Prostate Cancer Clinical Trials

287 studies are recruiting for prostate cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 11

1. Evaluation of Response to Abiraterone/Prednisone by Race/Ethnicity and Other Factors in Metastatic Hormone Naive Prostate Cancer

   The investigators are conducting this study with men that have prostate cancer and are getting standard of care treatment with the drugs abiraterone acetate and prednisone. The study will follow men with prostate cancer from initiation of participation in the study and for up to 10 years. The reaso…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Ben Taub General Hospital, Houston, Texas

   Locations

   3 in total

   Run by

   Martha Mims

   See if you can join NCT03833921 on ClinicalTrials.gov

2. RCT of NLP-Based Feedback for Improving SDM in Men With Localized Prostate Cancer

   The purpose of the research is to assess the impact of a natural language processing + artificial intelligence (NLP+AI)-based risk communication feedback system to improve quality of risk communication of key tradeoffs during prostate cancer consultations among physicians and to improve patient dec…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cedars Sinai Medical Center, Los Angeles, California

   Run by

   Cedars-Sinai Medical Center

   See if you can join NCT06856694 on ClinicalTrials.gov

3. A Study of MT-4561 in Patients With Various Advanced Solid Tumors

   This is a First In Human (FIH), multicenter, open-label, Phase I/II study to evaluate safety, tolerability, Pharmacokinetics (PK), pharmacodynamics, and efficacy of MT-4561 in patients with advanced solid tumors. This study will be conducted in 3 parts. Part 1 is aimed at evaluating safety, tolerab…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Southern California, Los Angeles, California

   Locations

   6 in total

   Run by

   Tanabe Pharma America, Inc.

   See if you can join NCT06943521 on ClinicalTrials.gov

4. Designing Visual Tools to Enhance Cancer Surgeon Decision-making

   This prospective study will compare pre-post pilot test of surgeon-facing, visual decision support among urologists seeing patients with newly diagnosed localized prostate and kidney cancer. Up to 20 urologists (10 academic and 10 community) will be enrolled. The goal will be to capture up to 10 pr…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

   Locations

   2 in total

   Run by

   UNC Lineberger Comprehensive Cancer Center

   See if you can join NCT06965192 on ClinicalTrials.gov

5. Utility of Biparametric MRI (Magnetic Resonance Imaging) as a Screening Tool for Prostate Cancer in a High-Risk Cohort

   To determine whether using bpMRI in subjects who are at high risk of developing prostate cancer in conjunction with PSA will improve prostate cancer screening protocols.

   Stage

   Not phased

   Ages

   40 to 55

   Site

   Cynthia Knauer, Lake Success, New York

   Run by

   Northwell Health

   See if you can join NCT05384535 on ClinicalTrials.gov

6. Interstitial Assessment of Architectural Heterogeneity in Prostate Cancer Using a Fine Needle Photoacoustic Probe

   In this project, we will integrate the Photoacoustic (PA) technology into a prostate biopsy procedure through a fine needle probe. The needle probe will be in the shape of a biopsy needle and compatible with the needle insertion mechanism in the transrectal ultrasound (TRUS) probe. When inserted in…

   Stage

   Not phased

   Ages

   40 to 80

   Site

   University of Michigan Rogel Cancer Center, Ann Arbor, Michigan

   Run by

   University of Michigan Rogel Cancer Center

   See if you can join NCT05965180 on ClinicalTrials.gov

7. Building on Trust: Navigating Preventive Lung, Breast, and Prostate Cancer Screenings at Community Resource Spots

   To evaluate a community-based outreach initiative for screening, diagnosis, and treatment of breast, lung, and prostate cancers in underserved adults using the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) implementation science framework.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Adventhealth, Orlando, Florida

   Run by

   AdventHealth

   See if you can join NCT07231159 on ClinicalTrials.gov

8. Stereotactic Magnetic Resonance Guided Radiation Therapy

   This is a master prospective Phase I-II trial evaluating feasibility and efficacy of stereotactic magnetic resonance (MR) guided adaptive radiation therapy (SMART) in patients with cancer. * The phase 1 study will evaluate the feasibility and safety of delivering SMART in patients with cancer. * Ph…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham & Women's Hospital, Boston, Massachusetts

