PTSD Clinical Trials

76 studies are recruiting for ptsd in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma

   The principal investigator for this study plans to build upon the psilocybin-assisted therapy intervention used in prior completed trials to conduct an open-label trial of two psilocybin administration sessions combined with psychotherapy to investigate the safety, tolerability, and clinical effica…

   Stage

   Phase 2

   Ages

   21 to 64

   Site

   Baylor College of Medicine, Houston, Texas

   Run by

   Baylor College of Medicine

   See if you can join NCT06888128 on ClinicalTrials.gov

2. Neural Connectivity During Therapy for Adolescent PTSD

   Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying cognitive, social and emotional skills. Neuroimaging research that seeks to identify the neural mechanisms of treatments for PTSD could lead to novel treatments, but progress has been slow using current methods…

   Stage

   Not phased

   Ages

   12 to 17

   Site

   UT Health Department of Psychiatry, San Antonio, Texas

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT05423444 on ClinicalTrials.gov

3. Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms

   Art therapy is used across the Military Health System for treatment of posttraumatic symptoms, but there is limited research on how art therapy is able to restore emotional expression and regulation in service members. This research hopes to learn about the effects of art therapy on emotional expre…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   National Intrepid Center of Excellence, Bethesda, Maryland

   Locations

   2 in total

   Run by

   Walter Reed National Military Medical Center

   See if you can join NCT05414708 on ClinicalTrials.gov

4. Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)

   By doing this research project, the investigators hope to learn which strategies work best to help veterans who are not benefiting from their first PTSD treatment or not completing between-session homework assignments regularly that might improve treatment response. The investigators also want to l…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Augusta VA, Augusta, Georgia

   Locations

   4 in total

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT07176273 on ClinicalTrials.gov

5. Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building

   This is a two-part study to develop and test a brief, virtual therapy program for lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people who have experienced trauma and use alcohol. Phase 1: You'll be invited to share your perspective to help make the program relevant, inclusive, and affirm…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Rhode Island, Providence, Rhode Island

   Run by

   University of Rhode Island

   See if you can join NCT07217795 on ClinicalTrials.gov

6. Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

   The purpose of this study is to use a non-invasive imaging technique called positron emission tomography/magnetic resonance imaging (PET/MRI) to investigate the effects of exercise on brain activity and arterial (blood vessel) inflammation in people with PTSD symptoms and evidence of or elevated ri…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07260032 on ClinicalTrials.gov

7. Patient Outcome Reporting for Timely Assessments of Life With Post-Traumatic Stress Disorder

   This study aims to implement and evaluate a more timely approach to post-traumatic stress disorder (PTSD) diagnosis and management, entitled Patient Outcome Reporting for Timely Assessments of Life with Post-Traumatic Stress Disorder (PORTAL-PTSD) in a primary care setting with a high prevalence of…

   Stage

   Not phased

   Ages

   18 and older

   Site

   CFHC South Chicago, Chicago, Illinois

   Locations

   2 in total

   Run by

   University of Chicago

   See if you can join NCT06479447 on ClinicalTrials.gov

8. Post-Traumatic Stress Disorder Focused Psychodynamic Psychotherapy

   This is a randomized controlled trial of Trauma-Focused Psychodynamic Psychotherapy (TFPP) in comparison with TAU (at the VA) in a 2:1 ratio in 75 Veterans with PTSD who have not responded to standard treatment at the VA.

