PTSD Clinical Trials

76 studies are recruiting for ptsd in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Neuromodulation of the Fear Extinction Circuit Using Temporally and Anatomically Specific TMS in Humans

   This study aims to explore the mechanisms of how transcranial magnetic stimulation (TMS) impacts fear circuits. The overarching objectives are to understand how varying TMS parameters affect targeted brain regions in order to optimize its impact on enhancing fear extinction memory consolidation in …

   Stage

   Not phased

   Ages

   18 to 70

   Site

   UTHealth Houston, Houston, Texas

   Run by

   The University of Texas Health Science Center, Houston

   See if you can join NCT05368987 on ClinicalTrials.gov

2. Psychotherapy Effects on Reward Processing in PTSD

   The purpose of this study is to identify how trauma-focused psychotherapy changes the function of brain circuitry in posttraumatic stress disorder (PTSD) and how this mediates improvements in the diminished ability to experience positive emotions following a traumatic or extremely stressful life ev…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin, Texas

   Run by

   University of Texas at Austin

   See if you can join NCT06096740 on ClinicalTrials.gov

3. Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)

   The goal of this clinical trial is to evaluate the safety and effectiveness of the gammaCore non-invasive vagus nerve stimulation (nVNS) device as an additional treatment for symptoms of post-traumatic stress disorder (PTSD) in adults. The vagus nerve connects the brain with many organs and systems…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Acacia Research Center, Sunnyvale, California

   Run by

   Acacia Clinics

   See if you can join NCT07523685 on ClinicalTrials.gov

4. Using Exercise to Enhance Fear Extinction Learning

   The goal of the current project is to establish the efficacy and mechanisms of exercise-enhanced fear extinction retrieval and generalization in posttraumatic stress disorder (PTSD). Exposure therapy is the gold standard treatment for PTSD, yet is only associated with remission rates of ~55% and in…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   Health Discovery Building, Austin, Texas

   Run by

   Josh Cisler

   See if you can join NCT07548125 on ClinicalTrials.gov

5. Positive Processes and Transition to Health - Single-Session (PATH-SS)

   The goal of this clinical trial is to test a brief, new psychotherapy (called Positive Processes and Transition to Health - Single Session, or PATH-SS) that aims to provide relief for people who are suffering after experiencing a sexual assault. This research will explore whether this new psychothe…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Case Western Reserve University, Cleveland, Ohio

   Run by

   Case Western Reserve University

   See if you can join NCT06900712 on ClinicalTrials.gov

6. A Trial Comparing Interpersonal Therapy to Exposure Therapy for PTSD Due to Military Sexual Trauma (MST) in Male and Female Military Personnel

   The purpose of this study is to compare two kinds of therapy for Posttraumatic Stress Disorder (PTSD): exposure therapy (ET) and Interpersonal Psychotherapy (IPT). The results of this study will allow us to see if IPT and ET are equally effective in treating PTSD due to Military Sexual Trauma, with…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT03803332 on ClinicalTrials.gov

7. Microbiome Modulation With Prebiotics in PTSD and Cirrhosis

   Despite medical advancements, PTSD remains a major issue in Veterans1. Current treatment strategies have relatively poor adherence. In patients with PTSD and cirrhosis, there is greater cognitive impairment as well as changes in gut microbiome structure and function2,3. In addition, when there is c…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Hunter Holmes McGuire VA Medical Center, Richmond, Virginia

   Run by

   Hunter Holmes Mcguire Veteran Affairs Medical Center

   See if you can join NCT06464952 on ClinicalTrials.gov

8. Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)

   The goal of this clinical trial is to test the extent to which different treatment components work to improve pediatric post-traumatic stress disorder (PTSD). It will also provide evidence for how these components work. The main research questions are: What are the effects of different components u…

   Stage

   Not phased

   Ages

   8 to 17

   Site

   The Mt. Hope Family Center, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT06956781 on ClinicalTrials.gov

9. Cognitive Processing Therapy (CPT) Memory Support (MS) Study

   The efficacy of psychological interventions for posttraumatic stress disorder (PTSD) is likely limited by the difficulty participants have learning and remembering important therapy content. Accordingly, the present study will examine the utility of integrating a Memory Support (MS) intervention in…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Boston Healthcare System, Jamaica Plain, Massachusetts

   Run by

   Boston University

   See if you can join NCT05310097 on ClinicalTrials.gov

10. Repurposing Low-Dose Clonidine for PTSD in Veterans

    Hypothesis: Veterans with PTSD prescribed clonidine will demonstrate improvements in PTSD symptoms, including daytime, nighttime, and sleep-related behaviors.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Aurora Psychiatric Hospital, Wauwatosa, Wisconsin

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT04877093 on ClinicalTrials.gov

11. Psychological Trauma, Post-Traumatic Stress Disorder, and Resilience in Adults With Congenital Heart Disease

    The purpose of this study, entitled "Psychological trauma, post-traumatic stress disorder, and resilience in adults with congenital heart disease in a large population sample", is to evaluate for exposures during a lifetime with congenital heart disease that may be associated with higher likelihood…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

    Locations

    3 in total

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT06952933 on ClinicalTrials.gov

12. Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series

    This study prospectively evaluates the effects of Integrative Bilateral Cervical Sympathetic Block (BCSB) on trauma-related symptoms in Special Operations Veterans, comparing outcomes in those receiving BCSB alone versus BCSB combined with structured integrative therapy. Using standardized FDA-appr…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Reset Medical and Wellness Center, Strongsville, Ohio

