Treatment Resistant Depression Clinical Trials in St Louis, Missouri

3 studies are recruiting for treatment resistant depression in St Louis, Missouri right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

  1. Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

    The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.

    Stage
    Not phased
    Ages
    22 to 70
    Site
    Washington University School of Medicine, St Louis, Missouri
    Locations
    25 in total
    Run by
    Abbott Medical Devices

    See if you can join NCT06423430 on ClinicalTrials.gov

  2. A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

    Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Washington University School of Medicine, St Louis, Missouri
    Locations
    101 in total
    Run by
    LivaNova

    See if you can join NCT03887715 on ClinicalTrials.gov

  3. Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

    Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.

    Stage
    Not phased
    Ages
    21 to 65
    Site
    Washington University School of Medicine/Barnes-Jewish Hospital, St Louis, Missouri
    Run by
    Washington University School of Medicine

    See if you can join NCT05905705 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.