Sepsis Clinical Trials

36 studies are recruiting for sepsis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

   This study will enroll adults aged 18 to 80 years diagnosed with sepsis due to a suspected or confirmed bacterial infection, within 7 days of being admitted to the hospital, and who have also developed acute kidney injury within 72 hours of the onset of sepsis. Eligible participants will be randoml…

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   Research Site, Newport Beach, California

   Locations

   74 in total

   Run by

   AstraZeneca

   See if you can join NCT07215702 on ClinicalTrials.gov

2. Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial

   The long-term goal is to test the clinical efficacy of senolytic therapies to reduce progression to and severity of sepsis in older patients. The central hypothesis is that a threshold burden of SnCs predisposes to a SASP mediated dysfunctional response to PAMPs, contributing to a disproportionate …

   Stage

   Phase 2

   Ages

   65 and older

   Site

   University of Iowa, Iowa City, Iowa

   Locations

   10 in total

   Run by

   University of Minnesota

   See if you can join NCT05758246 on ClinicalTrials.gov

3. MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial

   This study is being done to determine if early administration of Midodrine can improve outcomes by maintaining a higher mean blood pressure off of intravenous medications. Researchers want to see if Midodrine can help people with sepsis need fewer vasopressors, which could mean shorter hospital sta…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Mayo Clinic Arizona, Scottsdale, Arizona

   Locations

   5 in total

   Run by

   Mayo Clinic

   See if you can join NCT06319248 on ClinicalTrials.gov

4. Early Versus Late Adjunctive Vasopressin in Septic Shock

   The goal of the CASPER-Pilot study is to develop clinical decision support (CDS) technology within Epic to randomize patients with septic shock to early versus standard of care vasopressin initiation. The primary aim of this study will be to test the hypothesis that CDS technology can be utilized t…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT06709573 on ClinicalTrials.gov

5. Personalized Fluid Resuscitation in the Emergency Department: A Pilot Trial

   The goal of this pilot clinical trial is to learn if a fluid assessment using non-invasive cardiac output monitoring (NICOM) is helpful for patients with sepsis who have low blood pressure in the Emergency Department (ED). The study will measure whether the NICOM assessment changes fluid resuscitat…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Intermountain Medical Center Emergency Department, Murray, Utah

   Run by

   Intermountain Health Care, Inc.

   See if you can join NCT07779720 on ClinicalTrials.gov

6. Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis

   Adverse outcomes in surgical sepsis patients are secondary to dysregulated emergency myelopoiesis, and expansion of myeloid-derived suppressor cells. Here we propose to determine the underlying mechanisms behind the increased expansion of these leukocyte populations and the underlying mechanisms th…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   UF Health at Shands hospital, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT05110937 on ClinicalTrials.gov

7. The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)

   The VPT Safety Trial (VPS) compares two common antibiotic combinations to see how they affect the kidneys of patients in the hospital with serious infections. Both combinations are approved by the Food and Drug Administration (FDA). The goal is to help doctors know which combination is safer so the…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Bassett Medical Center, Cooperstown, New York

   Locations

   3 in total

   Run by

   Bassett Healthcare

   See if you can join NCT07556107 on ClinicalTrials.gov

8. Limited Versus Extended Trophic Feeding (LET-FEED) Trial

   Study Hypothesis/Question In infants born very preterm, advancing enteral feeds after 24 hours from birth (limited trophic feeds) versus after 72 hours (extended trophic feeds) reduces the risk of all-cause late onset sepsis (LOS) without increasing the risk of other adverse outcomes. Study Design …

   Stage

   Phase 2

   Ages

   0 to 2

   Site

   St. Joseph's Medical Center, Tacoma, Washington

   Locations

   6 in total

   Run by

   University of Washington

   See if you can join NCT06893939 on ClinicalTrials.gov

9. Evaluation of Pediatric eCART Implementation

   This is a study comparing 3 years of retrospective data (pre-implementation) to 2 years of prospective data after the implementation of a pediatric version of Electronic Cardiac Arrest Risk Triage (pediatric eCART), a clinical decision support (CDS) tool that uses electronic health records (EHR) to…

   Stage

   Not phased

   Ages

   Up to 17

   Site

   American Family Children's Hospital, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT06771830 on ClinicalTrials.gov

10. An Acupuncture Study for People At High Risk for Sepsis

    Researchers think acupuncture may improve outcomes for participants with sepsis, based on laboratory studies and previous studies in people with sepsis. The purpose of this study to see whether real acupuncture can improve outcomes for participants with sepsis when compared to sham acupuncture. Sha…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Susan Samueli Integrative Health Institute, University of California, Irvine, Irvine, California

    Run by

    University of California, Irvine

    See if you can join NCT06344819 on ClinicalTrials.gov

11. The Effects of Endotracheal Suctioning on Pain and Serum Markers

    The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Loma Linda University Medical Center Troesh Medical Campus, Loma Linda, California

    Run by

    Loma Linda University

    See if you can join NCT06692400 on ClinicalTrials.gov

12. MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients

    The goal of this clinical trial is to learn if a new medical device that sends electrical signals to the thigh muscles is safe and easy to use for people in the ICU (Intensive Care Unit) who are at risk of losing muscle strength. It will also explore whether this treatment can help slow down muscle…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Mayo Clinic, Rochester, Minnesota

