Prostate Cancer Clinical Trials

289 studies are recruiting for prostate cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 11

1. Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer

   The goal of this clinical trial is to evaluate a screening method to detect clinically relevant prostate cancer. This clinical trial is using genetic data to determine a man's risk of cancer, together with multiparametric magnetic resonance imaging (mpMRI) to identify men with higher grade cancer. …

   Stage

   Not phased

   Ages

   40 to 69

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Locations

   5 in total

   Run by

   Adam S. Kibel, MD

   See if you can join NCT06398639 on ClinicalTrials.gov

2. Understanding of Genetics by Men at Risk for Prostate Cancer

   With this greater certainty regarding prognosis, men with localized prostate cancer are now equipped with make better treatment planning decisions. This study is designed to investigate the understanding of prognostic genetic technology in African American and rural White men at risk for localized …

   Stage

   Not phased

   Ages

   40 to 95

   Site

   Mayo Clinic, Phoenix, Arizona

   Locations

   3 in total

   Run by

   Mayo Clinic

   See if you can join NCT04550845 on ClinicalTrials.gov

3. Effect of Text Message Reminders on M-ISI Score After Prostate Surgery

   The purpose of this study is to compare post-prostatectomy incontinence via Michigan Incontinence Score Index in patients receiving daily text message reminders for pelvic floor exercises when compared to those not receiving text reminders.

   Stage

   Not phased

   Ages

   18 and older

   Site

   158 Sawgrass clinic; Suite 3100, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT07071207 on ClinicalTrials.gov

4. Prostate Tissue BioBank

   Prostate cancer is also the most common cancer in men with inherited pathogenic variants in BRCA1 and BRCA2. Beyond BRCA1/2, other genes are known to increase the risk of prostate cancer, including ATM, TP53 and HOXB13. The investigators have shown that 5% of men diagnosed with prostate cancer loca…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   Abramson Cancer Center at Penn Medicine

   See if you can join NCT06659614 on ClinicalTrials.gov

5. Circulating Tumor DNA in High Risk Localized Prostate Cancer

   This prospective, non-therapeutic translational biomarker study will collect blood in patients with high risk localized prostate cancer prior to prostatectomy.

   Stage

   Not phased

   Ages

   18 and older

   Site

   UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT07222436 on ClinicalTrials.gov

6. Exercise in Prostate Cancer

   The goal of this clinical trial is to learn how exercise intervention affects circulating tumor cells (CTC) in men with advanced prostate cancer. The primary objective is to determine if an exercise intervention decreases CTCs in men with advanced prostate cancer. Participants will have baseline sc…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Johns Hopkins University, Baltimore, Maryland

   Run by

   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

   See if you can join NCT06165302 on ClinicalTrials.gov

7. ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials

   This study will follow men with metastatic castration resistant prostate cancer throughout their standard of care treatment for their disease to determine if the presence of different genes or proteins can predict which patients respond to the cancer treatment they receive. As tumors grow and begin…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Cancer Center, New York, New York

   Locations

   3 in total

   Run by

   Duke University

   See if you can join NCT06141993 on ClinicalTrials.gov

8. Feasibility of Timesaving When Using Histolog Confocal Laser Endomicroscopy for Margin Assessment in Prostatectomy Specimen

   This study investigates a new, faster way to find cancer cells on the surface of the prostate during radical prostatectomy surgery. A recently FDA-approved device, called the Histolog Scanner, gives high-resolution imaging of the surface of fresh tissue using ultra-fast confocal microscopy, which a…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Icahn School of Medicine at Mount Sinai, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT07141121 on ClinicalTrials.gov

9. Fusion or Cognitive Ultrasound-guided Biopsy to Detect Prostate Cancer

   The MRI-targeted biopsy for prostate cancer detection can be performed using one of two techniques: 1. Software-based fusion of MRI and ultrasound images (software fusion) or 2. Visually estimated MRI-informed (cognitive fusion) technique To date, there is a lack of adequately powered RCTs directly…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Lahey Clinic, Inc, Burlington, Massachusetts

