Type 2 Diabetes Clinical Trials

101 studies are recruiting for type 2 diabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Cooking Health-Oriented Meals to Prevent Dementia and Diabetes

   Previous research demonstrates that 1) adherence to a DASH dietary pattern and diets low in certain UPFs are linked to lower likelihood of experiencing cognitive impairments in later life, that 2) engagement in cooking is linked to healthier eating, reduced UPF consumption, and higher food self-eff…

   Stage

   Not phased

   Ages

   50 to 75

   Site

   Virginia Tech, Blacksburg, Virginia

   Run by

   Virginia Polytechnic Institute and State University

   See if you can join NCT07661368 on ClinicalTrials.gov

2. LINK-IT: Leveraging vIdeos and commuNity Health worKers to Improve Diabetes OuTcomes

   The overall goal of this study is to examine the efficacy of the video-based Diabetes Self-Management Education and Support (DSMES) (hereafter VIDEO), or the video-based DSMES+community health worker (CHW) intervention (hereafter VIDEO+CHW), compared with a wait-list control group (hereafter CONTRO…

   Stage

   Not phased

   Ages

   18 and older

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT06319716 on ClinicalTrials.gov

3. Ketogenic Diet and Diabetes Demonstration Project

   KDDP is a prospective, 12-month pilot study comparing the effects of a novel lifestyle program, the Ketogenic Diet and Diabetes Demonstration Project (KDDP) to those of the National Diabetes Prevention Program (NDDP). KDDP is modeled to mimic the delivery platform of NDPP with the exception that pa…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of New Mexico, Albuquerque, New Mexico

   Run by

   University of New Mexico

   See if you can join NCT06115265 on ClinicalTrials.gov

4. Alpelisib Challenge Test (ACT)

   The goal of this study is to test a potentially easier method for measuring how much insulin a person is capable of producing than the current gold-standard method, the "hyperglycemic clamp." Participants will come in for a two-day (overnight) visit in which they will first undergo a "hyperglycemic…

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT07778524 on ClinicalTrials.gov

5. Mechanisms of Fatigability With Diabetes

   Pre-diabetes (Pre-D) is a precursor to type 2 diabetes (T2D) and characterized by increased exercise fatigability of lower limb muscles, that can impede exercise performance. The cause for the increased fatigability in people with Pre-D is not known. Given the profound vascular disease present in p…

   Stage

   Not phased

   Ages

   30 to 85

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT04442451 on ClinicalTrials.gov

6. AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications

   This study is being conducted to find out how well zenagamtide works and how safe it is compared to insulin glargine in participants with type 2 diabetes who are at higher risk of heart and blood vessel problems and are already taking 1 to 3 diabetes medications. There are 2 study treatments in thi…

   Stage

   Phase 3

   Ages

   45 and older

   Site

   Eastern Shore Rsrch Inst, LLC, Fairhope, Alabama

   Locations

   330 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07797335 on ClinicalTrials.gov

7. Brown Adipose Tissue Activation by Spinal Cord Stimulation

   The objective of this study is to investigate and utilize spinal cord stimulation (SCS) as an effective approach to eliciting weight loss and potentially alleviating Type 2 diabetes mellitus (DM), as evidenced by increasing metabolism of adipose tissue.

   Stage

   Not phased

   Ages

   21 to 70

   Site

   Oregon Health & Science University, Portland, Oregon

   Run by

   Oregon Health and Science University

   See if you can join NCT04326192 on ClinicalTrials.gov

8. A Study to Identify and Characterize Patients With Type 2 Diabetes Mellitus for Possible Participation in Ongoing or Future Type 2 Diabetes Mellitus Clinical Studies

   The purpose of this study is to identify and characterize patients with known Type 2 Diabetes Mellitus (T2DM) for possible participation in ongoing or future T2DM clinical studies, and to characterize trends in key concomitant medication use in this patient population across different geographical …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Research Site, Little Rock, Arkansas

   Locations

   76 in total

   Run by

   AstraZeneca

   See if you can join NCT07606066 on ClinicalTrials.gov

9. Specimen and Data Collection in South Carolina Medicaid-Enrolled Patients With Type 2 Diabetes (T2D) and Metabolically Healthy Controls

   The primary purpose of this study is to use multiomic data in combination with clinical assessments, electronic health records, cognitive and mood assessments, wearable technologies and lifestyle/behavioral data to identify data elements or combinations of data elements with strong positive or nega…

   Stage

   Not phased

   Ages

   40 to 70

   Site

   Clemson Health Clinic at Orangeburg, Orangeburg, South Carolina

   Locations

   2 in total

   Run by

   Guardian Research Network, Inc.

   See if you can join NCT07731399 on ClinicalTrials.gov

10. Quantifying Hepatic Mitochondrial Fluxes in Humans

    In this study the investigators will quantitate hepatic mitochondrial fluxes in T2D patients with NAFL and NASH before and after 16-weeks treatment with the insulin sensitizer pioglitazone

    Stage

    Phase 4

    Ages

    18 to 80

    Site

    Texas Diabetes Institute - University Health System, San Antonio, Texas

    Locations

    2 in total

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT05305287 on ClinicalTrials.gov

11. NOURISH - A Healthcare-community Partnership to Improve Nutrition for Optimal Glycemic Control and Pregnancy Outcomes With Pregestational Diabetes

    Nutrition insecurity (inclusive of food insecurity + poor diet quality) is a fundamental social need that must be addressed to improve treatment and health outcomes for high-risk pregnant women with pregestational type 1 and 2 diabetes, poor glucose control, and food insecurity for whom a healthy d…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT07560813 on ClinicalTrials.gov

12. Acute Exercise and Endogenous Glucose Production in Type 2 Diabetes: Implications for Glycemic Control and Treatment of Hepatic Steatosis

    The overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by the liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis (fatty liver).

