrials.gov

20. Mechanism of SGLT2 Inhibition in the Kidney

    The goal of this open-label, non-randomized clinical trial is to determine what effects, if any, an FDA-approved drug class known as SGLT2 inhibitors (Canagliflozin or INVOKANA) has any protective effects on kidney function in Type 2 diabetes. We are looking for participants 18-80 years of age, who…

    Stage

    Phase 4

    Ages

    18 to 80

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06291155 on ClinicalTrials.gov

21. Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery

    The goal of this randomized controlled trial is to compare the efficacy and safety of the iLet Bionic Pancreas (BP) System in adults with insulin-treated diabetes (type 1 diabetes or type 2 diabetes) compared to standard of care when ordered by primary care providers. The main question it aims to a…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Locations

    2 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT07011147 on ClinicalTrials.gov

22. Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy

    This is a 17 - week study consisting of a one - week run - in period and a 16 - week intervention. The 16 - week pilot interventions aims to increase hydration in those beginning GLP - 1 RA therapy. Investigators aim to increase hydration to potentially decrease side effect severity, amount of side…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    State University of New York at Buffalo, South Campus, Buffalo, New York

    Run by

    State University of New York at Buffalo

    See if you can join NCT07641361 on ClinicalTrials.gov

23. Nutrition+: Effect of a High-Protein Diabetes Formula on Body Composition in Type 2 Diabetes Patients Treated With Incretin Mimetics

    A randomized clinical study to assess the efficacy of a high-protein diabetes specific formula (HPDSF) on lean muscle mass in overweight and obese patients with type 2 diabetes who are initiating treatment with incretin-mimetic drugs.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Joslin Diabetes Center, Boston, Massachusetts

    Run by

    Joslin Diabetes Center

    See if you can join NCT07271043 on ClinicalTrials.gov

24. A Phase 1, Multiple Ascending Dose Study to Evaluate HMS1005 in Participants With Type 2 Diabetes

    The study is to assess the safety, pharmacokinetics, and pharmacodynamic profile of HMS1005 in patient with diabetes

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Clinical Pharmacology of Miami, Miami, Florida

    Run by

    Hua Medicine Limited

    See if you can join NCT07568678 on ClinicalTrials.gov

25. Exercise and Protein Efficiency in T2D

    In this randomized controlled trial, 30 older adults (aged> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program. They will undergo pre- and post-testing that includes body composition measures; oral glucose tolerance testing; cardiovascular fitnes…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Freer Hall - University of Illinois, Urbana, Illinois

    Run by

    University of Illinois at Urbana-Champaign

    See if you can join NCT07477067 on ClinicalTrials.gov