Pain Clinical Trials

100 studies are recruiting for pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Options for Pain Management Using Nonpharmacological Strategies

   The purpose of this study is to help Veterans learn about different ways they can manage chronic pain that do not involve medications. Veterans will work with a coach to explore the Veterans' values and goals and how different non-medication approaches may fit into these values and goals.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Richard L. Roudebush VA Medical Center, Indianapolis, IN, Indianapolis, Indiana

   Run by

   VA Office of Research and Development

   See if you can join NCT05563792 on ClinicalTrials.gov

2. Suzetrigine in Total Hip Arthroplasty

   Total hip and knee joint replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery. Despite widespread use of multimodal regimens, many patients still rely on opioids, which can cause se…

   Stage

   Phase 3

   Ages

   18 to 80

   Site

   Hospital for Special Surgery, New York, New York

   Run by

   Hospital for Special Surgery, New York

   See if you can join NCT07226700 on ClinicalTrials.gov

3. Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism

   The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, fatigue, and quality of life when compared with placebo in men with chronic spinal pain treated with opioids who have opioid-induced hypogonadism…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Boston, Massachusetts

   Run by

   Brigham and Women's Hospital

   See if you can join NCT04798469 on ClinicalTrials.gov

4. Testing the Pain Clinical Practice Guideline

   There are evidence based processes for assessment and management of pain using pharmacologic and nonpharmacological approaches. These were reviewed and included within the Pain Management Clinical Practice Guideline (Pain Management CPG) recently developed by AMDA: The Society for Post-Acute and Lo…

   Stage

   Phase 2

   Ages

   60 and older

   Site

   Lorien Mays Chapel, Timonium, Maryland

   Locations

   11 in total

   Run by

   University of Maryland, Baltimore

   See if you can join NCT05858996 on ClinicalTrials.gov

5. Strength and Pain-Coping Through Resilience and Knowledge

   Older adults who are 50 years of age and older with depressive symptoms, pain and difficulty with mobility will participate in the SPARK intervention study that includes 8 nurse visits in participants' homes to help participants with participants' pain and mood.

   Stage

   Not phased

   Ages

   50 and older

   Site

   Johns Hopkins School of Nursing, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07228520 on ClinicalTrials.gov

6. Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype

   The purpose of this research study is to compare the effects of cannabidiol (CBD), tetrahydrocannabinol (THC), or both, on sleep and pain in persons with multiple sclerosis (MS). Little is known about how CBD and/or THC may help sleep, reduce pain, or perhaps even treat pain through better sleep.

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   Tiffany J. Braley, MD, MS

   See if you can join NCT05269628 on ClinicalTrials.gov

7. FDG PET/MR Imaging of Peripheral Pain Generators

   The purpose of this research is to determine if a PET/MRI scan using FDG can accurately identify the source of chronic pain. Identifying the source of pain may help doctors treat chronic pain more effectively. Approximately 128 participants will be enrolled and can expect to be on study for up to 1…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   UW School of Medicine and Public Health, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT06171659 on ClinicalTrials.gov

8. MucoLock™ for Treatment of Stomatitis

   The purpose of this research is to test how well people can tolerate MucoLock™ as a treatment for mouth pain or burning sensation and how well it works to reduce mouth pain or burning sensation. Study participants will be asked to use MucoLock™ topical solution as a "swish and spit" solution (simil…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Miami Cancer Institute at Baptist Health, Inc., Miami, Florida

   Run by

   Baptist Health South Florida

   See if you can join NCT07506018 on ClinicalTrials.gov

9. Effects of Dronabinol in Opioid Maintained Patients

   Twenty male and female (ages 18-70) participants with OUD currently receiving methadone or buprenorphine will be enrolled. Prior to their daily methadone or buprenorphine dose and thus at trough plasma levels of opioid, participants will receive dronabinol (2.5 mg, 5mg) or placebo. Subsequently, al…

   Stage

   EARLY_Phase 1

   Ages

   18 to 70

   Site

   VA Connecticut Healthcare System, West Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT04025359 on ClinicalTrials.gov

10. Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain

    This project is a single-site, three-arm, randomized controlled trial investigating whether different length audio-recorded mindfulness practices differentially decrease pain among patients in a waiting room awaiting orthopedic care.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tallahassee Orthopedic Clinic, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT07562412 on ClinicalTrials.gov

11. Biofield Therapy for the Support of Immunotherapy-related Symptoms Among Adult Cancer Patients - A Pilot Study

    Cancer treatment with immunotherapy is often associated with symptoms such as fatigue, pain, and emotional distress, which may affect patients' daily functioning and quality of life. Additional supportive care approaches are being studied to better understand their potential role in supporting thes…

    Stage

    Not phased

    Ages

    18 and older

    Site

    UCI Health Susan Samueli Integrative Health Institute, Irvine, California

    Locations

    2 in total

    Run by

    University of California, Irvine

    See if you can join NCT07581080 on ClinicalTrials.gov

12. Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)

    This project examines, in chronic pain, the mechanisms of immersive virtual reality compared to the mechanisms of placebo hypoalgesia. The potential of developing new non-pharmacological premises for low-risk interventions for pain management is high.

