PTSD Clinical Trials

74 studies are recruiting for ptsd in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Open-Label Psilocybin Study in Transdiagnostic Population

   The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms. The secondary objective of this study is to determine whether individuals with functional impairments due to…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Connecticut Mental Health Center - Yale School of Medicine, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06442423 on ClinicalTrials.gov

2. PTSD Screening in Pregnant Black Women

   This study will compare the effectiveness of two active screening interventions in improving post-traumatic stress disorder (PTSD) symptoms, maternal perinatal care utilization, satisfaction utilization of mental healthcare services, and maternal health and birth-related outcomes for Black pregnant…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Grady Health System, Atlanta, Georgia

   Locations

   2 in total

   Run by

   Emory University

   See if you can join NCT06522022 on ClinicalTrials.gov

3. Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder

   The Redefine Study (COMP202) is testing COMP360 to see if it may reduce post-traumatic stress disorder (PTSD) symptoms when administered alongside monitoring and support from a trained study team. COMP360 is a lab-made form of the naturally occurring chemical compound psilocybin.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   AZ, Tucson, Arizona

   Locations

   10 in total

   Run by

   COMPASS Pathways

   See if you can join NCT07570654 on ClinicalTrials.gov

4. Exercise and Emotional Learning in Posttraumatic Stress Disorder

   The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of ima…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   University of Kentucky, Lexington, Kentucky

   Locations

   2 in total

   Run by

   Christal L Badour

   See if you can join NCT06127342 on ClinicalTrials.gov

5. Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

   The purpose of this research is to determine if a brief treatment method is effective for preventing posttraumatic stress disorder (PTSD) and a number of other concerns following injury.

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Baylor University Medical Center, Dallas, Texas

   Locations

   3 in total

   Run by

   Baylor Research Institute

   See if you can join NCT06210711 on ClinicalTrials.gov

6. The ED-AWARENESS-2 Trial

   The investigators will screen all mechanically ventilated ED patients for study eligibility and will enroll all consecutive patients satisfying inclusion and exclusion criteria. The study design is a pragmatic, multicenter, stepped wedge cluster randomized trial, enrolling at five sites over a 3-ye…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa

   Locations

   4 in total

   Run by

   Washington University School of Medicine

   See if you can join NCT05534243 on ClinicalTrials.gov

7. K08 VR Fear Conditioning

   The goal of this clinical trial is to learn how people respond to fear-related experiences in a virtual reality (VR) environment. The study will also look at how brain activity and body responses are connected to learning and memory of fear. To do so, we recruit individuals who are already implante…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT07216222 on ClinicalTrials.gov

8. Cognitive Control Training for Extinction in PTSD

   The proposed study will test whether a working memory training (WMT) program improves fear extinction learning and its underlying neural circuitry in Veterans with posttraumatic stress disorder (PTSD). WMT is designed to improves the ability to maintain task-relevant information in mind. The projec…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   VA San Diego Healthcare System, San Diego, CA, San Diego, California

   Run by

   VA Office of Research and Development

   See if you can join NCT06629064 on ClinicalTrials.gov

9. Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)

   The goal of this clinical trial is to evaluate the safety and effectiveness of the gammaCore non-invasive vagus nerve stimulation (nVNS) device as an additional treatment for symptoms of post-traumatic stress disorder (PTSD) in adults. The vagus nerve connects the brain with many organs and systems…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Acacia Research Center, Sunnyvale, California

   Run by

   Acacia Clinics

   See if you can join NCT07523685 on ClinicalTrials.gov

10. Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder

    The goal of this study is to test whether anesthesia-induced experiences can help alleviate symptoms of PTSD in an (1) open-label trial (Phase I) and (2) single-center double-blind, randomized, active-comparator (dose-controlled) participant-and assessor-blinded Phase 2 clinical trial (Phase II) in…

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT06577636 on ClinicalTrials.gov

11. Psilocybin-Assisted Therapy

    This pilot study will examine the safety, tolerability, acceptability, and efficacy of combination psilocybin + psychotherapy to decrease PTSD symptoms. Participants will be randomized into two different treatment groups, allowing the investigators to directly compare PE augmented with psilocybin a…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Emory University Hospital, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07332143 on ClinicalTrials.gov

12. Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study

    The goal of this study is to examine changes in blood biomarkers following hyperbaric oxygen therapy (HBOT) in military veterans with traumatic brain injury and persistent post-concussive symptoms. The main questions it aims to answer are: 1. Does HBOT produce measurable changes in inflammatory, ne…

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Summit Hyperbarics and Wellness, Boise, Idaho

    Run by

    Summit Hyperbarics and Wellness

    See if you can join NCT07849465 on ClinicalTrials.gov

13. Comparing Telehealth to In-person a Combined Metacognitive Training in Veterans With mTBI/PTSD

    Veterans with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) commonly experience cognitive impairments including attention and executive function deficits that interfere with their ability to engage in productive personal and social activities. Of the limited intervent…

    Stage

    Not phased

    Ages

    30 to 55

    Site

    North Florida/South Georgia Veterans Health System, Gainesville, FL, Gainesville, Florida

    Run by

    VA Office of Research and Development

    See if you can join NCT05380050 on ClinicalTrials.gov

14. Safety and Efficacy of Cannabidiol (CBD) for Symptoms of PTSD in Adults

    Post-traumatic stress disorder (PTSD) is a psychiatric disorder than may develop following a traumatic event including serious incidents, natural or human-caused disasters, violence, death of a loved one, receipt of traumatic news, or serious illness/hospitalization. While half of US adults experie…

