Type 1 Diabetes Clinical Trials

59 studies are recruiting for type 1 diabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Cholesterol Lowering and Residual Risk in Diabetes, Type 1

   This is a prospective, interventional, cohort study, meaning that researchers will follow and observe a group of enrolled study participants over a period of time (one to two months) to gather information and record any developments of the outcomes in question. This study will recruit 125 participa…

   Stage

   Phase 4

   Ages

   18 to 89

   Site

   New York VA Hospital, New York, New York

   Locations

   4 in total

   Run by

   NYU Langone Health

   See if you can join NCT05641753 on ClinicalTrials.gov

2. T1CARE: A Trial of a Novel Intervention to Address Social Determinants of Health in Young Adults With Type 1 Diabetes

   Randomized controlled trial with a wait list control arm. Participants will be randomized 2:1 to T1CARE or wait list usual care arm. Participants will be recruited from the Yale Adult and Pediatric Diabetes Centers. Patients assigned to T1CARE will receive support from a Community Health Navigator …

   Stage

   Not phased

   Ages

   18 to 40

   Site

   Yale Adult Diabetes Center, New Haven, Connecticut

   Locations

   2 in total

   Run by

   Yale University

   See if you can join NCT07059806 on ClinicalTrials.gov

3. Sleep Coach for Adolescents With Type 1 Diabetes

   The goal of this work is to conduct a randomized trial evaluating the effects of a behavioral intervention to increase sleep duration and quality for adolescents with type 1 diabetes (T1D). The impact of the sleep-promoting intervention on executive function and glycemic outcomes will be assessed. …

   Stage

   Not phased

   Ages

   11 to 17

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT06516614 on ClinicalTrials.gov

4. Denosumab for Type 1 Diabetes

   Type 1 diabetes (T1D) arises from abnormal immune cell-mediated injury to beta cells that make insulin. The injured beta cells can then no longer make the needed amount of insulin to stay healthy. However, in the early stages of T1D, some beta cells are still alive and functioning. Treatment to pro…

   Stage

   Phase 1

   Ages

   18 to 50

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   3 in total

   Run by

   City of Hope Medical Center

   See if you can join NCT06524960 on ClinicalTrials.gov

5. Cardiometabolic Effects of Non-Nutritive Sweeteners (NNS) in Type 1 Diabetes (T1D)

   This project will apply a novel non-nutritive sweetener (NNS) dietary assessment tool with measurement of circulating NNS levels in a pediatric population, allowing correlation of NNS exposure to clinically meaningful cardiometabolic health outcomes.

   Stage

   Not phased

   Ages

   15 to 24

   Site

   Medical College of Wisconsin, Milwaukee, Wisconsin

   Run by

   Medical College of Wisconsin

   See if you can join NCT07434544 on ClinicalTrials.gov

6. Evaluation of MiniMed Next Generation Extended Wear Sensors and Algorithm in Patients With Type 1 and Type 2 Diabetes

   This study will collect sensor data in subjects with T1D or T2D, 2-80 years of age.

   Stage

   Not phased

   Ages

   2 to 80

   Site

   ProSciento, Chula Vista, California

   Locations

   18 in total

   Run by

   Medtronic MiniMed, Inc.

   See if you can join NCT07864168 on ClinicalTrials.gov

7. The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes

   The investigators recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1. These effects are more pronounced in people with early type 2 diabetes (T2DM) in keeping with increased expression o…

   Stage

   Phase 2

   Ages

   25 to 70

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06976619 on ClinicalTrials.gov

8. A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes

   This multi-center randomized controlled trial will assess the safety and efficacy of ATG followed by either adalimumab or verapamil in preserving insulin secretion 2 years from randomization in persons aged 9 to <21 with recent-onset stage 3 T1D.

