Spinal Cord Injuries Clinical Trials

87 studies are recruiting for spinal cord injuries in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning

   The purpose of this study is to validate the capacity of a reflex training system to change the size of the targeted reflex. For this, the researchers are recruiting 25 individuals with chronic incomplete SCI who have spasticity in the leg to participate in the reflex training procedure. The study …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Locations

   2 in total

   Run by

   Medical University of South Carolina

   See if you can join NCT05094362 on ClinicalTrials.gov

2. BioFLO for Respiratory Recovery in SCI

   Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (~15) of breathing low oxygen air to stimulate spinal neuroplasticity. Animal and human studies show that AIH improves motor function after spinal cord injury, particularly with slightly increased carbon dioxide (hypercapnic…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Brooks Rehabilitation, Jacksonville, Florida

   Run by

   University of Florida

   See if you can join NCT06011876 on ClinicalTrials.gov

3. Spinal Cord Injury Model Systems (SCIMS) - Education Module

   The purpose of this study is to find out if receiving education regarding increased risks of cardiometabolic disease helps subjects understand these risks and how these risks participants' health.

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Baylor Scott & White Institute for Research, Dallas, Texas

   Locations

   3 in total

   Run by

   University of Miami

   See if you can join NCT06003686 on ClinicalTrials.gov

4. Transcutaneous Spinal Stimulation and Exercise for Locomotion

   Growing evidence indicates that electrical spinal cord stimulation improves motor functions both immediately and over the long term via modulating the excitability of spinal circuitry in patients with spinal cord injury. Recently, a novel, non-invasive, well-tolerated, and painless lumbosacral tran…

   Stage

   Not phased

   Ages

   21 to 70

   Site

   University of Washington, Seattle, Washington

   Run by

   University of Washington

   See if you can join NCT03509558 on ClinicalTrials.gov

5. Spinal Neurorehabilitation for Veterans With SCI

   Chronic spinal cord injury (SCI) is a debilitating disorder in Veterans and the broader U.S. population that does not have a cure. Veterans with severe SCI demonstrate permanent loss of sensory and motor function below their injury resulting in decreased quality of life and independence. Recently, …

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Northern California Health Care System, Mather, CA, Sacramento, California

   Run by

   VA Office of Research and Development

   See if you can join NCT07222046 on ClinicalTrials.gov

6. Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions

   This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain Injury) to improve their wellness and self-management skills compared to tho…

   Stage

   Not phased

   Ages

   12 and older

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT02592291 on ClinicalTrials.gov

7. The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain

   Spinal cord stimulation modulates the nervous system to effectively block pain signals originating from the back and legs. Spinal cord stimulation has been shown to improve chronic pain, improve quality of life, and reduce disability. Unfortunately, spinal cord stimulation has a high trial failure …

   Stage

   Not phased

   Ages

   22 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05741788 on ClinicalTrials.gov

8. Dose Escalation Study of EG110A, Administered by Intradetrusor Injections to Adults With Neurogenic Detrusor Overactivity-related Incontinence Following Spinal Cord Injury Who Regularly Perform Clean Intermittent Catheterization

   This is a first-in-human, Phase 1b/2a, open-label, dose-escalation study of a single treatment course consisting of multiple intradetrusor injections of EG110A in male and female adult participants with Neurogenic Detrusor Overactivity (NDO)-related incontinence following Spinal Cord Injury (SCI), …

   Stage

   Phase 1

   Ages

   18 to 75

   Site

   Rancho Los Amigos National Rehabilitation Center, Downey, California

   Locations

   5 in total

   Run by

   Cyllene Therapeutics

   See if you can join NCT06596291 on ClinicalTrials.gov

9. cHAnging the Perceived Pain INtensity in divErSe Populations With Spinal Cord Injury

   Chronic neuropathic pain affects 69% of adults with spinal cord injury (SCI). Current treatment options are limited (primarily pain medications) with insufficient benefits and significant risks for addiction and adverse effects. Of the available mind and body approaches, Qigong is the most accessib…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Locations

   3 in total

   Run by

   University of Minnesota

   See if you can join NCT06140355 on ClinicalTrials.gov

10. Closed-loop Spinal Stimulation for Restoration of Upper Extremity Function After Spinal Cord Injury

    The purpose of this study is to assess the efficacy of non-invasive (transcutaneous) closed-loop electrical spinal cord stimulation for recovery of upper limb function (Aim 1) and spasticity (Aim 2) following spinal cord injury.

    Stage

    Not phased

    Ages

    21 to 70

    Site

    University of Washington, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT05267951 on ClinicalTrials.gov

11. Mild Intermittent Hypoxia: A Prophylactic for Autonomic Dysfunction in Individuals With Spinal Cord Injuries

    The prevalence of autonomic dysfunction and sleep disordered breathing (SDB) is increased in individuals with spinal cord injury (SCI). The loss of autonomic control results in autonomic dysreflexia (AD) and orthostatic hypotension (OH) which explains the increase in cardiovascular related mortalit…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan

    Run by

    VA Office of Research and Development

    See if you can join NCT05351827 on ClinicalTrials.gov

12. Brain-Controlled Spinal Stimulation Walking Therapy After Incomplete Spinal Cord Injury (SCI)

    The purpose of this research is to test the effectiveness of a new therapy, called Brain-Computer Interface (BCI)-Transcutaneous Spinal Cord Stimulation (TSCS), for improving walking in people with an incomplete spinal cord injury (SCI).

