Treatment Resistant Depression Clinical Trials

18 studies are recruiting for treatment resistant depression in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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By city

New York, New York 6 Austin, Texas 4 Houston, Texas 4 San Diego, California 4 Chicago, Illinois 3 Columbus, Ohio 3 Dallas, Texas 3 Minneapolis, Minnesota 3 Philadelphia, Pennsylvania 3 St Louis, Missouri 3 Tampa, Florida 3

Studies now recruiting

  1. Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression

    The core objective of this study is to enhance the translational potential of this electroencephalogram (EEG) biomarker by using ketamine(KET)-induced gamma potentiation as a prognostic marker of 4-week treatment outcome. Previous research focused exclusively on KET-induced gamma band potentiation …

    Stage
    Phase 1
    Ages
    21 to 45
    Site
    Wells Medicine, Houston, Texas
    Locations
    2 in total
    Run by
    Texas A&M University

    See if you can join NCT06480201 on ClinicalTrials.gov

  2. DBS for Depression

    The goal of this clinical trial is to demonstrate the feasibility and safety of deep brain stimulation in treatment resistant depression. The main questions it aims to answer are: * Is deep brain stimulation effective in treating treatment resistant depression? * Does deep brain stimulation improve…

    Stage
    Phase 1
    Ages
    18 to 65
    Site
    Zucker Hillside Hospital, Queens, New York
    Run by
    Northwell Health

    See if you can join NCT06096207 on ClinicalTrials.gov

  3. PCS in Severe Treatment Resistant Depression

    This research study is designed to test if electrical stimulation of the surface of the brain in the frontal region will help treat depressive symptoms. Participants receive intermittent electrical stimulation to the brain, which involves surgically placing electric leads in between the tough fibro…

    Stage
    Not phased
    Ages
    22 to 70
    Site
    University of Minnesota, Minneapolis, Minnesota
    Run by
    University of Minnesota

    See if you can join NCT04124341 on ClinicalTrials.gov

  4. Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

    The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.

    Stage
    Not phased
    Ages
    22 to 70
    Site
    University of Alabama at Birmingham - Dept. of Psychiatry, Birmingham, Alabama
    Locations
    25 in total
    Run by
    Abbott Medical Devices

    See if you can join NCT06423430 on ClinicalTrials.gov

  5. Natural History of Depression, Bipolar Disorder and Suicide Risk

    Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different treatments. In this study, researchers want to perform tests on people undergoing clinical care for…

    Stage
    Not phased
    Ages
    18 to 120
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Mental Health (NIMH)

    See if you can join NCT06462196 on ClinicalTrials.gov

  6. Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression

    Treatment resistant depression remains a major problem for individuals and society. Surgical procedures may provide relief for some of these patients. The most frequently considered surgical approach is deep brain stimulation (DBS) of a part of the brain called the subcallosal cingulate region. How…

    Stage
    Not phased
    Ages
    21 to 70
    Site
    UT Southwestern Medical Center, Dallas, Texas
    Run by
    Nader Pouratian

    See if you can join NCT03952962 on ClinicalTrials.gov

  7. DBS for TRD With the Medtronic Percept PC

    Of the estimated 30 million Americans who suffer from Major Depressive Disorder, approximately 10% are considered treatment resistant. Deep brain stimulation (DBS) to a region of the brain called the subcallosal cingulate (SCC) is an emerging strategy for treatment resistant depression (TRD), which…

    Stage
    Not phased
    Ages
    25 to 70
    Site
    Icahn School of Medicine at Mount Sinai, Mount Sinai West, New York, New York
    Run by
    Helen Mayberg, MD

    See if you can join NCT05773755 on ClinicalTrials.gov

  8. A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

    Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Alabama at Birmingham, Birmingham, Alabama
    Locations
    101 in total
    Run by
    LivaNova

    See if you can join NCT03887715 on ClinicalTrials.gov

  9. A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

    This Phase 2 study (protocol number VLS-01-203) will determine the efficacy, safety, and tolerability of short-term treatment with a VLS-01 transmucosal buccal film (VLS-01-BU) in patients with treatment resistant Major Depressive disorder (TRD) and will characterize the onset and durability of ant…

    Stage
    Phase 2
    Ages
    18 to 65
    Site
    Noble Clinical Research, Tucson, Arizona
    Locations
    48 in total
    Run by
    atai Therapeutics, Inc.

