Traumatic Brain Injury Clinical Trials

78 studies are recruiting for traumatic brain injury in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function

   This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without stimulation. DBS parameters would be adjusted prior to motor testing. Patien…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   Jorge Gonzalez-Martinez

   See if you can join NCT07056348 on ClinicalTrials.gov

2. Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control

   In this study the investigators aim to enroll patients scheduled to undergo deep brain stimulation (DBS) implantation for movement disorders for intra-operative testing. In addition to standard-of-care surgical procedure to implant deep brain stimulation electrode leads, participants will also be s…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   Jorge Gonzalez-Martinez

   See if you can join NCT07056361 on ClinicalTrials.gov

3. Pilot Study of BCAA on Sleep

   Individuals will be recruited from the VA Portland Health Care System and the community affiliated with Oregon Health \& Science University. Traumatic brain injury status will be assessed as a contributing factor. Subjects will be randomized to one of 3 groups (BCAA or one of 2 placebo conditions) …

   Stage

   Not phased

   Ages

   18 to 89

   Site

   VA Portland Health Care System, Portland, Oregon

   Run by

   Portland VA Medical Center

   See if you can join NCT03990909 on ClinicalTrials.gov

4. Examining the Efficacy of the Man Therapy Platform in Reducing Problematic Anger Among Military Service Members With and Without a TBI History

   The goal of this randomized controlled trial is to determine if an interactive digital solution, Man Therapy, reduces indices of problematic anger in male military service members who screen positive for problematic anger. The man questions this study aims to answer are: * Does Man Therapy reduce i…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Fort Carson, Colorado Springs, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07604701 on ClinicalTrials.gov

5. Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training

   The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Georgetown University Medical Center, Washington D.C., District of Columbia

   Run by

   Georgetown University

   See if you can join NCT07105358 on ClinicalTrials.gov

6. Home-based Vision Rehabilitation Guided by Brain Imaging

   The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss. Using a prospective, crossover design, BRIGHT combines visu…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Georgetown University Medical Center, Washington D.C., District of Columbia

   Run by

   Georgetown University

   See if you can join NCT07635329 on ClinicalTrials.gov

7. Objectively Diagnose and Monitor Treatment of Light Sensitivity

   The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of Iowa Health Care, Iowa City, Iowa

   Run by

   Randy Kardon

   See if you can join NCT03694626 on ClinicalTrials.gov

8. The EBC Recovery Study

   The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up in the future.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Jackson Memorial Hospital, Miami, Florida

   Locations

   2 in total

   Run by

   University of Miami

   See if you can join NCT04712591 on ClinicalTrials.gov

9. CoMind Early Feasibility Study

   The purpose of this research, which has been determined as non-significant risk by the central IRB overseeing the study, is to obtain information to help further develop a machine (a medical device) to measure the pressure around the brain from the outside (this pressure is called intracranial pres…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UC Davis Medical Center, Sacramento, California

   Locations

   16 in total

   Run by

   CoMind Technologies Limited

   See if you can join NCT06368648 on ClinicalTrials.gov

10. Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions

    This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain Injury) to improve their wellness and self-management skills compared to tho…

    Stage

    Not phased

    Ages

    12 and older

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT02592291 on ClinicalTrials.gov

11. Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI

    The investigators want to test a treatment for posttraumatic stress disorder (PTSD) especially designed for military veterans and service members with mild or moderate traumatic brain injuries (TBI) and PTSD. The treatment will include individual psychotherapy sessions to manage PTSD.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Carl R Darnall Army Medical Center, Fort Hood, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT07351305 on ClinicalTrials.gov

12. Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children

    This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit (PICU). TCD is already used for clinical reasons in many children, but it is…

    Stage

    Not phased

    Ages

    0 to 17

    Site

    American Family Children's Hospital PICU, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT07613918 on ClinicalTrials.gov

13. Cranial Ultrasound for Point of Care Intracranial Pathology Detection in Pediatrics

    To improve patient selection for head CT, a safe and high sensitivity screening neuroimaging modality is needed. Currently many clinicians must make treatment decisions based solely on the patients clinical exam, which has low sensitivity and specificity and low inter-rater reliability. This study …

    Stage

    Not phased

    Ages

    Up to 18

    Site

    Atrium Health Carolinas Medical Center, Charlotte, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT06697808 on ClinicalTrials.gov

14. Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury

    The CONNECT-TBI Trial aims to develop safe, effective treatments for complex mTBI that improve cognitive functioning. Based on the compelling preliminary data generated by our study team, the objective of this study is to conduct a randomized, double-blinded, sham-controlled Phase II clinical trial…

