Spinal Cord Injuries Clinical Trials

87 studies are recruiting for spinal cord injuries in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

   The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of California, Davis, Sacramento, California

   Locations

   6 in total

   Run by

   Leigh R. Hochberg, MD, PhD.

   See if you can join NCT00912041 on ClinicalTrials.gov

2. Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury

   The purpose of this research is to learn about how the participant's body is able to balance changes in blood pressure, and how spinal cord stimulation affects these changes as well as immune \& cardiovascular function in participants with spinal cord injury.

   Stage

   Not phased

   Ages

   18 to 50

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT07210411 on ClinicalTrials.gov

3. Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI

   The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT07210437 on ClinicalTrials.gov

4. Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone Technology and E-coaching

   The goal of this research is to increase physical activity among individuals with a spinal cord injury (SCI) through a customized, interactive smartphone-based health app and e-coaching using three phases: (1) leading focus groups of potential app users and clinicians to gain information regarding …

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Shirley Ryan AbilityLab, Chicago, Illinois

   Run by

   Shirley Ryan AbilityLab

   See if you can join NCT05424172 on ClinicalTrials.gov

5. Nomad P-KAFO Study

   The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk. The main questions it aims to answer are to quantify the effectiveness of the Nomad in improving mobilit…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Shirley Ryan AbilityLab, Chicago, Illinois

   Run by

   Shirley Ryan AbilityLab

   See if you can join NCT05644522 on ClinicalTrials.gov

6. Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI

   Spinal cord injury (SCI) can make it hard for the body to self-regulate some of its automatic functions like blood pressure, breathing, and heart rate. This can also make it hard for those living with SCI to exercise or complete their usual daily activities. The goal of this randomized trial is to …

   Stage

   Not phased

   Ages

   21 to 65

   Site

   University of Washington, Seattle, Washington

   Run by

   University of Washington

   See if you can join NCT06313515 on ClinicalTrials.gov

7. Bacteriophage Therapy in Spinal Cord Injury Patients With Bacteriuria

   This is a Phase 1b study to assess the safety, tolerability, PK, and PD of investigational phage therapy (IP) in adults with SCI and bladder colonization (ASB). It is a single-center, randomized, double-blind, placebo-controlled study in adults with SCI with neurogenic bladders and bacteriuria who …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Washington University in St Louis, St Louis, Missouri

   Locations

   2 in total

   Run by

   Barbara Trautner

   See if you can join NCT06559618 on ClinicalTrials.gov

8. Locomotor and Bladder Function in Individuals With Acute Spinal Cord Injury

   The loss of movement and walking ability significantly affects quality of life after spinal cord injury. In addition, bladder dysfunction consistently ranks as one of the top disorders affecting quality of life after spinal cord injury. The overall objective of this study is to demonstrate that epi…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Kessler Foundation - Center for Spinal Stimulation, West Orange, New Jersey

   Run by

   Claudia Angeli

   See if you can join NCT04879862 on ClinicalTrials.gov

9. Non-invasive BCI-controlled Assistive Devices

   Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   The University of Texas at Austin, Austin, Texas

   Run by

   University of Texas at Austin

   See if you can join NCT05183152 on ClinicalTrials.gov

10. Diet and Exercise Solutions to Postprandial Hypotension

    The purpose of this study is to determine if a low glycemic diet and lower-body electrical stimulation can reduce postprandial hypotension in individuals with chronic spinal cord injury.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Dodd Rehabilitation Hospital, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06882460 on ClinicalTrials.gov

11. Upper Extremity Functional Electrical Stimulation (FES) for Restoration of Upper Extremity Function After Spinal Cord Injury (SCI)

    The purpose of this research is to examine the effects that functional electrical stimulation (FES) therapy has on the way the arms, brain and spinal cord work. The study team wants to understand what recovery looks like in persons with a spinal cord injury (SCI) or peripheral nerve injury (PNI) us…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Miami - Miami Project to Cure Paralysis, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06672458 on ClinicalTrials.gov

12. Multi-speed Ergonomic Wheelchair

    Over one million Americans rely on their upper extremities for manual wheelchair propulsion. Shoulder overuse injuries are prevalent among manual wheelchair users and these injuries often result in shoulder pain. Severe shoulder pain can lead some wheelchair users to transition from manual to power…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota

    Run by

    VA Office of Research and Development

    See if you can join NCT05776030 on ClinicalTrials.gov

13. Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes

    It is not known whether a new diabetes drug, semaglutide, is an effective treatment for type 2 diabetes for persons with spinal cord injury (SCI), a population at higher risk for this condition. Therefore, this study looks at the effect of semaglutide on glucose levels in the body and other informa…

