Post Traumatic Stress Disorder Clinical Trials

67 studies are recruiting for post traumatic stress disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD

   This study is evaluating the safety and efficacy of TSND-201 in adults with PTSD. Eligible participants will enter a 4-week Treatment Period where they will be randomized 1:1:1 to receive one of two doses of TSND-201 or placebo, once per week. Following the Treatment Period, participants will enter…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Mountain View Clinical Research, Denver, Colorado

   Locations

   6 in total

   Run by

   Transcend Therapeutics

   See if you can join NCT07836647 on ClinicalTrials.gov

2. Recovering Sleep After Trauma

   The main objective of this pilot trial is to assess the feasibility and preliminary efficacy of telehealth-delivered behavioral therapy to reduce the development of posttraumatic stress and depressive symptoms following motor vehicle collision among individuals at high risk. This pilot trial will p…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT07196332 on ClinicalTrials.gov

3. Randomized Trial of Tele Vs. Clinic TF-CBT in Puerto Rico

   The current study will evaluate TF-CBT delivered via tele-health for youth presenting with trauma symptoms via a randomized controlled trial. Goals of the current study are to examine the effectiveness of Tele-TF-CBT delivered by community providers in Puerto Rico in improving youth trauma outcomes…

   Stage

   Not phased

   Ages

   7 to 18

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06332209 on ClinicalTrials.gov

4. OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit

   Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone. This is especially true in residential settings where both disorders are more sev…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA San Diego Healthcare System, San Diego, CA, San Diego, California

   Run by

   VA Office of Research and Development

   See if you can join NCT05156112 on ClinicalTrials.gov

5. Mindfulness-based Psilocybin Therapy for PTSD

   The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD). This is an assessor-blinded, randomized, controlled study in participants with PTSD. The study will investigate the changes in brain activity, connec…

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   The Ohio State University Medical Center, Columbus, Ohio

   Run by

   Anthony P King

   See if you can join NCT07104916 on ClinicalTrials.gov

6. Neuromodulation and Neurorehabilitation for mTBI

   This study will determine (i) the magnitude of immediate and sustained effects of a current clinical standard interactive computer attention processing training (APT) when combined with intermittent theta burst stimulation (iTBS), a type of repetitive transcranial magnetic stimulation and (ii) dete…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Northwestern University, Chicago, Illinois

   Locations

   2 in total

   Run by

   Northwestern University

   See if you can join NCT03819608 on ClinicalTrials.gov

7. Cognitive Control Training for Extinction in PTSD

   The proposed study will test whether a working memory training (WMT) program improves fear extinction learning and its underlying neural circuitry in Veterans with posttraumatic stress disorder (PTSD). WMT is designed to improves the ability to maintain task-relevant information in mind. The projec…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   VA San Diego Healthcare System, San Diego, CA, San Diego, California

   Run by

   VA Office of Research and Development

   See if you can join NCT06629064 on ClinicalTrials.gov

8. Non-invasive Vagus Nerve Stimulation (nVNS) for Post-Traumatic Stress Disorder (PTSD)

   The goal of this clinical trial is to evaluate the safety and effectiveness of the gammaCore non-invasive vagus nerve stimulation (nVNS) device as an additional treatment for symptoms of post-traumatic stress disorder (PTSD) in adults. The vagus nerve connects the brain with many organs and systems…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Acacia Research Center, Sunnyvale, California

   Run by

   Acacia Clinics

   See if you can join NCT07523685 on ClinicalTrials.gov

9. Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder

   The goal of this study is to test whether anesthesia-induced experiences can help alleviate symptoms of PTSD in an (1) open-label trial (Phase I) and (2) single-center double-blind, randomized, active-comparator (dose-controlled) participant-and assessor-blinded Phase 2 clinical trial (Phase II) in…

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   Stanford University, Stanford, California

   Run by

   Stanford University

   See if you can join NCT06577636 on ClinicalTrials.gov

10. Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms

    Many combat veterans (c-Vs), service members (SMs) and civilians with mild traumatic brain injury (mTBI, also termed concussion) suffer from persistent post-concussion symptoms (PPCS) that degrade physical and cognitive well-being and have been linked with early neurodegeneration. PPCS include soma…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Virginia Commonwealth University, Richmond, Virginia

    Run by

    Virginia Commonwealth University

    See if you can join NCT07071350 on ClinicalTrials.gov

11. Multifaceted Intervention to Restore Resilience and Overcome Risk

    The MIRROR study will compare the effectiveness of two interventions in improving emotion regulation and reducing PTSD symptoms in female Veterans with military sexual trauma (MST) and/or intimate partner violence (IPV) and co-occurring brain injury.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Baylor College of Medicine, Houston, Texas

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06988787 on ClinicalTrials.gov

12. An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

    This study is evaluating the safety and efficacy of TSND-201 in adults with PTSD. Eligible participants will enter a 4-week Treatment Period where they will be randomized 1:1:1 to receive one of two doses of TSND-201 or placebo, once per week. Following the Treatment Period, participants will enter…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Mountain Clinical Trials LLC, Phoenix, Arizona