    Stage

    Not phased

    Ages

    18 to 59

    Site

    Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota

    Locations

    5 in total

    Run by

    University of New Mexico

    See if you can join NCT05236010 on ClinicalTrials.gov

15. A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

    The study is intended to cover two purposes: first, to develop a blood-based biomarker test for aiding the diagnosis of traumatic brain injury (TBI) in adult participants and for prognosis of outcome of TBI (CLIN12.1); and second, for monitoring the development of secondary events in adult particip…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California San Francisco, San Francisco, California

    Locations

    14 in total

    Run by

    Hoffmann-La Roche

    See if you can join NCT07455136 on ClinicalTrials.gov

16. Electrical Stimulation Exercise for Individuals With Lower Limb Paralysis

    The purpose of this research study is to evaluate the effectiveness of an exercise training intervention (24-36 sessions) to improve muscle strength and endurance in the lower limbs of individuals with paralysis. Specifically, surface electrical stimulation or previously implanted stimulator will b…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio

    Run by

    Louis Stokes VA Medical Center

    See if you can join NCT07768761 on ClinicalTrials.gov

17. Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)

    The purpose of this research is to understand and treat Traumatic Brain Injury (TBI) associated photophobia (light sensitivity) and its impact on visual function.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06293300 on ClinicalTrials.gov

18. Evaluation of the SCALED (SCaling AcceptabLE cDs)

    This project will adapt a currently deployed Clinical Decision Support (CDS) system to deliver a VTE prevention guideline for adult patients with traumatic brain injury (TBI). We believe this is an ideal PCOR use case given PCORI's continued effort to combat VTE in trauma and our experience previou…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05628207 on ClinicalTrials.gov

19. Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury

    The goal of this clinical trial is to test the safety of the drug Angiotensin (1-7) and learn whether it works well as a treatment in people who have suffered a moderate to severe traumatic brain injury (TBI). The main questions this trial aims to answer are: * Is Angiotensin (1-7) safe? * Does Ang…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Arizona, Tucson, Arizona

    Run by

    University of Arizona

    See if you can join NCT06282965 on ClinicalTrials.gov

20. Long-Term Outcomes Following HBOT

    This study is designed to better understand the long-term effects of hyperbaric oxygen therapy (HBOT). Our goal is to determine whether improvements after treatment are maintained over time and whether additional benefits appear months after treatment has ended. We will evaluate changes in cognitiv…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Summit Hyperbarics and Wellness, Boise, Idaho

    Run by

    Summit Hyperbarics and Wellness

    See if you can join NCT07732374 on ClinicalTrials.gov

21. Vagus Nerve Stimulation in Patients in Comatose State

    Some patients with severe traumatic brain injury cannot respond at the bedside, yet about 1 in 4 may be aware but unable to show it - a hidden state called cognitive motor dissociation. This study tests a gentle, non-invasive treatment delivered through clips on the left ear that stimulates two ner…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Stony Brook University Hospital, Stony Brook, New York

    Run by

    Sima Mofakham

    See if you can join NCT07719595 on ClinicalTrials.gov

22. Promoting Neuroplastic Changes of Patients With TBI

    This project will develop a wearable rehabilitation robot suitable for in-bed acute stage rehabilitation. It involves robot-guided motor relearning, passive and active motor-sensory rehabilitation early in the acute stage post-TBI including patients who are paralyzed with no motor output. The early…

    Stage

    Not phased

    Ages

    30 to 85

    Site

    Li-Qun Zhang, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT06465290 on ClinicalTrials.gov

23. Community-based Implementation of Online EmReg

    This is a hybrid type III implementation-effectiveness trial; this study design blends elements of implementation and clinical effectiveness research, with the primary aim of determining the utility of an implementation strategy and a secondary aim of assessing clinical outcomes associated with the…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Icahn School of Medicine at Mount Sinai, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT05933629 on ClinicalTrials.gov

24. Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury

    The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem cells) on brain structure, neurocognitive/functional outcomes, and neuroinflammation after traumati…

    Stage

    Phase 2

    Ages

    18 to 55

    Site

    Memorial Hermann Hospital / UTHealth McGovern Medical School at Houston, Houston, Texas

    Locations

    2 in total

    Run by

    Hope Biosciences LLC

    See if you can join NCT05951777 on ClinicalTrials.gov

25. Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury

    The goal of this blinded, adaptive, randomized, placebo-controlled clinical trial is to investigate the use of hyperbaric oxygen as a therapy to treat mild to moderate traumatic brain injury in Veterans and active military. The main questions it aims to answer are: * Does Hyperbaric Oxygen Therapy …

    Stage

    Phase 3

    Ages

    18 to 75

    Site

    University of South Florida, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT06581003 on ClinicalTrials.gov