Type 2 Diabetes Clinical Trials

101 studies are recruiting for type 2 diabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar

   This study aims to find out whether a study medicine called survodutide helps people control their blood sugar. Adults who live with type 2 diabetes and with a body mass index (BMI) of 23 kg/m2 or higher can join. The study has 3 parts. In each part the study compares survodutide with placebo. Surv…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Royal Prince Alfred Hospital, Camperdown, New South Wales

   Locations

   101 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT07754461 on ClinicalTrials.gov

2. New T-UP: Engaging Vulnerable Students in Diabetes Prevention

   The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity. The specific aims are: Aim 1 - Evaluate the efficacy of an AYA-tail…

   Stage

   Not phased

   Ages

   17 to 25

   Site

   University of California, Los Angeles, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT07225218 on ClinicalTrials.gov

3. Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy

   This is a phase 2 randomized, double-blind, placebo-controlled trial assessing the efficacy and safety of icovamenib in participants with Type 2 Diabetes (T2D) not achieving glycemic targets despite GLP-1-based therapy.

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Central Research Associates, LLC dba Flourish Research, Birmingham, Alabama

   Locations

   20 in total

   Run by

   Biomea Fusion Inc.

   See if you can join NCT07502508 on ClinicalTrials.gov

4. Evaluation of MiniMed Next Generation Extended Wear Sensors and Algorithm in Patients With Type 1 and Type 2 Diabetes

   This study will collect sensor data in subjects with T1D or T2D, 2-80 years of age.

   Stage

   Not phased

   Ages

   2 to 80

   Site

   ProSciento, Chula Vista, California

   Locations

   18 in total

   Run by

   Medtronic MiniMed, Inc.

   See if you can join NCT07864168 on ClinicalTrials.gov

5. The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes

   The investigators recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1. These effects are more pronounced in people with early type 2 diabetes (T2DM) in keeping with increased expression o…

   Stage

   Phase 2

   Ages

   25 to 70

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06976619 on ClinicalTrials.gov

6. A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Semaglutide Medication

   The purpose of this clinical study is to find out which zenagamtide dose can be switched to, from maintenance dose of semaglutide in people with overweight or obesity, with or without type 2 diabetes (T2D). All participants will get semaglutide and zenagamtide.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   PAREXEL Glendale/LA EPCU, Glendale, California

   Locations

   2 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07855133 on ClinicalTrials.gov

7. A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Tirzepatide Medication

   The purpose of this clinical study is to find out which zenagamtide dose can be switched to, from maintenance dose of tirzepatide in people with overweight or obesity, with or without type 2 diabetes (T2D). All participants will get tirzepatide and zenagamtide.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   PAREXEL Glendale/LA EPCU, Glendale, California

   Locations

   2 in total

   Run by

   Novo Nordisk A/S

   See if you can join NCT07868354 on ClinicalTrials.gov

8. Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

   This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced …

   Stage

   Not phased

   Ages

   14 to 18

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT06007404 on ClinicalTrials.gov

9. A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

   The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with LY3457263 compared with placebo in participants with type 2 diabetes who are not at HbA1c goal when treated with a stable dose of semaglutide or tirzepatide. Participation in the study will last about 9 months.

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Helios Clinical Research - Phoenix, Phoenix, Arizona

   Locations

   60 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT06897475 on ClinicalTrials.gov

10. KPSC MNT Pilot RCT

    The purpose of this pilot randomized trial is to evaluate the implementation and effectiveness of a Diabetes Medical Nutrition Therapy (DM MNT) program for adults with type 2 diabetes and poor glycemic control receiving care in a large integrated health system. The study will assess implementation …

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Kaiser Permanente San Bernardino County Medical Center, Fontana, California

    Run by

    Kaiser Permanente

    See if you can join NCT07868250 on ClinicalTrials.gov

11. Multimodal Glucose Prediction in Type 2 Diabetes

    The primary objective of this research, funded by Samsung Strategic Alliance for Research and Technology, is to develop multi-modal foundation models that integrate Continuous Glucose Monitoring (CGM) data with patient behavior data (food intake, medication, and physical activity) to improve real-t…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Johns Hopkins Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT07633171 on ClinicalTrials.gov

12. A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes

    This study will evaluate the efficacy and safety of petrelintide compared with placebo, in conjunction with a reduced-calorie diet and increased physical activity, for weight management in participants living with overweight or obesity and with Type 2 Diabetes (T2D).

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Institute for Metabolic Research Los Angeles, Los Angeles, California

    Locations

    2 in total

    Run by

    Hoffmann-La Roche

    See if you can join NCT07843485 on ClinicalTrials.gov

13. Advancing Diabetes Management for People With Physical Disabilities Optimally Through Primary Care-Based Telehealth (ADDOPT)

    The purpose of the study is to compare 2 primary care based telehealth interventions- 1) digital health coaching and 2) remote patient monitoring for improving glycemic (blood sugar levels) control and overall health outcomes in individuals with physical disabilities, type 2 diabetes (T2DM) and at …

    Stage

    Not phased

    Ages

    18 to 89

    Site

    UAB Highlands Hospital/Department of Family and Community Medicine, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT07032844 on ClinicalTrials.gov

14. Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)

    CAPTAIN-T2D will take place in two parts. Part 1 (Screening) will evaluate patients with type 2 diabetes and elevated cortisol risk factors for trial eligibility and the presence of elevated cortisol. Participants deemed eligible from Part 1 will be randomized to either clofutriben or placebo in th…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Arizona Clinical Trials - Pecos, Chandler, Arizona

