Post Traumatic Stress Disorder Clinical Trials

68 studies are recruiting for post traumatic stress disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Exploring Virtual Reality Adventure Training Exergaming

   The current project aims to design and implement an 8-week Virtual Reality Adventure Therapy Exergaming (V-RATE) intervention focused on women veterans. A randomized controlled trial using a repeated measure design with a 1-month follow-up assessment will be employed to examine effects on physical …

   Stage

   Not phased

   Ages

   18 to 45

   Site

   University of Texas at Arlington, Arlington, Texas

   Run by

   The University of Texas at Arlington

   See if you can join NCT05563805 on ClinicalTrials.gov

2. MDMA-Assisted Massed Exposure Therapy for PTSD

   The goal of this clinical trial is to investigate the efficacy of 3,4-methylenedioxy-methamphetamine hydrochloride (MDMA) combined with Massed Prolonged Exposure (PE) therapy for the treatment of posttraumatic stress disorder (PTSD) in adult participants diagnosed with PTSD. This randomized, placeb…

   Stage

   Phase 2

   Ages

   21 to 70

   Site

   Emory Brain Health Center, Atlanta, Georgia

   Run by

   Emory University

   See if you can join NCT07288151 on ClinicalTrials.gov

3. Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation

   This study will test the clinical efficacy of an accelerated TMS (accel-TMS) protocol that rapidly addresses PTSD symptoms with 1 week (25 sessions over 5 days) of condensed treatment.

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Florida State University, Tallahassee, Florida

   Run by

   Florida State University

   See if you can join NCT06544408 on ClinicalTrials.gov

4. Neuromodulation and Neurorehabilitation for mTBI

   This study will determine (i) the magnitude of immediate and sustained effects of a current clinical standard interactive computer attention processing training (APT) when combined with intermittent theta burst stimulation (iTBS), a type of repetitive transcranial magnetic stimulation and (ii) dete…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Northwestern University, Chicago, Illinois

   Locations

   2 in total

   Run by

   Northwestern University

   See if you can join NCT03819608 on ClinicalTrials.gov

5. The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects

   The purpose of this study is to test the hypothesis that the anti-depressant and anti-suicidal effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist Ketamine is critically dependent on stimulation of Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid receptors (AMPAR).

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   VA Connecticut Healthcare System, West Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT05786066 on ClinicalTrials.gov

6. Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response

   The proposed study will assess the combined effect of perampanel and ketamine on the anti-depressant response in individuals with treatment resistant depression. The purpose of this study is to test the hypothesis that stimulation of Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid recept…

   Stage

   Phase 1

   Ages

   18 to 60

   Site

   Yale University, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT05915013 on ClinicalTrials.gov

7. Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study

   The purpose of the study is to evaluate a trauma informed digital multicomponent intervention design to improve health and safety outcomes for women with lifetime exposures to violence and co-occurring PTSD and/or depression symptoms

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins University, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07227337 on ClinicalTrials.gov

8. Fear and Avoidance in PTSD Patients

   The purpose of this research study is to study how the brain learns to avoid certain stimuli or situations using an experimental paradigm. The big goal is to measure brain responses and subject's feelings and expectations when they are learning to actively avoid experimental stimuli, and how fear e…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   UTHealth Houston, Houston, Texas

   Run by

   The University of Texas Health Science Center, Houston

   See if you can join NCT04770584 on ClinicalTrials.gov

9. Pimavanserin for Insomnia in Veterans With PTSD

   This is a preliminary randomized, double-blind, placebo-controlled trial comparing pimavanserin 34mg at bedtime vs. placebo for the treatment of insomnia associated with post-traumatic stress disorder.

   Stage

   Phase 2

   Ages

   18 to 64

   Site

   Michael E. DeBakey VA Medical Center, Houston, TX, Houston, Texas

   Run by

   VA Office of Research and Development

   See if you can join NCT05441280 on ClinicalTrials.gov

10. Recovering Sleep After Trauma

    The main objective of this pilot trial is to assess the feasibility and preliminary efficacy of telehealth-delivered behavioral therapy to reduce the development of posttraumatic stress and depressive symptoms following motor vehicle collision among individuals at high risk. This pilot trial will p…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT07196332 on ClinicalTrials.gov

11. Psychotherapy Effects on Reward Processing in PTSD

    The purpose of this study is to identify how trauma-focused psychotherapy changes the function of brain circuitry in posttraumatic stress disorder (PTSD) and how this mediates improvements in the diminished ability to experience positive emotions following a traumatic or extremely stressful life ev…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT06096740 on ClinicalTrials.gov

12. Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning

    The aim of the present study is to assess the availability of cannabinoid receptors (CB1R) in the human brain. CB1R are present in everyone's brain, regardless of whether or not someone has used cannabis. The investigators will image brain cannabinoid receptors using Positron Emission Tomography (P…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    Connecticut Mental Health Center, Clinical Neuroscience Research Unit, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT01730781 on ClinicalTrials.gov

13. Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)

