Traumatic Brain Injury Clinical Trials

78 studies are recruiting for traumatic brain injury in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

   This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and mindfulness-based treatment for insomnia (MBTI) in treating insomnia sy…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Intrepid Spirit Center - Eglin Air Force Base, Eglin Air Force Base, Florida

   Locations

   5 in total

   Run by

   Johns Hopkins University

   See if you can join NCT05663034 on ClinicalTrials.gov

2. Implementation of TBI-RECOVER in Substance Use Treatment

   The goal of this hybrid type 2 pilot trial is to understand the implementation and effectiveness of the TBI-RECOVER intervention model (e.g., brain injury screening, cognitive and behavioral challenges screening, and neurocognitive accommodations) on patient retention in outpatient substance use di…

   Stage

   Not phased

   Ages

   18 and older

   Site

   OSU Hospital System, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT07215221 on ClinicalTrials.gov

3. Improving Sleep in Veterans With the Polytrauma Clinical Triad

   The "polytrauma clinical triad" (PCT), a highly disabling constellation of factors, is defined by the coexistence of traumatic brain injury, post-traumatic stress disorder, and chronic pain. Veterans with the PCT are medically complex, often refractory to conventional therapies, and suffer from add…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   VA Portland Health Care System, Portland, OR, Portland, Oregon

   Run by

   VA Office of Research and Development

   See if you can join NCT06477796 on ClinicalTrials.gov

4. Neurologic Stem Cell Treatment Study

   This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will provide improvement in neurologic function for patients with certain n…

   Stage

   Not phased

   Ages

   18 and older

   Site

   MD Stem Cells, Westport, Connecticut

   Locations

   3 in total

   Run by

   MD Stem Cells

   See if you can join NCT02795052 on ClinicalTrials.gov

5. Emotional Awareness Therapy Study

   The purpose of this study is to learn about the potential benefits of two different training programs in helping improve emotional health and well-being in people who have had a traumatic brain injury. Participants will be assigned to one of two programs based on the time since their injury. One of…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Hackensack Meridian Health - JFK Johnson Rehabilitation Institute, Edison, New Jersey

   Run by

   Hackensack Meridian Health

   See if you can join NCT07624825 on ClinicalTrials.gov

6. University of Pittsburgh Brain Health Initiative

   This project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehensive assessment of clinical, neuroimaging, and biomarker measures.

   Stage

   Not phased

   Ages

   29 to 59

   Site

   University of Pittsburgh Department of Neurosurgery, Pittsburgh, Pennsylvania

   Run by

   David Okonkwo, MD, PhD

   See if you can join NCT04708613 on ClinicalTrials.gov

7. The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)

   There are no therapeutic agents that have been shown to improve outcomes from severe traumatic brain injury (TBI). Critical barriers to progress in developing treatments for severe TBI are the lack of: 1) monitoring biomarkers for assessing individual patient response to treatment; 2) predictive bi…

   Stage

   Not phased

   Ages

   16 to 65

   Site

   UCSD Medical Center - Hillcrest Hospital, San Diego, California

   Locations

   11 in total

   Run by

   University of Michigan

   See if you can join NCT04855396 on ClinicalTrials.gov

8. Hyperbaric Oxygen Brain Injury Treatment Trial

   The purpose of this innovative adaptive phase II trial design is to determine the optimal combination of hyperbaric oxygen treatment parameters that is most likely to demonstrate improvement in the outcome of severe TBI patients in a subsequent phase III trial.

   Stage

   Phase 2

   Ages

   16 to 65

   Site

   UCSD Medical Center - Hillcrest Hospital, San Diego, California

   Locations

   11 in total

   Run by

   Gaylan Rockswold

   See if you can join NCT02407028 on ClinicalTrials.gov

9. Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation

   This study will test the clinical efficacy of an accelerated TMS (accel-TMS) protocol that rapidly addresses PTSD symptoms with 1 week (25 sessions over 5 days) of condensed treatment.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Florida State University, Tallahassee, Florida

   Run by

   Florida State University

   See if you can join NCT06544408 on ClinicalTrials.gov

10. Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model System

    TBI rehabilitation care transitions refer to the processes of preparing patients, families, and community-based healthcare providers for the patient's passage from inpatient rehabilitation to the home and community or to another level of care. Persons with TBI have heterogenous neurological impairm…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Virginia Commonwealth University, Richmond, Virginia

    Run by

    Virginia Commonwealth University

    See if you can join NCT06188364 on ClinicalTrials.gov

11. Verbal Working Memory and Attention Remediation for Adults With Traumatic Brain Injury.

    This project will examine if computerized cognitive remediation will improve working memory and attention in 25 adults with a mild, moderate, or severe brain injury and compare their cognitive performance to the control group of 25 adults with a mild, moderate, or severe brain injury. The control g…

    Stage

    Not phased

    Ages

    18 and older

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT04349852 on ClinicalTrials.gov

12. Non-invasive BCI-controlled Assistive Devices

    Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    The University of Texas at Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT05183152 on ClinicalTrials.gov

13. Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide

    The purpose of this study is to assess the incidence of early post-traumatic seizures. The study will also assess the benefit of lacosamide compared to levetiracetam in regards to agitation and behavioral adverse effects in patients with traumatic brain injury requiring seizure prophylaxis.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Wake Forest University Health Sciences, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT06866691 on ClinicalTrials.gov

14. Eye Recovery Automation for Post Injury Dysfunction (iRAPID)

    This study will test a portable virtual reality (VR) system with integrated eye tracking called Virtual Eye Rotation Vision Exercises (VERVE). The proposed VERVE platform will deliver vergence therapy in an automated manner. This research will involve 30 non-traumatic brain injury (TBI) binocularly…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    New Mexico VA Health Care System, Albuquerque, New Mexico

    Run by

    New Jersey Institute of Technology

    See if you can join NCT06105892 on ClinicalTrials.gov

15. Longitudinal Assessment of Traumatic Microvascular Injury-2

    The goal of this observational study is to learn about changes in the brain of patients over the first 3 years following a traumatic brain injury (TBI). The main question it aims to answer are: - How TBI effect the rate of brain tissue loss compare to healthy brain Participants will give blood samp…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT05725993 on ClinicalTrials.gov

16. Improving Speech in Noise Using Noninvasive Stimulation

    Traumatic brain injury, a common injury in military service personnel, often leads to poor processing of speech in noisy environments. The goal of the current study is to better understand the brain basis for this difficulty and evaluate a new approach to improving speech in noise perception.

    Stage

    Not phased

    Ages

    25 to 55

    Site

    UF Health at the University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT07176936 on ClinicalTrials.gov

17. Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series

    This study prospectively evaluates the effects of Integrative Bilateral Cervical Sympathetic Block (BCSB) on trauma-related symptoms in Special Operations Veterans, comparing outcomes in those receiving BCSB alone versus BCSB combined with structured integrative therapy. Using standardized FDA-appr…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Reset Medical and Wellness Center, Strongsville, Ohio

    Run by

    Reset Medical and Wellness Center

    See if you can join NCT07473505 on ClinicalTrials.gov

18. Carbon Dioxide Administration and Brain Waste Clearance

    The current study tests whether different exposures to carbon dioxide (CO2) can safely result in the increased movement of proteins from the brain into the blood. The investigators believe that this would be a proxy for the brain clearing waste products more effectively. The current study will use …

    Stage

    Not phased

    Ages

    18 to 82

    Site

    The Mind Research Network, Albuquerque, New Mexico

    Run by

    Andrew Mayer

    See if you can join NCT07357090 on ClinicalTrials.gov

19. University of Colorado - Restoring Efficient Sleep After TBI

    Sleep disturbance is a common condition following traumatic brain injury (TBI) and impairs recovery and quality of life. While efficacious interventions exist many are not accessible to all patients due to a variety of factors (e.g., rurality, access to providers). Further, many of the available tr…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Rocky Mountain Regional VAMC, Aurora, Colorado

    Run by

    VA Eastern Colorado Health Care System

    See if you can join NCT05683145 on ClinicalTrials.gov

20. Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI

    This will be a randomized placebo controlled study to test the efficacy of cannabidiol (CBD) as a treatment for symptoms of post-traumatic stress disorder (PTSD). Subjects, 120 in total, will be males and females with PTSD, half of which will have comorbid mild traumatic brain injury (TBI). There w…

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    New York University School of Medicine, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT04550377 on ClinicalTrials.gov

21. Retinal Imaging in Neurodegenerative Disease

    This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT03233646 on ClinicalTrials.gov

22. MENTOR Wellness Program

    This randomized trial aims to determine the effectiveness a virtual wellness intervention program in individuals with traumatic brain injury (TBI). Participants will be randomized at enrollment into two groups: immediate treatment (IT) and delayed treatment (DT) group. This study will also provide …

    Stage

    Not phased

    Ages

    18 to 70

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06148324 on ClinicalTrials.gov

23. Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research

    The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related neuroinflammatory conditions. Participants in the United States aged 2 years…

    Stage

    Not phased

    Ages

    2 and older

    Site

    Brain Inflammation Collaborative, Delafield, Wisconsin

    Run by

    Brain Inflammation Collaborative

    See if you can join NCT04806620 on ClinicalTrials.gov

24. tPBM in Older Adults With Traumatic Brain Injury

    The purpose of this study is to evaluate the effect of transcranial photobiomodulation (tPBM) in older patients with chronic traumatic brain injury (TBI). The study aims to examine the effect of tPBM on prefrontal cerebral blood flow (CBF) and executive function (EF)

    Stage

    Not phased

    Ages

    55 to 85

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT06956404 on ClinicalTrials.gov

25. Ketamine in Severe Traumatic Brain Injury

    Traumatic brain injury (TBI) accounts for approximately 2.5 million visits to emergency departments in the United States each year. After decades of research, management strategies for severe TBI (sTBI) patients are still evolving. Optimizing intracranial pressure (ICP) and cerebral perfusion press…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Parkland Memorial Hospital, Dallas, Texas

    Locations

    2 in total

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT06062628 on ClinicalTrials.gov