Post Traumatic Stress Disorder Clinical Trials

68 studies are recruiting for post traumatic stress disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

   This study is evaluating the safety and efficacy of TSND-201 in adults with PTSD. Eligible participants will enter a 4-week Treatment Period where they will be randomized 1:1:1 to receive one of two doses of TSND-201 or placebo, once per week. Following the Treatment Period, participants will enter…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Mountain Clinical Trials LLC, Phoenix, Arizona

   Locations

   37 in total

   Run by

   Transcend Therapeutics

   See if you can join NCT07456696 on ClinicalTrials.gov

2. Efficacy of a Multi-level School Intervention for LGBTQ Youth

   Efficacy of a Multi-level School Intervention for LGBTQ Youth

   Stage

   Not phased

   Ages

   12 to 20

   Site

   Washington University in St. Louis, St Louis, Missouri

   Locations

   23 in total

   Run by

   Washington University School of Medicine

   See if you can join NCT05541406 on ClinicalTrials.gov

3. Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

   Investigators' overall objective is to compare methods of identifying individuals who may be experiencing challenges in Cognitive Processing Therapy (CPT) and compare methods of intervening to optimize treatment retention and outcomes. Investigators' specific aims are: 1. to determine whether the u…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Phoenix Health Care System, Phoenix, Arizona

   Locations

   4 in total

   Run by

   United States Department of Defense

   See if you can join NCT06957067 on ClinicalTrials.gov

4. A Hybrid 1 Effectiveness-Implementation Trial of Partner-Assisted Prolonged Exposure for PTSD

   PTSD occurs in up to 17% of post-9/11 US Service Members and is associated with long-term functional impairment, family problems, unemployment, and suicidality. Trauma-focused therapies (TFTs), such as Prolonged Exposure (PE), result in significant relief for many. Yet, TFTs are not equally effecti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   San Diego VA Healthcare System, San Diego, California

   Locations

   4 in total

   Run by

   United States Department of Defense

   See if you can join NCT06990191 on ClinicalTrials.gov

5. Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat

   The overall objective of this study it to use Positron Emission Tomography (PET) brain imaging and a radiotracer that measures the epigenetic marker Histone Deacetylase 6 (HDAC6) to examine HDAC6 expression in people with Post-Traumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), or concurr…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   Yale University, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06371404 on ClinicalTrials.gov

6. Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI

   The investigators want to test a treatment for posttraumatic stress disorder (PTSD) especially designed for military veterans and service members with mild or moderate traumatic brain injuries (TBI) and PTSD. The treatment will include individual psychotherapy sessions to manage PTSD.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Carl R Darnall Army Medical Center, Fort Hood, Texas

   Run by

   The University of Texas Health Science Center at San Antonio

   See if you can join NCT07351305 on ClinicalTrials.gov

7. Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD

   The purpose of this study is to examine the benefits of combining repetitive Transcranial Magnetic Stimulation (rTMS) coupled with Cognitive Processing Therapy (CPT) in treating combat-related Posttraumatic Stress Disorder (PTSD) symptoms. The study will also examine change in depression, psychosoc…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   Florida State University College of Medicine, Tallahassee, Florida

   Locations

   3 in total

   Run by

   The University of Texas at Dallas

   See if you can join NCT03932773 on ClinicalTrials.gov

8. MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

   This randomized, double-blind, single-site phase II 2-arm study will investigate the safety and preliminary efficacy of MDMA-assisted therapy compared with low dose d-amphetamine-assisted therapy on the severity of PTSD symptoms in participants aged 18 years and older with PTSD of at least moderate…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   West Los Angeles Veteran Affairs, Los Angeles, California

   Locations

   2 in total

   Run by

   Stephen Robert Marder

   See if you can join NCT05790239 on ClinicalTrials.gov

9. Warrior CARE: Cannabis Behavioral Health

   This study is a randomized, controlled clinical trial to examine the therapeutic potential of cannabinoids for treating veterans with PTSD and suicidal ideation.

   Stage

   Phase 1

   Ages

   19 to 69

   Site

   Wayne State University, Detroit, Michigan

   Run by

   Wayne State University

   See if you can join NCT06381180 on ClinicalTrials.gov

10. Cognitive Control Training for Extinction in PTSD

    The proposed study will test whether a working memory training (WMT) program improves fear extinction learning and its underlying neural circuitry in Veterans with posttraumatic stress disorder (PTSD). WMT is designed to improves the ability to maintain task-relevant information in mind. The projec…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    VA San Diego Healthcare System, San Diego, CA, San Diego, California

    Run by

    VA Office of Research and Development

    See if you can join NCT06629064 on ClinicalTrials.gov

11. The Effects of Very Brief Exposure on PTSD in U.S. Combat Veterans

    The goal of this clinical trial is to develop a new behavioral treatment for U.S. combat veterans with post-traumatic stress disorder (PTSD), very brief exposure to combat-related stimuli. The main questions it aims to answer are: 1. How does Very Brief Exposure (combat images and control everyday …

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Brain Imaging Lab, Los Angeles, California

    Run by

    Children's Hospital Los Angeles

    See if you can join NCT06218381 on ClinicalTrials.gov

12. Long-Term Outcomes Following HBOT

    This study is designed to better understand the long-term effects of hyperbaric oxygen therapy (HBOT). Our goal is to determine whether improvements after treatment are maintained over time and whether additional benefits appear months after treatment has ended. We will evaluate changes in cognitiv…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Summit Hyperbarics and Wellness, Boise, Idaho