    Stage

    Phase 4

    Ages

    18 to 70

    Site

    University Health - Texas Diabetic Institute, San Antonio, Texas

    Locations

    2 in total

    Run by

    Marzieh Salehi

    See if you can join NCT06706284 on ClinicalTrials.gov

14. Epidural Stimulation After Neurologic Damage

    This study will evaluate a method to optimize parameter settings in epidural spinal cord stimulation used to recover lower extremity volitional movement. The study will also characterize improvement in autonomic function (such as blood pressure control) and other functions related to spinal cord in…

    Stage

    Not phased

    Ages

    22 and older

    Site

    Hennepin County Medical Center, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT03026816 on ClinicalTrials.gov

15. Physical Therapy Wound Care Modalities in Patients With Spinal Cord Injury (SCI)

    To examine the effects of Physical Therapist (PT) wound care modalities (pulsed wound irrigation (PWI) + electrical stimulation (ES), PWI only, and ES only) on wound healing in patients with spinal cord injuries (SCI).

    Stage

    Not phased

    Ages

    18 and older

    Site

    Carolinas Rehabilitation, Charlotte, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT05458947 on ClinicalTrials.gov

16. Augmenting Rehabilitation Outcomes and Functional Neuroplasticity Using Epidural Stimulation of Cervical Spinal Cord

    The goal of this study is to investigate the effects of cervical epidural spinal stimulation with upper extremity training. This is an investigational study. The device used for epidural spinal stimulation (ESS) to deliver spinal stimulation is called the CoverEdgeX 32 Surgical Lead system. This de…

    Stage

    Not phased

    Ages

    22 to 65

    Site

    The Methodist Hospital Research Institute, Houston, Texas

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT06225245 on ClinicalTrials.gov

17. Spinal Cord Stimulation and Training

    This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of spinal cord stimulation (SCS) mediated motor function.

    Stage

    Not phased

    Ages

    16 to 65

    Site

    Washington University, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05472584 on ClinicalTrials.gov

18. Abdominal Functional Electrical Stimulation to Improve Bowel Function in Spinal Cord Injury

    The primary objective of this study is to gather information about the effectiveness of abdominal FES to improve bowel management time (BMT) for people with chronic SCI. This study will also evaluate whether abdominal FES can improve: 1) bowel-related quality of life, 2) participant-reported bowel …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Craig Hospital, Englewood, Colorado

    Run by

    Craig Hospital

    See if you can join NCT06345781 on ClinicalTrials.gov

19. Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury

    It has been demonstrated that the human lumbosacral spinal cord can be neuromodulated with epidural (ESS) and transcutaneous (TSS) spinal cord stimulation to enable recovery of standing and volitional control of the lower limbs after complete motor paralysis due to spinal cord injury (SCI). The wor…

    Stage

    Not phased

    Ages

    22 to 75

    Site

    Houston Methodist Hospital, Houston, Texas

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT06213012 on ClinicalTrials.gov

20. Remote Ischemic Conditioning for PwSCI

    The long-term goal of this project is to improve the overall cardiometabolic health of persons with spinal cord injury (SCI). This pilot study will test the feasibility and acceptability of remote ischemic conditioning implemented in a home setting by persons with SCI and collect cardiometabolic he…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT07488793 on ClinicalTrials.gov

21. Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury

    Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI). The goal of the study is to understand th…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Spaulding Rehabilitation Hospital, Cambridge, Massachusetts

    Run by

    Spaulding Rehabilitation Hospital

    See if you can join NCT02323945 on ClinicalTrials.gov

22. Combination Therapy to Improve SCI Recovery.

    The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury.

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Shirley Ryan AbilityLab, Chicago, Illinois

    Locations

    2 in total

    Run by

    Spaulding Rehabilitation Hospital

    See if you can join NCT05563103 on ClinicalTrials.gov

23. Low Oxygen Therapy to Enhance Walking Recovery After SCI.

    The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury of different age groups.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Brooks Rehabilitation Hospital, Jacksonville, Florida

    Locations

    2 in total

    Run by

    Spaulding Rehabilitation Hospital

    See if you can join NCT06521723 on ClinicalTrials.gov

24. Spinal Cord Stimulation and Respiration After Injury

    Respiratory motor control deficit is the leading cause of morbidity and mortality in patients with spinal cord injury. The long-term goal of this NIH-funded study is to develop a rehabilitation strategy for respiration in patients with spinal cord injury as a standard of care. Respiratory function …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Frazier Rehabilitation and Neuroscience Institute, Louisville, Kentucky

    Run by

    University of Louisville

    See if you can join NCT05178056 on ClinicalTrials.gov

25. Spinal Cord Stimulation for Respiratory Rehabilitation in Patients With Chronic Spinal Cord Injury

    Respiratory complications are among the leading causes of death in patients with chronic spinal cord injury (SCI). Our previous work showed that pulmonary function can be improved by using our original respiratory training method. However, the effectiveness of this intervention is limited due to th…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Frazier Rehabilitation and Neuroscience Institute, Louisville, Kentucky

    Run by

    University of Louisville

    See if you can join NCT06019949 on ClinicalTrials.gov