Traumatic Brain Injury Clinical Trials

78 studies are recruiting for traumatic brain injury in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. University of Colorado - Restoring Efficient Sleep After TBI

   Sleep disturbance is a common condition following traumatic brain injury (TBI) and impairs recovery and quality of life. While efficacious interventions exist many are not accessible to all patients due to a variety of factors (e.g., rurality, access to providers). Further, many of the available tr…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   Rocky Mountain Regional VAMC, Aurora, Colorado

   Run by

   VA Eastern Colorado Health Care System

   See if you can join NCT05683145 on ClinicalTrials.gov

2. Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI

   This will be a randomized placebo controlled study to test the efficacy of cannabidiol (CBD) as a treatment for symptoms of post-traumatic stress disorder (PTSD). Subjects, 120 in total, will be males and females with PTSD, half of which will have comorbid mild traumatic brain injury (TBI). There w…

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   New York University School of Medicine, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT04550377 on ClinicalTrials.gov

3. Retinal Imaging in Neurodegenerative Disease

   This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mi…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Duke University Medical Center, Durham, North Carolina

   Run by

   Duke University

   See if you can join NCT03233646 on ClinicalTrials.gov

4. MENTOR Wellness Program

   This randomized trial aims to determine the effectiveness a virtual wellness intervention program in individuals with traumatic brain injury (TBI). Participants will be randomized at enrollment into two groups: immediate treatment (IT) and delayed treatment (DT) group. This study will also provide …

   Stage

   Not phased

   Ages

   18 to 70

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT06148324 on ClinicalTrials.gov

5. Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research

   The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related neuroinflammatory conditions. Participants in the United States aged 2 years…

   Stage

   Not phased

   Ages

   2 and older

   Site

   Brain Inflammation Collaborative, Delafield, Wisconsin

   Run by

   Brain Inflammation Collaborative

   See if you can join NCT04806620 on ClinicalTrials.gov

6. tPBM in Older Adults With Traumatic Brain Injury

   The purpose of this study is to evaluate the effect of transcranial photobiomodulation (tPBM) in older patients with chronic traumatic brain injury (TBI). The study aims to examine the effect of tPBM on prefrontal cerebral blood flow (CBF) and executive function (EF)

   Stage

   Not phased

   Ages

   55 to 85

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT06956404 on ClinicalTrials.gov

7. Remote Stimulation and Training to Advance Recovery From TBI in Seniors

   The goal of this clinical trial is to learn if combining brain stimulation with cognitive training can improve thinking skills in older adults who have had a traumatic brain injury (TBI). The main questions are: * Does transcranial direct current stimulation (tDCS) make cognitive training more effe…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Minneapolis VA Health Care System, Minneapolis, Minnesota

   Run by

   Minneapolis Veterans Affairs Medical Center

   See if you can join NCT07332299 on ClinicalTrials.gov

8. Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)

   This study is a randomized Phase 2 trial to determine the feasibility of real-time electrocorticographic monitoring of spreading depolarizations (SD) to guide implementation of a tier-based protocol of intensive care therapies, aimed at SD suppression, for the management of patients who have underg…

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   University of Cincinnati, Cincinnati, Ohio

   Run by

   University of Cincinnati

   See if you can join NCT05337618 on ClinicalTrials.gov

9. Sildenafil for Microvasculopathy in Chronic TBI

   Traumatic Cerebral Vascular Injury (TCVI) is a common consequence of traumatic brain injury (TBI), including mild TBI (mTBI). TCVI is associated with poor recovery after TBI in animal models. TCVI can be measured non-invasively in humans, and therapies targeting TCVI are attractive candidates to am…

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT05782244 on ClinicalTrials.gov

10. Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents

    This cohort study aims to compare the efficacy of Xeomin injections for migraine management in patients with a history of Traumatic Brain Injury (TBI) versus those with a history of Anomalous Health Incidents (AHI). The study will be conducted at the National Intrepid Center of Excellence (NICOE) i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    National Intrepid Center of Excellence (NICOE), Bethesda, Maryland

    Run by

    Uniformed Services University of the Health Sciences

    See if you can join NCT07267819 on ClinicalTrials.gov

11. A Study to Evaluate the SENSE Device's Ability to Detect TBI

    The study population will consist of 3 mutually-exclusive sets of patients and subjects: * TBI patients with intracranial bleeding * TBI patients without intracranial bleeding * Control subjects with normal brain health. Research subjects ages 22 and older will be enrolled. All TBI patients must be…

    Stage

    Not phased

    Ages

    22 and older

    Site

    University of Florida, Gainesville, Florida

    Locations

    6 in total

    Run by

    Sense Diagnostics, LLC

    See if you can join NCT06828107 on ClinicalTrials.gov

12. Evaluation of the Efficacy of STRATAFIX for Neurosurgical Cranial and Spine Procedures

    This research is studying a device already approved by the Food and Drug Administration (FDA) to treat wound closures. Researchers are studying a large group of people to continue to learn information about the safety of the STRATAFIX suture and how people's bodies react to using it over a long per…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    University of Michigan Health Sparrow, Lansing, Michigan

