Pain Clinical Trials

100 studies are recruiting for pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. ESPBs vs TAPs for Satisfactory Analgesia Following DIEP Surgery

   Breast cancer is the second most common cancer diagnosed in American women . For patients who have undergone surgical mastectomy, autologous breast reconstruction is an alternative option to breast implants. Deep Inferior Epigastric Perforator (DIEP) flaps are the gold standard for autologous breas…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   University of Kansas Medical Center, Kansas City, Kansas

   Run by

   University of Kansas Medical Center

   See if you can join NCT06091241 on ClinicalTrials.gov

2. Ketamine and Propofol NeuroImaging

   This is a multi-visit which will collect MRI (pictures of the brain) and EEG (brain waves) data to determine changes in brain connectivity and brain activity for memory formation and pain perception while receiving the commonly-used anesthetic agents ketamine and propofol, both alone and in combina…

   Stage

   EARLY_Phase 1

   Ages

   18 to 59

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   Keith M Vogt

   See if you can join NCT07294092 on ClinicalTrials.gov

3. Pain Outcomes Associated With Exogenous Hormone Therapy in Adults

   TRANSPIRE is an observational study of ~200 individuals who (1) will be initiating gender-affirming hormone therapy (GHT) or (2) are gender minority individuals who do not use GHT. The primary outcome will be to identify how the presence of chronic pain changes overtime with GHT through the use of …

   Stage

   Not phased

   Ages

   18 to 50

   Site

   The University of Kansas Medical Center, Kansas City, Kansas

   Run by

   University of Kansas Medical Center

   See if you can join NCT06939257 on ClinicalTrials.gov

4. TENS Analgesia During Outpatient Urethral Bulking for Stress Urinary Incontinence.

   This will be a double-blind randomized control trial in women with stress urinary incontinence who are undergoing an outpatient transurethral bulking procedure for stress urinary incontinence. Subjects will be identified by the University of Rochester urologists and urogynecologists participating i…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Pelvic Health and Continence Specialties, Rochester, New York

   Run by

   University of Rochester

   See if you can join NCT06369922 on ClinicalTrials.gov

5. Regional Blocks for Lateral Condyle Fractures

   The purpose of this study is to investigate the post-operative pain control in pediatric patients with closed lateral condyle fractures who undergo open reduction and percutaneous pinning. Patients will be randomized into one of two groups. Group 1 will receive an infraclavicular nerve block to the…

   Stage

   Phase 4

   Ages

   4 to 12

   Site

   Orthopaedic Institute for Children, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT03796572 on ClinicalTrials.gov

6. Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery

   Postoperative pain is prevalent after intracranial surgery. Patients undergoing craniotomy are typically managed with short acting opioids to enable early and reliable post-operative neurological exam as well as avoid the risk of respiratory depression. However, a plethora of studies have shown tha…

   Stage

   EARLY_Phase 1

   Ages

   18 to 65

   Site

   University of Virginia, Charlottesville, Virginia

   Run by

   University of Virginia

   See if you can join NCT06810336 on ClinicalTrials.gov

7. The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults

   Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, we will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-indu…

   Stage

   EARLY_Phase 1

   Ages

   45 to 85

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT05761860 on ClinicalTrials.gov

8. Music Use in Parturients Admitted to Labor & Delivery

   The goal of this clinical trial is to learn if music use affects anxiety or pain levels in parturients admitted to labor and delivery. It will also learn about the effect of music use on patient satisfaction. The main questions it aims to answer are: Does music use affect anxiety levels in parturie…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tufts Medical Center, Boston, Massachusetts

   Run by

   Tufts Medical Center

   See if you can join NCT06969105 on ClinicalTrials.gov

9. Opioid-Free Orthopaedics

   The goal of this investigation is to compare effectiveness of this multimodal regimen at controlling postoperative pain with and without the use of opioid medications.

   Stage

   Phase 3

   Ages

   18 and older

   Site

   The Emory Clinic, Atlanta, Georgia

   Locations

   3 in total

   Run by

   Emory University

   See if you can join NCT04659317 on ClinicalTrials.gov

10. Stress and Pain in People Living With HIV

    This is a basic human experimental study utilizing 4 groups of individuals with and without HIV and complex morbidities of cannabis use disorder and major depression who will participate in 2 sessions of the Yale Pain Stress Task (YPST) and follow-up phase to assess drug use and mood symptoms.

    Stage

    Not phased

    Ages

    18 to 68

    Site

    The Yale Stress Center, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06784908 on ClinicalTrials.gov

11. Evaluation of Post-PACU Pain Management in Pediatric Surgery

    This study aims to assess the differences in overall pain severity, pain management, and satisfaction during recovery period between two groups of children who either receive or do not receive additional education related to expectation and management of postoperative pain.

    Stage

    Not phased

    Ages

    1 to 6

    Site

    Columbia University, New York, New York

    Run by

    Columbia University

    See if you can join NCT02352116 on ClinicalTrials.gov

12. Post-Op Pain Control for Prophylactic Intramedullary Nailing.

    Nationally, the opioid crisis has become a major epidemic with increasing mortality rates each year. Orthopedic surgeons routinely prescribe narcotics instead of NSAIDs for post-op pain control because of risk of delayed healing and nonunion due to NSAID use. Orthopedic oncology, however, has a uni…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Saint Louis University, St Louis, Missouri

    Run by

    St. Louis University

    See if you can join NCT03823534 on ClinicalTrials.gov

13. Exploring the Acute and Dynamic Relationships Between Movement and Pain in Older Adults With Musculoskeletal Pain

    The purpose of this research study is to evaluate the effect of brief bouts of intermittent walking on bodily pain, pain during movement, and how the body adapts to musculoskeletal pain in older adults.

