Traumatic Brain Injury Clinical Trials

78 studies are recruiting for traumatic brain injury in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Remote Stimulation and Training to Advance Recovery From TBI in Seniors

   The goal of this clinical trial is to learn if combining brain stimulation with cognitive training can improve thinking skills in older adults who have had a traumatic brain injury (TBI). The main questions are: * Does transcranial direct current stimulation (tDCS) make cognitive training more effe…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Minneapolis VA Health Care System, Minneapolis, Minnesota

   Run by

   Minneapolis Veterans Affairs Medical Center

   See if you can join NCT07332299 on ClinicalTrials.gov

2. Reliability and Validity of the PReFS

   This study is testing the psychometric properties of a new tool to determine recommendations for pressure relief frequency in wheelchair users.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Baylor University, Waco, Texas

   Run by

   Baylor University

   See if you can join NCT07280923 on ClinicalTrials.gov

3. Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)

   This study is a randomized Phase 2 trial to determine the feasibility of real-time electrocorticographic monitoring of spreading depolarizations (SD) to guide implementation of a tier-based protocol of intensive care therapies, aimed at SD suppression, for the management of patients who have underg…

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   University of Cincinnati, Cincinnati, Ohio

   Run by

   University of Cincinnati

   See if you can join NCT05337618 on ClinicalTrials.gov

4. Sildenafil for Microvasculopathy in Chronic TBI

   Traumatic Cerebral Vascular Injury (TCVI) is a common consequence of traumatic brain injury (TBI), including mild TBI (mTBI). TCVI is associated with poor recovery after TBI in animal models. TCVI can be measured non-invasively in humans, and therapies targeting TCVI are attractive candidates to am…

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT05782244 on ClinicalTrials.gov

5. Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents

   This cohort study aims to compare the efficacy of Xeomin injections for migraine management in patients with a history of Traumatic Brain Injury (TBI) versus those with a history of Anomalous Health Incidents (AHI). The study will be conducted at the National Intrepid Center of Excellence (NICOE) i…

   Stage

   Not phased

   Ages

   18 and older

   Site

   National Intrepid Center of Excellence (NICOE), Bethesda, Maryland

   Run by

   Uniformed Services University of the Health Sciences

   See if you can join NCT07267819 on ClinicalTrials.gov

6. A Study to Evaluate the SENSE Device's Ability to Detect TBI

   The study population will consist of 3 mutually-exclusive sets of patients and subjects: * TBI patients with intracranial bleeding * TBI patients without intracranial bleeding * Control subjects with normal brain health. Research subjects ages 22 and older will be enrolled. All TBI patients must be…

   Stage

   Not phased

   Ages

   22 and older

   Site

   University of Florida, Gainesville, Florida

   Locations

   6 in total

   Run by

   Sense Diagnostics, LLC

   See if you can join NCT06828107 on ClinicalTrials.gov

7. Predict Severe Traumatic Brain Injury

   Severe traumatic brain injury (TBI) is associated with a 20-30% mortality rate and significant disability among most survivors. The Centers for Disease Control and Prevention (CDC) estimate that 2% of the U.S. population lives with disabilities directly attributable to TBI, with annual costs exceed…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Chicago, Chicago, Illinois

   Locations

   2 in total

   Run by

   University of Chicago

   See if you can join NCT06966713 on ClinicalTrials.gov

8. Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures

   This research is studying a device already approved by the Food and Drug Administration (FDA) to treat wound closures. Researchers are studying a large group of people to continue to learn information about the safety of the STRATAFIX suture and how people's bodies react to using it over a long per…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of Michigan Health Sparrow, Lansing, Michigan

   Run by

   University of Michigan

   See if you can join NCT07225101 on ClinicalTrials.gov

9. Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury

   The purpose of this study is to learn more about how brain stimulation affects word finding problems in people who have a traumatic brain injury (TBI). The type of brain stimulation used is called transcranial direct current stimulation (tDCS). tDCS delivers low levels of electric current to the br…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Beth Israel Deaconess Medical Center, Boston, Massachusetts

   Run by

   Beth Israel Deaconess Medical Center

   See if you can join NCT06848140 on ClinicalTrials.gov

10. Cognitive and Vascular Functioning Following TBI

    This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia. Cerebrovascular, inflammatory, and neurodegenerative blood biomarkers as well as clinical and neuroimaging d…

    Stage

    Not phased

    Ages

    18 to 74

    Site

    Walter Reed National Military Medical Center, Bethesda, Maryland

    Run by

    Walter Reed National Military Medical Center

    See if you can join NCT06034509 on ClinicalTrials.gov

11. Treating Mild Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation

    The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., presupplementary motor area) thought to aid in memory will improve verbal retrieval in military veteran participants with histories of t…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    The University of Texas at Dallas, Dallas, Texas

    Run by

    The University of Texas at Dallas

    See if you can join NCT04869059 on ClinicalTrials.gov

12. Cortical Spreading Depolarization After Severe Traumatic Brain Injury

    Preliminary evaluation of electrodes placed on the brain for recording brain activity and novel algorithms to determine cortical spreading depolarization foci of origination following severe traumatic brain injury requiring neurosurgical intervention.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Hennepn Healthcare, Minneapolis, Minnesota