    Run by

    University of Michigan

    See if you can join NCT07225101 on ClinicalTrials.gov

13. Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury

    The purpose of this study is to learn more about how brain stimulation affects word finding problems in people who have a traumatic brain injury (TBI). The type of brain stimulation used is called transcranial direct current stimulation (tDCS). tDCS delivers low levels of electric current to the br…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06848140 on ClinicalTrials.gov

14. Cognitive and Vascular Functioning Following TBI

    This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia. Cerebrovascular, inflammatory, and neurodegenerative blood biomarkers as well as clinical and neuroimaging d…

    Stage

    Not phased

    Ages

    18 to 74

    Site

    Walter Reed National Military Medical Center, Bethesda, Maryland

    Run by

    Walter Reed National Military Medical Center

    See if you can join NCT06034509 on ClinicalTrials.gov

15. Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

    In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04296604 on ClinicalTrials.gov

16. Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury

    New learning and memory impairment (NLMI) is a common and devastating manifestation of TBI associated with substantial life burdens. Persons with moderate to severe TBI have shown improvement in NLM for prose material (e.g. story) as well as beneficial changes in default-mode network (DMN) activati…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Kessler Foundation, West Orange, New Jersey

    Run by

    Kessler Foundation

    See if you can join NCT05716048 on ClinicalTrials.gov

17. NEUROBALANCE Training to Improve Postural Control in Individuals With Traumatic Brain Injury

    Our proposed study, \"NEUROBALANCE,\" aims to evaluate the effectiveness of a combined intervention involving robotic balance training and noninvasive brain stimulation in improving balance functions in individuals with chronic traumatic brain injury (TBI). The study will recruit 45 partici…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Kessler Foundation, West Orange, New Jersey

    Run by

    Kessler Foundation

    See if you can join NCT06584591 on ClinicalTrials.gov

18. Amygdala Memory Enhancement

    The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05065450 on ClinicalTrials.gov

19. Non-invasive Nerve Stimulation for PTSD and Sleep

    In this study, our objective is to determine the effect of two different nerve stimulation types in changing sleep architecture.

    Stage

    Not phased

    Ages

    18 to 55

    Site

    UF Health Jacksonville, Gainesville, Florida

    Locations

    3 in total

    Run by

    University of Florida

    See if you can join NCT03170440 on ClinicalTrials.gov

20. Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery

    This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial. To achieve the second goal, we will employ a between-groups randomized treatment design with repeated measures at baseline, one…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT05622461 on ClinicalTrials.gov

21. TBI Rehabilitation and Activation in Veterans

    This trial will evaluate the impact of a multicomponent program (TBI Rehabilitation and Activation in Veterans; TRAIN-Vets) on improving cognitive function over an 8-month trial period in older Veterans with traumatic brain injury (TBI). Older Veterans with a history of TBI and subjective cognitive…

    Stage

    Not phased

    Ages

    50 to 89

    Site

    VA Palo Alto Health Care System, Palo Alto, California

    Locations

    2 in total

    Run by

    Northern California Institute of Research and Education

    See if you can join NCT06562127 on ClinicalTrials.gov

22. Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury

    The purpose of this study is to examine the safety and feasibility of using hyperpolarized metabolic MRI to study early brain metabolism changes in subjects presenting with head injury and suspected non-penetrating traumatic brain injury (TBI). This study will also compare HP pyruvate MRI-derived m…

    Stage

    Phase 1

    Ages

    18 to 80

    Site

    University of Maryland Baltimore, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT06103201 on ClinicalTrials.gov

23. Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation

    The purpose of this study is to examine the feasibility and preliminary efficacy of using transcutaneous auricular vagus nerve stimulation (tVNS) to enhance cognitive recovery in patients with mild-moderate traumatic brain injury (TBI).

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Shirley Ryan AbilityLab, Chicago, Illinois

    Run by

    Shirley Ryan AbilityLab

    See if you can join NCT06589362 on ClinicalTrials.gov

24. GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI

    The goal of this clinical trial is to evaluate GetUp\&Go, a program for promoting increased physical activity in individuals at least 6 months post moderate-to-severe traumatic brain injury. GetUp\&Go is a remotely delivered 10-week program that includes one-on-one sessions with a therapist and a m…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Moss Rehabilitation Research Institute, Elkins Park, Pennsylvania

    Run by

    Albert Einstein Healthcare Network

    See if you can join NCT06028334 on ClinicalTrials.gov

25. Robotic Balance Training to Improve Postural Control and Balance Post-Traumatic Brain Injury

    The purpose of this study is to assess a balance training program to see if it can be helpful to improve balance and avoid falls in people who have had traumatic brain injuries (TBIs). The study will involve three groups of research subjects: 1) TBI-intervention group, 2) TBI- non-intervention grou…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Kessler Foundation, West Orange, New Jersey

    Run by

    Kessler Foundation

    See if you can join NCT06184295 on ClinicalTrials.gov