   Locations

   4 in total

   Run by

   Albany Medical College

   See if you can join NCT06517901 on ClinicalTrials.gov

10. Study to Assess the Feasibility of Stopping Prostate Cancer Treatment Early in Elderly Patients

    This study seeks to identify if it is feasible to stop Luteinizing Hormone-Releasing Hormone (LHRH) Agonist Therapy in elderly men with prostate cancer. We hypothesize that elderly prostate cancer patients on long term androgen ablation with LHRH agonists will be permanently castrated and do not re…

    Stage

    Not phased

    Ages

    70 and older

    Site

    The University of Illinois at Chicago (UIC), Chicago, Illinois

    Locations

    2 in total

    Run by

    University of Chicago

    See if you can join NCT06824818 on ClinicalTrials.gov

11. Evaluating Tolerability of ePUHRT With Brachytherapy Boost

    The purpose of this study is to evaluate the tolerability and toxicity of combining two radiation therapy methods for prostate cancer: Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT), which is an external beam radiotherapy with High Dose Rate Brachytherapy Boost (form of inter…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT06817668 on ClinicalTrials.gov

12. Connect2Care: Prostate Cancer Education and Screenings for African American Men

    Prostate cancer is the most diagnosed cancer in African American men and the second-leading cause of cancer-related death. The prostate-specific antigen (PSA) test is an early detection screening tool for prostate cancer, however, knowledge about prostate cancer and screening benefits and risks and…

    Stage

    Not phased

    Ages

    45 to 69

    Site

    TSET Health Promotion Research Center, Oklahoma City, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT07055165 on ClinicalTrials.gov

13. Precise Oncology Interventions in Nutrition and Training (OnPoint)

    The purpose of this study is to see if survivors of breast, prostate, or colorectal cancer who receive a personal referral to a targeted nutrition and exercise program will be able to eat a healthier diet and be more physically activity.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT06534918 on ClinicalTrials.gov

14. Comprehensive Assessment of Cancer Theranostic Response

    The intent of this study is to evaluate actionable outputs from TRAQinform Theranostics in a prospective, multi-center, non-interventional clinical study. The primary objective is to investigate intent-to-change treatment decisions after the addition of TRAQinform Theranostics. The exploratory obje…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Weill Medical College of Cornell, New York, New York

    Locations

    2 in total

    Run by

    AIQ Solutions

    See if you can join NCT06815354 on ClinicalTrials.gov

15. Hypo-fractionated Radiation Therapy With or Without Androgen Suppression for Intermediate Risk Prostate Cancer

    The purpose of this study is to compare the effects, good and/or bad of two treatment methods on subjects and their cancer. Proton beam radiation therapy is one of the treatments for men with prostate cancer who have localized disease. The benefit of the combination with androgen suppression is not…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Mayo Clinic, Scottsdale, Arizona

    Locations

    4 in total

    Run by

    Proton Collaborative Group

    See if you can join NCT01492972 on ClinicalTrials.gov

16. The CArdiovascular Risk Evaluation in Men With Prostate Cancer Study (CARE-PC) Pilot Feasibility Study

    The overarching goal of this trial is to develop mechanisms to improve cardiovascular care among such prostate cancer patients receiving ADT by increasing patient awareness of individualized cardiovascular risk estimates and mitigation opportunities. Patients will be given access to a web-based qua…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Vivek Narayan

    See if you can join NCT06064149 on ClinicalTrials.gov

17. Impact of Multimodal Telerehabilitation in Rural Patients With Metastatic Prostate Cancer

    People with prostate cancer may have a decreased quality of life due to the cancer itself and due to a lifesaving cancer treatment. Physical therapy, including regular exercise, helps patients with cancer to reduce disease symptoms and improve their quality of life. However, cancer rehabilitation p…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Utah Huntsman Cancer Institute, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT07032584 on ClinicalTrials.gov

18. Prostate Cancer IMAGing IN Early Detection (IMAGINED Trial)

    The researchers hope to learn if specific types of MRI software and techniques can help improve early prostate cancer detection at time of a MRI-guided prostate biopsy.