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06406855 on ClinicalTrials.gov

13. Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

    Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target only brain regions involved in one aspect of the pa…

    Stage

    Not phased

    Ages

    22 to 80

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT04144972 on ClinicalTrials.gov

14. Evaluation of an Advanced Lower Extremity Neuroprostheses

    The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate exercise, standing, stepping and/or balance in people with various degrees of paralysis.

    Stage

    Not phased

    Ages

    21 to 75

    Site

    Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio

    Locations

    2 in total

    Run by

    Case Western Reserve University

    See if you can join NCT00623389 on ClinicalTrials.gov

15. Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury

    The goal of this clinical trial is to evaluate safety and tolerability of multiple oral doses of EC5026 in male and female patients with neuropathic pain due to traumatic or non-traumatic (degenerative) spinal cord injury. The main question it aims to answer is whether EC5026 is safe and well toler…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    AU Medical Center, Augusta, Georgia

    Run by

    EicOsis Human Health Inc.

    See if you can join NCT06438471 on ClinicalTrials.gov

16. Wrist Extensor MEP Up-conditioning for Individuals With Incomplete Spinal Cord Injury

    The purpose of this study is to examine the relationship between common clinical assessments and measurements of the function of brain-spinal cord-muscle connections, and to examine the effects of training a brain-spinal cord-muscle response in individuals with incomplete spinal cord injury. A tran…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05321017 on ClinicalTrials.gov

17. Promoting Recovery Outcomes Through Precise Early Locomotor Interventions in Persons With Spinal Cord Injury

    The purpose of this study is to evaluate if a specific type of additional walking therapy, called body weight supported treadmill training (BWSTT) affects walking ability following a traumatic spinal cord injury. Specifically, the study will look at whether starting BWSTT, which uses a body harness…

    Stage

    Not phased

    Ages

    16 to 75

    Site

    The Shirley Ryan AbilityLab, Chicago, Illinois

    Locations

    2 in total

    Run by

    Milap Sandhu

    See if you can join NCT06176833 on ClinicalTrials.gov

18. Efficacy of a Wearable Noninvasive Neuromodulation Device

    The aim of this study is to investigate the potential of transcutaneous neuromodulation (TNM) to treat slow colonic transit and constipation, termed the Neurogenic bowel dysfunction (NBD), in people with SCI. In this project, the study team will investigate the impact of an active treatment interve…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07171489 on ClinicalTrials.gov

19. Hybrid HIIT-FES Cycling Program on Individuals With Spinal Cord Injury to Improve Health

    Project Summary/Abstract Obesity and metabolic syndrome (obesity, dyslipidemia, hyperglycemia, hypertension) are epidemic in the spinal cord injured (SCI) population. A recent study assessing the body composition and metabolic syndrome rates of 72 motor complete chronic SCI individuals revealed an …

    Stage

    Not phased

    Ages

    21 to 70

    Site

    William Carey University, Hattiesburg, Mississippi

    Run by

    William Carey University

    See if you can join NCT07648173 on ClinicalTrials.gov

20. Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)

    People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), or other disorders can become unable to move or speak despite being awake and alert. In this project, the investigators seek to further translate knowledge about interpreting brain signal…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Masssachusetts General Hospital, Boston, Massachusetts

    Run by

    Leigh R. Hochberg, MD, PhD.

    See if you can join NCT06511934 on ClinicalTrials.gov

21. Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury

    The overarching goal of this research study is to evaluate a sensor-enabled, just-in-time adaptive intervention (JITAI) strategy to increase and sustain physical activity levels among individuals with spinal cord injury (SCI) in their communities. A primary objective of this study is to evaluate th…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Temple University, Philadelphia, Pennsylvania

    Run by

    Temple University

    See if you can join NCT05317832 on ClinicalTrials.gov

22. Development of a Novel Evaluation Scale of Mental Body Representation (MBR) for Adults With Spinal Cord Injury

    The purpose of this study is twofold: (1) Develop a new evaluation scale for mental body representations (MBR, i.e., body awareness and visuospatial body maps) for adults with spinal cord injury (SCI) with and without neuropathic pain. (2) Assess the psychometric properties of usability, reliabilit…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07029802 on ClinicalTrials.gov

23. ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury

    Empower BP is a pivotal, interventional, multicenter, prospective, randomized, controlled double-blinded study to evaluate the safety and effectiveness of the ARC-IM System in managing symptomatic blood pressure instability in individuals with chronic SCI (>1 year after SCI). The primary effectiven…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of Arkansas for medical Sciences, Little Rock, Arkansas

    Locations

    13 in total

    Run by

    ONWARD Medical, Inc.

    See if you can join NCT07147296 on ClinicalTrials.gov

24. Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury

    This is a study about deep brain stimulation (DBS) as an investigational treatment for walking impairment following spinal cord injury (SCI). The purpose of this study is to assess the feasibility and inform on the safety, and efficacy of CnF DBS to improve gait in SCI patients with incomplete inju…

    Stage

    Not phased

    Ages

    22 to 70

    Site

    The Miami Project to Cure Paralysis, Miami, Florida

    Locations

    2 in total

    Run by

    University of Miami

    See if you can join NCT07109804 on ClinicalTrials.gov

25. Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia

    The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Stanford University School of Medicine, Stanford, California

    Locations

    2 in total

    Run by

    Leigh R. Hochberg, MD, PhD.

    See if you can join NCT05724173 on ClinicalTrials.gov