Traumatic Brain Injury Clinical Trials

78 studies are recruiting for traumatic brain injury in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)

   The purpose of this research is to understand and treat Traumatic Brain Injury (TBI) associated photophobia (light sensitivity) and its impact on visual function.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Miami, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT06293300 on ClinicalTrials.gov

2. Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury

   The goal of this clinical trial is to test the safety of the drug Angiotensin (1-7) and learn whether it works well as a treatment in people who have suffered a moderate to severe traumatic brain injury (TBI). The main questions this trial aims to answer are: * Is Angiotensin (1-7) safe? * Does Ang…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Arizona, Tucson, Arizona

   Run by

   University of Arizona

   See if you can join NCT06282965 on ClinicalTrials.gov

3. Long-Term Outcomes Following HBOT

   This study is designed to better understand the long-term effects of hyperbaric oxygen therapy (HBOT). Our goal is to determine whether improvements after treatment are maintained over time and whether additional benefits appear months after treatment has ended. We will evaluate changes in cognitiv…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Summit Hyperbarics and Wellness, Boise, Idaho

   Run by

   Summit Hyperbarics and Wellness

   See if you can join NCT07732374 on ClinicalTrials.gov

4. Vagus Nerve Stimulation in Patients in Comatose State

   Some patients with severe traumatic brain injury cannot respond at the bedside, yet about 1 in 4 may be aware but unable to show it - a hidden state called cognitive motor dissociation. This study tests a gentle, non-invasive treatment delivered through clips on the left ear that stimulates two ner…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Stony Brook University Hospital, Stony Brook, New York

   Run by

   Sima Mofakham

   See if you can join NCT07719595 on ClinicalTrials.gov

5. Promoting Neuroplastic Changes of Patients With TBI

   This project will develop a wearable rehabilitation robot suitable for in-bed acute stage rehabilitation. It involves robot-guided motor relearning, passive and active motor-sensory rehabilitation early in the acute stage post-TBI including patients who are paralyzed with no motor output. The early…

   Stage

   Not phased

   Ages

   30 to 85

   Site

   Li-Qun Zhang, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT06465290 on ClinicalTrials.gov

6. Community-based Implementation of Online EmReg

   This is a hybrid type III implementation-effectiveness trial; this study design blends elements of implementation and clinical effectiveness research, with the primary aim of determining the utility of an implementation strategy and a secondary aim of assessing clinical outcomes associated with the…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Icahn School of Medicine at Mount Sinai, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT05933629 on ClinicalTrials.gov

7. Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury

   The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem cells) on brain structure, neurocognitive/functional outcomes, and neuroinflammation after traumati…

   Stage

   Phase 2

   Ages

   18 to 55

   Site

   Memorial Hermann Hospital / UTHealth McGovern Medical School at Houston, Houston, Texas

   Locations

   2 in total

   Run by

   Hope Biosciences LLC

   See if you can join NCT05951777 on ClinicalTrials.gov

8. Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury

   The goal of this blinded, adaptive, randomized, placebo-controlled clinical trial is to investigate the use of hyperbaric oxygen as a therapy to treat mild to moderate traumatic brain injury in Veterans and active military. The main questions it aims to answer are: * Does Hyperbaric Oxygen Therapy …

   Stage

   Phase 3

   Ages

   18 to 75

   Site

   University of South Florida, Tampa, Florida

   Run by

   University of South Florida

   See if you can join NCT06581003 on ClinicalTrials.gov

9. CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

   This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and mindfulness-based treatment for insomnia (MBTI) in treating insomnia sy…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Intrepid Spirit Center - Eglin Air Force Base, Eglin Air Force Base, Florida

   Locations

   5 in total

   Run by

   Johns Hopkins University

   See if you can join NCT05663034 on ClinicalTrials.gov

10. Implementation of TBI-RECOVER in Substance Use Treatment

    The goal of this hybrid type 2 pilot trial is to understand the implementation and effectiveness of the TBI-RECOVER intervention model (e.g., brain injury screening, cognitive and behavioral challenges screening, and neurocognitive accommodations) on patient retention in outpatient substance use di…

    Stage

    Not phased

    Ages

    18 and older

    Site

    OSU Hospital System, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT07215221 on ClinicalTrials.gov

11. Improving Sleep in Veterans With the Polytrauma Clinical Triad

    The "polytrauma clinical triad" (PCT), a highly disabling constellation of factors, is defined by the coexistence of traumatic brain injury, post-traumatic stress disorder, and chronic pain. Veterans with the PCT are medically complex, often refractory to conventional therapies, and suffer from add…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    VA Portland Health Care System, Portland, OR, Portland, Oregon

    Run by

    VA Office of Research and Development

    See if you can join NCT06477796 on ClinicalTrials.gov

12. Neurologic Stem Cell Treatment Study

    This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will provide improvement in neurologic function for patients with certain n…

    Stage

    Not phased

    Ages

    18 and older

    Site

    MD Stem Cells, Westport, Connecticut

    Locations

    3 in total

    Run by

    MD Stem Cells

    See if you can join NCT02795052 on ClinicalTrials.gov

13. Emotional Awareness Therapy Study

    The purpose of this study is to learn about the potential benefits of two different training programs in helping improve emotional health and well-being in people who have had a traumatic brain injury. Participants will be assigned to one of two programs based on the time since their injury. One of…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Hackensack Meridian Health - JFK Johnson Rehabilitation Institute, Edison, New Jersey

    Run by

    Hackensack Meridian Health

    See if you can join NCT07624825 on ClinicalTrials.gov

14. University of Pittsburgh Brain Health Initiative

    This project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehensive assessment of clinical, neuroimaging, and biomarker measures.

