Type 1 Diabetes Clinical Trials

57 studies are recruiting for type 1 diabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Aurora, Colorado 10 Indianapolis, Indiana 7 Boston, Massachusetts 6 Gainesville, Florida 6 Seattle, Washington 6 Atlanta, Georgia 5 Buffalo, New York 5 Columbus, Ohio 5 Miami, Florida 5 New Haven, Connecticut 5 New York, New York 5 San Francisco, California 5 Chicago, Illinois 4 Houston, Texas 4 Kansas City, Missouri 4 Nashville, Tennessee 4 Baltimore, Maryland 3 Charlottesville, Virginia 3 Dallas, Texas 3 Jacksonville, Florida 3 Philadelphia, Pennsylvania 3 Pittsburgh, Pennsylvania 3

Studies now recruiting

  1. CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)

    This study is a Phase 1b/2a First-in-Human (FIH) clinical trial to assess the safety, tolerability, pharmacodynamics (PD), and efficacy of multiple ascending doses of CNP-103. The approximately 393-days study consists of a Screening Period (28 days), Treatment Period (90 days), and Post-Dose Evalua…

    Stage
    Phase 1
    Ages
    12 to 35
    Site
    Wake Research - Tucson, Tucson, Arizona
    Locations
    45 in total
    Run by
    COUR Pharmaceutical Development Company, Inc.

    See if you can join NCT06783309 on ClinicalTrials.gov

  2. Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes

    The goal of this clinical trial is to test whether a new intervention works to treat eating disorders in type 1 diabetes. Participants are assigned to one of the following: (1) Acceptance and Commitment Therapy (ACT), (2) Supportive Diabetes Counseling, or (3) a 6-month Waitlist Control. Participan…

    Stage
    Not phased
    Ages
    16 to 50
    Site
    Duke University, Durham, North Carolina
    Locations
    2 in total
    Run by
    Duke University

    See if you can join NCT05540704 on ClinicalTrials.gov

  3. The iLet Experience Study

    A one-year, prospective single-arm cohort study to collect safety and effectiveness data on the iLet Dosing Decision Software during real-world use in people 6 years of age or older with type 1 diabetes (T1D) with 12 months follow-up.

    Stage
    Not phased
    Ages
    6 and older
    Site
    Beta Bionics, Irvine, California
    Run by
    Beta Bionics, Inc.

    See if you can join NCT06891898 on ClinicalTrials.gov

  4. C-Carbs: A CGM-guided Approach to Teaching Carb Awareness

    The goal of this randomized study is to learn whether a CGM-guided insulin dosing education program can help adults with diabetes improve how they dose mealtime insulin. The main question it aims to answer is: 1. Does CGM-guided insulin dosing education improve insulin dosing behaviors and glycemic…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of California Los Angeles, Los Angeles, California
    Run by
    University of California, Los Angeles

    See if you can join NCT07807280 on ClinicalTrials.gov

  5. A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes

    This multi-center randomized controlled trial will assess the safety and efficacy of ATG followed by either adalimumab or verapamil in preserving insulin secretion 2 years from randomization in persons aged 9 to <21 with recent-onset stage 3 T1D.

    Stage
    Phase 1
    Ages
    9 to 20
    Site
    UCSF, San Francisco, California
    Locations
    10 in total
    Run by
    City of Hope Medical Center

    See if you can join NCT07061574 on ClinicalTrials.gov

  6. Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families

    This R01 is in response to RFA-DK-19-021, Treating Diabetes Distress to Improve Glycemic Outcomes in Type 1 Diabetes. The objective is to test the feasibility and acceptability of a novel, practical, and potentially scalable screen to treat program for diabetes distress in families of school-age ch…

    Stage
    Not phased
    Ages
    8 to 65
    Site
    Nemours Children's Health, Jacksonville, Florida
    Locations
    2 in total
    Run by
    Nemours Children's Clinic

    See if you can join NCT05268250 on ClinicalTrials.gov

  7. Family Intervention for Black Teens With Type 1 Diabetes

    The purpose of this study is to conduct a multicenter, randomized effectiveness trial of The 3Ms 2.0 compared to an educational control condition for improving adolescent glycemic control and diabetes-related family relationships and reducing primary caregiver diabetes-related distress among Black …

    Stage
    Not phased
    Ages
    10 to 14
    Site
    Children's National Hospital, Washington D.C., District of Columbia
    Locations
    4 in total
    Run by
    Wayne State University

    See if you can join NCT06275412 on ClinicalTrials.gov

  8. Long-Term Outcomes of Teplizumab in Routine Clinical Care

    This is an observational, prospective cohort study designed to evaluate the outcomes after teplizumab treatment in participants with Stage 2 Type 1 Diabetes (T1D) for delaying the onset of Stage 3 T1D. The study will monitor participants receiving teplizumab as part of routine clinical care across …

    Stage
    Not phased
    Ages
    Any age
    Site
    Investigational Site Number: 8400003, Atlanta, Georgia
    Locations
    10 in total
    Run by
    Sanofi

    See if you can join NCT07360080 on ClinicalTrials.gov

  9. SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

    This is a Phase 2b, investigator- and participant-blinded, placebo-controlled, parallel-arm study to evaluate the efficacy, safety and tolerability of SAB 142 in patients with Stage 3 New Onset of Type 1 Diabetes (NOT1D).