   Stage

   Not phased

   Ages

   18 to 70

   Site

   VA New York Harbor Healthcare System - Manhattan Campus, New York, New York

   Run by

   Montefiore Medical Center

   See if you can join NCT03755401 on ClinicalTrials.gov

9. PTSD Screening in Pregnant Black Women

   This study will compare the effectiveness of two active screening interventions in improving post-traumatic stress disorder (PTSD) symptoms, maternal perinatal care utilization, satisfaction utilization of mental healthcare services, and maternal health and birth-related outcomes for Black pregnant…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Grady Health System, Atlanta, Georgia

   Locations

   2 in total

   Run by

   Emory University

   See if you can join NCT06522022 on ClinicalTrials.gov

10. Comparing Telehealth to In-person a Combined Metacognitive Training in Veterans With mTBI/PTSD

    Veterans with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) commonly experience cognitive impairments including attention and executive function deficits that interfere with their ability to engage in productive personal and social activities. Of the limited intervent…

    Stage

    Not phased

    Ages

    30 to 55

    Site

    North Florida/South Georgia Veterans Health System, Gainesville, FL, Gainesville, Florida

    Run by

    VA Office of Research and Development

    See if you can join NCT05380050 on ClinicalTrials.gov

11. Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset

    Although most people recover from acute pain (such as pain caused by injury, surgery, repetitive motion, or unknown causes), many people do not fully recover and will experience chronic pain. Untreated posttraumatic stress disorder (PTSD) appears to be a key risk factor for the transition from acut…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Rush University Medical Center, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT05700279 on ClinicalTrials.gov

12. Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families

    The proposed study draws on prior research to evaluate the feasibility, acceptability and explore preliminary effectiveness of Coffee and Family Education and Support, Version (CAFES2) using a pilot randomized type 1 hybrid effectiveness-implementation design. CAFES2 is a peer-led family and social…

    Stage

    Not phased

    Ages

    12 to 55

    Site

    University of Illinios Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT06261463 on ClinicalTrials.gov

13. Self-Management Interventions After an ICD Shock

    This study, "Biobehavioral Intervention to Reduce PTSD Symptoms After an ICD Shock," addresses a critical need in cardiology care by describing the feasibility and acceptability of a timely, highly promising, electronically-delivered intervention for patients who have recently received an ICD deliv…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Washington, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06037785 on ClinicalTrials.gov

14. Determining the Right Acupuncture for Good Recovery Over Neuropsychiatric Trauma

    This study seeks to verify that a specific acupuncture treatment is effective at reducing symptoms of neuropsychiatric trauma found in those diagnosed with Post-Traumatic Stress Disorder (PTSD).

    Stage

    Not phased

    Ages

    18 to 74

    Site

    Mike O'Callaghan Military Medical Center, Nellis Air Force Base, Nevada

    Run by

    Paul Crawford

    See if you can join NCT05516862 on ClinicalTrials.gov

15. MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress Disorder

    In partnership with the Veterans Affairs (VA) Palo Alto Health Care System and Stanford University, this study aims to evaluate clinical outcomes, assess implementation feasibility, and health economics of MDMA-assisted Cognitive Processing Therapy (MDMA-aCPT) in the treatment of posttraumatic stre…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    VA Palo Alto Health Care System / Stanford University, Palo Alto, California

    Run by

    Patricia Suppes

    See if you can join NCT05837845 on ClinicalTrials.gov

16. Project Safe Guard-Trauma

    The goal of this randomized controlled trial is to determine if a counseling intervention, Project Safe Guard-Trauma (PSG-T), increases secure firearm storage practices in adults who screen positive for posttraumatic stress disorder (PTSD). The main questions this study aims to answer are: * Does P…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06876740 on ClinicalTrials.gov

17. Glecaprevir/Pibrentasvir for Post-traumatic Stress Disorder

    A double-blind randomized placebo-controlled trial to further investigate glecaprevir/pibrentasvir (GLE/PIB), a direct acting antiviral (DAA) that has been associated with posttraumatic stress disorder (PTSD) symptom improvement when prescribed for the treatment of chronic hepatitis C viral infecti…

    Stage

    Phase 2

    Ages

    19 to 70

    Site

    White River Junction VAMC, White River Junction, Vermont

    Run by

    White River Junction Veterans Affairs Medical Center

    See if you can join NCT05637879 on ClinicalTrials.gov

18. A Comparative Effectiveness Study of PTSD Treatments Among Sexual and Gender Minority Populations

    The goal of this clinical trial is see if Cognitive Processing Therapy and STAIR Narrative Therapy work to treat posttraumatic stress disorder (PTSD) among lesbian, gay, bisexual, transgender, queer/questioning, intersex, asexual/aromantic, and all other sexual or gender minority (LGBTQIA+) adults.…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Stanford University, Palo Alto, California