    Stage

    Not phased

    Ages

    29 to 59

    Site

    University of Pittsburgh Department of Neurosurgery, Pittsburgh, Pennsylvania

    Run by

    David Okonkwo, MD, PhD

    See if you can join NCT04708613 on ClinicalTrials.gov

15. The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)

    There are no therapeutic agents that have been shown to improve outcomes from severe traumatic brain injury (TBI). Critical barriers to progress in developing treatments for severe TBI are the lack of: 1) monitoring biomarkers for assessing individual patient response to treatment; 2) predictive bi…

    Stage

    Not phased

    Ages

    16 to 65

    Site

    UCSD Medical Center - Hillcrest Hospital, San Diego, California

    Locations

    11 in total

    Run by

    University of Michigan

    See if you can join NCT04855396 on ClinicalTrials.gov

16. Hyperbaric Oxygen Brain Injury Treatment Trial

    The purpose of this innovative adaptive phase II trial design is to determine the optimal combination of hyperbaric oxygen treatment parameters that is most likely to demonstrate improvement in the outcome of severe TBI patients in a subsequent phase III trial.

    Stage

    Phase 2

    Ages

    16 to 65

    Site

    UCSD Medical Center - Hillcrest Hospital, San Diego, California

    Locations

    11 in total

    Run by

    Gaylan Rockswold

    See if you can join NCT02407028 on ClinicalTrials.gov

17. Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation

    This study will test the clinical efficacy of an accelerated TMS (accel-TMS) protocol that rapidly addresses PTSD symptoms with 1 week (25 sessions over 5 days) of condensed treatment.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Florida State University, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT06544408 on ClinicalTrials.gov

18. Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model System

    TBI rehabilitation care transitions refer to the processes of preparing patients, families, and community-based healthcare providers for the patient's passage from inpatient rehabilitation to the home and community or to another level of care. Persons with TBI have heterogenous neurological impairm…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Virginia Commonwealth University, Richmond, Virginia

    Run by

    Virginia Commonwealth University

    See if you can join NCT06188364 on ClinicalTrials.gov

19. Verbal Working Memory and Attention Remediation for Adults With Traumatic Brain Injury.

    This project will examine if computerized cognitive remediation will improve working memory and attention in 25 adults with a mild, moderate, or severe brain injury and compare their cognitive performance to the control group of 25 adults with a mild, moderate, or severe brain injury. The control g…

    Stage

    Not phased

    Ages

    18 and older

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT04349852 on ClinicalTrials.gov

20. Non-invasive BCI-controlled Assistive Devices

    Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    The University of Texas at Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT05183152 on ClinicalTrials.gov

21. Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide

    The purpose of this study is to assess the incidence of early post-traumatic seizures. The study will also assess the benefit of lacosamide compared to levetiracetam in regards to agitation and behavioral adverse effects in patients with traumatic brain injury requiring seizure prophylaxis.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Wake Forest University Health Sciences, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT06866691 on ClinicalTrials.gov

22. Eye Recovery Automation for Post Injury Dysfunction (iRAPID)

    This study will test a portable virtual reality (VR) system with integrated eye tracking called Virtual Eye Rotation Vision Exercises (VERVE). The proposed VERVE platform will deliver vergence therapy in an automated manner. This research will involve 30 non-traumatic brain injury (TBI) binocularly…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    New Mexico VA Health Care System, Albuquerque, New Mexico

    Run by

    New Jersey Institute of Technology

    See if you can join NCT06105892 on ClinicalTrials.gov

23. Longitudinal Assessment of Traumatic Microvascular Injury-2

    The goal of this observational study is to learn about changes in the brain of patients over the first 3 years following a traumatic brain injury (TBI). The main question it aims to answer are: - How TBI effect the rate of brain tissue loss compare to healthy brain Participants will give blood samp…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT05725993 on ClinicalTrials.gov

24. Improving Speech in Noise Using Noninvasive Stimulation

    Traumatic brain injury, a common injury in military service personnel, often leads to poor processing of speech in noisy environments. The goal of the current study is to better understand the brain basis for this difficulty and evaluate a new approach to improving speech in noise perception.

    Stage

    Not phased

    Ages

    25 to 55

    Site

    UF Health at the University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT07176936 on ClinicalTrials.gov

25. Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series

    This study prospectively evaluates the effects of Integrative Bilateral Cervical Sympathetic Block (BCSB) on trauma-related symptoms in Special Operations Veterans, comparing outcomes in those receiving BCSB alone versus BCSB combined with structured integrative therapy. Using standardized FDA-appr…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Reset Medical and Wellness Center, Strongsville, Ohio

    Run by

    Reset Medical and Wellness Center

    See if you can join NCT07473505 on ClinicalTrials.gov