    Stage

    Phase 2

    Ages

    21 to 65

    Site

    University of Nebraska Medical Center, Omaha, Nebraska

    Run by

    University of Nebraska

    See if you can join NCT05269459 on ClinicalTrials.gov

15. Cervical Plexus Hydrodissection With D5W Versus NS for Treatment-Resistant PTSD

    PTSD is a chronic mental health condition that drastically reduces an individual's quality of life Dextrose injection with a small needle has been used for chronic pain patients and observational results have shown it to be effective in reducing anxiety, brain fog, and depression in patients with P…

    Stage

    Phase 4

    Ages

    19 to 90

    Site

    Wellward Medical, Lexington, Kentucky

    Locations

    4 in total

    Run by

    Dr. Dean Reeves Clinic

    See if you can join NCT07382596 on ClinicalTrials.gov

16. Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children

    The goal of this study is to assess Parenting STAIR Modular (PSTAIR-M), a promising and innovative intervention for military-connected mothers (MCM) who have experienced trauma and their young children (ages 2-10). PSTAIR-M aims to help mothers manage the strong feelings that sometimes happen after…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Steven A. Cohen Military Family Clinic at Endeavors, El Paso, El Paso, Texas

    Locations

    3 in total

    Run by

    New York University

    See if you can join NCT06262178 on ClinicalTrials.gov

17. Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans

    Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. The purpose of this study is to understand the brain mechanisms that produce…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of California Los Angeles, Los Angeles, California

    Locations

    2 in total

    Run by

    Duke University

    See if you can join NCT05120635 on ClinicalTrials.gov

18. Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI

    The investigators want to test a treatment for posttraumatic stress disorder (PTSD) especially designed for military veterans and service members with mild or moderate traumatic brain injuries (TBI) and PTSD. The treatment will include individual psychotherapy sessions to manage PTSD.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Carl R Darnall Army Medical Center, Fort Hood, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT07351305 on ClinicalTrials.gov

19. COPEWeb Training for Providers

    Post-traumatic stress disorder (PTSD) and substance use disorders (SUD) are two of the most common and debilitating mental health conditions afflicting military Veterans. PTSD and SUD frequently co-occur and are associated with poorer treatment outcomes. The investigators' team developed a trauma-f…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina

    Run by

    VA Office of Research and Development

    See if you can join NCT05812131 on ClinicalTrials.gov

20. Treatments for Insomnia in Veterans With PTSD

    This randomized trial will compare a novel treatment, Acceptance of the Behavioral Changes to Treat Insomnia (ABC-I) to Cognitive Behavioral Therapy for Insomnia (CBT-I) among Veterans with comorbid Post-Traumatic Stress Disorder (PTSD) and insomnia disorder. ABC-I combines the behavioral component…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Greater Los Angeles Healthcare System, Sepulveda, CA, Sepulveda, California

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT05194930 on ClinicalTrials.gov

21. FLOAT for Healthcare PTSS

    This early-stage pilot trial aims to examine the feasibility, tolerability, and safety of Floatation-REST, or Reduced Environmental Stimulation Therapy via floatation in frontline healthcare workers, first responders, and emergency medical personnel who experience post-traumatic stress symptoms.

    Stage

    EARLY_Phase 1

    Ages

    18 to 64

    Site

    Laureate Institute for Brain Research, Tulsa, Oklahoma

    Run by

    Laureate Institute for Brain Research, Inc.

    See if you can join NCT07710417 on ClinicalTrials.gov

22. Temporal Interference in Psychiatry (TIP): Neuromodulation Using Temporal Interference

    This study aims to understand the neural, behavioral and clinical effects of temporal interference (TI), a type of neuromodulation method, in healthy populations and in individuals with anxiety and stress-related conditions.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Emory University, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07558759 on ClinicalTrials.gov

23. Improving Behavioral Health for Caregivers and Children After Pediatric Injury

    Pediatric traumatic injury (PTI) is a public health priority, with more than 125,000 children experiencing injuries that require hospitalization each year. These children, and their caregivers, are affected in many ways that may affect quality of life, emotional and behavioral health, physical reco…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Children's Hospital Los Angeles, Los Angeles, California

    Locations

    4 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT06856057 on ClinicalTrials.gov

24. Adolescent Stress and Substance Intervention Subsequent to Trauma

    The long-term goal of this study is to address the adoption of the new trauma center requirement to establish best practices of screening for acute stress with an intervention to prevent both adolescent PTSD and substance use. The investigators will develop, refine, and pilot test the Adolescent St…

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Rhode Island Hospital, Providence, Rhode Island

    Run by

    Rhode Island Hospital

    See if you can join NCT07197476 on ClinicalTrials.gov

25. Examining the Efficacy of Short-Term Intensive PTSD Treatment on Psychological and Cognitive Impairment Symptoms

    Our long-term goal is to provide rapid and sustained reductions of trauma and cognitive-related symptoms among Special Operations personnel with PTSD or subthreshold PTSD. The primary objective of this project is to examine the effectiveness of massed PTSD treatment (i.e., CPT and EMDR) in "real-wo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Fort Bragg, Fayetteville, North Carolina

    Run by

    Ohio State University

    See if you can join NCT07680517 on ClinicalTrials.gov