Spinal Cord Injuries Clinical Trials

85 studies are recruiting for spinal cord injuries in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury

   Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI). The goal of the study is to understand th…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Spaulding Rehabilitation Hospital, Cambridge, Massachusetts

   Run by

   Spaulding Rehabilitation Hospital

   See if you can join NCT02323945 on ClinicalTrials.gov

2. Combination Therapy to Improve SCI Recovery.

   The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury.

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Shirley Ryan AbilityLab, Chicago, Illinois

   Locations

   2 in total

   Run by

   Spaulding Rehabilitation Hospital

   See if you can join NCT05563103 on ClinicalTrials.gov

3. Low Oxygen Therapy to Enhance Walking Recovery After SCI.

   The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury of different age groups.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Brooks Rehabilitation Hospital, Jacksonville, Florida

   Locations

   2 in total

   Run by

   Spaulding Rehabilitation Hospital

   See if you can join NCT06521723 on ClinicalTrials.gov

4. Spinal Cord Stimulation and Respiration After Injury

   Respiratory motor control deficit is the leading cause of morbidity and mortality in patients with spinal cord injury. The long-term goal of this NIH-funded study is to develop a rehabilitation strategy for respiration in patients with spinal cord injury as a standard of care. Respiratory function …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Frazier Rehabilitation and Neuroscience Institute, Louisville, Kentucky

   Run by

   University of Louisville

   See if you can join NCT05178056 on ClinicalTrials.gov

5. Spinal Cord Stimulation for Respiratory Rehabilitation in Patients With Chronic Spinal Cord Injury

   Respiratory complications are among the leading causes of death in patients with chronic spinal cord injury (SCI). Our previous work showed that pulmonary function can be improved by using our original respiratory training method. However, the effectiveness of this intervention is limited due to th…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Frazier Rehabilitation and Neuroscience Institute, Louisville, Kentucky

   Run by

   University of Louisville

   See if you can join NCT06019949 on ClinicalTrials.gov

6. Restoring Motor and Sensory Hand Function in Tetraplegia Using a Neural Bypass System

   This is a single-cohort early feasibility trial to determine whether an investigational device called the Bidirectional Neural Bypass System can lead to the restoration of movement and sensation in the hand and wrist of up to seven individuals with tetraplegia.

   Stage

   Not phased

   Ages

   22 to 65

   Site

   Northwell Health's The Feinstein Institute for Medical Research, Manhasset, New York

   Run by

   Chad Bouton

   See if you can join NCT03680872 on ClinicalTrials.gov

7. Yoga Breath Training to Improve Cardiorespiratory Synchrony in Spinal Cord Injury

   The goal of this interventional study is to understand how regular yogic breathing practice, particularly a slow resistive yogic breathing technique called Ujjayi, would benefit individuals between the ages of 18 and 60 with spinal cord injuries. Previously yogic breathing has shown to improve resp…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   Spaulding Rehabilitation Hospital, Cambridge, Massachusetts

   Run by

   Spaulding Rehabilitation Hospital

   See if you can join NCT06514950 on ClinicalTrials.gov

8. Treatment of Depression Post-SCI

   Depression is more common after a spinal cord injury (SCI) than in the general population. Unfortunately, it is unknown how depression is typically treated in individuals with SCI or if commonly used treatment methods are effective. This study will investigate the safety and impact of a novel metho…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT04263285 on ClinicalTrials.gov

9. Transcutaneous Spinal Cord Stimulation in Children With Incomplete Spinal Cord Injury

   Aim 1: Determine the safety and feasibility of administration of TSCS to children in a clinical setting. Participants will be randomly assigned to experimental (TSCS) or control (sham stimulation) groups. Both groups will receive eight-weeks of individualized gait training. We will measure adverse …

   Stage

   Not phased

   Ages

   3 to 16

   Site

   Kennedy Krieger Institute, Baltimore, Maryland

   Run by

   Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

   See if you can join NCT06242873 on ClinicalTrials.gov

10. Patient and Caregiver Perspectives on Intravesical Instillations for Urinary Symptoms

    The goal of this observational qualitative study is to learn about the experiences and perspectives of patients with neurogenic lower urinary tract dysfunction (NLUTD) and their caregivers regarding different types of intravesical instillations used for urinary health. The study aims to understand …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medstar National Rehabilitation Hospital, Washington D.C., District of Columbia

    Run by

    Medstar Health Research Institute

    See if you can join NCT07390591 on ClinicalTrials.gov

11. Dosing rTMS for Depression Post-SCI

    Depression is a leading cause of disability worldwide and is more commonly seen in individual's post-spinal cord injury (SCI) than in the general population. Depression post-SCI impacts an individuals' quality of life and recovery. It has been reported that among Veterans with an SCI, those without…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina

    Run by

    VA Office of Research and Development

    See if you can join NCT05553353 on ClinicalTrials.gov

12. Epidural Stimulation and Resistance Training After SCI

    Spinal cord injury (SCI) is a devastating health problem for tens of thousands of military personnel, Veterans and civilians annually. Many persons with SCI must use a wheelchair for their entire life. A new scientific breakthrough called "lumbosacral epidural stimulation" or "ES" can help people w…

    Stage

    Phase 2

    Ages

    18 to 60

    Site

    Hunter Holmes McGuire VA Medical Center, Richmond, Virginia

    Run by

    United States Department of Defense

    See if you can join NCT04782947 on ClinicalTrials.gov

13. The Impact of Expressive Emotional Writing on Facilitating Grief Resolution in Adults With Spinal Cord Injury

    The aim of this study is to evaluate the therapeutic benefits of a 10-week online coach-guided EEWP on psychosocial health among adults with SCI.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06147258 on ClinicalTrials.gov

