Post Traumatic Stress Disorder Clinical Trials

68 studies are recruiting for post traumatic stress disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. Morning Bright Light to Improve Sleep Quality in Veterans

   One of the principal complicating factors associated with traumatic brain injury (TBI) is sleep-wake disturbances (e.g., insomnia, excessive daytime sleepiness, and circadian rhythm sleep disorders). Morning bright light therapy (MBLT) has been shown to improve sleep quality in a variety of conditi…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA Portland Health Care System, Portand, Oregon

   Run by

   Portland VA Medical Center

   See if you can join NCT03578003 on ClinicalTrials.gov

2. Mechanisms Underlying Efficacy of Prolonged Exposure

   The primary objective of this research is to collect pilot data that demonstrates that proposed neural, psychophysiological and subjective markers measured before, during, and after treatment change over the course of Prolonged Exposure therapy (PE) for posttraumatic stress disorder (PTSD). The aim…

   Stage

   Not phased

   Ages

   18 and older

   Site

   MGH, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT05788302 on ClinicalTrials.gov

3. Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.

   Purpose: About 6.4% of the U.S. population suffers from posttraumatic stress disorder (PTSD). Trauma-focused psychotherapies are generally effective in PTSD, but responses vary greatly across individuals and PTSD subpopulations. Neurobiological factors impacted by life experiences, stress, and gene…

   Stage

   Phase 2

   Ages

   18 to 55

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07079761 on ClinicalTrials.gov

4. OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit

   Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone. This is especially true in residential settings where both disorders are more sev…

   Stage

   Not phased

   Ages

   18 and older

   Site

   VA San Diego Healthcare System, San Diego, CA, San Diego, California

   Run by

   VA Office of Research and Development

   See if you can join NCT05156112 on ClinicalTrials.gov

5. Disrupting Fear-based Memory Consolidation

   This project represents a unique collaborative opportunity to pursue the essential proof-of-principle demonstration that non-invasive interference of sensory cortical memory consolidation shortly after an emotional experience can attenuate the cued fear response and potentially reduce the risk of d…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Emory Rehabilitation Hospital, Atlanta, Georgia

   Locations

   2 in total

   Run by

   Emory University

   See if you can join NCT05560113 on ClinicalTrials.gov

6. Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

   The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program t…

   Stage

   Phase 2

   Ages

   21 to 55

   Site

   UC San Diego, San Diego, California

   Run by

   University of California, San Diego

   See if you can join NCT06273527 on ClinicalTrials.gov

7. Determining the Right Acupuncture for Good Recovery Over Neuropsychiatric Trauma

   This study seeks to verify that a specific acupuncture treatment is effective at reducing symptoms of neuropsychiatric trauma found in those diagnosed with Post-Traumatic Stress Disorder (PTSD).

   Stage

   Not phased

   Ages

   18 to 74

   Site

   Mike O'Callaghan Military Medical Center, Nellis Air Force Base, Nevada

   Run by

   Paul Crawford

   See if you can join NCT05516862 on ClinicalTrials.gov

8. Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms

   Many combat veterans (c-Vs), service members (SMs) and civilians with mild traumatic brain injury (mTBI, also termed concussion) suffer from persistent post-concussion symptoms (PPCS) that degrade physical and cognitive well-being and have been linked with early neurodegeneration. PPCS include soma…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Virginia Commonwealth University, Richmond, Virginia

   Run by

   Virginia Commonwealth University

   See if you can join NCT07071350 on ClinicalTrials.gov

9. Building Resilience at Schools: Emotional and Biological Assessment and Treatment of Traumatic Stress

   In the last four years alone, residents of Puerto Rico have experienced a slew of natural disasters including Hurricane Maria in 2017, earthquakes in 2019 and 2020, the continued COVID-19 pandemic from 2020-2022, and most recently Hurricane Fiona. This series of distressing events can lead to an in…

   Stage

   Not phased

   Ages

   11 to 17

   Site

   Department of Education Puerto Rico, San Juan,

   Locations

   3 in total

   Run by

   Stanford University

   See if you can join NCT05701111 on ClinicalTrials.gov

10. Amygdala Memory Enhancement

    The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Washington University School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT05065450 on ClinicalTrials.gov

11. Non-invasive Nerve Stimulation for PTSD and Sleep

    In this study, our objective is to determine the effect of two different nerve stimulation types in changing sleep architecture.

