Spinal Cord Injuries Clinical Trials

85 studies are recruiting for spinal cord injuries in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Wrist Extensor MEP Up-conditioning for Individuals With Incomplete Spinal Cord Injury

   The purpose of this study is to examine the relationship between common clinical assessments and measurements of the function of brain-spinal cord-muscle connections, and to examine the effects of training a brain-spinal cord-muscle response in individuals with incomplete spinal cord injury. A tran…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT05321017 on ClinicalTrials.gov

2. Promoting Recovery Outcomes Through Precise Early Locomotor Interventions in Persons With Spinal Cord Injury

   The purpose of this study is to evaluate if a specific type of additional walking therapy, called body weight supported treadmill training (BWSTT) affects walking ability following a traumatic spinal cord injury. Specifically, the study will look at whether starting BWSTT, which uses a body harness…

   Stage

   Not phased

   Ages

   16 to 75

   Site

   The Shirley Ryan AbilityLab, Chicago, Illinois

   Locations

   2 in total

   Run by

   Milap Sandhu

   See if you can join NCT06176833 on ClinicalTrials.gov

3. Efficacy of a Wearable Noninvasive Neuromodulation Device

   The aim of this study is to investigate the potential of transcutaneous neuromodulation (TNM) to treat slow colonic transit and constipation, termed the Neurogenic bowel dysfunction (NBD), in people with SCI. In this project, the study team will investigate the impact of an active treatment interve…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT07171489 on ClinicalTrials.gov

4. Hybrid HIIT-FES Cycling Program on Individuals With Spinal Cord Injury to Improve Health

   Project Summary/Abstract Obesity and metabolic syndrome (obesity, dyslipidemia, hyperglycemia, hypertension) are epidemic in the spinal cord injured (SCI) population. A recent study assessing the body composition and metabolic syndrome rates of 72 motor complete chronic SCI individuals revealed an …

   Stage

   Not phased

   Ages

   21 to 70

   Site

   William Carey University, Hattiesburg, Mississippi

   Run by

   William Carey University

   See if you can join NCT07648173 on ClinicalTrials.gov

5. Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury

   The overarching goal of this research study is to evaluate a sensor-enabled, just-in-time adaptive intervention (JITAI) strategy to increase and sustain physical activity levels among individuals with spinal cord injury (SCI) in their communities. A primary objective of this study is to evaluate th…

   Stage

   Phase 2

   Ages

   18 to 75

   Site

   Temple University, Philadelphia, Pennsylvania

   Run by

   Temple University

   See if you can join NCT05317832 on ClinicalTrials.gov

6. Development of a Novel Evaluation Scale of Mental Body Representation (MBR) for Adults With Spinal Cord Injury

   The purpose of this study is twofold: (1) Develop a new evaluation scale for mental body representations (MBR, i.e., body awareness and visuospatial body maps) for adults with spinal cord injury (SCI) with and without neuropathic pain. (2) Assess the psychometric properties of usability, reliabilit…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT07029802 on ClinicalTrials.gov

7. ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury

   Empower BP is a pivotal, interventional, multicenter, prospective, randomized, controlled double-blinded study to evaluate the safety and effectiveness of the ARC-IM System in managing symptomatic blood pressure instability in individuals with chronic SCI (>1 year after SCI). The primary effectiven…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   University of Arkansas for medical Sciences, Little Rock, Arkansas

   Locations

   13 in total

   Run by

   ONWARD Medical, Inc.

   See if you can join NCT07147296 on ClinicalTrials.gov

8. Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia

   The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Stanford University School of Medicine, Stanford, California

   Locations

   2 in total

   Run by

   Leigh R. Hochberg, MD, PhD.

   See if you can join NCT05724173 on ClinicalTrials.gov

9. BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

   The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of California, Davis, Sacramento, California

   Locations

   6 in total

   Run by

   Leigh R. Hochberg, MD, PhD.

   See if you can join NCT00912041 on ClinicalTrials.gov

10. Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury

    The purpose of this research is to learn about how the participant's body is able to balance changes in blood pressure, and how spinal cord stimulation affects these changes as well as immune \& cardiovascular function in participants with spinal cord injury.