    The goal of this clinical trial is to evaluate the safety and effectiveness of the gammaCore non-invasive vagus nerve stimulation (nVNS) device as an additional treatment for symptoms of post-traumatic stress disorder (PTSD) in adults. The vagus nerve connects the brain with many organs and systems…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Acacia Research Center, Sunnyvale, California

    Run by

    Acacia Clinics

    See if you can join NCT07523685 on ClinicalTrials.gov

14. Randomized Trial of Tele Vs. Clinic TF-CBT in Puerto Rico

    The current study will evaluate TF-CBT delivered via tele-health for youth presenting with trauma symptoms via a randomized controlled trial. Goals of the current study are to examine the effectiveness of Tele-TF-CBT delivered by community providers in Puerto Rico in improving youth trauma outcomes…

    Stage

    Not phased

    Ages

    7 to 18

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06332209 on ClinicalTrials.gov

15. Approach-Avoidance and Alcohol Challenge Study in PTSD

    Individuals with posttraumatic stress disorder (PTSD) have greater prevalence of alcohol use disorders (AUDs), with this comorbidity associated with worse illness outcomes, yet there remains limited mechanistic understanding of how PTSD confers risk for AUD. Understanding risk factors that associat…

    Stage

    Not phased

    Ages

    21 to 60

    Site

    University of Texas at Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT06002633 on ClinicalTrials.gov

16. BXCL501 After Stress to Increase Recovery Success

    This study will examine the safety and efficacy of BXCL501 to reduce ASR symptoms and behavioral changes among patients presenting to the Emergency Department (ED) after Motor Vehicle Collision (MVC). Specifically, the investigators will perform the BXCL501 (BASIS) Trial, a double-blind placebo-con…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    University of Florida College of Medicine - Jacksonville, Jacksonville, Florida

    Locations

    3 in total

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT06943404 on ClinicalTrials.gov

17. Nitric Oxide (NO) and Endothelial Dysfunction in Women With PTSD

    This research study is conducted to better understand why women with post-traumatic stress disorder (PTSD) have higher risk of cardiovascular disease as they get older. This study looks at how trauma and PTSD affect blood vessels in young women by testing whether the dietary supplement beetroot jui…

    Stage

    Not phased

    Ages

    18 to 40

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT07485231 on ClinicalTrials.gov

18. Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

    The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old. Chronic symptoms could include dizziness, headache, fatigue, brain fog, memory difficulty, sleep disruption, irritability, or anxiety that oc…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    UCLA, Westwood, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT06073886 on ClinicalTrials.gov

19. Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder

    The goal of this study is to test whether anesthesia-induced dreaming can help alleviate symptoms of PTSD in an (1) open-label trial (Phase I) and (2) double-blind, randomized controlled trial (Phase II) in a non-surgical setting. The investigators predict that inducing and sustaining a dream state…

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT06577636 on ClinicalTrials.gov

20. Cannabidiol as a Treatment for PTSD and PTSD Comorbid With TBI

    This will be a randomized placebo controlled study to test the efficacy of cannabidiol (CBD) as a treatment for symptoms of post-traumatic stress disorder (PTSD). Subjects, 120 in total, will be males and females with PTSD, half of which will have comorbid mild traumatic brain injury (TBI). There w…

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    New York University School of Medicine, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT04550377 on ClinicalTrials.gov

21. Retinal Imaging in Neurodegenerative Disease

    This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT03233646 on ClinicalTrials.gov

22. Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder

    The goal of this trial is to test how augmented reality exposure therapy (ARET) may potentiate the effects of traditional exposure therapy administered to U.S. military personnel diagnosed with PTSD. 40 adult males and females over the age of 18 that have served, or are currently serving, in the U.…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ralph H. Johnson VA Health Care System, Charleston, South Carolina

    Run by

    Wayne State University

    See if you can join NCT06740487 on ClinicalTrials.gov

23. Sympathetic Overactivity in Post-traumatic Stress Disorder

    Post-traumatic stress disorder (PTSD) is a highly prevalent anxiety disorder that is associated with an increased risk of cardiovascular (CV) disease and hypertension. One potential mechanism is overactivation of the sympathetic nervous system (SNS), both at rest and particularly during stress. Thi…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Atlanta VA Medical Center, Decatur, Georgia

    Run by

    Emory University

    See if you can join NCT01627301 on ClinicalTrials.gov

24. rTMS-augmented Written Exposure Therapy for PTSD

    Post-traumatic stress disorder (PTSD) is prevalent and represents a high healthcare burden among Veterans. Repetitive transcranial magnetic stimulation (rTMS) is a brain-based therapy that may be effective for treating PTSD. The theorized mechanism of rTMS is enhancement of emotional flexibility vi…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Central Texas Veterans Health Care System, Temple, TX, Temple, Texas

    Run by

    VA Office of Research and Development

    See if you can join NCT05149534 on ClinicalTrials.gov

25. Multifaceted Intervention to Restore Resilience and Overcome Risk

    The MIRROR study will compare the effectiveness of two interventions in improving emotion regulation and reducing PTSD symptoms in female Veterans with military sexual trauma (MST) and/or intimate partner violence (IPV) and co-occurring brain injury.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Baylor College of Medicine, Houston, Texas

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06988787 on ClinicalTrials.gov