Pain Clinical Trials

100 studies are recruiting for pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Transcutaneous Electrical Nerve Stimulation for Pain Mitigation During Intrauterine Device Placement

   Investigators are conducting a study to determine whether high frequency transcutaneous electrical nerve stimulation (hfTENS) is effective at reducing pain in women having an IUD inserted.

   Stage

   Not phased

   Ages

   18 and older

   Site

   MUSC Women's Health- Cannon Street, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06991075 on ClinicalTrials.gov

2. Impact of Art Therapy on Self-Reported Pain and Anxiety Scores of Patients Waiting to Be Seen in the Emergency Department

   The objective of this research is to assess the effects of engaging in coloring activities on patients' self-reported pain and anxiety scores while they wait to be seen by a physician in an emergency department (ED). The current literature on patient visits in the ED highlights the significance of …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Stony Brook University Hospital, Stony Brook, New York

   Run by

   Stony Brook University

   See if you can join NCT05540106 on ClinicalTrials.gov

3. State-dependent Interoception, Value-based Decision-making, and Introspection

   Background: Negative emotional states can affect a person s behavior as they make decisions. For example, hunger may make people more impatient; they may then make riskier choices. Other negative emotional states that can change behavior include stress, pain, and sadness. By learning more about how…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT05666726 on ClinicalTrials.gov

4. Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children

   Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies. This clinical trial aims to see how well pre-recorded guided imagery therapy sessions help …

   Stage

   Not phased

   Ages

   7 to 12

   Site

   Baylor College of Medicine/Texas Children's Hospital, Austin, Texas

   Locations

   2 in total

   Run by

   Baylor College of Medicine

   See if you can join NCT07222943 on ClinicalTrials.gov

5. Clinical and Scientific Assessment of Pain and Painful Disorders

   Background: Researchers want to better understand pain by studying people with and without different kinds of pain. To do this, researchers will expose people to pleasant and unpleasant sensations. They will ask them questions about their pain. Researchers also want to see if these people are eligi…

   Stage

   Not phased

   Ages

   12 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Center for Complementary and Integrative Health (NCCIH)

   See if you can join NCT02707029 on ClinicalTrials.gov

6. Transdiagnostic Cognitive Biomarkers

   The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cogniti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT04864080 on ClinicalTrials.gov

7. Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure

   This project is a single-site, randomized controlled trial designed to investigate the impact of a 7-minute mindfulness intervention on pain among patients undergoing kyphoplasty or radiofrequency ablation.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Tallahassee Orthopedic Clinic (TOC), Tallahassee, Florida

   Run by

   Florida State University

   See if you can join NCT06471075 on ClinicalTrials.gov

8. RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain

   To compile characteristics of real-world clinical outcomes for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable Instructions for Use - and - To evaluate the economic value and technical performance of Bosto…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Denver Back Pain Specialists, Greenwood Village, Colorado

   Locations

   118 in total

   Run by

   Boston Scientific Corporation

   See if you can join NCT01719055 on ClinicalTrials.gov

9. Neural and Psychological Mechanisms of Pain Perception

   Background: - Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, not just pain. Researchers want to understand how different factors influence pain. They want to test what happens when people expect differen…

   Stage

   Not phased

   Ages

   18 to 50

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Center for Complementary and Integrative Health (NCCIH)

   See if you can join NCT02446262 on ClinicalTrials.gov

10. Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

    Objective The current proposal investigates behavioral, psychophysiological, and social processes that may help explain biases and disparate outcomes in pain. Health disparities, or health outcomes that adversely affect disadvantaged populations, are pervasive and apparent in many diseases and symp…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Center for Complementary and Integrative Health (NCCIH)

    See if you can join NCT03258580 on ClinicalTrials.gov

11. High Potency Cannabis: Acute and Protracted Effects

    The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.

    Stage

    Phase 1

    Ages

    21 to 55

    Site

    UCLA Center for Cannabis and Cannabinoids, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT06859723 on ClinicalTrials.gov

12. Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy

    This single-site, single-arm study evaluates the feasibility, safety, tolerability, and efficacy of trans-arterial embolization (TAE) using Embozene microparticles for treating facetogenic pain due to facet arthropathy (osteoarthritis of the facet joints) in the lumbar spine.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    North Shore University Hospital, Manhasset, New York

    Run by

    Northwell Health

    See if you can join NCT06965452 on ClinicalTrials.gov

13. Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions

    The objective of this study is to assess the safety and efficacy of the Freesolve resorbable magnesium scaffold (RMS) in the treatment of subjects with up to two de novo lesions in native coronary arteries compared to the Xience coronary drug-eluting stent (DES) system