   Locations

   2 in total

   Run by

   Dana-Farber Cancer Institute

   See if you can join NCT04115254 on ClinicalTrials.gov

9. Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer

   The goal of this clinical trial is to evaluate a screening method to detect clinically relevant prostate cancer. This clinical trial is using genetic data to determine a man's risk of cancer, together with multiparametric magnetic resonance imaging (mpMRI) to identify men with higher grade cancer. …

   Stage

   Not phased

   Ages

   40 to 69

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Locations

   5 in total

   Run by

   Adam S. Kibel, MD

   See if you can join NCT06398639 on ClinicalTrials.gov

10. Understanding of Genetics by Men at Risk for Prostate Cancer

    With this greater certainty regarding prognosis, men with localized prostate cancer are now equipped with make better treatment planning decisions. This study is designed to investigate the understanding of prognostic genetic technology in African American and rural White men at risk for localized …

    Stage

    Not phased

    Ages

    40 to 95

    Site

    Mayo Clinic, Phoenix, Arizona

    Locations

    3 in total

    Run by

    Mayo Clinic

    See if you can join NCT04550845 on ClinicalTrials.gov

11. Effect of Text Message Reminders on M-ISI Score After Prostate Surgery

    The purpose of this study is to compare post-prostatectomy incontinence via Michigan Incontinence Score Index in patients receiving daily text message reminders for pelvic floor exercises when compared to those not receiving text reminders.

    Stage

    Not phased

    Ages

    18 and older

    Site

    158 Sawgrass clinic; Suite 3100, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT07071207 on ClinicalTrials.gov

12. Prostate Tissue BioBank

    Prostate cancer is also the most common cancer in men with inherited pathogenic variants in BRCA1 and BRCA2. Beyond BRCA1/2, other genes are known to increase the risk of prostate cancer, including ATM, TP53 and HOXB13. The investigators have shown that 5% of men diagnosed with prostate cancer loca…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT06659614 on ClinicalTrials.gov

13. Circulating Tumor DNA in High Risk Localized Prostate Cancer

    This prospective, non-therapeutic translational biomarker study will collect blood in patients with high risk localized prostate cancer prior to prostatectomy.

    Stage

    Not phased

    Ages

    18 and older

    Site

    UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT07222436 on ClinicalTrials.gov

14. ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials

    This study will follow men with metastatic castration resistant prostate cancer throughout their standard of care treatment for their disease to determine if the presence of different genes or proteins can predict which patients respond to the cancer treatment they receive. As tumors grow and begin…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Cancer Center, New York, New York

    Locations

    3 in total

    Run by

    Duke University

    See if you can join NCT06141993 on ClinicalTrials.gov

15. Fusion or Cognitive Ultrasound-guided Biopsy to Detect Prostate Cancer

    The MRI-targeted biopsy for prostate cancer detection can be performed using one of two techniques: 1. Software-based fusion of MRI and ultrasound images (software fusion) or 2. Visually estimated MRI-informed (cognitive fusion) technique To date, there is a lack of adequately powered RCTs directly…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Lahey Clinic, Inc, Burlington, Massachusetts

    Locations

    4 in total

    Run by

    Albany Medical College

    See if you can join NCT06517901 on ClinicalTrials.gov

16. Study to Assess the Feasibility of Stopping Prostate Cancer Treatment Early in Elderly Patients

    This study seeks to identify if it is feasible to stop Luteinizing Hormone-Releasing Hormone (LHRH) Agonist Therapy in elderly men with prostate cancer. We hypothesize that elderly prostate cancer patients on long term androgen ablation with LHRH agonists will be permanently castrated and do not re…

    Stage

    Not phased

    Ages

    70 and older

    Site

    The University of Illinois at Chicago (UIC), Chicago, Illinois

    Locations

    2 in total

    Run by

    University of Chicago

    See if you can join NCT06824818 on ClinicalTrials.gov

17. Connect2Care: Prostate Cancer Education and Screenings for African American Men

    Prostate cancer is the most diagnosed cancer in African American men and the second-leading cause of cancer-related death. The prostate-specific antigen (PSA) test is an early detection screening tool for prostate cancer, however, knowledge about prostate cancer and screening benefits and risks and…

