Type 1 Diabetes Clinical Trials

57 studies are recruiting for type 1 diabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Aurora, Colorado 10 Indianapolis, Indiana 7 Boston, Massachusetts 6 Gainesville, Florida 6 Seattle, Washington 6 Atlanta, Georgia 5 Buffalo, New York 5 Columbus, Ohio 5 Miami, Florida 5 New Haven, Connecticut 5 New York, New York 5 San Francisco, California 5 Chicago, Illinois 4 Houston, Texas 4 Kansas City, Missouri 4 Nashville, Tennessee 4 Baltimore, Maryland 3 Charlottesville, Virginia 3 Dallas, Texas 3 Jacksonville, Florida 3 Philadelphia, Pennsylvania 3 Pittsburgh, Pennsylvania 3

Studies, page 2

  1. Permissive Versus Strict Intrapartum Glucose Management in Type 1 Diabetes (PRISM-T1D)

    PRISM-TID is a single center non-inferiority randomized controlled trial of permissive intrapartum glucose management (intervention) versus strict intrapartum glucose management (standard of care) among pregnant individuals with type 1 diabetes (T1D) using hybrid closed loop therapy (HCL) who are a…

    Stage
    Phase 4
    Ages
    18 and older
    Site
    The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio
    Run by
    Ohio State University

    See if you can join NCT07293715 on ClinicalTrials.gov

  2. A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500

    The goal of this clinical trial is to assess the safety of a new U500 insulin formulation and to determine how rapidly it is absorbed and how long it takes to act when administered intraperitoneally. The trial will be conducted in people with Type 1 Diabetes. The main questions it aims to answer ar…

    Stage
    Phase 1
    Ages
    18 to 60
    Site
    ProSciento, Inc., Chula Vista, California
    Run by
    Portal Diabetes, Inc.

    See if you can join NCT07341373 on ClinicalTrials.gov

  3. Registry for Stage 2 Type 1 Diabetes

    Stage 2 Type 1 Diabates (T1D) is an early stage of T1D characterized by dysglycemia but not yet leading to clinical symptoms. Progression of the disease to Stage 3 (clinical T1D), leads to overt hyperglycemia requiring eventually exogenous insulin. TZIELD® (teplizumab-mzwv) has been approved to del…

    Stage
    Not phased
    Ages
    Any age
    Site
    University of California Los Angeles Health- Site Number : 8400020, Los Angeles, California
    Locations
    37 in total
    Run by
    Sanofi

    See if you can join NCT06481904 on ClinicalTrials.gov

  4. Immune Function and the Progression to T1D

    To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells, defective regulatory/effector mechanisms in T cells, inflammato…

    Stage
    Not phased
    Ages
    0 to 100
    Site
    Kieran McGrail, Gainesville, Florida
    Locations
    3 in total
    Run by
    University of Florida

    See if you can join NCT05899439 on ClinicalTrials.gov

  5. An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant

    This study will evaluate the efficacy, safety, and tolerability of VX-880 in participants with Type 1 Diabetes (TID) with a kidney transplant.

    Stage
    Phase 3
    Ages
    18 to 65
    Site
    Perelman Center for Advanced Medicine - Endocrinology, Philadelphia, Pennsylvania
    Locations
    7 in total
    Run by
    Vertex Pharmaceuticals Incorporated

    See if you can join NCT06832410 on ClinicalTrials.gov

  6. Home-based Oral Glucose Tolerance Test for Type 1 Diabetes Screening

    This study aims at quantifying the accuracy of a self-administered fingerstick based glucose tolerance test (GTT@Home) respect to the gold-standard in-clinic venous plasma measures during the oral glucose tolerance test (OGTT) across a wide range of glycemic values in people at risk for clinical ty…

    Stage
    Not phased
    Ages
    8 to 45
    Site
    Yale University Pediatric and Adult Diabetes Clinic, New Haven, Connecticut
    Run by
    Yale University

    See if you can join NCT07155252 on ClinicalTrials.gov

  7. General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery

    In partnership with Helmsley Charitable Trust, the Sanford PLEDGE Study is a large-scale, observational, feasibility study of general population screening for T1D and celiac autoantibodies. Screening is incorporated into routine health care visits within an integrated health system.