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07210411 on ClinicalTrials.gov

11. Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI

    The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07210437 on ClinicalTrials.gov

12. Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone Technology and E-coaching

    The goal of this research is to increase physical activity among individuals with a spinal cord injury (SCI) through a customized, interactive smartphone-based health app and e-coaching using three phases: (1) leading focus groups of potential app users and clinicians to gain information regarding …

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Shirley Ryan AbilityLab, Chicago, Illinois

    Run by

    Shirley Ryan AbilityLab

    See if you can join NCT05424172 on ClinicalTrials.gov

13. Nomad P-KAFO Study

    The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk. The main questions it aims to answer are to quantify the effectiveness of the Nomad in improving mobilit…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Shirley Ryan AbilityLab, Chicago, Illinois

    Run by

    Shirley Ryan AbilityLab

    See if you can join NCT05644522 on ClinicalTrials.gov

14. Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI

    Spinal cord injury (SCI) can make it hard for the body to self-regulate some of its automatic functions like blood pressure, breathing, and heart rate. This can also make it hard for those living with SCI to exercise or complete their usual daily activities. The goal of this randomized trial is to …

    Stage

    Not phased

    Ages

    21 to 65

    Site

    University of Washington, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06313515 on ClinicalTrials.gov

15. Bacteriophage Therapy in Spinal Cord Injury Patients With Bacteriuria

    This is a Phase 1b study to assess the safety, tolerability, PK, and PD of investigational phage therapy (IP) in adults with SCI and bladder colonization (ASB). It is a single-center, randomized, double-blind, placebo-controlled study in adults with SCI with neurogenic bladders and bacteriuria who …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Washington University in St Louis, St Louis, Missouri

    Locations

    2 in total

    Run by

    Barbara Trautner

    See if you can join NCT06559618 on ClinicalTrials.gov

16. Locomotor and Bladder Function in Individuals With Acute Spinal Cord Injury

    The loss of movement and walking ability significantly affects quality of life after spinal cord injury. In addition, bladder dysfunction consistently ranks as one of the top disorders affecting quality of life after spinal cord injury. The overall objective of this study is to demonstrate that epi…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Kessler Foundation - Center for Spinal Stimulation, West Orange, New Jersey

    Run by

    Claudia Angeli

    See if you can join NCT04879862 on ClinicalTrials.gov

17. Non-invasive BCI-controlled Assistive Devices

    Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    The University of Texas at Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT05183152 on ClinicalTrials.gov

18. Diet and Exercise Solutions to Postprandial Hypotension

    The purpose of this study is to determine if a low glycemic diet and lower-body electrical stimulation can reduce postprandial hypotension in individuals with chronic spinal cord injury.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Dodd Rehabilitation Hospital, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06882460 on ClinicalTrials.gov

19. Upper Extremity Functional Electrical Stimulation (FES) for Restoration of Upper Extremity Function After Spinal Cord Injury (SCI)

    The purpose of this research is to examine the effects that functional electrical stimulation (FES) therapy has on the way the arms, brain and spinal cord work. The study team wants to understand what recovery looks like in persons with a spinal cord injury (SCI) or peripheral nerve injury (PNI) us…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Miami - Miami Project to Cure Paralysis, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06672458 on ClinicalTrials.gov

20. Multi-speed Ergonomic Wheelchair

    Over one million Americans rely on their upper extremities for manual wheelchair propulsion. Shoulder overuse injuries are prevalent among manual wheelchair users and these injuries often result in shoulder pain. Severe shoulder pain can lead some wheelchair users to transition from manual to power…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota

    Run by

    VA Office of Research and Development

    See if you can join NCT05776030 on ClinicalTrials.gov

21. Epidural Stimulation After Neurologic Damage

    This study will evaluate a method to optimize parameter settings in epidural spinal cord stimulation used to recover lower extremity volitional movement. The study will also characterize improvement in autonomic function (such as blood pressure control) and other functions related to spinal cord in…

    Stage

    Not phased

    Ages

    22 and older

    Site

    Hennepin County Medical Center, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT03026816 on ClinicalTrials.gov

22. Spinal Cord Stimulation and Training

    This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of spinal cord stimulation (SCS) mediated motor function.

    Stage

    Not phased

    Ages

    16 to 65

    Site

    Washington University, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05472584 on ClinicalTrials.gov

23. Abdominal Functional Electrical Stimulation to Improve Bowel Function in Spinal Cord Injury

    The primary objective of this study is to gather information about the effectiveness of abdominal FES to improve bowel management time (BMT) for people with chronic SCI. This study will also evaluate whether abdominal FES can improve: 1) bowel-related quality of life, 2) participant-reported bowel …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Craig Hospital, Englewood, Colorado

    Run by

    Craig Hospital

    See if you can join NCT06345781 on ClinicalTrials.gov

24. Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury

    It has been demonstrated that the human lumbosacral spinal cord can be neuromodulated with epidural (ESS) and transcutaneous (TSS) spinal cord stimulation to enable recovery of standing and volitional control of the lower limbs after complete motor paralysis due to spinal cord injury (SCI). The wor…

    Stage

    Not phased

    Ages

    22 to 75

    Site

    Houston Methodist Hospital, Houston, Texas

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT06213012 on ClinicalTrials.gov

25. Remote Ischemic Conditioning for PwSCI

    The long-term goal of this project is to improve the overall cardiometabolic health of persons with spinal cord injury (SCI). This pilot study will test the feasibility and acceptability of remote ischemic conditioning implemented in a home setting by persons with SCI and collect cardiometabolic he…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT07488793 on ClinicalTrials.gov