    Stage

    Not phased

    Ages

    25 to 55

    Site

    AdventHealth Translational Research Institute, Orlando, Florida

    Run by

    AdventHealth Translational Research Institute

    See if you can join NCT06993454 on ClinicalTrials.gov

13. A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)

    The main purpose of this study is to evaluate additional dosing options for dulaglutide in pediatric participants with Type 2 Diabetes. Participation in this study will last about 8 months.

    Stage

    Phase 3

    Ages

    10 to 17

    Site

    University of Arizona, Tucson, Arizona

    Locations

    51 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT06739122 on ClinicalTrials.gov

14. Circadian Intervention to Improve Cardiometabolic Health

    The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD). Participants will undergo a randomized controlled trial, with circadian intervention and control (healthy lifestyle) groups. The circadian interven…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    College of Health Research Complex--University of Utah, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT05943626 on ClinicalTrials.gov

15. Effect of Sleep Extension on Ceramides in People With Overweight and Obesity

    The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity. Participants will undergo a randomized controlled trial, with sleep extension (interve…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    College of Health Research Complex--University of Utah, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT06180837 on ClinicalTrials.gov

16. Families Implementing Good Health Traditions for Life

    This study will provide evidence for the utility of using a community-engaged research approach to implement a tailored, family-oriented adaptation of the Diabetes Prevention Program that will have positive effects on risk factors associated with type 2 diabetes morbidity and mortality among Black …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Morehouse School of Medicine, Albany, Georgia

    Run by

    Morehouse School of Medicine

    See if you can join NCT07441655 on ClinicalTrials.gov

17. Polypill for Prevention of Cardiomyopathy

    This study will investigate the utility of a polypill-based strategy for patients with type 2 diabetes mellitus and high risk of heart failure (HF), as assessed via the WATCH-DM risk score. Polypill therapy will consist of empagliflozin 12.5 mg, losartan 25, 50 or 100 mg, and finerenone 10 mg daily…

    Stage

    Phase 1

    Ages

    18 to 100

    Site

    UT Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06143566 on ClinicalTrials.gov

18. Outcomes of Physiologic Insulin Resensitization (PIR) in Patients With Chronic Kidney Disease and Type 2 Diabetes Mellitus

    The purpose of this research is to evaluate outcomes of physiologic insulin re-sensitization (PIR) in patients with Chronic Kidney Disease (CKD) and Type 2 Diabetes Mellitus (T2DM).

    Stage

    Not phased

    Ages

    18 and older

    Site

    Arizona Kidney Disease and Hypertension Center, Phoenix, Arizona

    Locations

    2 in total

    Run by

    Well Cell Global

    See if you can join NCT07187479 on ClinicalTrials.gov

19. Time-restricted Eating for Patients With Type 2 Diabetes

    This is a single-arm pragmatic clinical trial of time-restricted eating in patients with type 2 diabetes. Patients will be recruited from the University of Kentucky Barnstable Brown Diabetes Center. Subjects will participate in a 10-hour time-restricted eating intervention for 1-year.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kentucky Barnstable Brown Diabetes Center, Lexington, Kentucky

    Run by

    Justin (Matt) Thomas

    See if you can join NCT07318207 on ClinicalTrials.gov

20. SALUD-M: Acceptance Based Coping Skills for Hispanic/Latinx Military Patients With Type 2 Diabetes

    People of Hispanic or Latino/a/x ("H/L") ethnicity, including US military servicemembers, Veterans, and their families, experience a higher prevalence of type 2 diabetes and more challenges managing diabetes than non-Hispanic White populations. Uncontrolled diabetes is linked with lower quality of …

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Brooke Army Medical Center, San Antonio, Texas

    Run by

    Baylor College of Medicine

    See if you can join NCT07674628 on ClinicalTrials.gov

21. SGLTi, Hepatic Glucose Production and Ketogenesis

    In this study, we will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) and type 1 diabetes (T1D), and that the increases in ketone production an…

    Stage

    Phase 1

    Ages

    30 to 75

    Site

    Texas Diabetes Institute/UH, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT05960656 on ClinicalTrials.gov

22. SGLT2i, Hepatic Glucose Production, and SNS

    In this study, PI will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) that the increases in ketone production and lipolysis can be prevented by…

    Stage

    EARLY_Phase 1

    Ages

    30 to 75

    Site

    Texas Diabetes Institute/UH, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT07053293 on ClinicalTrials.gov

23. SGLT2i, Ketoacidosis, Volume Contraction, and Insulinopenia

    To examine the 2-HIT hypothesis that the SGLT2i-induced stimulation of EGP, lipolysis, and ketone production requires the combination of volume depletion plus insulinopenia in T2D individuals.

    Stage

    Phase 1

    Ages

    30 to 75

    Site

    Texas Diabetes Institute/UH, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT07053306 on ClinicalTrials.gov

24. SGLT2i, Pioglitazone, and Ketone Production in T2D

    To examine whether the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T2D individuals can be blocked by pioglitazone (which has direct hepatic and adipose tissue effects).

    Stage

    Phase 1

    Ages

    30 to 75

    Site

    Texas Diabetes Institute/UH, San Antonio, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT07053319 on ClinicalTrials.gov

25. Individualized Diabetes Education Assisted by CGM (IDEA-CGM)

    This project will compare medical nutrition therapy personalized by continuous glucose monitor (CGM) feedback to control interventions in participants with type 2 diabetes mellitus (T2DM).

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06784375 on ClinicalTrials.gov