Type 2 Diabetes Clinical Trials

95 studies are recruiting for type 2 diabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study

   Background: Type 2 diabetes is a disease that affects blood sugar levels. Complications can include heart and blood vessel (vascular) diseases. Rates of type 2 diabetes have tripled in children and young adults over the last 40 years. Vascular diseases are also increasing in young people. Objective…

   Stage

   Not phased

   Ages

   12 to 25

   Site

   Children's National Hospital (CNH), Washington D.C., District of Columbia

   Locations

   2 in total

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT06730113 on ClinicalTrials.gov

2. Plant-Based Online Weight Loss Through Education and Resources Program and Study

   This is an interventional study that will evaluate the feasibility, implementation, and efficacy of an online, 12-week, plant-based, nutrition education program in a community setting. Participants will meet with a physician and a registered dietitian once a week to learn about a plant-based diet a…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Physicians Committee for Responsible Medicine, Washington D.C., District of Columbia

   Run by

   Physicians Committee for Responsible Medicine

   See if you can join NCT07095543 on ClinicalTrials.gov

3. A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar

   This study aims to find out whether a study medicine called survodutide helps people control their blood sugar. Adults who live with type 2 diabetes and with a body mass index (BMI) of 23 kg/m2 or higher can join. The study has 3 parts. In each part the study compares survodutide with placebo. Surv…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Woodland International Research Group, Inc., Little Rock, Arkansas

   Locations

   121 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT07754461 on ClinicalTrials.gov

4. Cooking Health-Oriented Meals to Prevent Dementia and Diabetes

   Previous research demonstrates that 1) adherence to a DASH dietary pattern and diets low in certain UPFs are linked to lower likelihood of experiencing cognitive impairments in later life, that 2) engagement in cooking is linked to healthier eating, reduced UPF consumption, and higher food self-eff…

   Stage

   Not phased

   Ages

   50 to 75

   Site

   Virginia Tech, Blacksburg, Virginia

   Run by

   Virginia Polytechnic Institute and State University

   See if you can join NCT07661368 on ClinicalTrials.gov

5. LINK-IT: Leveraging vIdeos and commuNity Health worKers to Improve Diabetes OuTcomes

   The overall goal of this study is to examine the efficacy of the video-based Diabetes Self-Management Education and Support (DSMES) (hereafter VIDEO), or the video-based DSMES+community health worker (CHW) intervention (hereafter VIDEO+CHW), compared with a wait-list control group (hereafter CONTRO…

   Stage

   Not phased

   Ages

   18 and older

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT06319716 on ClinicalTrials.gov

6. A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

   The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with LY3457263 compared with placebo in participants with type 2 diabetes who are not at HbA1c goal when treated with a stable dose of semaglutide or tirzepatide. Participation in the study will last about 9 months.

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Helios Clinical Research - Phoenix, Phoenix, Arizona

   Locations

   60 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT06897475 on ClinicalTrials.gov

7. Advancing Diabetes Management for People With Physical Disabilities Optimally Through Primary Care-Based Telehealth (ADDOPT)

   The purpose of the study is to compare 2 primary care based telehealth interventions- 1) digital health coaching and 2) remote patient monitoring for improving glycemic (blood sugar levels) control and overall health outcomes in individuals with physical disabilities, type 2 diabetes (T2DM) and at …

   Stage

   Not phased

   Ages

   18 to 89

   Site

   UAB Highlands Hospital/Department of Family and Community Medicine, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT07032844 on ClinicalTrials.gov

8. Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)

   CAPTAIN-T2D will take place in two parts. Part 1 (Screening) will evaluate patients with type 2 diabetes and elevated cortisol risk factors for trial eligibility and the presence of elevated cortisol. Participants deemed eligible from Part 1 will be randomized to either clofutriben or placebo in th…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Arizona Clinical Trials - Pecos, Chandler, Arizona