    Stage

    Not phased

    Ages

    55 to 85

    Site

    250 University Blvd, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT06886906 on ClinicalTrials.gov

14. Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery

    The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following cleft palate surgery in infants and young children.

    Stage

    Phase 4

    Ages

    0 to 4

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06962306 on ClinicalTrials.gov

15. Measuring Analgesic Interventions

    It is generally recognized that pain assessment and management especially in newborns, children and other nonverbal populations is an unmet need. According to the American Medical Association, "the pediatric population is at risk of inadequate pain management, with age-related factors affecting pai…

    Stage

    Not phased

    Ages

    7 to 21

    Site

    Children's National Health System, Washington D.C., District of Columbia

    Run by

    Julia Finkel

    See if you can join NCT03794362 on ClinicalTrials.gov

16. Remimazolam NeuroImaging

    This is a single-arm functional MRI study that will determine the effects of remimazolam on cognition and brain activity and connectivity at rest, during noxious stimulation, and during a memory encoding task

    Stage

    EARLY_Phase 1

    Ages

    18 to 59

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    Keith M Vogt

    See if you can join NCT07290205 on ClinicalTrials.gov

17. Pain in Aging Former Athletes, Master's Athletes, and Nonathletes

    The goal of this clinical trial is to determine how male and female former athletes experience pain and respond to moderate-intensity exercise (strength versus aerobic) compared with both current master's athletes and nonathletes. The main questions this study aims to address are: 1. How do former …

    Stage

    Not phased

    Ages

    35 to 65

    Site

    Marquette University, Milwaukee, Wisconsin

    Run by

    Marquette University

    See if you can join NCT07502742 on ClinicalTrials.gov

18. Association Between Body Composition and Pain in Spinal Cord Injury

    The purposes of the study are to quantify and compare relationships among acute changes in inflammatory markers and evoked pain sensitivity after a high-fat meal (HFM) challenge, compared to a moderate-fat meal challenge, and explore the influence of body composition on these responses, in individu…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of Miami, Coral Gables, Florida

    Run by

    University of Miami

    See if you can join NCT05459207 on ClinicalTrials.gov

19. Contrast and Anesthetic Level With Lumbar Erector Spinae Plan (ESP) Block

    As per usual care for spine surgery, participants will have their back cleaned with alcohol and a needle will be placed using ultrasound for the ESP block. Through the needle, a small catheter will be placed in the participants back and the needle removed. Approximately one hour prior to the start …

    Stage

    Not phased

    Ages

    21 to 75

    Site

    University Hospitals Cleveland Medical Center, Cleveland, Ohio

    Run by

    University Hospitals Cleveland Medical Center

    See if you can join NCT07174440 on ClinicalTrials.gov

20. Virtual Reality (VR) for Interventional Radiology (IR) Procedures

    The goal of this clinical trial is to to utilize Virtual Reality during their interventional radiology procedure to help reduce any pain and anxiety experienced during the procedure in patients above the age of 8 undergoing interventional radiology procedures. The main questions it aims to answer a…

    Stage

    Not phased

    Ages

    8 and older

    Site

    Children's Hospital Los Angeles, Los Angeles, California

    Run by

    Children's Hospital Los Angeles

    See if you can join NCT07427862 on ClinicalTrials.gov

21. Phase 1 Study of SBS-147 in Healthy Adults

    This study is part of the HEAL Initiative supported by the NIH. The purpose of this study is to learn how safe the study drug, SBS-147, is and how people's bodies respond to and process it. Researchers will also look for any side effects that may occur when taking SBS-147. Some participants will re…

    Stage

    Phase 1

    Ages

    18 to 55

    Site

    AltaSciences, Inc, Cypress, California

    Run by

    Sparian Biosciences, Inc

    See if you can join NCT07335913 on ClinicalTrials.gov

22. Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain

    The purpose of this study is to assess thalamocortical (TC) connectivity during tonic pressure pain, to evaluate alpha activity during tonic pressure pain and to determine pressure pain ratings by using Electroencephalography (EEG), Functional Magnetic Resonance Imaging (fMRI), Transcranial Alterna…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT06968689 on ClinicalTrials.gov

23. Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain

    The goal of this pilot study is to assess whether 4-weeks of verified smoking abstinence following financial incentive treatment for smoking cessation improves physiological markers of chronic pain risk in adult Native American smokers. The main aims to answer are: 1. Determine study feasibility. 2…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Oklahoma - Schusterman Center, Tulsa, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT07080788 on ClinicalTrials.gov

24. Behavioral Economic & Staffing Strategies in the ICU

    The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill adults with known health disparities. Investigators will specifically e…

    Stage

    Not phased

    Ages

    19 and older

    Site

    University of Iowa Hospitals and Clinics, Iowa City, Iowa

    Locations

    3 in total

    Run by

    University of Nebraska

    See if you can join NCT06184945 on ClinicalTrials.gov

25. The Effect of Intraoral Transcutaneous Electrical Nerve Stimulation in Orthodontics Pain

    The goal of this clinical trial is to determine whether an intraoral Transcutaneous Electrical Nerve Stimulation (TENS) device can reduce pain during orthodontic alignment and leveling in adolescents and adults. The study aims to compare the effectiveness of the TENS device in reducing pain on one …

    Stage

    Not phased

    Ages

    12 and older

    Site

    University of the Pacific, Arthur A. Dugoni School of Dentistry, San Francisco, California

    Run by

    University of the Pacific

    See if you can join NCT06573996 on ClinicalTrials.gov