    Stage
    Phase 2
    Ages
    5 to 40
    Site
    University of California San Francisco Benioff Children's Hospital, San Francisco, California
    Locations
    70 in total
    Run by
    SAb Biotherapeutics, Inc.

    See if you can join NCT07187531 on ClinicalTrials.gov

  10. The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action

    Ovwerweight and obesity prevalence in persons with T1D has increased, which further complicates management and risk for complications. The proposed study is relevant to public health because it helps us understand the role of the gut microbiome in disease pathophysiology in T1D youth with overweigh…

    Stage
    Phase 2
    Ages
    11 to 18
    Site
    Indiana University School of Medicine, Indianapolis, Indiana
    Run by
    Heba M. Ismail

    See if you can join NCT05414409 on ClinicalTrials.gov

  11. A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

    This study is First In Human study for Encapsulated Porcine Islet Cells for Xenotransplantation (OPF-310). The purpose of this study to assess the safety, tolerability, and efficacy of OPF-310 transplantation and to define the recommended Phase 2 dose (RP2D) in adult subjects with unstable Type 1 D…

    Stage
    Phase 1
    Ages
    35 to 70
    Site
    University of Illinois Hospital & Health Sciences System, Chicago, Illinois
    Run by
    Otsuka Pharmaceutical Factory, Inc.

    See if you can join NCT06575426 on ClinicalTrials.gov

  12. NOURISH - A Healthcare-community Partnership to Improve Nutrition for Optimal Glycemic Control and Pregnancy Outcomes With Pregestational Diabetes

    Nutrition insecurity (inclusive of food insecurity + poor diet quality) is a fundamental social need that must be addressed to improve treatment and health outcomes for high-risk pregnant women with pregestational type 1 and 2 diabetes, poor glucose control, and food insecurity for whom a healthy d…

    Stage
    Not phased
    Ages
    18 and older
    Site
    The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio
    Run by
    Ohio State University

    See if you can join NCT07560813 on ClinicalTrials.gov

  13. Telehealth Music Therapy for Adults With Endocrine Disorder and Depression

    The goal of this clinical trial is to explore if a telehealth music therapy intervention helps with quality of life, depression symptoms, anxiety symptoms. It will also explore the participants' relationship to music. The main questions it aims to answer are: * Refine and tailor the music therapy i…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Appalachian State University, Boone, North Carolina
    Run by
    Appalachian State University

    See if you can join NCT07413874 on ClinicalTrials.gov

  14. Denosumab for Type 1 Diabetes

    Type 1 diabetes (T1D) arises from abnormal immune cell-mediated injury to beta cells that make insulin. The injured beta cells can then no longer make the needed amount of insulin to stay healthy. However, in the early stages of T1D, some beta cells are still alive and functioning. Treatment to pro…

    Stage
    Phase 1
    Ages
    18 to 50
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Locations
    3 in total
    Run by
    City of Hope Medical Center

    See if you can join NCT06524960 on ClinicalTrials.gov

  15. Commercial or Open Source Closed Loop Impact on Pregnancy Study

    The goal of this observational study is to better understand what happens when pregnant people with type 1 diabetes (T1D) use automated insulin delivery (AID) systems. The main questions this study aims to answer are: * What are the maternal and neonatal outcomes with AID system use in pregnancy? *…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of California, San Francisco, San Francisco, California
    Run by
    University of California, San Francisco

    See if you can join NCT06654713 on ClinicalTrials.gov

  16. ACCESS 2: AI for pediatriC diabetiC Eye examS Study 2

    The purpose of this study is to determine if use of a nonmydriatic fundus camera using autonomous artificial intelligence software at the point of care increases the proportion of underserved youth with diabetes screened for diabetic retinopathy, and to determine the diagnostic accuracy of the auto…

    Stage
    Not phased
    Ages
    8 to 21
    Site
    Johns Hopkins Pediatric Diabetes Center, Baltimore, Maryland
    Run by
    Johns Hopkins University

    See if you can join NCT05463289 on ClinicalTrials.gov

  17. Post Market Registry for the Omnipod 5 System in Children and Adults With Type 1 Diabetes

    This is a decentralized observational clinical registry to collect real-world evidence related to the safety and effectiveness of the Omnipod 5 system in children and adults with Type 1 Diabetes.