    Locations

    2 in total

    Run by

    Stanford University

    See if you can join NCT06367764 on ClinicalTrials.gov

19. NYSCF Scientific Discovery Biobank

    The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, and store th…

    Stage

    Not phased

    Ages

    0 and older

    Site

    New York Stem Cell Foundation Research Institute, New York, New York

    Run by

    New York Stem Cell Foundation Research Institute

    See if you can join NCT06203106 on ClinicalTrials.gov

20. The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD

    This study is aimed to evaluate outpatient ketamine infusion within a military chronic neuropathic pain population and its effect on PTSD. Currently, this is a pilot study with 30 participants. Participants will be randomized to (1) a moderate dose ketamine, (2) moderate dose ketamine +Mg, or (3) a…

    Stage

    Phase 4

    Ages

    18 to 70

    Site

    Brooke Army Medical Center, San Antonio, Texas

    Run by

    Margaux M. Salas, PhD

    See if you can join NCT06414356 on ClinicalTrials.gov

21. Evaluation of the H.O.O.V.E.S. Healing Intensives Program

    The aim of this study is to measure the impact of these H.O.O.V.E.S. healing intensives on Veteran participants using several psychological instruments. The investigators are planning to administer the demographic questionnaires and psychological instruments to Veteran participants before the heali…

    Stage

    Not phased

    Ages

    18 to 120

    Site

    George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah

    Run by

    VA Salt Lake City Health Care System

    See if you can join NCT06300255 on ClinicalTrials.gov

22. Biomarkers in the Retina for Prognosticating Mental Health Treatments

    Title: ERG as a potential biomarker of SSRI-responsive PTSD: A pilot study Posttraumatic stress disorder (PTSD) affects many individuals who experience a traumatic event. Previous studies suggest that there is a connection between the brain and the retina, and that the electroretinogram (ERG) may b…

    Stage

    Not phased

    Ages

    21 to 75

    Site

    VA Puget Sound Health Care System, Seattle, Washington

    Run by

    VA Puget Sound Health Care System

    See if you can join NCT06363968 on ClinicalTrials.gov

23. Targeting the Default Mode Network: A TMS-fMRI Study

    In post-traumatic stress disorder (PTSD), intrusive, traumatic, autobiographical memories lead to anxiety symptoms. Recent work suggests a new repetitive pulse transcranial magnetic stimulation (rTMS) brain target that might bring relief. Since this proposed target is not well understood, the goal …

    Stage

    Not phased

    Ages

    18 to 55

    Site

    VA Palo Alto, Palo Alto, California

    Run by

    Allyson Rosen

    See if you can join NCT05646732 on ClinicalTrials.gov

24. The Influence of Aerobic Exercise on Consolidation of Fear Extinction Learning in PTSD

    This study aims to test whether aerobic exercise performed after fear extinction learning improves cognitive, physiological, and neural indices of extinction recall in a sample of trauma-exposed men and women with and without posttraumatic stress disorder (PTSD). Participants will complete a clinic…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    Wade Hall - University of Alabama, Tuscaloosa, Alabama

    Run by

    University of Alabama, Tuscaloosa

    See if you can join NCT06144203 on ClinicalTrials.gov

25. Improving Therapeutic Learning for PTSD

    The proposed project seeks to demonstrate the engagement of post-exposure dopamine neurotransmission and downstream acute reorganization of dopaminergic resting-state neural networks as a means of increasing consolidation of extinction memories formed during analogue exposure therapy in adult women…

    Stage

    Phase 2

    Ages

    21 to 50

    Site

    University of Texas, Austin, Texas

    Locations

    2 in total

    Run by

    University of Wisconsin, Madison

    See if you can join NCT04558112 on ClinicalTrials.gov