    Stage

    Not phased

    Ages

    45 to 69

    Site

    TSET Health Promotion Research Center, Oklahoma City, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT07055165 on ClinicalTrials.gov

18. Impact of Multimodal Telerehabilitation in Rural Patients With Metastatic Prostate Cancer

    People with prostate cancer may have a decreased quality of life due to the cancer itself and due to a lifesaving cancer treatment. Physical therapy, including regular exercise, helps patients with cancer to reduce disease symptoms and improve their quality of life. However, cancer rehabilitation p…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Utah Huntsman Cancer Institute, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT07032584 on ClinicalTrials.gov

19. Prostate Cancer IMAGing IN Early Detection (IMAGINED Trial)

    The researchers hope to learn if specific types of MRI software and techniques can help improve early prostate cancer detection at time of a MRI-guided prostate biopsy.

    Stage

    Not phased

    Ages

    Any age

    Site

    University of California, San Diego, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT05882253 on ClinicalTrials.gov

20. Geriatric Assessment and Technology Evaluation in Prostate Cancer

    By doing this study, doctors hope to learn more about factors that contribute to frailty (a condition where older adults feel weak, get tired easily, and struggle more with everyday activities) and serious side effects among men over the age of 65 who will receive androgen deprivation therapy (also…

    Stage

    Not phased

    Ages

    Any age

    Site

    o University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06215508 on ClinicalTrials.gov

21. Preop Laxatives in Robotic Urologic Surgery

    Minimally-invasive surgery, either laparoscopic or robotic, is commonly used in urology. Several urologic procedures including prostatectomy, radical nephrectomy, and partial nephrectomy are now commonly performed robotically. Patients undergoing these procedures often have delayed return of bowel …

    Stage

    Phase 4

    Ages

    30 to 100

    Site

    University of Iowa Hospitals & Clinics, Iowa City, Iowa

    Run by

    Chad R. Tracy

    See if you can join NCT05805436 on ClinicalTrials.gov

22. Treatment of Patients With Progressive mCRPC With 177Lu-PSMA-617

    The purpose of this study is to evaluate the safety and tolerability of Lutetium-177-PSMA-617 (PLUVICTO) in patients with metastatic castration-resistant prostate cancer (mCRPC) and extensive bone metastases, which appear as a "super scan" pattern on a bone scan. Pluvicto is FDA-approved, but patie…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Excel Diagnostics & Nuclear Oncology Center, Houston, Texas

    Run by

    Ebrahim S Delpassand

    See if you can join NCT06972628 on ClinicalTrials.gov

23. A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies

    ATLAS-101 is a Phase I/II clinical trial of AMXI-5001 in adult participants with advanced malignancies who have previously failed other therapies. The study has two phases. The purpose of Phase I (Dose Escalation) is to confirm the appropriate treatment dose and Phase II (Dose Expansion) is to char…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of California, Los Angles (UCLA) Department of Medicine - Hematology/Oncology, Los Angeles, California

    Locations

    4 in total

    Run by

    AtlasMedx, Incorporated

    See if you can join NCT04503265 on ClinicalTrials.gov

24. SAFE Nerve Sparing Guided by Micro-ultrasound (MUS)

    Robotic-assisted radical prostatectomy (RALP) has become the standard of care in the management of localized prostate cancer. However, post-prostatectomy erectile dysfunction (ED) and urinary incontinence still pose a challenge that adversely affects the patient's quality of life. Hydrodissection (…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Mount Sinai Hospital, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06945315 on ClinicalTrials.gov

25. Prostate Assessment with Restriction Spectrum Imaging (RSI) MRI

    This single-center study will enroll 40 male participants to complete 2 diffusion magnetic resonance images within 30 days of each other.

    Stage

    Not phased

    Ages

    18 and older

    Site

    UCSD Moores Cancer Center, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT04992728 on ClinicalTrials.gov