    Locations

    61 in total

    Run by

    Sparrow Pharmaceuticals

    See if you can join NCT07296484 on ClinicalTrials.gov

15. SMART 2D: Study of Montelukast's Effects on Renal and Cardiovascular Health in Adolescents and Young Adults With Type 2 Diabetes

    Adolescents and young adults (AYA) with type 2 diabetes (T2D) have a more severe phenotype than what is seen in youth-onset type 1 diabetes or adult-onset T2D including earlier kidney and cardiovascular disease complications; and prioritizing new treatments, either for standalone use or in combinat…

    Stage

    EARLY_Phase 1

    Ages

    14 to 24

    Site

    University of Colorado, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT07409714 on ClinicalTrials.gov

16. Imaging in Semaglutide Study

    In this preliminary observation study, the investigators will assess muscle function in terms of muscle strength and leverage imaging (MRI) and spectroscopy (31P-MRS) based techniques to assess longitudinal changes in muscle volume, quality and metabolic function in patients with T2D and obesity pr…

    Stage

    Not phased

    Ages

    45 to 75

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT07695454 on ClinicalTrials.gov

17. Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes

    It is not known whether a new diabetes drug, semaglutide, is an effective treatment for type 2 diabetes for persons with spinal cord injury (SCI), a population at higher risk for this condition. Therefore, this study looks at the effect of semaglutide on glucose levels in the body and other informa…

    Stage

    Phase 4

    Ages

    18 to 70

    Site

    University Health - Texas Diabetic Institute, San Antonio, Texas

    Locations

    2 in total

    Run by

    Marzieh Salehi

    See if you can join NCT06706284 on ClinicalTrials.gov

18. Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy

    This is a 17 - week study consisting of a one - week run - in period and a 16 - week intervention. The 16 - week pilot interventions aims to increase hydration in those beginning GLP - 1 RA therapy. Investigators aim to increase hydration to potentially decrease side effect severity, amount of side…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    State University of New York at Buffalo, South Campus, Buffalo, New York

    Run by

    State University of New York at Buffalo

    See if you can join NCT07641361 on ClinicalTrials.gov

19. A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

    This clinical study is testing how the study medicine CagriSema helps people living with obesity, with or without type 2 diabetes (T2D), lose weight. The purpose of the study is to find out how safe and effective CagriSema is for body weight loss in these participants. Participants will receive eit…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Renew Clinic Sp. z o.o., Bialystok,

    Locations

    303 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT07564414 on ClinicalTrials.gov

20. NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study

    A pragmatic, randomized clinical trial to evaluate the effect of a heart failure (HF) risk assessment and prevention strategy incorporating HF clinical risk scores (WATCH-DM) with cardiac biomarker (NT-proBNP) paired with a clinical decision support tool to implement an intensive prevention strateg…

    Stage

    Not phased

    Ages

    Any age

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Locations

    3 in total

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06593327 on ClinicalTrials.gov

21. A Study of PATAS Using Single Ascending Doses in Healthy Volunteers and Multiple Ascending Doses in Diabetic Subjects

    This is 2-part study. The primary objective of Part 1 is to evaluate safety and tolerability of single subcutaneous (SC) doses of PATAS in healthy subjects. The secondary objective of this study is to determine the pharmacokinetics (PK) of single SC doses of PATAS in healthy subjects. The primary o…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Arizona Clinical Trials, Chandler, Arizona

    Locations

    3 in total

    Run by

    AdipoPharma LLC

    See if you can join NCT07223333 on ClinicalTrials.gov

22. Using Continuous Glucose Monitoring to Quantify the Effects of NOURISH's Culturally Modified Meals on Asian Americans With Type 2 Diabetes

    The investigators are hoping to determine whether tailoring the diet of someone with type 2 diabetes to their ethnic group while following American Diabetes Association guidelines can make a significant difference in their blood sugar controls. Participants will be required to wear a Continuous Glu…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT06836479 on ClinicalTrials.gov

23. ACCESS 2: AI for pediatriC diabetiC Eye examS Study 2

    The purpose of this study is to determine if use of a nonmydriatic fundus camera using autonomous artificial intelligence software at the point of care increases the proportion of underserved youth with diabetes screened for diabetic retinopathy, and to determine the diagnostic accuracy of the auto…

    Stage

    Not phased

    Ages

    8 to 21

    Site

    Johns Hopkins Pediatric Diabetes Center, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05463289 on ClinicalTrials.gov

24. Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study

    Background: Type 2 diabetes is a disease that affects blood sugar levels. Complications can include heart and blood vessel (vascular) diseases. Rates of type 2 diabetes have tripled in children and young adults over the last 40 years. Vascular diseases are also increasing in young people. Objective…

    Stage

    Not phased

    Ages

    12 to 25

    Site

    Children's National Hospital (CNH), Washington D.C., District of Columbia

    Locations

    2 in total

    Run by

    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    See if you can join NCT06730113 on ClinicalTrials.gov

25. Plant-Based Online Weight Loss Through Education and Resources Program and Study

    This is an interventional study that will evaluate the feasibility, implementation, and efficacy of an online, 12-week, plant-based, nutrition education program in a community setting. Participants will meet with a physician and a registered dietitian once a week to learn about a plant-based diet a…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Physicians Committee for Responsible Medicine, Washington D.C., District of Columbia

    Run by

    Physicians Committee for Responsible Medicine

    See if you can join NCT07095543 on ClinicalTrials.gov