Pain Clinical Trials

100 studies are recruiting for pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. Virtual Reality vs. Music Relaxation for Reducing Anxiety and Pain During Breast Biopsies

   This study aims to compare the effectiveness of a Virtual Reality (VR) application computer simulation [(CS) VR Mindful Meditation App')] versus music relaxation in reducing anxiety and pain in women undergoing breast biopsies. Participants will be randomized into three groups: VR, music relaxation…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Westwood, Los Angeles, California

   Run by

   Jonsson Comprehensive Cancer Center

   See if you can join NCT07310004 on ClinicalTrials.gov

2. Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits

   The primary aim of this implementation-effectiveness trial is to examine the effectiveness of Mindfulness-Oriented Recovery Enhancement (MORE) and patient-centered chronic pain management visits in primary care as interventions to reduce chronic pain, improve quality of life, and reduce opioid-rela…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   UCSD Health, La Jolla, California

   Locations

   3 in total

   Run by

   University of Utah

   See if you can join NCT06387290 on ClinicalTrials.gov

3. Defense and Veterans Center for Integrative Pain Management (DVCIPM) Pain Registry Biobank

   This Pain Registry Biobank is a prospective cohort design study whereby data (PASTOR survey, blood and saliva specimens, clinical data) is collected from participants in a longitudinal fashion with continual enrollment.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Naval Medical Center San Diego, San Diego, California

   Locations

   2 in total

   Run by

   Defense and Veterans Center for Integrative Pain Management

   See if you can join NCT04004286 on ClinicalTrials.gov

4. Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination

   Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on expe…

   Stage

   EARLY_Phase 1

   Ages

   21 to 45

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT04218409 on ClinicalTrials.gov

5. The Warmth, Anticipation, Sensation, Aversion, and Body-part Imaging Study

   This functional magnetic-resonance imaging study of the brain will feature a within-subject crossover design to investigate the effects of a placebo cream on painful thermal stimulation rendered upon eight body sites. The investigators aim to 1.) improve the understanding of how the brain represent…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Dartmouth College, Hanover, New Hampshire

   Run by

   Trustees of Dartmouth College

   See if you can join NCT04653064 on ClinicalTrials.gov

6. Low-dose Buccal Buprenorphine: Relative Abuse Potential and Analgesia

   The goal of this study is to compare the abuse potential of low-dose equianalgesic buccal buprenorphine to a commonly used full mu opioid receptor (MOR) agonist in a highly controlled experimental setting. This is a translational study in which healthy participants are phenotyped for psychosocial a…

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT05988710 on ClinicalTrials.gov

7. Age-dependent Effects of Smoked and Oral Delta-9-THC

   This study will assess the age-dependent effects of smoked and oral THC on abuse liability, intoxication, analgesia and impairment as a function of age.

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   UCLA Center for Cannabis and Cannabinoids, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT05865470 on ClinicalTrials.gov

8. Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

   The study, known as the Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE), aims to determine the effectiveness of digital CBT in reducing pain, opioid use, and healthcare utilization among AYAs with SCD. It also s…

   Stage

   Not phased

   Ages

   16 to 30

   Site

   University of South Alabama Medical Center, Mobile, Alabama

   Locations

   14 in total

   Run by

   University of Pittsburgh

   See if you can join NCT06374238 on ClinicalTrials.gov

9. Feasibility of a Mindfulness Intervention for Endometriosis Surgery

   Endometriosis is a common cause of pelvic pain in women which has been historically under-studied and under-diagnosed. The goal of this research is to pilot-test the feasibility and acceptability of a manualized, single-session brief mindfulness-based intervention (BMBI) among participants with end…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Penn State Health, Hershey, Pennsylvania

   Run by

   Milton S. Hershey Medical Center

   See if you can join NCT06141720 on ClinicalTrials.gov

10. THC and CBD: A Controlled Human Study Probing a Harm Reduction Strategy

    The purpose of this research is to assess the impact of CBD on the effects of THC.

    Stage

    Phase 1

    Ages

    21 to 55

    Site

    UCLA Center for Cannabis and Cannabinoids, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT06859710 on ClinicalTrials.gov

11. Pain and Split-belt Motor Learning in Older Adults

    The purpose of this research is to investigate the impact of acute pain, induced using an experimental pain paradigm of capsaicin paired with heat, on implicit locomotor learning and its retention in older adults.

    Stage

    Not phased

    Ages

    55 to 90

    Site

    Health Sciences Complex, Newark, Delaware

    Run by

    University of Delaware

    See if you can join NCT07054840 on ClinicalTrials.gov

12. The Influence of Sleep on Cardiovascular Outcomes

    The goal of this study is to identify the effects of sleep regularity on cardiovascular regulatory mechanisms. The investigators are hoping to discover if improving the regularity of sleep timing will improve metabolic and vascular health markers. The protocol is a 12-week prospective cohort study …

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT06535178 on ClinicalTrials.gov

13. M2VA Pain Care Pathway

    The goal of this 2-cohort, cluster randomized, type 2 hybrid trial is to test the effectiveness, cost-effectiveness and patient-level effects of an implementation facilitation strategy in helping M2VA case managers adopt a Military2VA Pain Care Pathway (M2VAPCP) intervention. The main questions it …

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Connecticut Healthcare System (VACHS), West Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06526143 on ClinicalTrials.gov

14. Impact of the NeuroCuple Device on Pain Management After Cesarean Delivery

    This will be a single-center, sham-controlled, 3 arms, randomized (1:1:1) prospective study in females undergoing cesarean delivery to investigate the impact of NeuroCuple™ non-pharmacological analgesic device for management of postoperative pain. The investigators hypothesize that women treated wi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Inova Fairfax Medical Campus, Falls Church, Virginia

    Run by

    Inova Health Care Services

    See if you can join NCT07185425 on ClinicalTrials.gov

15. Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI

    The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involve…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05492188 on ClinicalTrials.gov

16. Augmented Reality For MRI-Guided Interventions

    The purpose of this study is to determine feasibility and safety of using an augmented reality system in patients undergoing MRI-Guided needle procedures.