   Locations

   61 in total

   Run by

   Sparrow Pharmaceuticals

   See if you can join NCT07296484 on ClinicalTrials.gov

9. SMART 2D: Study of Montelukast's Effects on Renal and Cardiovascular Health in Adolescents and Young Adults With Type 2 Diabetes

   Adolescents and young adults (AYA) with type 2 diabetes (T2D) have a more severe phenotype than what is seen in youth-onset type 1 diabetes or adult-onset T2D including earlier kidney and cardiovascular disease complications; and prioritizing new treatments, either for standalone use or in combinat…

   Stage

   EARLY_Phase 1

   Ages

   14 to 24

   Site

   University of Colorado, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07409714 on ClinicalTrials.gov

10. Ketogenic Diet and Diabetes Demonstration Project

    KDDP is a prospective, 12-month pilot study comparing the effects of a novel lifestyle program, the Ketogenic Diet and Diabetes Demonstration Project (KDDP) to those of the National Diabetes Prevention Program (NDDP). KDDP is modeled to mimic the delivery platform of NDPP with the exception that pa…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of New Mexico, Albuquerque, New Mexico

    Run by

    University of New Mexico

    See if you can join NCT06115265 on ClinicalTrials.gov

11. Alpelisib Challenge Test (ACT)

    The goal of this study is to test a potentially easier method for measuring how much insulin a person is capable of producing than the current gold-standard method, the "hyperglycemic clamp." Participants will come in for a two-day (overnight) visit in which they will first undergo a "hyperglycemic…

    Stage

    Phase 1

    Ages

    18 to 70

    Site

    Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT07778524 on ClinicalTrials.gov

12. Mechanisms of Fatigability With Diabetes

    Pre-diabetes (Pre-D) is a precursor to type 2 diabetes (T2D) and characterized by increased exercise fatigability of lower limb muscles, that can impede exercise performance. The cause for the increased fatigability in people with Pre-D is not known. Given the profound vascular disease present in p…

    Stage

    Not phased

    Ages

    30 to 85

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT04442451 on ClinicalTrials.gov

13. AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications

    This study is being conducted to find out how well zenagamtide works and how safe it is compared to insulin glargine in participants with type 2 diabetes who are at higher risk of heart and blood vessel problems and are already taking 1 to 3 diabetes medications. There are 2 study treatments in thi…

    Stage

    Phase 3

    Ages

    45 and older

    Site

    Eastern Shore Rsrch Inst, LLC, Fairhope, Alabama

    Locations

    330 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07797335 on ClinicalTrials.gov

14. A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

    This clinical study is testing how the study medicine CagriSema helps people living with obesity, with or without type 2 diabetes (T2D), lose weight. The purpose of the study is to find out how safe and effective CagriSema is for body weight loss in these participants. Participants will receive eit…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    CEMEDIC, CABA, Buenos Aires

    Locations

    303 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07564414 on ClinicalTrials.gov

15. Brown Adipose Tissue Activation by Spinal Cord Stimulation

    The objective of this study is to investigate and utilize spinal cord stimulation (SCS) as an effective approach to eliciting weight loss and potentially alleviating Type 2 diabetes mellitus (DM), as evidenced by increasing metabolism of adipose tissue.

    Stage

    Not phased

    Ages

    21 to 70

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT04326192 on ClinicalTrials.gov

16. A Study to Identify and Characterize Patients With Type 2 Diabetes Mellitus for Possible Participation in Ongoing or Future Type 2 Diabetes Mellitus Clinical Studies

    The purpose of this study is to identify and characterize patients with known Type 2 Diabetes Mellitus (T2DM) for possible participation in ongoing or future T2DM clinical studies, and to characterize trends in key concomitant medication use in this patient population across different geographical …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Research Site, Little Rock, Arkansas

    Locations

    76 in total

    Run by

    AstraZeneca

    See if you can join NCT07606066 on ClinicalTrials.gov

17. Specimen and Data Collection in South Carolina Medicaid-Enrolled Patients With Type 2 Diabetes (T2D) and Metabolically Healthy Controls

    The primary purpose of this study is to use multiomic data in combination with clinical assessments, electronic health records, cognitive and mood assessments, wearable technologies and lifestyle/behavioral data to identify data elements or combinations of data elements with strong positive or nega…

    Stage

    Not phased

    Ages

    40 to 70

    Site

    Clemson Health Clinic at Orangeburg, Orangeburg, South Carolina

    Locations

    2 in total

    Run by

    Guardian Research Network, Inc.