    Run by

    Summit Hyperbarics and Wellness

    See if you can join NCT07732374 on ClinicalTrials.gov

13. Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

    Conditions treated in intensive care units (ICUs) such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis are common. These can lead to high rates of depression, anxiety, and PTSD that worsen quality of life. Yet there are few effective strategi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06538246 on ClinicalTrials.gov

14. Sleep and Emotion Processing in Adolescent Post-traumatic Stress Disorder

    The goal of this clinical trial is to characterize the role of sleep, emotion processing, and daily affect in post-traumatic stress disorder (PTSD) and whether improving sleep quality using slow wave activity enhancement will impact next-day affect in youth. Participants will attend 4 study visits:…

    Stage

    Not phased

    Ages

    14 to 18

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06341413 on ClinicalTrials.gov

15. Walk With Me (WWM) for Perinatal Grief

    The goal of this clinical trial is to learn if the Along With Me web-based intervention works to decrease posttraumatic stress symptoms and suicidal ideation among bereaved parents following pregnancy and early infant loss. It will also learn whether peer guides provide additional improvements on t…

    Stage

    Not phased

    Ages

    15 and older

    Site

    Oregon Research Behavioral Intervention Strategies, Inc., Eugene, Oregon

    Locations

    2 in total

    Run by

    Oregon Research Behavioral Intervention Strategies, Inc.

    See if you can join NCT07011940 on ClinicalTrials.gov

16. Stepped Care for Posttraumatic Stress Disorder Study

    Less than 20% of people with PTSD receive any treatment. This study extends a program of research by the investigator focused on developing adaptive (stepped) interventions for PTSD. The adaptive intervention sequences a digital mental health intervention (DMHI) and brief trauma- and skills-focused…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Boston Medical Center, Boston, Massachusetts

    Run by

    Boston Medical Center

    See if you can join NCT06947538 on ClinicalTrials.gov

17. eTMS for Veterans and First Responders With PTSD

    A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD. Study will be a double-blind, sham-controlled, parallel group, randomized clinical trial.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Fralin Biomedical Research Institute, Roanoke, Virginia

    Run by

    Virginia Polytechnic Institute and State University

    See if you can join NCT06294106 on ClinicalTrials.gov

18. Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers

    This study addresses PTSD symptoms in First Responders and Healthcare workers. Specifically, it tests whether a brief PTSD treatment (talk therapy) effectively treats PTSD when provided to First Responders and Healthcare workers by counselors in Employee Assistance Programs (EAPs). The central hypo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tanner Health System, Carrollton, Georgia

    Locations

    14 in total

    Run by

    University of Michigan

    See if you can join NCT05751473 on ClinicalTrials.gov

19. Psilocybin-Assisted Therapy for Sexual Assault-Related PTSD

    A Phase 2, Open-Label Study to explore the efficacy, safety, and tolerability of psilocybin-assisted therapy in women with sexual assault-related Posttraumatic Stress Disorder (PTSD).

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Sunstone Medical, PC, Rockville, Maryland

    Run by

    Sunstone Medical

    See if you can join NCT06902974 on ClinicalTrials.gov

20. MDMA Therapy in Veterans With PTSD

    A Phase 2, single-center, fixed-dose, open-label study will explore the efficacy, safety, and tolerability of a 120 mg dose of oral MDMA followed by a supplemental dose of 60 mg MDMA in conjunction with therapy in individual versus group settings for adult veterans diagnosed with PTSD.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Sunstone Therapies, Rockville, Maryland

    Run by

    Sunstone Medical

    See if you can join NCT07569159 on ClinicalTrials.gov

21. Improving Sleep in Veterans With the Polytrauma Clinical Triad

    The "polytrauma clinical triad" (PCT), a highly disabling constellation of factors, is defined by the coexistence of traumatic brain injury, post-traumatic stress disorder, and chronic pain. Veterans with the PCT are medically complex, often refractory to conventional therapies, and suffer from add…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    VA Portland Health Care System, Portland, OR, Portland, Oregon

    Run by

    VA Office of Research and Development

    See if you can join NCT06477796 on ClinicalTrials.gov

22. Mindfulness-based Psilocybin Therapy for PTSD

    The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD). This is an assessor-blinded, randomized, controlled study in participants with PTSD. The study will investigate the changes in brain activity, connec…

    Stage

    Phase 2

    Ages

    21 to 65

    Site

    The Ohio State University Medical Center, Columbus, Ohio

    Run by

    Anthony P King

    See if you can join NCT07104916 on ClinicalTrials.gov

23. General Psychological Distress, PTSD, and Co-Morbidities in Healthcare Workers Consequent to Occupational Trauma

    It is expected that large numbers of healthcare workers experience a broad range of psychological reactions and symptoms including anxiety, depression, moral distress, and trauma symptoms that will cause both significant suffering as well as occupational and social impairment. The purpose of this s…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT04626050 on ClinicalTrials.gov

24. CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy

    Anxiety-, obsessive-compulsive and trauma- and stressor-related disorders reflect a significant public health problem. This study is designed to evaluate the predictive power of a novel biomarker based on a CO2 challenge, thus addressing the central question "can this easy-to-administer assay aid c…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Boston University, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Jasper A. Smits

    See if you can join NCT05467683 on ClinicalTrials.gov

25. MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder

    The study investigators are conducting the first randomized placebo-controlled trial of MDMA-assisted therapy with a comorbid sample of military Veterans with a co-occurring diagnosis of Alcohol Use Disorder (AUD) and Post-Traumatic Stress Disorder (PTSD). This novel experimental treatment package …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT07118839 on ClinicalTrials.gov