    Stage

    Not phased

    Ages

    18 to 80

    Site

    MedStar Washington Hospital Center, Washington D.C., District of Columbia

    Locations

    3 in total

    Run by

    Teleflex

    See if you can join NCT07258290 on ClinicalTrials.gov

14. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

    The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

    Stage

    Not phased

    Ages

    0 to 20

    Site

    Lucile Packard Children's Hospital, Palo Alto, California

    Locations

    52 in total

    Run by

    Duke University

    See if you can join NCT04278404 on ClinicalTrials.gov

15. Effect of Magnesium on Neuromonitoring

    Intraoperative neurophysiologic monitoring (IONM) is commonly used during complex spinal surgery to monitor the integrity of neural structures and improve the perioperative safety profile. Transcranial Motor Evoked Potentials (TcMEPs) monitor the integrity of the motor pathways and are one of the m…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    University of California San Francisco Hospital, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06975072 on ClinicalTrials.gov

16. Pivotal Study on the NOVABLOC System for Patients Undergoing Primary Total Knee Arthroplasty

    Multi-center, randomized, blinded, sham-controlled study to determin the safety and efficacy of the NOVABLOC system on post-operative pain in patients undergoing TKA procedures.

    Stage

    Not phased

    Ages

    21 and older

    Site

    Alabama Orthopedic Sports Medicine & Baldwin County Surgery Center, Daphne, Alabama

    Locations

    5 in total

    Run by

    Synaptrix, Inc.

    See if you can join NCT07191067 on ClinicalTrials.gov

17. Diphenhydramine as an Adjunct to Moderate Sedation for Procedural First Trimester Abortions

    This single center, double blind, randomized controlled trial will evaluate whether adding intravenous diphenhydramine to a standard moderate sedation regimen improves pain control during first trimester procedural abortion. Participants undergoing uterine aspiration at less than 13 weeks gestation…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Gender Wellness OB/GYN, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT07542730 on ClinicalTrials.gov

18. A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD

    The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, a…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Weill Cornell Medicine, White Plains, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05081596 on ClinicalTrials.gov

19. Evaluation of Pain Treatment After Total Knee Arthroplasty

    The purpose of the study is to characterize opioid use after total knee arthroplasty (TKA).

    Stage

    Phase 4

    Ages

    18 to 80

    Site

    Legent Orthopedic and Spine Hospital, Bellaire, Texas

    Locations

    2 in total

    Run by

    Vertex Pharmaceuticals Incorporated

    See if you can join NCT07538570 on ClinicalTrials.gov

20. Pain Intervention With Needling: Pilot Of Integrated Neuromodulation Techniques

    The study will be conducted on site in Galveston, Texas, United States. Study-related assessments and procedures will be performed at the designated clinical study site by qualified study personnel in accordance with the study protocol and applicable regulatory requirements. The study's purpose is …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of Texas Medical Branch, Galveston, Galveston, Texas

    Run by

    The University of Texas Medical Branch, Galveston

    See if you can join NCT07112404 on ClinicalTrials.gov

21. Hip Arthroscopy Postoperative Opioid Demands

    This study will be a prospective, single-blinded, randomized controlled trial (RCT), investigating the influence of the number of opioid pills prescribed following primary hip arthroscopy. All patients who sign the consent form will be enrolled in the suited and randomized to one of the two treatme…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Rush University Medical Center, Chicago, Illinois

    Run by

    Rush University Medical Center

    See if you can join NCT04094701 on ClinicalTrials.gov

22. Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0

    The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupuncture analgesia in patients with sickle cell disease.

    Stage

    Not phased

    Ages

    14 to 80

    Site

    University of Cincinnati College of Medicine, Cincinnati, Ohio

    Run by

    University of Cincinnati

    See if you can join NCT06725550 on ClinicalTrials.gov

23. Anesthetics and Analgesics in Children

    The purpose of this study is to characterize the pharmacokinetic (PK) and safety profile of anesthetics and analgesics in children and adolescents.

    Stage

    Not phased

    Ages

    0 to 17

    Site

    Lucile Packard Children's Hospital, Stanford, California

    Locations

    13 in total

    Run by

    Chi Dang Hornik

    See if you can join NCT03427736 on ClinicalTrials.gov

24. Pain With Dementia

    The purpose of the study is to develop a caregiver-assisted pain coping skills training program for older adults who have pain and mild to moderate dementia and are living at home with a family caregiver. The investigators are planning to recruit 30 patient-caregiver dyads (60 individuals).

    Stage

    Not phased

    Ages

    50 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT06854718 on ClinicalTrials.gov

25. Effect of Music on Pain and Anxiety During Nail Biopsies

    This study is looking at whether listening to music during a nail biopsy can reduce pain and anxiety. Patients scheduled for a nail biopsy at the Weill Cornell Medicine dermatology clinic will be randomly assigned to either listen to a calming instrumental/classical music playlist during their proc…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Weill Cornell Medicine Department of Dermatology, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT07518953 on ClinicalTrials.gov