    Locations

    3 in total

    Run by

    Health Discovery Labs

    See if you can join NCT07362862 on ClinicalTrials.gov

13. Smart Discharges for Older Children

    This study is an observational multi-country cohort study that aims to build algorithms that can identify children between 5 and 16 years of age admitted for proven or suspected sepsis who are at risk of mortality after they are discharged in East Africa. In low- and middle-income countries, about …

    Stage

    Not phased

    Ages

    5 to 16

    Site

    The Rwanda Paediatric Association, Kigali,

    Locations

    7 in total

    Run by

    University of British Columbia

    See if you can join NCT07629154 on ClinicalTrials.gov

14. Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?

    The aim of this project is to test the utility of The Gene Z device (as of 2018 Gene Z no longer being used), now using In-Dx and other rapid identification techniques that the investigators have developed in the lab on clinically obtained bodily fluid samples taken from patients with suspected inf…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan Health/Sparrow (name change only), Lansing, Michigan

    Locations

    2 in total

    Run by

    Michigan State University

    See if you can join NCT01904188 on ClinicalTrials.gov

15. Recovery of Physical Function After Critical Illness In Older Adults

    The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially. Patients will be enrolled after life-saving modalities have been weaned near hospit…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    University of Kentucky, Lexington, Kentucky 40536, Lexington, Kentucky

    Run by

    University of Kentucky

    See if you can join NCT07225257 on ClinicalTrials.gov

16. Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention

    The goal of this clinical trial is to determine if vancomycin dosing in children with sepsis can be improved by using updated, personalized dosing models that account for new markers of an individual's kidney function. Vancomycin is prescribed based on the known information of how the body breaks t…

    Stage

    Phase 1

    Ages

    0 to 17

    Site

    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

    Run by

    Children's Hospital of Philadelphia

    See if you can join NCT07084129 on ClinicalTrials.gov

17. UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial

    This study is designed to test two new risk scores - one designed to predict a patient's four-hour risk of developing sepsis and one designed to predict a patient's four-hour risk of deterioration (cardiac arrest, death, unplanned ICU transfer, or rapid response team call). The goal of this study i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Maryland Medical Center - Midtown, Baltimore, Maryland

    Locations

    8 in total

    Run by

    University of Maryland, Baltimore

    See if you can join NCT06779617 on ClinicalTrials.gov

18. Biomarkers in Infection

    The purpose of this investigation is to evaluate how early biomarkers of infection and inflammation perform in identifying patients at risk for poor outcome in sepsis and septic shock.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT02545478 on ClinicalTrials.gov

19. Assessing Immune Dysfunction in Sepsis

    Sepsis leads to sustained immune system dysfunction resulting in increased susceptibility to secondary infection while in the hospital or after discharge. Consequently, many of the ~2 million Americans that develop sepsis every year will end up back in the ICU, weeks and months later. The objective…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07154615 on ClinicalTrials.gov

20. Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis

    In this research study we want to learn more about the characteristics of neutrophils that are present in the blood and secretions from a breathing tube of patients with sepsis. Sepsis is a severe type of infection, affecting various parts of the body. Neutrophils are a type of white blood cell tha…

    Stage

    Not phased

    Ages

    2 to 50

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Run by

    Boston Children's Hospital

    See if you can join NCT04103281 on ClinicalTrials.gov

21. Safe and Explainable AI

    While current AI technology is suitable for automating some repetitive clinical tasks, technical challenges remain in solving critical and gainful problems in the domains of patient and disease management. The proposed research seeks to address issues in medical AI, such as integrating medical know…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT06694181 on ClinicalTrials.gov

22. The APS Phenotyping Study

    The goal of the observational APS phenotyping study is to better understand risk factors, potential biomarkers, length and severity of illness, and recovery for adults with ARDS, pneumonia, and/ or sepsis. This study will also generate a biobank of specimens collected from these patients that will …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Fresno Community Hospital and Medical Center, Fresno, California

    Locations

    20 in total

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT06521502 on ClinicalTrials.gov

23. Predicton of Sepsis Recovery Performance Subtypes Pilot Study

    This study addresses critically ill sepsis patients' current literature reports of ongoing post-hospital discharge weakness and hospital readmissions. This study is aimed at capture and interpretation of a complex set of tests, administered during a subject's sepsis functional recovery trajectory, …

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of Alabama at Birmingham (UAB) Hospital, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05912413 on ClinicalTrials.gov

24. External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients

    To demonstrate that external drainage of thoracic duct lymph during sepsis results in a reduction in circulating pro-inflammatory cytokines. To demonstrate safety and feasibility of early thoracic duct cannulation and external lymph drainage for up to 7 days in adult surgical intensive care patient…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT04855786 on ClinicalTrials.gov

25. BLOOM: Pragmatic Feasibility Trial

    The goal of this study is to compare two different ways of dosing cefepime, an antibiotic for very sick patients - the usual approach to dosing or a new dosing method. The new dosing method uses only doses that are available in normal care, but choosing between the different doses is based on more …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07287332 on ClinicalTrials.gov