    Locations

    37 in total

    Run by

    Transcend Therapeutics

    See if you can join NCT07456696 on ClinicalTrials.gov

13. Efficacy of a Multi-level School Intervention for LGBTQ Youth

    Efficacy of a Multi-level School Intervention for LGBTQ Youth

    Stage

    Not phased

    Ages

    12 to 20

    Site

    Washington University in St. Louis, St Louis, Missouri

    Locations

    23 in total

    Run by

    Washington University School of Medicine

    See if you can join NCT05541406 on ClinicalTrials.gov

14. Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

    Investigators' overall objective is to compare methods of identifying individuals who may be experiencing challenges in Cognitive Processing Therapy (CPT) and compare methods of intervening to optimize treatment retention and outcomes. Investigators' specific aims are: 1. to determine whether the u…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Phoenix Health Care System, Phoenix, Arizona

    Locations

    4 in total

    Run by

    United States Department of Defense

    See if you can join NCT06957067 on ClinicalTrials.gov

15. A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD

    PTSD occurs in up to 17% of post-9/11 US Service Members and is associated with long-term functional impairment, family problems, unemployment, and suicidality. Trauma-focused therapies (TFTs), such as Prolonged Exposure (PE), result in significant relief for many. Yet, TFTs are not equally effecti…

    Stage

    Not phased

    Ages

    18 and older

    Site

    San Diego VA Healthcare System, San Diego, California

    Locations

    4 in total

    Run by

    United States Department of Defense

    See if you can join NCT06990191 on ClinicalTrials.gov

16. Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat

    The overall objective of this study it to use Positron Emission Tomography (PET) brain imaging and a radiotracer that measures the epigenetic marker Histone Deacetylase 6 (HDAC6) to examine HDAC6 expression in people with Post-Traumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), or concurr…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06371404 on ClinicalTrials.gov

17. Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI

    The investigators want to test a treatment for posttraumatic stress disorder (PTSD) especially designed for military veterans and service members with mild or moderate traumatic brain injuries (TBI) and PTSD. The treatment will include individual psychotherapy sessions to manage PTSD.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Carl R Darnall Army Medical Center, Fort Hood, Texas

    Run by

    The University of Texas Health Science Center at San Antonio

    See if you can join NCT07351305 on ClinicalTrials.gov

18. Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD

    The purpose of this study is to examine the benefits of combining repetitive Transcranial Magnetic Stimulation (rTMS) coupled with Cognitive Processing Therapy (CPT) in treating combat-related Posttraumatic Stress Disorder (PTSD) symptoms. The study will also examine change in depression, psychosoc…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Florida State University College of Medicine, Tallahassee, Florida

    Locations

    3 in total

    Run by

    The University of Texas at Dallas

    See if you can join NCT03932773 on ClinicalTrials.gov

19. MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

    This randomized, double-blind, single-site phase II 2-arm study will investigate the safety and preliminary efficacy of MDMA-assisted therapy compared with low dose d-amphetamine-assisted therapy on the severity of PTSD symptoms in participants aged 18 years and older with PTSD of at least moderate…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    West Los Angeles Veteran Affairs, Los Angeles, California

    Locations

    2 in total

    Run by

    Stephen Robert Marder

    See if you can join NCT05790239 on ClinicalTrials.gov

20. Warrior CARE: Cannabis Behavioral Health

    This study is a randomized, controlled clinical trial to examine the therapeutic potential of cannabinoids for treating veterans with PTSD and suicidal ideation.

    Stage

    Phase 1

    Ages

    19 to 69

    Site

    Wayne State University, Detroit, Michigan

    Run by

    Wayne State University

    See if you can join NCT06381180 on ClinicalTrials.gov

21. The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans

    The goal of this clinical trial is to develop a new behavioral treatment for U.S. combat veterans with post-traumatic stress disorder (PTSD), very brief exposure to combat-related stimuli. The main questions it aims to answer are: 1. How does Very Brief Exposure (combat images and control everyday …

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Brain Imaging Lab, Los Angeles, California

    Run by

    Children's Hospital Los Angeles

    See if you can join NCT06218381 on ClinicalTrials.gov

22. Long-Term Outcomes Following HBOT

    This study is designed to better understand the long-term effects of hyperbaric oxygen therapy (HBOT). Our goal is to determine whether improvements after treatment are maintained over time and whether additional benefits appear months after treatment has ended. We will evaluate changes in cognitiv…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Summit Hyperbarics and Wellness, Boise, Idaho

    Run by

    Summit Hyperbarics and Wellness

    See if you can join NCT07732374 on ClinicalTrials.gov

23. Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

    Conditions treated in intensive care units (ICUs) such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis are common. These can lead to high rates of depression, anxiety, and PTSD that worsen quality of life. Yet there are few effective strategi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06538246 on ClinicalTrials.gov

24. Sleep and Emotion Processing in Adolescent Post-traumatic Stress Disorder

    The goal of this clinical trial is to characterize the role of sleep, emotion processing, and daily affect in post-traumatic stress disorder (PTSD) and whether improving sleep quality using slow wave activity enhancement will impact next-day affect in youth. Participants will attend 4 study visits:…

    Stage

    Not phased

    Ages

    14 to 18

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06341413 on ClinicalTrials.gov

25. Walk With Me (WWM) for Perinatal Grief

    The goal of this clinical trial is to learn if the Along With Me web-based intervention works to decrease posttraumatic stress symptoms and suicidal ideation among bereaved parents following pregnancy and early infant loss. It will also learn whether peer guides provide additional improvements on t…

    Stage

    Not phased

    Ages

    15 and older

    Site

    Oregon Research Behavioral Intervention Strategies, Inc., Eugene, Oregon

    Locations

    2 in total

    Run by

    Oregon Research Behavioral Intervention Strategies, Inc.

    See if you can join NCT07011940 on ClinicalTrials.gov