    Stage
    Not phased
    Ages
    Up to 17
    Site
    Sanford Bemidji Region Clinics, Bemidji, Minnesota
    Locations
    4 in total
    Run by
    Sanford Health

    See if you can join NCT04477928 on ClinicalTrials.gov

  8. Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes

    This study will examine the potential cardiovascular effect(s) of artificial pancreas (AP) technology in patients with type 1 diabetes. AP technology is a system of devices that closely mimics the glucose-regulating function of a healthy human pancreas. It includes an insulin pump and a continuous …

    Stage
    Not phased
    Ages
    18 to 40
    Site
    University of Virginia Health System, Charlottesville, Virginia
    Run by
    University of Virginia

    See if you can join NCT05653518 on ClinicalTrials.gov

  9. Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes

    The brief purpose of this research study is to learn about the safety and efficacy of intra-arterial administration of CELZ-201 in patients with newly diagnosed Type 1 Diabetes Mellitus (T1D).

    Stage
    Phase 1
    Ages
    18 to 35
    Site
    Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, Florida
    Run by
    Creative Medical Technology Holdings Inc

    See if you can join NCT05626712 on ClinicalTrials.gov

  10. To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes.

    The goal of this clinical trial is to evaluate the efficacy and safety of Medtronic 780G automated insulin delivery system in adult persons with type 1 diabetes and gastroparesis.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Indiana University Health, Univeristy hospital, Indianapolis, Indiana
    Run by
    Viral N. Shah

    See if you can join NCT07287943 on ClinicalTrials.gov

  11. Effect of C-peptide on Hypoglycemic Counterregulation

    Iatrogenic hypoglycemia is the most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes due to periodic over-insulinization. During insulin-induced hypoglycemia, glucagon secretion is diminished in type 1 diabetes which, in turn, reduces hepatic glucose…

    Stage
    EARLY_Phase 1
    Ages
    18 to 40
    Site
    University of Cincinnati, Cincinnati, Ohio
    Run by
    University of Cincinnati

    See if you can join NCT06470295 on ClinicalTrials.gov

  12. Lipoprotein Kinetics in T1D

    The purpose of this research study is to understand how type 1 diabetes (T1D) increases the risk for cardiovascular diseases (heart attack and stroke). To this end, the investigators will compare apolipoprotein and triglyceride kinetics in people wtih T1D and healthy control participants.

    Stage
    Not phased
    Ages
    18 to 45
    Site
    University of Missouri School of Medicine, Columbia, Missouri
    Run by
    University of Missouri-Columbia

    See if you can join NCT05179954 on ClinicalTrials.gov

  13. T1CARE: A Trial of a Novel Intervention to Address Social Determinants of Health in Young Adults With Type 1 Diabetes

    Randomized controlled trial with a wait list control arm. Participants will be randomized 1:1 to T1CARE or wait list usual care arm. Participants will be recruited from the Yale Adult and Pediatric Diabetes Centers. Patients assigned to T1CARE will receive support from a Community Health Navigator …

    Stage
    Not phased
    Ages
    18 to 40
    Site
    Yale Adult Diabetes Center, New Haven, Connecticut
    Locations
    2 in total
    Run by
    Yale University

    See if you can join NCT07059806 on ClinicalTrials.gov

  14. Cholesterol Lowering and Residual Risk in Diabetes, Type 1

    This is a prospective, interventional, cohort study, meaning that researchers will follow and observe a group of enrolled study participants over a period of time (one to two months) to gather information and record any developments of the outcomes in question. This study will recruit 125 participa…

    Stage
    Phase 4
    Ages
    18 to 89
    Site
    New York VA Hospital, New York, New York
    Locations
    4 in total
    Run by
    NYU Langone Health

    See if you can join NCT05641753 on ClinicalTrials.gov

  15. Discovery Diabetes

    The goal of this clinical trial is to learn if the Discovery Program can help improve diabetes management in adolescents and young adults with type 1 diabetes (T1D). The main questions it aims to answer are: Does the Discovery Program lead to better glycemic control as measured by HbA1c levels? How…

    Stage
    Not phased
    Ages
    13 to 21
    Site
    Vanderbilt University, Nashville, Tennessee
    Run by
    Vanderbilt University Medical Center

    See if you can join NCT07116434 on ClinicalTrials.gov

  16. GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab

    The goal of this study is to determine how a drug class called glucagon-like peptide-1 receptor agonists (GLP-1Ra) affects people during an early stage of Type 1 Diabetes undergoing clinical teplizumab treatment. This study involves giving participants a liquid meal under different conditions and o…

    Stage
    EARLY_Phase 1
    Ages
    12 to 50
    Site
    Vanderbilt University Medical Center, Nashville, Tennessee
    Run by
    Vanderbilt University Medical Center

    See if you can join NCT06338553 on ClinicalTrials.gov

  17. InvesT1D: Promoting Adolescent Investment in Diabetes Care

    The goal of this clinical trial is to see if a financial incentives program called InvesT1D is helpful to support diabetes management in adolescents with type 1 diabetes. Adolescent participants will be randomized to usual care or receive financial incentives for meeting diabetes self-management an…