    Stage

    Not phased

    Ages

    18 to 88

    Site

    Luana Colloca, Baltimore, Maryland

    Locations

    2 in total

    Run by

    University of Maryland, Baltimore

    See if you can join NCT06214923 on ClinicalTrials.gov

13. Pervasive Sensing and AI in Intelligent ICU

    Important information related to the visual assessment of patients, such as facial expressions, head and extremity movements, posture, and mobility are captured sporadically by overburdened nurses, or are not captured at all. Consequently, these important visual cues, although associated with criti…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Florida Health Shands Hospital, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT05127265 on ClinicalTrials.gov

14. State of Hormones Impact Nociceptive Expression

    The Investigators have recently published on differences in pain sensitivity measures between cis and trans individuals in the local area. The investigators observed the anticipated differences in pain sensitivity between CM and CW (CW > CM), but found that the TW were phenotypically similar to CW …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT05787470 on ClinicalTrials.gov

15. A Study to Evaluate Ibuprofen (IBU) 62.5 mg and Acetaminophen (APAP) 125 mg/5 ml in an Oral Liquid Suspension Fixed-Dose Combination Product in Children Aged 6 to 11 Years

    The purpose of this study will be to characterize the pharmacokinetic (PK) profile of the Fixed-Dose Combination (FDC) IBU 62.5 milligram (mg)/APAP 125 mg per 5 milliliter (mL) suspension in children 6 to 11 years of age, inclusive, to satisfy Pediatric Research Equity Act (PREA) requirements.

    Stage

    Phase 1

    Ages

    6 to 11

    Site

    CenExel Salt Lake, Salt Lake City, Utah

    Run by

    HALEON

    See if you can join NCT07632274 on ClinicalTrials.gov

16. Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients

    This is a single-center, pilot randomized controlled trial designed to evaluate the feasibility of a definitive trial comparing opioid-free discharge prescriptions to usual care (which includes opioids) in patients undergoing major orthopaedic surgery. The main objective is to inform the design and…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mass, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07265557 on ClinicalTrials.gov

17. Real-World Efficacy of Evoke® Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy in Chronic Pain Patients (ULTRA).

    This observational, prospective data collection is designed to evaluate the efficacy of CL-SCS therapy in real-world patients suffering from chronic pain.

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Spine and Nerve Center of Saint Francis Hospital, Charleston, West Virginia

    Run by

    Saint Francis Hospital

    See if you can join NCT06246526 on ClinicalTrials.gov

18. Virtual Reality for Pain Management in Burn Patients

    This study is a randomized proof-of-concept study to assess the efficacy of Virtual Reality (VR) vs standard of care in 50 adult patients in the New York Presbyterian Burn Unit. The participants who are randomized to receive the virtual reality intervention will also receive opioids, which is the s…

    Stage

    Not phased

    Ages

    8 and older

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT04685486 on ClinicalTrials.gov

19. Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries

    Animal assisted therapy (AAT) with dogs has been shown to be beneficial for a wide range of patients with both acute and chronic illnesses, including spinal cord injuries, heart failure, myocardial infarctions, strokes, cancer, post-traumatic stress disorder, and depression. Studies have also demon…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Boston Medical Center, Trauma Inpatient Service, Boston, Massachusetts

    Run by

    Boston Medical Center

    See if you can join NCT06812247 on ClinicalTrials.gov

20. Training in Evidence-based Treatments in Psycho-Oncology

    The goal of this research study is to train psychotherapists to administer individualized evidence-based psychotherapies in a cancer care setting to patients and caregivers with elevated levels of distress. The intervention will mirror clinical care in psycho-oncology in which the therapist, collab…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital Cancer Center, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05674357 on ClinicalTrials.gov

21. A Randomized Controlled Trial to Assess the Impact of Live and Recorded Music-Based Interventions on Pre-operative Stress, Mood, Pain and Biomarkers, in Neurosurgical Patients (Music-STAR Trial)

    The study plans to enroll a total of 132 patients. The goal of this study is to measure pre-and post-music intervention changes in patients' vital signs, serum- and plasma-level biomarkers by broad-spectrum proteomics analysis, metabolic analysis, and perceived pain, anxiety, and mood states as mea…

    Stage

    Not phased

    Ages

    18 and older

    Site

    MD Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT06536504 on ClinicalTrials.gov

22. Registry of Outcomes of Dezawa MuseCells®

    The goal of this observational study is to learn about the long-term effects of Dezawa MuseCells to treat various diseases. The Primary Goal: What is the short-term and long- term outcomes of Dezawa Musecells? Participants treated with Dezawa MuseCells as part of their regular medical care and will…

    Stage

    Not phased

    Ages

    Up to 89

    Site

    Bioreset Medical, North Palm Beach, Florida

    Locations

    2 in total

    Run by

    MuseCell Innovations Pte LTD

    See if you can join NCT07645989 on ClinicalTrials.gov

23. Psychophysical Studies of Cancer Therapy Pain

    The Aim of this Study is to examine the feasibility of using quantitative sensory testing procedures, widely applied to the experimental study of sensory processing in humans both with and without various pain syndromes, to now characterize the psychophysical properties of neuropathic pain that has…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Texas MD Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT00515060 on ClinicalTrials.gov

24. Cannabidiol and Older Adult Cannabis Users

    Cannabis use increased 10 fold among adults over the age of 65 between 2014 and 2016 but very little data exists on the extent of their harmful effects on health and behavior. The overarching goal of this project is to test a novel harm reduction strategy in which older individuals who seek to use …

    Stage

    Phase 2

    Ages

    60 and older

    Site

    University of Colorado at Boulder, Boulder, Colorado

    Run by

    University of Colorado, Boulder

    See if you can join NCT06290063 on ClinicalTrials.gov

25. Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals

    Study of LIFU on fMRI pain signals. Participants receive low-intensity focused ultrasound (LIFU) and fMRI scans to measure changes in both resting and heat pain signals. Physiology may also be measured. Questionnaires and symptom monitoring will take place. The study takes place over 4 study visits.

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Fralin Biomedical Research Institute, Roanoke, Virginia

    Run by

    Virginia Polytechnic Institute and State University

    See if you can join NCT05303415 on ClinicalTrials.gov