PTSD Clinical Trials

76 studies are recruiting for ptsd in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Safety and Efficacy of Cannabidiol (CBD) for Symptoms of PTSD in Adults

   Post-traumatic stress disorder (PTSD) is a psychiatric disorder than may develop following a traumatic event including serious incidents, natural or human-caused disasters, violence, death of a loved one, receipt of traumatic news, or serious illness/hospitalization. While half of US adults experie…

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   University of Nebraska Medical Center, Omaha, Nebraska

   Run by

   University of Nebraska

   See if you can join NCT05269459 on ClinicalTrials.gov

2. Exercise and Emotional Learning in Posttraumatic Stress Disorder

   The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of ima…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   University of Kentucky, Lexington, Kentucky

   Locations

   2 in total

   Run by

   Christal L Badour

   See if you can join NCT06127342 on ClinicalTrials.gov

3. Cervical Plexus Hydrodissection With D5W Versus NS for Treatment-Resistant PTSD

   PTSD is a chronic mental health condition that drastically reduces an individual's quality of life Dextrose injection with a small needle has been used for chronic pain patients and observational results have shown it to be effective in reducing anxiety, brain fog, and depression in patients with P…

   Stage

   Phase 4

   Ages

   19 to 90

   Site

   Wellward Medical, Lexington, Kentucky

   Locations

   4 in total

   Run by

   Dr. Dean Reeves Clinic

   See if you can join NCT07382596 on ClinicalTrials.gov

4. Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children

   The goal of this study is to assess Parenting STAIR Modular (PSTAIR-M), a promising and innovative intervention for military-connected mothers (MCM) who have experienced trauma and their young children (ages 2-10). PSTAIR-M aims to help mothers manage the strong feelings that sometimes happen after…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Steven A. Cohen Military Family Clinic at Endeavors, El Paso, El Paso, Texas

   Locations

   3 in total

   Run by

   New York University

   See if you can join NCT06262178 on ClinicalTrials.gov

5. Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder

   The Redefine Study (COMP202) is testing COMP360 to see if it may reduce post-traumatic stress disorder (PTSD) symptoms when administered alongside monitoring and support from a trained study team. COMP360 is a lab-made form of the naturally occurring chemical compound psilocybin.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Florida, Orlando, Florida

   Locations

   2 in total

   Run by

   COMPASS Pathways

   See if you can join NCT07570654 on ClinicalTrials.gov

6. Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans

   Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. The purpose of this study is to understand the brain mechanisms that produce…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   University of California Los Angeles, Los Angeles, California

   Locations

   2 in total

   Run by

   Duke University

   See if you can join NCT05120635 on ClinicalTrials.gov

7. Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI

   The investigators want to test a treatment for posttraumatic stress disorder (PTSD) especially designed for military veterans and service members with mild or moderate traumatic brain injuries (TBI) and PTSD. The treatment will include individual psychotherapy sessions to manage PTSD.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Carl R Darnall Army Medical Center, Fort Hood, Texas

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT07351305 on ClinicalTrials.gov

8. Cognitive Control Training for Extinction in PTSD

   The proposed study will test whether a working memory training (WMT) program improves fear extinction learning and its underlying neural circuitry in Veterans with posttraumatic stress disorder (PTSD). WMT is designed to improves the ability to maintain task-relevant information in mind. The projec…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   VA San Diego Healthcare System, San Diego, CA, San Diego, California

   Run by

   VA Office of Research and Development

   See if you can join NCT06629064 on ClinicalTrials.gov

9. COPEWeb Training for Providers

   Post-traumatic stress disorder (PTSD) and substance use disorders (SUD) are two of the most common and debilitating mental health conditions afflicting military Veterans. PTSD and SUD frequently co-occur and are associated with poorer treatment outcomes. The investigators' team developed a trauma-f…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina

   Run by

   VA Office of Research and Development

   See if you can join NCT05812131 on ClinicalTrials.gov

10. Treatments for Insomnia in Veterans With PTSD

    This randomized trial will compare a novel treatment, Acceptance of the Behavioral Changes to Treat Insomnia (ABC-I) to Cognitive Behavioral Therapy for Insomnia (CBT-I) among Veterans with comorbid Post-Traumatic Stress Disorder (PTSD) and insomnia disorder. ABC-I combines the behavioral component…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Greater Los Angeles Healthcare System, Sepulveda, CA, Sepulveda, California

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT05194930 on ClinicalTrials.gov

11. Vagal Nerve Stimulation in mTBI

    Mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) are important conditions for the Veterans Administration (VA) that frequently occur together in combat Veterans from the conflicts in Afghanistan and Iraq. In many Veterans these become chronic, raising the risk the burden …

    Stage

    Not phased

    Ages

    18 to 55

    Site

    Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia

    Run by

    VA Office of Research and Development

    See if you can join NCT04437498 on ClinicalTrials.gov

12. FLOAT for Healthcare PTSS

    This early-stage pilot trial aims to examine the feasibility, tolerability, and safety of Floatation-REST, or Reduced Environmental Stimulation Therapy via floatation in frontline healthcare workers, first responders, and emergency medical personnel who experience post-traumatic stress symptoms.

    Stage

    EARLY_Phase 1

    Ages

    18 to 64

    Site

    Laureate Institute for Brain Research, Tulsa, Oklahoma

    Run by

    Laureate Institute for Brain Research, Inc.