   Stage

   Phase 1

   Ages

   9 to 20

   Site

   UCSF, San Francisco, California

   Locations

   11 in total

   Run by

   City of Hope Medical Center

   See if you can join NCT07061574 on ClinicalTrials.gov

9. Safety and Efficacy of Adjunct Therapies in Adults With Type 1 Diabetes: Multicenter, Registry Study

   This will be a multicenter registry-based study to evaluate safety and efficacy of GLP-1RA and SGLTi therapies in adjunct to insulin in adults with type 1 diabetes (T1D) over 1 year. This study will enroll participants who have been prescribed adjunct therapy as part of usual care.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Hoag Memorial Hospital, Newport Beach, California

   Locations

   17 in total

   Run by

   Indiana University

   See if you can join NCT07676565 on ClinicalTrials.gov

10. SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

    This is a Phase 2b, investigator- and participant-blinded, placebo-controlled, parallel-arm study to evaluate the efficacy, safety and tolerability of SAB 142 in patients with Stage 3 New Onset of Type 1 Diabetes (NOT1D).

    Stage

    Phase 2

    Ages

    5 to 40

    Site

    University of California San Francisco Benioff Children's Hospital, San Francisco, California

    Locations

    68 in total

    Run by

    SAb Biotherapeutics, Inc.

    See if you can join NCT07187531 on ClinicalTrials.gov

11. To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes.

    The goal of this clinical trial is to evaluate the efficacy and safety of Medtronic 780G automated insulin delivery system in adult persons with type 1 diabetes and gastroparesis.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Indiana University Health, Univeristy hospital, Indianapolis, Indiana

    Run by

    Viral N. Shah

    See if you can join NCT07287943 on ClinicalTrials.gov

12. Advancing Precision Nutrition: Wearable Technology for Noninvasive Insulin Monitoring

    Noninvasively monitoring insulin is crucial for advancing precision nutrition and promoting healthy living by enabling a deeper understanding of individual metabolic responses to dietary intake. Insulin is a key regulator of blood sugar and energy metabolism, and its dysregulation is linked to cond…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Texas A&M University, College Station, Texas

    Run by

    Texas A&M University

    See if you can join NCT07254364 on ClinicalTrials.gov

13. ACCESS 2: AI for pediatriC diabetiC Eye examS Study 2

    The purpose of this study is to determine if use of a nonmydriatic fundus camera using autonomous artificial intelligence software at the point of care increases the proportion of underserved youth with diabetes screened for diabetic retinopathy, and to determine the diagnostic accuracy of the auto…

    Stage

    Not phased

    Ages

    8 to 21

    Site

    Johns Hopkins Pediatric Diabetes Center, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05463289 on ClinicalTrials.gov

14. CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)

    This study is a Phase 1b/2a First-in-Human (FIH) clinical trial to assess the safety, tolerability, pharmacodynamics (PD), and efficacy of multiple ascending doses of CNP-103. The approximately 393-days study consists of a Screening Period (28 days), Treatment Period (90 days), and Post-Dose Evalua…

    Stage

    Phase 1

    Ages

    12 to 35

    Site

    Wake Research - Tucson, Tucson, Arizona

    Locations

    45 in total

    Run by

    COUR Pharmaceutical Development Company, Inc.

    See if you can join NCT06783309 on ClinicalTrials.gov

15. Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes

    The goal of this clinical trial is to test whether a new intervention works to treat eating disorders in type 1 diabetes. Participants are assigned to one of the following: (1) Acceptance and Commitment Therapy (ACT), (2) Supportive Diabetes Counseling, or (3) a 6-month Waitlist Control. Participan…

    Stage

    Not phased

    Ages

    16 to 50

    Site

    Duke University, Durham, North Carolina

    Locations

    2 in total

    Run by

    Duke University

    See if you can join NCT05540704 on ClinicalTrials.gov

16. The iLet Experience Study

    A one-year, prospective single-arm cohort study to collect safety and effectiveness data on the iLet Dosing Decision Software during real-world use in people 6 years of age or older with type 1 diabetes (T1D) with 12 months follow-up.

    Stage

    Not phased

    Ages

    6 and older

    Site

    Beta Bionics, Irvine, California

    Run by

    Beta Bionics, Inc.