    Stage
    Not phased
    Ages
    2 and older
    Site
    Circuit Clinical, Buffalo, New York
    Run by
    Insulet Corporation

    See if you can join NCT06144554 on ClinicalTrials.gov

  18. Safety and Efficacy of Adjunct Therapies in Adults With Type 1 Diabetes: Multicenter, Registry Study

    This will be a multicenter registry-based study to evaluate safety and efficacy of GLP-1RA and SGLTi therapies in adjunct to insulin in adults with type 1 diabetes (T1D) over 1 year. This study will enroll participants who have been prescribed adjunct therapy as part of usual care.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Hoag Memorial Hospital, Newport Beach, California
    Locations
    7 in total
    Run by
    Indiana University

    See if you can join NCT07676565 on ClinicalTrials.gov

  19. Transdisciplinary Care for Young Adults With Type 1 Diabetes

    The incidence of type 1 diabetes (T1D) is increasing globally with the most substantial increases occurring in the youngest age groups. A growing number of youths with T1D must therefore transition their healthcare from pediatric to adult T1D care settings as they approach young adulthood. This hea…

    Stage
    Not phased
    Ages
    17 and older
    Site
    Nemours Children's Health, Delaware, Wilmington, Delaware
    Locations
    2 in total
    Run by
    Nemours Children's Clinic

    See if you can join NCT06172166 on ClinicalTrials.gov

  20. Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes

    The objectives of this study are to examine how sex hormones (use of hormonal birth control, menstrual cycle phase) impact glycemic control among women with type 1 diabetes (T1D), and to test adjustments to insulin dosing and food intake to ameliorate cycle-related glycemic variability. A secondary…

    Stage
    Not phased
    Ages
    18 to 45
    Site
    University of Colorado, Aurora, Colorado
    Run by
    University of Colorado, Denver

    See if you can join NCT06297980 on ClinicalTrials.gov

  21. Accuracy of Continuous Glucose Monitors During the Perioperative Period in Youth With Type 1 Diabetes

    This study is assessing the accuracy of continuous glucose monitors during surgical procedures requiring anesthesia.

    Stage
    Not phased
    Ages
    2 to 26
    Site
    Barbara Davis Center, Aurora, Colorado
    Run by
    University of Colorado, Denver

    See if you can join NCT06575842 on ClinicalTrials.gov

  22. Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes

    The primary objective of this study is to determine the effects of semaglutide on change in albuminuria from baseline to 26 weeks in type 1 diabetes. The secondary objective is to determine the effects of semaglutide on change in kidney parameters (including kidney oxygenation and function) measure…

    Stage
    Phase 2
    Ages
    18 and older
    Site
    University of Colorado Anschutz Medical Campus, Aurora, Colorado
    Locations
    4 in total
    Run by
    University of Washington

    See if you can join NCT05822609 on ClinicalTrials.gov

  23. ACT1VATE: Addressing Emotional Distress to Improve Outcomes Among Diverse Adults With Type 1 Diabetes

    This research will compare a psychological intervention ("ACT1VATE") versus diabetes self-management education and support (DSME/S; usual care) in improving clinical, behavioral, psychosocial, process, and cost outcomes among adults with poorly controlled type 1 diabetes (T1D) who are experiencing …

    Stage
    Phase 2
    Ages
    18 and older
    Site
    Scripps Whittier Diabetes Institute, San Diego, California
    Run by
    Scripps Whittier Diabetes Institute

    See if you can join NCT04933851 on ClinicalTrials.gov

  24. Type 1 Diabetes Adolescents for Healthier Lifestyles Study

    Before the 1990s, obesity was rare among young people with type 1 diabetes (T1D), but now it is more common. Recent studies show that over 50% of young people with T1D will have overweight or obesity within five years of being diagnosed with T1D. Both obesity and T1D increase the risk of heart dise…

    Stage
    Not phased
    Ages
    13 to 18
    Site
    Weight Control and Diabetes Research Center, Providence, Rhode Island
    Run by
    The Miriam Hospital

    See if you can join NCT06878872 on ClinicalTrials.gov

  25. Impact of Obesity on Microvascular Insulin Action and Cardiorespiratory Fitness in Type 1 Diabetes

    The purpose of this study is: * To see if insulin resistance (how sensitive your muscle tissue is to insulin) is associated with lower cardio fitness in people with Type 1 diabetes compared to healthy controls, before and after a High Intensity Interval Training (HIIT) exercise program. * To see if…

    Stage
    Not phased
    Ages
    21 to 50
    Site
    University of Virginia, Charlottesville, Virginia
    Run by
    University of Virginia

    See if you can join NCT07573228 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.