    Stage

    Not phased

    Ages

    Any age

    Site

    University of California, San Diego, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT05882253 on ClinicalTrials.gov

19. Geriatric Assessment and Technology Evaluation in Prostate Cancer

    By doing this study, doctors hope to learn more about factors that contribute to frailty (a condition where older adults feel weak, get tired easily, and struggle more with everyday activities) and serious side effects among men over the age of 65 who will receive androgen deprivation therapy (also…

    Stage

    Not phased

    Ages

    Any age

    Site

    o University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06215508 on ClinicalTrials.gov

20. Real World Prostate Cancer Registry

    Prostate cancer is the most common cancer diagnosed in men in the USA with 268,490 cases diagnosed in 2022 constituting 27% of male cancers and 34,500 deaths (11%) occurred in same year.1 Prostate cancer is a very heterogeneous disease that has different presentations, molecular and pathological fe…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cincinnati Cancer Advisors, Cincinnati, Ohio

    Run by

    Cincinnati Cancer Advisors

    See if you can join NCT06355336 on ClinicalTrials.gov

21. Preop Laxatives in Robotic Urologic Surgery

    Minimally-invasive surgery, either laparoscopic or robotic, is commonly used in urology. Several urologic procedures including prostatectomy, radical nephrectomy, and partial nephrectomy are now commonly performed robotically. Patients undergoing these procedures often have delayed return of bowel …

    Stage

    Phase 4

    Ages

    30 to 100

    Site

    University of Iowa Hospitals & Clinics, Iowa City, Iowa

    Run by

    Chad R. Tracy

    See if you can join NCT05805436 on ClinicalTrials.gov

22. Barrigel® PPRT (Post-Prostatectomy Radiation Therapy) Trial

    Barrigel is intended to temporarily position the anterior rectal wall away from the prostate or prostate bed during radiotherapy treatment for prostate cancer and, in creating this space, it is the intent of Barrigel to reduce the radiation dose delivered to the anterior rectum.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dana Farber Cancer Institute, Boston, Massachusetts

    Locations

    5 in total

    Run by

    Palette Life Sciences, Inc.

    See if you can join NCT06496256 on ClinicalTrials.gov

23. Treatment of Patients With Progressive mCRPC With 177Lu-PSMA-617

    The purpose of this study is to evaluate the safety and tolerability of Lutetium-177-PSMA-617 (PLUVICTO) in patients with metastatic castration-resistant prostate cancer (mCRPC) and extensive bone metastases, which appear as a "super scan" pattern on a bone scan. Pluvicto is FDA-approved, but patie…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Excel Diagnostics & Nuclear Oncology Center, Houston, Texas

    Run by

    Ebrahim S Delpassand

    See if you can join NCT06972628 on ClinicalTrials.gov

24. A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies

    ATLAS-101 is a Phase I/II clinical trial of AMXI-5001 in adult participants with advanced malignancies who have previously failed other therapies. The study has two phases. The purpose of Phase I (Dose Escalation) is to confirm the appropriate treatment dose and Phase II (Dose Expansion) is to char…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of California, Los Angles (UCLA) Department of Medicine - Hematology/Oncology, Los Angeles, California

    Locations

    4 in total

    Run by

    AtlasMedx, Incorporated

    See if you can join NCT04503265 on ClinicalTrials.gov

25. SAFE Nerve Sparing Guided by Micro-ultrasound (MUS)

    Robotic-assisted radical prostatectomy (RALP) has become the standard of care in the management of localized prostate cancer. However, post-prostatectomy erectile dysfunction (ED) and urinary incontinence still pose a challenge that adversely affects the patient's quality of life. Hydrodissection (…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Mount Sinai Hospital, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06945315 on ClinicalTrials.gov