Spinal Cord Injuries Clinical Trials

85 studies are recruiting for spinal cord injuries in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury

   This is a study about deep brain stimulation (DBS) as an investigational treatment for walking impairment following spinal cord injury (SCI). The purpose of this study is to assess the feasibility and inform on the safety, and efficacy of CnF DBS to improve gait in SCI patients with incomplete inju…

   Stage

   Not phased

   Ages

   22 to 70

   Site

   The Miami Project to Cure Paralysis, Miami, Florida

   Locations

   2 in total

   Run by

   University of Miami

   See if you can join NCT07109804 on ClinicalTrials.gov

2. Physical Therapy Wound Care Modalities in Patients With Spinal Cord Injury (SCI)

   To examine the effects of Physical Therapist (PT) wound care modalities (pulsed wound irrigation (PWI) + electrical stimulation (ES), PWI only, and ES only) on wound healing in patients with spinal cord injuries (SCI).

   Stage

   Not phased

   Ages

   18 and older

   Site

   Carolinas Rehabilitation, Charlotte, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT05458947 on ClinicalTrials.gov

3. Augmenting Upper Limb Function and Functional Neuroplasticity Using Epidural Stimulation of the Cervical Spinal Cord

   This study will test whether spinal stimulation combined with rehabilitation can improve arm and hand function in people with tetraplegia after spinal cord injury. Tetraplegia causes weakness or paralysis in the arms and legs. The stimulation sends electrical pulses through a paddle placed near the…

   Stage

   Not phased

   Ages

   22 to 70

   Site

   The Methodist Hospital Research Institute, Houston, Texas

   Run by

   The Methodist Hospital Research Institute

   See if you can join NCT06225245 on ClinicalTrials.gov

4. Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)

   People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), or other disorders can become unable to move or speak despite being awake and alert. In this project, the investigators seek to further translate knowledge about interpreting brain signal…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Masssachusetts General Hospital, Boston, Massachusetts

   Run by

   Leigh R. Hochberg, MD, PhD.

   See if you can join NCT06511934 on ClinicalTrials.gov

5. Safety of Cultured Allogeneic Adult Umbilical-cord or Placental Derived Mesenchymal Stem Cell Intrathecal Injection for SCI

   This trial will study the safety and efficacy of intrathecal injection of cultured allogeneic adult umbilical-cord or placental derived mesenchymal stem cells for the treatment of spinal cord injury

   Stage

   Phase 1

   Ages

   Any age

   Site

   Prodromos Stem Cell Institute, Naples, Florida

   Locations

   2 in total

   Run by

   The Foundation for Orthopaedics and Regenerative Medicine

   See if you can join NCT05018793 on ClinicalTrials.gov

6. Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cells for SCI

   This trial will study the safety and efficacy of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of Spinal Cord Injury.

   Stage

   Phase 1

   Ages

   Any age

   Site

   Prodromos Stem Cell Institute, Naples, Florida

   Locations

   2 in total

   Run by

   The Foundation for Orthopaedics and Regenerative Medicine

   See if you can join NCT05152290 on ClinicalTrials.gov

7. Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI

   The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involve…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT05492188 on ClinicalTrials.gov

8. Utility of Multisensory Body-Representation in Spinal Cord Injury (SCI) With Pain

   The purpose of this study is to investigate the effectiveness of bodily illusions combined with transcranial direct current stimulation (tDCS) on neuropathic pain symptoms and sensory functions in participants with spinal cord injury (SCI) and neuropathic pain.

   Stage

   Not phased

   Ages

   18 to 70

   Site

   University of Miami, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT06010251 on ClinicalTrials.gov

9. MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury

   The purpose of this study is to develop and test the hardware and software components of the MyHand-SCI device to assist with hand function for individuals with C6-C7 spinal cord injury.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Columbia University Irving Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT05553457 on ClinicalTrials.gov

10. Virtual Walking Therapy for Neuropathic Pain Following Incomplete Spinal Cord Injury

    The purpose of this study is to determine if playing a virtual reality walking game can help improve neuropathic pain in adults with incomplete spinal cord injury.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Texas A&M University, College Station, Texas

    Run by

    Texas A&M University

    See if you can join NCT06330181 on ClinicalTrials.gov

11. Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes

    It is not known whether a new diabetes drug, semaglutide, is an effective treatment for type 2 diabetes for persons with spinal cord injury (SCI), a population at higher risk for this condition. Therefore, this study looks at the effect of semaglutide on glucose levels in the body and other informa…

    Stage

    Phase 4

    Ages

    18 to 70

    Site

    University Health - Texas Diabetic Institute, San Antonio, Texas

    Locations

    2 in total

    Run by

    Marzieh Salehi

    See if you can join NCT06706284 on ClinicalTrials.gov

12. Spinal Cord Injury Model Systems (SCIMS) - Education Module

    The purpose of this study is to find out if receiving education regarding increased risks of cardiometabolic disease helps subjects understand these risks and how these risks participants' health.