    See if you can join NCT07731399 on ClinicalTrials.gov

18. Quantifying Hepatic Mitochondrial Fluxes in Humans

    In this study the investigators will quantitate hepatic mitochondrial fluxes in T2D patients with NAFL and NASH before and after 16-weeks treatment with the insulin sensitizer pioglitazone

    Stage

    Phase 4

    Ages

    18 to 80

    Site

    Texas Diabetes Institute - University Health System, San Antonio, Texas

    Locations

    2 in total

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT05305287 on ClinicalTrials.gov

19. NOURISH - A Healthcare-community Partnership to Improve Nutrition for Optimal Glycemic Control and Pregnancy Outcomes With Pregestational Diabetes

    Nutrition insecurity (inclusive of food insecurity + poor diet quality) is a fundamental social need that must be addressed to improve treatment and health outcomes for high-risk pregnant women with pregestational type 1 and 2 diabetes, poor glucose control, and food insecurity for whom a healthy d…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT07560813 on ClinicalTrials.gov

20. Acute Exercise and Endogenous Glucose Production in Type 2 Diabetes: Implications for Glycemic Control and Treatment of Hepatic Steatosis

    The overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by the liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis (fatty liver).

    Stage

    Not phased

    Ages

    25 to 55

    Site

    AdventHealth Translational Research Institute, Orlando, Florida

    Run by

    AdventHealth Translational Research Institute

    See if you can join NCT06993454 on ClinicalTrials.gov

21. A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)

    The main purpose of this study is to evaluate additional dosing options for dulaglutide in pediatric participants with Type 2 Diabetes. Participation in this study will last about 8 months.

    Stage

    Phase 3

    Ages

    10 to 17

    Site

    University of Arizona, Tucson, Arizona

    Locations

    51 in total

    Run by

    Eli Lilly and Company

    See if you can join NCT06739122 on ClinicalTrials.gov

22. The GRoceries Aimed at Increasing Nutrition Study

    Only 2% of Americans meet the recommended levels of whole grain consumption, despite its association with reduced risk of type 2 diabetes. This study aims to assess if consumers with prediabetes or type 2 diabetes can be encouraged to switch from buying refined grain products to whole grain product…

    Stage

    Not phased

    Ages

    45 to 70

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT07167004 on ClinicalTrials.gov

23. Circadian Intervention to Improve Cardiometabolic Health

    The overall goal is to examine the efficacy of a circadian intervention in people with overweight and obesity and habitual short sleep duration (HSSD). Participants will undergo a randomized controlled trial, with circadian intervention and control (healthy lifestyle) groups. The circadian interven…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    College of Health Research Complex--University of Utah, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT05943626 on ClinicalTrials.gov

24. Effect of Sleep Extension on Ceramides in People With Overweight and Obesity

    The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity. Participants will undergo a randomized controlled trial, with sleep extension (interve…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    College of Health Research Complex--University of Utah, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT06180837 on ClinicalTrials.gov

25. Families Implementing Good Health Traditions for Life

    This study will provide evidence for the utility of using a community-engaged research approach to implement a tailored, family-oriented adaptation of the Diabetes Prevention Program that will have positive effects on risk factors associated with type 2 diabetes morbidity and mortality among Black …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Morehouse School of Medicine, Albany, Georgia

    Run by

    Morehouse School of Medicine

    See if you can join NCT07441655 on ClinicalTrials.gov