    Stage

    Not phased

    Ages

    3 to 21

    Site

    Children's National Hospital, Washington D.C., District of Columbia

    Run by

    Children's National Research Institute

    See if you can join NCT06224933 on ClinicalTrials.gov

17. Cannabis for Palliative Care in Cancer

    Many cancer patients suffer from pain, sleep, and mood problems and are using cannabis to relieve these symptoms. Cannabis may provide such relief but may also produce negative side effects including cognitive impairment, an especially problematic issue for cancer patients, indicating more research…

    Stage

    Phase 2

    Ages

    25 and older

    Site

    Anschutz Health Sciences Building, Aurora, Colorado

    Run by

    University of Colorado, Boulder

    See if you can join NCT06266611 on ClinicalTrials.gov

18. Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment

    This hybrid implementation-effectiveness trial will evaluate Mindfulness-Oriented Recovery Enhancement (MORE) for patients with opioid use disorder receiving methadone treatment (MT). The investigators will also assess barriers and facilitators to integrating MORE into methadone treatment, and eval…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey

    Locations

    2 in total

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT06032559 on ClinicalTrials.gov

19. PAINED: Project Addressing INequities in the Emergency Department

    Racial and ethnic inequities in health care quality have been described across a broad range of clinical settings, patient populations, and outcomes. Our overarching goal is to eradicate health care inequities through evidence-based interventions. The objectives of this proposal are to develop and …

    Stage

    Not phased

    Ages

    0 and older

    Site

    Children's National Hospital, Washington D.C., District of Columbia

    Run by

    Children's National Research Institute

    See if you can join NCT05488080 on ClinicalTrials.gov

20. Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial

    Two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial evaluating the efficacy of standard pain management without NSAIDs (Group 1) vs. standard pain management plus up to 6 weeks of NSAIDs (Group 2) in the treatment of tibial shaft fractures.

    Stage

    Phase 3

    Ages

    18 to 80

    Site

    Eskenazi Hospital, Indianapolis, Indiana

    Locations

    14 in total

    Run by

    Major Extremity Trauma Research Consortium

    See if you can join NCT07006675 on ClinicalTrials.gov

21. Scrambler Therapy With Duloxetine-based Usual Care vs Duloxetine-based Usual Care for Chemotherapy-induced Peripheral Neuropathy.

    The investigators hypothesize that Scrambler therapy with duloxetine, compared to duloxetine-based usual care, will result in greater improvement in CIPN as measured by the BPI-Short Form. In addition, the investigators will further assess pain using the EORTC CIPN-20 and determine whether Scramble…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Fox Chase Cancer Center, Philadelphia, Pennsylvania

    Run by

    Fox Chase Cancer Center

    See if you can join NCT06914557 on ClinicalTrials.gov

22. Oklahoma Study of Native American Pain Risk III: Stress and Resilience

    The goal of this observational study is to learn about the relationship between environmental structural racism and discrimination and chronic pain risk in Native American adults. The main questions it aims to answer are: 1. How does environmental structural racism and discrimination affect chronic…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Oklahoma - Schusterman Center, Tulsa, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT05723081 on ClinicalTrials.gov

23. Low-Dose Ketamine Infusion During Burn Wound Care

    The current standard of care (SOC) (i.e. fentanyl and midazolam) offers limited efficacy for preventing or relieving pain. Ketamine infusions may provide the benefits of analgesia, minimize adverse events, and reduce opioid use. The purpose of this study is to determine if adding a low dose ketamin…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Regional One Health, Memphis, Tennessee

    Run by

    University of Tennessee

    See if you can join NCT06506565 on ClinicalTrials.gov

24. AIMS Medical Outcomes Study

    This epidemiologic research is being conducted as an observational prospective case series outcomes study of the use of advanced integrative specialty medical care and its effect on adult and pediatric patients with chronic or serious illnesses or mental health disorders.

    Stage

    Not phased

    Ages

    Any age

    Site

    AIMS Institute, Seattle, Washington

    Run by

    Advanced Integrative Medical Science Institute

    See if you can join NCT04512755 on ClinicalTrials.gov

25. Optimizing Pain Control in Transurethral Resection of the Prostate

    The purpose of this study is to develop a multi-modal protocol for pain management after TURP that minimizes opioid use. The investigators hypothesize this approach will provide non-inferior pain control to the current standard of care which includes opioids as the primary agent. The investigators …

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Virginia Mason Medical Center, Seattle, Washington

    Run by

    Benaroya Research Institute

    See if you can join NCT04102566 on ClinicalTrials.gov