14. Eccentric Muscle Training, Stimulation, and Biomarkers in SCI

    The investigators are studying a new rehabilitation treatment for individuals trying to recover walking after spinal cord injury (SCI). The investigators will test conditions in the blood and spinal fluid to determine the best time to start this new training program. This will include checking for …

    Stage

    Not phased

    Ages

    18 to 85

    Site

    The Ohio State University, Columbus, Ohio

    Locations

    2 in total

    Run by

    Ohio State University

    See if you can join NCT05337982 on ClinicalTrials.gov

15. Multi-functional Neuroprosthetic System for Restoration of Motor Function in Spinal Cord Injury

    This study is to evaluate the use of a fully implanted device for providing hand function, reach, and trunk function to individuals with cervical spinal cord injury. Funding Sources: FDA OOPD NIH NINDS

    Stage

    Not phased

    Ages

    17 and older

    Site

    MetroHealth Medical Center, Cleveland, Ohio

    Run by

    Anne Bryden

    See if you can join NCT02329652 on ClinicalTrials.gov

16. Grasp-Release Assessment of a Networked Neuroprosthesis Device

    The overall objective of this trial is to characterize the safety and effectiveness of the Networked Neuroprosthesis Device - Upper Extremity (NP-UE) in individuals living with cervical SCI.

    Stage

    Not phased

    Ages

    16 and older

    Site

    MetroHealth Medical Center, Cleveland, Ohio

    Run by

    MetroHealth Medical Center

    See if you can join NCT05863754 on ClinicalTrials.gov

17. Virtual Walking Intervention for Neuropathic Pain in Spinal Cord Injury

    The purpose of this study is to determine if playing a virtual reality walking game can help improve neuropathic pain in adults with chronic spinal cord injury.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    3 in total

    Run by

    Texas A&M University

    See if you can join NCT05005026 on ClinicalTrials.gov

18. Impact of Gut Microbiome on Metabolic and Bowel Function During the First Year After Spinal Cord Injury

    The Investigators will recruit 35 participants with acute SCI (within 6 weeks of injury) Fasting blood collection and bowel function survey will be conducted 3 times: at baseline [within 6 weeks of injury], 6, and 12 months after SCI. Stool will be collected for gut microbiome analysis 3 times.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    The University of Alabama at Birmingahm, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05670288 on ClinicalTrials.gov

19. Spinal Decompression Plus Nerve Graft Implantation Following TSCI

    This is a single-blinded (with outcome assessors blinded to treatment allocation), 12-month pilot study to evaluate of the safety, feasibility, and preliminary efficacy of dorsal myelotomy and expansive duraplasty performed either without or with autologous nerve graft implantation after acute trau…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Kentucky - Chandler Medical Center, Lexington, Kentucky

    Run by

    Francis Farhadi

    See if you can join NCT06243211 on ClinicalTrials.gov

20. Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)

    The goal of this study is to improve our understanding of speech production, and to translate this into medical devices called intracortical brain-computer interfaces (iBCIs) that will enable people who have lost the ability to speak fluently to communicate via a computer just by trying to speak.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of California, Davis, Sacramento, California

    Run by

    Leigh R. Hochberg, MD, PhD.

    See if you can join NCT06094205 on ClinicalTrials.gov

21. Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury

    Heart attacks and strokes are among the most common causes of premature death in individuals living with spinal cord injury (SCI) and appear to occur earlier in life. The factors that lead to the heighten and accelerated risk of heart attacks and strokes in adults living with SCI remain poorly unde…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Craig Hospital, Englewood, Colorado

    Run by

    Craig Hospital

    See if you can join NCT07227740 on ClinicalTrials.gov

22. Endothelial Dysfunction After SCI

    This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Craig Hospital, Englewood, Colorado

    Run by

    Craig Hospital

    See if you can join NCT07227727 on ClinicalTrials.gov

23. Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury

    This is a phase 1 study of safety and feasibility of cervical spinal cord stimulator implantation in cervical SCI subjects who are ventilator dependent. The Investigators will be focusing on the safety and feasibility of this approach. Participants may qualify for the study if they are male or fema…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Semel Institute of Neuroscience at UCLA, Los Angeles, California

    Locations

    2 in total

    Run by

    University of California, Los Angeles

    See if you can join NCT04883463 on ClinicalTrials.gov

24. Influence of Spinal Stimulation Frequency on Spasticity, Motor Control, and Pain After Spinal Cord Injury

    The goal of this study is to identify the effect of different types of noninvasive spinal stimulation on spasticity (involuntary muscle activity), muscle strength, and pain in people with spinal cord injury. The spinal stimulation consists of electrical stimulation applied through one electrode ove…

    Stage

    Not phased

    Ages

    16 and older

    Site

    Shepherd Center, Inc., Atlanta, Georgia

    Run by

    Shepherd Center, Atlanta GA

    See if you can join NCT06214208 on ClinicalTrials.gov

25. Finding the Best Combination of Brain and Spinal Cord Stimulation With Hand Training After Spinal Cord Injury

    While physical exercise remains the foundation for any rehabilitation therapy, the team seeks to improve the benefits of exercise by combining it with the concept of "Fire Together, Wire Together" - when brain stimulation is synchronized with spinal cord stimulation, nerve circuits in the spinal co…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    James J. Peters VA Medical Center, Bronx, NY, The Bronx, New York

    Run by

    Bronx VA Medical Center

    See if you can join NCT06104735 on ClinicalTrials.gov