    Stage

    Not phased

    Ages

    18 to 55

    Site

    UF Health Jacksonville, Gainesville, Florida

    Locations

    3 in total

    Run by

    University of Florida

    See if you can join NCT03170440 on ClinicalTrials.gov

12. Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD

    This is a double-blind, 2-group randomized controlled trial evaluating the effects of topiramate versus placebo in patients with comorbid PTSD and moderate-to-severe AUD. This trial will provide one of the first rigorous tests of whether the effects of topiramate in AUD generalize to patients with …

    Stage

    Phase 2

    Ages

    18 to 70

    Site

    New York University School of Medicine, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT03667846 on ClinicalTrials.gov

13. NYSCF Scientific Discovery Biobank

    The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, and store th…

    Stage

    Not phased

    Ages

    0 and older

    Site

    New York Stem Cell Foundation Research Institute, New York, New York

    Run by

    New York Stem Cell Foundation Research Institute

    See if you can join NCT06203106 on ClinicalTrials.gov

14. Creative Arts Program to Reduce Burnout in Healthcare Professionals

    This study plans to learn if creative arts programs that include visual, musical, written, or physical expression can reduce symptoms of burnout syndrome, Post Traumatic Stress Disorder (PTSD), depression, and anxiety in critical care healthcare professionals. This study also explores if creative a…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    University of Colorado - Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT04276922 on ClinicalTrials.gov

15. RIVER At Home Ketamine Protocols

    Multiple site studies with the recruitment of other sub-investigators and sites. It's sobering to consider how chronic illness makes us more vulnerable to suicidal thoughts and behavior. However, the existence of multiple risk factors also means that there are numerous ways to intervene. Addressing…

    Stage

    Not phased

    Ages

    18 and older

    Site

    RIVER Foundation, Bigfork, Montana

    Locations

    2 in total

    Run by

    RIVER Foundation

    See if you can join NCT06070766 on ClinicalTrials.gov

16. Brief Treatment for Trauma Nightmares in Trauma-exposed Adults With Bipolar Disorder

    Exposure, relaxation, and rescripting therapy (ERRT) is a promising psychological intervention developed to target trauma-related nightmares and sleep disturbances. Though further evidence is needed, ERRT has shown strong support in reducing the number and intensity of nightmares, as well as improv…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Tulsa, Tulsa, Oklahoma

    Run by

    University of Tulsa

    See if you can join NCT02242110 on ClinicalTrials.gov

17. Targeting the Default Mode Network: A TMS-fMRI Study

    In post-traumatic stress disorder (PTSD), intrusive, traumatic, autobiographical memories lead to anxiety symptoms. Recent work suggests a new repetitive pulse transcranial magnetic stimulation (rTMS) brain target that might bring relief. Since this proposed target is not well understood, the goal …

    Stage

    Not phased

    Ages

    18 to 55

    Site

    VA Palo Alto, Palo Alto, California

    Run by

    Allyson Rosen

    See if you can join NCT05646732 on ClinicalTrials.gov

18. Improving Therapeutic Learning for PTSD

    The proposed project seeks to demonstrate the engagement of post-exposure dopamine neurotransmission and downstream acute reorganization of dopaminergic resting-state neural networks as a means of increasing consolidation of extinction memories formed during analogue exposure therapy in adult women…

    Stage

    Phase 2

    Ages

    21 to 50

    Site

    University of Texas, Austin, Texas

    Locations

    2 in total

    Run by

    University of Wisconsin, Madison

    See if you can join NCT04558112 on ClinicalTrials.gov