    See if you can join NCT07710417 on ClinicalTrials.gov

13. Temporal Interference in Psychiatry (TIP): Neuromodulation Using Temporal Interference

    This study aims to understand the neural, behavioral and clinical effects of temporal interference (TI), a type of neuromodulation method, in healthy populations and in individuals with anxiety and stress-related conditions.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Emory University, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07558759 on ClinicalTrials.gov

14. Improving Behavioral Health for Caregivers and Children After Pediatric Injury

    Pediatric traumatic injury (PTI) is a public health priority, with more than 125,000 children experiencing injuries that require hospitalization each year. These children, and their caregivers, are affected in many ways that may affect quality of life, emotional and behavioral health, physical reco…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Children's Hospital Los Angeles, Los Angeles, California

    Locations

    4 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT06856057 on ClinicalTrials.gov

15. Adolescent Stress and Substance Intervention Subsequent to Trauma

    The long-term goal of this study is to address the adoption of the new trauma center requirement to establish best practices of screening for acute stress with an intervention to prevent both adolescent PTSD and substance use. The investigators will develop, refine, and pilot test the Adolescent St…

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Rhode Island Hospital, Providence, Rhode Island

    Run by

    Rhode Island Hospital

    See if you can join NCT07197476 on ClinicalTrials.gov

16. Examining the Efficacy of Short-Term Intensive PTSD Treatment on Psychological and Cognitive Impairment Symptoms

    Our long-term goal is to provide rapid and sustained reductions of trauma and cognitive-related symptoms among Special Operations personnel with PTSD or subthreshold PTSD. The primary objective of this project is to examine the effectiveness of massed PTSD treatment (i.e., CPT and EMDR) in "real-wo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Fort Bragg, Fayetteville, North Carolina

    Run by

    Ohio State University

    See if you can join NCT07680517 on ClinicalTrials.gov

17. Testing Adaptive Interventions to Improve Posttraumatic Stress Disorder Treatment Outcomes in Federally Qualified Health Centers

    This trial is being completed to develop a stepped-care talk therapy model for patients with PTSD. Specifically, this study is testing whether beginning with one type of therapy is better than beginning with another type of therapy, and whether moving to a different therapy after four sessions is m…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Grace Health, Battle Creek, Michigan

    Locations

    13 in total

    Run by

    University of Michigan

    See if you can join NCT05457985 on ClinicalTrials.gov

18. Psilocybin-Assisted Therapy for Sexual Assault-Related PTSD

    A Phase 2, Open-Label Study to explore the efficacy, safety, and tolerability of psilocybin-assisted therapy in women with sexual assault-related Posttraumatic Stress Disorder (PTSD).

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Sunstone Medical, PC, Rockville, Maryland

    Run by

    Sunstone Medical

    See if you can join NCT06902974 on ClinicalTrials.gov

19. Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD

    The long-term goal of this study is to reduce suicidal thoughts and behaviors among treatment-seeking individuals who also have posttraumatic stress disorder (PTSD). Prolonged exposure (PE) and crisis response plan (CRP) have demonstrated empirical support for reducing suicide attempts as compared …

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06285708 on ClinicalTrials.gov

20. Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma

    The U.S. Deaf community - a group of more than one million Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure compared to the general population. Although there are several treatments f…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Massachusetts Medical School, Worcester, Massachusetts

    Run by

    University of Massachusetts, Worcester

    See if you can join NCT06278922 on ClinicalTrials.gov

21. Integrated PTSD and Chronic Pain Treatment

    Posttraumatic stress disorder (PTSD) occurs in approximately 7% of adults in the general population. PTSD greatly impacts quality of life and often co-occurs with other conditions such as chronic pain. Individuals with co-morbid PTSD and chronic pain demonstrate higher PTSD symptoms and pain (as we…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT07225049 on ClinicalTrials.gov

22. Evaluating The Efficacy Of Combined Cognitive Processing Therapy and Stellate Ganglion Blocks for PTSD

    The purpose of this study is to understand if we can improve the treatment for posttraumatic stress disorder (PTSD). We are looking into whether the combination of Stellate Ganglion Block (SGB) treatment and Cognitive Processing Therapy (CPT) can reduce symptoms of PTSD. CPT is a trauma-focused tal…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Rush University Medical Center, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT06570213 on ClinicalTrials.gov

23. Treatment for Antepartum Posttraumatic Stress Disorder/PTSD Study

    The majority of women with perinatal posttraumatic stress disorder (PTSD) do not receive mental health treatment despite the documented associations between PTSD and adverse pregnancy outcomes; this is likely due to workforce shortages, lack of data on the effectiveness of existing evidence-based t…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Boston Medical Center and remote, Boston, Massachusetts

    Run by

    Boston University

    See if you can join NCT05486793 on ClinicalTrials.gov

24. Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder

    This study is a community-informed, pragmatic, open-label, phase 1 clinical trial of group-format psilocybin-assisted therapy (GPAT) for individuals with post-traumatic stress disorder (PTSD). The primary objectives of this phase 1 study are to assess the safety and feasibility of (GPAT) for indivi…

    Stage

    Phase 1

    Ages

    18 to 89

    Site

    Interdisciplinary Substance Use and Brain Injury (ISUBI), Albuquerque, New Mexico

    Run by

    University of New Mexico

    See if you can join NCT07506395 on ClinicalTrials.gov

25. Safe Mothers, Safe Children Initiative

    The purpose of this study is to assess the efficacy of the combined interventions, Skills Training in Affective and Interpersonal Regulation (STAIR) and Parent-Child Interaction Therapy (PCIT) or P-STAIR, for treating maternal PTSD and reducing maltreatment recidivism.

    Stage

    Not phased

    Ages

    18 and older

    Site

    McSilver Institute for Poverty Policy and Research, New York, New York

    Run by

    New York University

    See if you can join NCT04752618 on ClinicalTrials.gov