    Stage
    Not phased
    Ages
    12 and older
    Site
    Seattle Children's, Seattle, Washington
    Run by
    Harvard Pilgrim Health Care

    See if you can join NCT06384911 on ClinicalTrials.gov

  18. A Longitudinal, Observational Study Comparing Real-World Experiences of Teplizumab-Treated and Untreated Participants With Stage 2 Type 1 Diabetes in the United States

    This study is an observational, longitudinal, non-interventional real-world study in the United States. The study is meant to describe the experience of participants with a history of stage 2 type 1 diabetes who have been infused with teplizumab and the experience of participants with stage 2 type …

    Stage
    Not phased
    Ages
    8 and older
    Site
    Investigational Site, San Francisco, California
    Run by
    Sanofi

    See if you can join NCT07260110 on ClinicalTrials.gov

  19. Precision Administration of Anti-thymocyte Globulin With or Without Verapamil

    T cell directed therapy, anti-thymocyte globulin (ATG), in low doses, has been shown to lower HbA1c and preserve endogenous insulin production (measured by C-peptide) in individuals with recently diagnosed type 1 diabetes (T1D). However, not all individuals who received ATG responded to the therapy…

    Stage
    Phase 2
    Ages
    6 to 35
    Site
    Barbara Davis Center for Diabetes, Aurora, Colorado
    Locations
    2 in total
    Run by
    University of Florida

    See if you can join NCT06455319 on ClinicalTrials.gov

  20. Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression

    This project will evaluate a telemedicine-delivered, Unified Protocol for Cognitive-Behavioral Therapy (UP-CBT) enhanced with continuous glucose monitor (CGM) review to target anxiety and depressive symptoms and glycemic control in adults with type 1 diabetes.

    Stage
    Not phased
    Ages
    18 to 64
    Site
    Boston University, Boston, Massachusetts
    Locations
    2 in total
    Run by
    Albert Einstein College of Medicine

    See if you can join NCT05734313 on ClinicalTrials.gov

  21. The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes

    The investigators recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1. These effects are more pronounced in people with early type 2 diabetes (T2DM) in keeping with increased expression o…

    Stage
    Phase 2
    Ages
    25 to 70
    Site
    Mayo Clinic in Rochester, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT06976619 on ClinicalTrials.gov

  22. A Study Comparing Dexcom Continuous Glucose Monitoring to Point of Care Glucose Testing for the Management of Hospital and Post-Discharge Subjects With Type 1 Diabetes

    This study aims to compare inpatient glycemic control by measuring the percentage of time in the range of 70-180 mg/dl and the frequency of hypoglycemia between Dexcom G7 Continuous Glucose Monitoring (CGM) and Point of Care (POC) Blood Glucose Testing in poorly controlled subjects with Type 1 Diab…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Grady Memorial Hospital, Atlanta, Georgia
    Run by
    Emory University

    See if you can join NCT06752928 on ClinicalTrials.gov

  23. Sleep Coach for Adolescents With Type 1 Diabetes

    The goal of this work is to conduct a randomized trial evaluating the effects of a behavioral intervention to increase sleep duration and quality for adolescents with type 1 diabetes (T1D). The impact of the sleep-promoting intervention on executive function and glycemic outcomes will be assessed. …

    Stage
    Not phased
    Ages
    11 to 17
    Site
    Vanderbilt University Medical Center, Nashville, Tennessee
    Run by
    Vanderbilt University Medical Center

    See if you can join NCT06516614 on ClinicalTrials.gov

  24. Glu-COACH: a Peer-mentoring Intervention to Reduce Disparities in Continuous Glucose Monitor (CGM) Use

    This is a study to develop and evaluate a peer mentoring intervention for Black and Latinx adolescents with type 1 diabetes to increase the initiation and maintenance of a continuous glucose monitoring (CGM) device. This device is a standard of care to improve diabetes management related to diet, e…

    Stage
    Not phased
    Ages
    13 to 21
    Site
    Yale Children's Diabetes Clinic, New Haven, Connecticut
    Run by
    Yale University

    See if you can join NCT06171412 on ClinicalTrials.gov

  25. Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial

    The goal of this study is to learn about the effect of the study drug acetazolamide in individuals with Type 1 Diabetes. Specifically, whether acetazolamide provides benefits to the kidneys while minimizing any side effects of the drug. These changes will be measured by laboratory tests that tell u…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    UC San Diego Altman Clinical & Translational Research Institute, La Jolla, California
    Run by
    University of California, San Diego

    See if you can join NCT06981234 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.