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Baylor Scott & White Institute for Research, Dallas, Texas

    Locations

    3 in total

    Run by

    University of Miami

    See if you can join NCT06003686 on ClinicalTrials.gov

13. Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning

    The purpose of this study is to validate the capacity of a reflex training system to change the size of the targeted reflex. For this, the researchers are recruiting 25 individuals with chronic incomplete SCI who have spasticity in the leg to participate in the reflex training procedure. The study …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Locations

    2 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT05094362 on ClinicalTrials.gov

14. BioFLO for Respiratory Recovery in SCI

    Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (~15) of breathing low oxygen air to stimulate spinal neuroplasticity. Animal and human studies show that AIH improves motor function after spinal cord injury, particularly with slightly increased carbon dioxide (hypercapnic…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Brooks Rehabilitation, Jacksonville, Florida

    Run by

    University of Florida

    See if you can join NCT06011876 on ClinicalTrials.gov

15. Transcutaneous Spinal Stimulation and Exercise for Locomotion

    Growing evidence indicates that electrical spinal cord stimulation improves motor functions both immediately and over the long term via modulating the excitability of spinal circuitry in patients with spinal cord injury. Recently, a novel, non-invasive, well-tolerated, and painless lumbosacral tran…

    Stage

    Not phased

    Ages

    21 to 70

    Site

    University of Washington, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT03509558 on ClinicalTrials.gov

16. Spinal Neurorehabilitation for Veterans With SCI

    Chronic spinal cord injury (SCI) is a debilitating disorder in Veterans and the broader U.S. population that does not have a cure. Veterans with severe SCI demonstrate permanent loss of sensory and motor function below their injury resulting in decreased quality of life and independence. Recently, …

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Northern California Health Care System, Mather, CA, Sacramento, California

    Run by

    VA Office of Research and Development

    See if you can join NCT07222046 on ClinicalTrials.gov

17. Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions

    This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain Injury) to improve their wellness and self-management skills compared to tho…

    Stage

    Not phased

    Ages

    12 and older

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT02592291 on ClinicalTrials.gov

18. The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain

    Spinal cord stimulation modulates the nervous system to effectively block pain signals originating from the back and legs. Spinal cord stimulation has been shown to improve chronic pain, improve quality of life, and reduce disability. Unfortunately, spinal cord stimulation has a high trial failure …

    Stage

    Not phased

    Ages

    22 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05741788 on ClinicalTrials.gov

19. Dose Escalation Study of EG110A, Administered by Intradetrusor Injections to Adults With Neurogenic Detrusor Overactivity-related Incontinence Following Spinal Cord Injury Who Regularly Perform Clean Intermittent Catheterization

    This is a first-in-human, Phase 1b/2a, open-label, dose-escalation study of a single treatment course consisting of multiple intradetrusor injections of EG110A in male and female adult participants with Neurogenic Detrusor Overactivity (NDO)-related incontinence following Spinal Cord Injury (SCI), …

    Stage

    Phase 1

    Ages

    18 to 75

    Site

    Rancho Los Amigos National Rehabilitation Center, Downey, California

    Locations

    5 in total

    Run by

    Cyllene Therapeutics

    See if you can join NCT06596291 on ClinicalTrials.gov

20. cHAnging the Perceived Pain INtensity in divErSe Populations With Spinal Cord Injury

    Chronic neuropathic pain affects 69% of adults with spinal cord injury (SCI). Current treatment options are limited (primarily pain medications) with insufficient benefits and significant risks for addiction and adverse effects. Of the available mind and body approaches, Qigong is the most accessib…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Locations

    3 in total

    Run by

    University of Minnesota

    See if you can join NCT06140355 on ClinicalTrials.gov

21. Closed-loop Spinal Stimulation for Restoration of Upper Extremity Function After Spinal Cord Injury

    The purpose of this study is to assess the efficacy of non-invasive (transcutaneous) closed-loop electrical spinal cord stimulation for recovery of upper limb function (Aim 1) and spasticity (Aim 2) following spinal cord injury.

    Stage

    Not phased

    Ages

    21 to 70

    Site

    University of Washington, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT05267951 on ClinicalTrials.gov

22. Mild Intermittent Hypoxia: A Prophylactic for Autonomic Dysfunction in Individuals With Spinal Cord Injuries

    The prevalence of autonomic dysfunction and sleep disordered breathing (SDB) is increased in individuals with spinal cord injury (SCI). The loss of autonomic control results in autonomic dysreflexia (AD) and orthostatic hypotension (OH) which explains the increase in cardiovascular related mortalit…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    John D. Dingell VA Medical Center, Detroit, MI, Detroit, Michigan

    Run by

    VA Office of Research and Development

    See if you can join NCT05351827 on ClinicalTrials.gov

23. Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

    Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target only brain regions involved in one aspect of the pa…

    Stage

    Not phased

    Ages

    22 to 80

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT04144972 on ClinicalTrials.gov

24. Evaluation of an Advanced Lower Extremity Neuroprostheses

    The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate exercise, standing, stepping and/or balance in people with various degrees of paralysis.

    Stage

    Not phased

    Ages

    21 to 75

    Site

    Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio

    Locations

    2 in total

    Run by

    Case Western Reserve University

    See if you can join NCT00623389 on ClinicalTrials.gov

25. Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury

    The goal of this clinical trial is to evaluate safety and tolerability of multiple oral doses of EC5026 in male and female patients with neuropathic pain due to traumatic or non-traumatic (degenerative) spinal cord injury. The main question it aims to answer is whether EC5026 is safe and well toler…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    AU Medical Center, Augusta, Georgia

    Run by

    EicOsis Human Health Inc.

    See if you can join NCT06438471 on ClinicalTrials.gov