    See if you can join NCT06891898 on ClinicalTrials.gov

17. C-Carbs: A CGM-guided Approach to Teaching Carb Awareness

    The goal of this randomized study is to learn whether a CGM-guided insulin dosing education program can help adults with diabetes improve how they dose mealtime insulin. The main question it aims to answer is: 1. Does CGM-guided insulin dosing education improve insulin dosing behaviors and glycemic…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT07807280 on ClinicalTrials.gov

18. Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families

    This R01 is in response to RFA-DK-19-021, Treating Diabetes Distress to Improve Glycemic Outcomes in Type 1 Diabetes. The objective is to test the feasibility and acceptability of a novel, practical, and potentially scalable screen to treat program for diabetes distress in families of school-age ch…

    Stage

    Not phased

    Ages

    8 to 65

    Site

    Nemours Children's Health, Jacksonville, Florida

    Locations

    2 in total

    Run by

    Nemours Children's Clinic

    See if you can join NCT05268250 on ClinicalTrials.gov

19. Family Intervention for Black Teens With Type 1 Diabetes

    The purpose of this study is to conduct a multicenter, randomized effectiveness trial of The 3Ms 2.0 compared to an educational control condition for improving adolescent glycemic control and diabetes-related family relationships and reducing primary caregiver diabetes-related distress among Black …

    Stage

    Not phased

    Ages

    10 to 14

    Site

    Children's National Hospital, Washington D.C., District of Columbia

    Locations

    4 in total

    Run by

    Wayne State University

    See if you can join NCT06275412 on ClinicalTrials.gov

20. Long-Term Outcomes of Teplizumab in Routine Clinical Care

    This is an observational, prospective cohort study designed to evaluate the outcomes after teplizumab treatment in participants with Stage 2 Type 1 Diabetes (T1D) for delaying the onset of Stage 3 T1D. The study will monitor participants receiving teplizumab as part of routine clinical care across …

    Stage

    Not phased

    Ages

    Any age

    Site

    Investigational Site Number: 8400003, Atlanta, Georgia

    Locations

    10 in total

    Run by

    Sanofi

    See if you can join NCT07360080 on ClinicalTrials.gov

21. The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action

    Ovwerweight and obesity prevalence in persons with T1D has increased, which further complicates management and risk for complications. The proposed study is relevant to public health because it helps us understand the role of the gut microbiome in disease pathophysiology in T1D youth with overweigh…

    Stage

    Phase 2

    Ages

    11 to 18

    Site

    Indiana University School of Medicine, Indianapolis, Indiana

    Run by

    Heba M. Ismail

    See if you can join NCT05414409 on ClinicalTrials.gov

22. A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

    This study is First In Human study for Encapsulated Porcine Islet Cells for Xenotransplantation (OPF-310). The purpose of this study to assess the safety, tolerability, and efficacy of OPF-310 transplantation and to define the recommended Phase 2 dose (RP2D) in adult subjects with unstable Type 1 D…

    Stage

    Phase 1

    Ages

    35 to 70

    Site

    University of Illinois Hospital & Health Sciences System, Chicago, Illinois

    Run by

    Otsuka Pharmaceutical Factory, Inc.

    See if you can join NCT06575426 on ClinicalTrials.gov

23. NOURISH - A Healthcare-community Partnership to Improve Nutrition for Optimal Glycemic Control and Pregnancy Outcomes With Pregestational Diabetes

    Nutrition insecurity (inclusive of food insecurity + poor diet quality) is a fundamental social need that must be addressed to improve treatment and health outcomes for high-risk pregnant women with pregestational type 1 and 2 diabetes, poor glucose control, and food insecurity for whom a healthy d…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT07560813 on ClinicalTrials.gov

24. Telehealth Music Therapy for Adults With Endocrine Disorder and Depression

    The goal of this clinical trial is to explore if a telehealth music therapy intervention helps with quality of life, depression symptoms, anxiety symptoms. It will also explore the participants' relationship to music. The main questions it aims to answer are: * Refine and tailor the music therapy i…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Appalachian State University, Boone, North Carolina

    Run by

    Appalachian State University

    See if you can join NCT07413874 on ClinicalTrials.gov

25. Commercial or Open Source Closed Loop Impact on Pregnancy Study

    The goal of this observational study is to better understand what happens when pregnant people with type 1 diabetes (T1D) use automated insulin delivery (AID) systems. The main questions this study aims to answer are: * What are the maternal and neonatal outcomes with AID system use in pregnancy? *…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06654713 on ClinicalTrials.gov