    Run by

    Hennepin County Medical Center, Minneapolis

    See if you can join NCT03321370 on ClinicalTrials.gov

13. Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

    In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04296604 on ClinicalTrials.gov

14. Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury

    New learning and memory impairment (NLMI) is a common and devastating manifestation of TBI associated with substantial life burdens. Persons with moderate to severe TBI have shown improvement in NLM for prose material (e.g. story) as well as beneficial changes in default-mode network (DMN) activati…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Kessler Foundation, West Orange, New Jersey

    Run by

    Kessler Foundation

    See if you can join NCT05716048 on ClinicalTrials.gov

15. NEUROBALANCE Training to Improve Postural Control in Individuals With Traumatic Brain Injury

    Our proposed study, \"NEUROBALANCE,\" aims to evaluate the effectiveness of a combined intervention involving robotic balance training and noninvasive brain stimulation in improving balance functions in individuals with chronic traumatic brain injury (TBI). The study will recruit 45 partici…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Kessler Foundation, West Orange, New Jersey

    Run by

    Kessler Foundation

    See if you can join NCT06584591 on ClinicalTrials.gov

16. Amygdala Memory Enhancement

    The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05065450 on ClinicalTrials.gov

17. Non-invasive Nerve Stimulation for PTSD and Sleep

    In this study, our objective is to determine the effect of two different nerve stimulation types in changing sleep architecture.

    Stage

    Not phased

    Ages

    18 to 55

    Site

    UF Health Jacksonville, Gainesville, Florida

    Locations

    3 in total

    Run by

    University of Florida

    See if you can join NCT03170440 on ClinicalTrials.gov

18. Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery

    This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial. To achieve the second goal, we will employ a between-groups randomized treatment design with repeated measures at baseline, one…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT05622461 on ClinicalTrials.gov

19. TBI Rehabilitation and Activation in Veterans

    This trial will evaluate the impact of a multicomponent program (TBI Rehabilitation and Activation in Veterans; TRAIN-Vets) on improving cognitive function over an 8-month trial period in older Veterans with traumatic brain injury (TBI). Older Veterans with a history of TBI and subjective cognitive…

    Stage

    Not phased

    Ages

    50 to 89

    Site

    VA Palo Alto Health Care System, Palo Alto, California

    Locations

    2 in total

    Run by

    Northern California Institute of Research and Education

    See if you can join NCT06562127 on ClinicalTrials.gov

20. Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury

    The purpose of this study is to examine the safety and feasibility of using hyperpolarized metabolic MRI to study early brain metabolism changes in subjects presenting with head injury and suspected non-penetrating traumatic brain injury (TBI). This study will also compare HP pyruvate MRI-derived m…

    Stage

    Phase 1

    Ages

    18 to 80

    Site

    University of Maryland Baltimore, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT06103201 on ClinicalTrials.gov

21. Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation

    The purpose of this study is to examine the feasibility and preliminary efficacy of using transcutaneous auricular vagus nerve stimulation (tVNS) to enhance cognitive recovery in patients with mild-moderate traumatic brain injury (TBI).

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Shirley Ryan AbilityLab, Chicago, Illinois

    Run by

    Shirley Ryan AbilityLab

    See if you can join NCT06589362 on ClinicalTrials.gov

22. GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI

    The goal of this clinical trial is to evaluate GetUp\&Go, a program for promoting increased physical activity in individuals at least 6 months post moderate-to-severe traumatic brain injury. GetUp\&Go is a remotely delivered 10-week program that includes one-on-one sessions with a therapist and a m…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Moss Rehabilitation Research Institute, Elkins Park, Pennsylvania

    Run by

    Albert Einstein Healthcare Network

    See if you can join NCT06028334 on ClinicalTrials.gov

23. High Intensity Step Training After Traumatic Brain Injury

    This study will explore whether the types and intensity of the interventions being delivered will yield measurable cognitive benefits in addition to improved mobility and balance. The study evaluates three therapeutic approaches to improve mobility and balance after traumatic brain injury (TBI): Co…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Craig Hospital, Englewood, Colorado

    Run by

    Craig Hospital

    See if you can join NCT05702138 on ClinicalTrials.gov

24. Evaluation of the Abbott i-STAT TBI Biomarker Test

    According to the Centers for Disease Control and Prevention, approximately 200,000 hospitalizations occurred in 2020 related to Traumatic Brain Injury (TBI), which does not include many TBIs treated only in emergency departments, urgent care, primary care, or that are not evaluated by a clinician. …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mount Sinai Morningside, New York, New York

    Locations

    3 in total

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06766435 on ClinicalTrials.gov

25. Robotic Balance Training to Improve Postural Control and Balance Post-Traumatic Brain Injury

    The purpose of this study is to assess a balance training program to see if it can be helpful to improve balance and avoid falls in people who have had traumatic brain injuries (TBIs). The study will involve three groups of research subjects: 1) TBI-intervention group, 2) TBI- non-intervention grou…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Kessler Foundation, West Orange, New Jersey

    Run by

    Kessler Foundation

    See if you can join NCT06184295 on ClinicalTrials.gov