    See if you can join NCT06524830 on ClinicalTrials.gov

  10. Mindfulness Engaged Neurostimulation for Depression (MEND II)

    Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of ~30%. Additionally, r…

    Stage
    Phase 2
    Ages
    18 to 65
    Site
    UC San Diego Health Psychiatry, San Diego, California
    Run by
    University of California, San Diego

    See if you can join NCT07512284 on ClinicalTrials.gov

  11. Maintenance rTMS for Depression (Maitr-De)

    Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for treatment-resistant depression (TRD), yet substantial uncertainties persist regarding its efficacy as a maintenance treatment. This prospective study seeks to investigate the efficacy of maintenance rTMS…

    Stage
    Not phased
    Ages
    18 to 80
    Site
    University of California, San Diego, San Diego, California
    Locations
    3 in total
    Run by
    University of California, San Diego

    See if you can join NCT06938841 on ClinicalTrials.gov

  12. Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

    Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.

    Stage
    Not phased
    Ages
    21 to 65
    Site
    Washington University School of Medicine/Barnes-Jewish Hospital, St Louis, Missouri
    Run by
    Washington University School of Medicine

    See if you can join NCT05905705 on ClinicalTrials.gov

  13. University of Iowa Interventional Psychiatry Service Patient Registry

    The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion a…

    Stage
    Not phased
    Ages
    18 to 99
    Site
    University of Iowa Health Care, Iowa City, Iowa
    Run by
    Mark Niciu

    See if you can join NCT04480918 on ClinicalTrials.gov

  14. Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression

    Approximately one third of individuals with Major Depressive Disorder (MDD) are considered treatment-resistant, subject to severe disability and risk of suicide, and exhibit symptoms anchored in abnormalities of Research Domain Criteria (RDoC) Negative Valence Systems behavioral processes. In the p…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Laureate Institute for Brain Research, Tulsa, Oklahoma
    Run by
    Laureate Institute for Brain Research, Inc.

    See if you can join NCT07166289 on ClinicalTrials.gov

  15. Biomarker-guided rTMS for Treatment Resistant Depression

    Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. The investigators are continuing to learn how to optimize outcomes from rTMS treatment. The purpose of this research project is to use brain network connectivity patterns as measured by resting state functional magne…

    Stage
    Phase 3
    Ages
    22 to 65
    Site
    Stanford University, Stanford, California
    Locations
    2 in total
    Run by
    Weill Medical College of Cornell University

    See if you can join NCT04041479 on ClinicalTrials.gov

  16. Psilocybin rTMS for Treatment Resistant Depression

    The purpose of this study is to determine the safety and feasibility of sequencing psilocybin therapy with a short-duration, aiTBS protocol (Stanford Accelerated Intelligent Neuromodulation Therapy, or SAINT) in individuals with treatment-resistant major depressive disorder.

    Stage
    Phase 2
    Ages
    22 to 65
    Site
    Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin, Texas
    Run by
    University of Texas at Austin

    See if you can join NCT06132178 on ClinicalTrials.gov

  17. Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI

    This is a prospective clinical trial to confirm the effectiveness of bilateral accelerated theta burst stimulation (aTBS) on suicidal ideation (SI), while exploring cortical inhibition measures in this treatment paradigm. In this proposed study, the investigators will evaluate the anti-suicidal eff…

    Stage
    Not phased
    Ages
    18 to 70
    Site
    UCSD Interventional Psychiatry, San Diego, California
    Run by
    University of California, San Diego

    See if you can join NCT05377177 on ClinicalTrials.gov

  18. Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing

    The overall goal of this study is to map the spatiotemporal dynamics of social affective processing and to examine selective modulation of these dynamics in humans undergoing invasive intracranial monitoring for treatment-resistant epilepsy and depression. Pursuing this signal from a novel platform…

    Stage
    Not phased
    Ages
    22 to 70
    Site
    Baylor College of Medicine, Houston, Texas
    Run by
    Baylor College of Medicine

    See if you can join NCT05418894 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.