    Run by

    Reset Medical and Wellness Center

    See if you can join NCT07473505 on ClinicalTrials.gov

13. Testing an Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial

    Obesity and post-traumatic stress disorder (PTSD) are common among Veterans. PTSD increases risk for obesity, impacting functioning, health, quality of life, and premature mortality. Use of proven treatments for PTSD and obesity in VA is low. Furthermore, Veterans with PTSD lose less weight than th…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle, Washington

    Run by

    VA Office of Research and Development

    See if you can join NCT07010757 on ClinicalTrials.gov

14. The ED-AWARENESS-2 Trial

    The investigators will screen all mechanically ventilated ED patients for study eligibility and will enroll all consecutive patients satisfying inclusion and exclusion criteria. The study design is a pragmatic, multicenter, stepped wedge cluster randomized trial, enrolling at five sites over a 3-ye…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa

    Locations

    4 in total

    Run by

    Washington University School of Medicine

    See if you can join NCT05534243 on ClinicalTrials.gov

15. Behavioral Health Collaborative Care Model in an ICU Recovery Clinic

    Survivors of critical illness are at high risk for mental health issues such as anxiety, depression, and PTSD. This single-site, randomized controlled trial at the Medical University of South Carolina will enroll 150 patients to compare outcomes between a behavioral health Collaborative Care Model …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07372586 on ClinicalTrials.gov

16. Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot

    This pilot study evaluates the feasibility and acceptability of implementing a Behavioral Health Collaborative Care Model (BH CoCM) for family members of ICU survivors. The intervention includes telehealth-enabled behavioral health assessments and access to the NeuroFlow platform. A subset of parti…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07390786 on ClinicalTrials.gov

17. Open-Label Psilocybin Study in Transdiagnostic Population

    The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms. The secondary objective of this study is to determine whether individuals with functional impairments due to…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Connecticut Mental Health Center - Yale School of Medicine, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06442423 on ClinicalTrials.gov

18. A Mixed Methods Pilot Trial of the STEP Home Workshop to Improve Reintegration and Reduce Suicide Risk for Recently Transitioned Veterans

    Risk of Veteran suicide is elevated during the first year of transition from military service to civilian life. Most Veteran suicides occur among Veterans who are not connected to VA healthcare. Suicide prevention and connection to care are therefore critical for recently transitioning Veterans. Tr…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, Massachusetts

    Run by

    VA Office of Research and Development

    See if you can join NCT05995678 on ClinicalTrials.gov

19. Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder

    The goal of this study is to test whether anesthesia-induced dreaming can help alleviate symptoms of PTSD in an (1) open-label trial (Phase I) and (2) double-blind, randomized controlled trial (Phase II) in a non-surgical setting. The investigators predict that inducing and sustaining a dream state…

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT06577636 on ClinicalTrials.gov

20. The BEAR Program for Women With Trauma Who Have Suicidal Thoughts

    The current study aims to test the feasibility of a new form of group therapy for women who have a history of interpersonal trauma and current suicidal ideation. The Building Empowerment and Resilience (BEAR) Therapeutic group has been adapted for women who have experienced trauma and have current …

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Stanford University School of Medicine, Stanford, California

    Run by

    Stanford University

    See if you can join NCT07346638 on ClinicalTrials.gov

21. Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

    The purpose of this research is to determine if a brief treatment method is effective for preventing posttraumatic stress disorder (PTSD) and a number of other concerns following injury.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Baylor University Medical Center, Dallas, Texas

    Locations

    3 in total

    Run by

    Baylor Research Institute

    See if you can join NCT06210711 on ClinicalTrials.gov

22. Enhancing Rehabilitation for Veterans With Serious Mental Illness

    This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs). The vast majority of individuals with SMI suffer from cognitive impairments, leading to chro…

    Stage

    Not phased

    Ages

    18 to 83

    Site

    VA San Diego Healthcare System, San Diego, CA, San Diego, California

    Run by

    VA Office of Research and Development

    See if you can join NCT06586164 on ClinicalTrials.gov

23. PTSD Treatment for Incarcerated Men and Women: AV

    This research will help identify if a PTSD treatment group, called Cognitive Processing Therapy (CPT), that is used in community settings is helpful in reducing PTSD symptoms among people who are incarcerated. The goal of CPT is to create a space for people to modify unhelpful beliefs related to tr…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Psychiatric Institute and Clinic, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT07283757 on ClinicalTrials.gov

24. Phase IIa Trial of a Selective Glucocorticoid Receptor Antagonist in the Treatment of Veterans With Posttraumatic Stress Disorder (PTSD) (Seven Study)

    The purpose of this study is to test the drug CORT108297, which blocks the hormone cortisol, for treatment of PTSD in Veterans, and establish a safety profile that will inform the design of future studies.

    Stage

    Phase 2

    Ages

    18 to 69

    Site

    Tuscaloosa VA Medical Center, Tuscaloosa, AL, Tuscaloosa, Alabama

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT04452500 on ClinicalTrials.gov

25. Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder

    The goal of this trial is to test how augmented reality exposure therapy (ARET) may potentiate the effects of traditional exposure therapy administered to U.S. military personnel diagnosed with PTSD. 40 adult males and females over the age of 18 that have served, or are currently serving, in the U.…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ralph H. Johnson VA Health Care System, Charleston, South Carolina

    Run by

    Wayne State University

    See if you can join NCT06740487 on ClinicalTrials.gov