Pain Clinical Trials

104 studies are recruiting for pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery

   The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in patients after major non-cardiac surgery. The main questions the trial ai…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT07224711 on ClinicalTrials.gov

2. Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy

   This single-site, single-arm study evaluates the feasibility, safety, tolerability, and efficacy of trans-arterial embolization (TAE) using Embozene microparticles for treating facetogenic pain due to facet arthropathy (osteoarthritis of the facet joints) in the lumbar spine.

   Stage

   Not phased

   Ages

   18 to 85

   Site

   North Shore University Hospital, Manhasset, New York

   Run by

   Northwell Health

   See if you can join NCT06965452 on ClinicalTrials.gov

3. Behavioral Economic & Staffing Strategies in the ICU

   The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill adults with known health disparities. Investigators will specifically e…

   Stage

   Not phased

   Ages

   19 and older

   Site

   University of Iowa Hospitals and Clinics, Iowa City, Iowa

   Locations

   3 in total

   Run by

   University of Nebraska

   See if you can join NCT06184945 on ClinicalTrials.gov

4. An Open-Label, Safety and Efficacy Study of Cebranopadol in Participants With Acute Pain With Surgical or Non-Surgical Origin

   The purpose of this study is to evaluate the safety and effectiveness of cebranopadol in treating acute pain.

   Stage

   Phase 3

   Ages

   18 to 75

   Site

   Adneuris Site 001115, Phoenix, Arizona

   Locations

   15 in total

   Run by

   Adneuris Therapeutics, Inc.

   See if you can join NCT07845071 on ClinicalTrials.gov

5. A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain

   This Phase 2 study will evaluate whether multiple doses of cebranopadol suppress opioid withdrawal signs and symptoms compared with placebo in adults with chronic pain who are physically dependent on prescribed opioids. Participants whose physical dependence is confirmed will be assigned by chance …

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   001127, North Canton, Ohio

   Locations

   2 in total

   Run by

   Adneuris Therapeutics, Inc.

   See if you can join NCT07874620 on ClinicalTrials.gov

6. This Study is Comparing Pain Outcomes After Urethral Bulking When Participants Are Randomized to Two Different Pain Medication Regimens.

   We are doing this study to find the best way to manage pain during a procedure called urethral bulking. This procedure treats urine leakage that happens with coughing, laughing, sneezing, or physical activity. It works by injecting a gel-like substance around the urethra (the tube that urine comes …

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Northwell health physician partners, Bay Shore, New York

   Locations

   3 in total

   Run by

   Northwell Health

   See if you can join NCT07889687 on ClinicalTrials.gov

7. Neural and Psychological Mechanisms of Pain Perception

   Background: - Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, not just pain. Researchers want to understand how different factors influence pain. They want to test what happens when people expect differen…

   Stage

   Not phased

   Ages

   18 to 50

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Center for Complementary and Integrative Health (NCCIH)

   See if you can join NCT02446262 on ClinicalTrials.gov

8. Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

   Objective The current proposal investigates behavioral, psychophysiological, and social processes that may help explain biases and disparate outcomes in pain. Health disparities, or health outcomes that adversely affect disadvantaged populations, are pervasive and apparent in many diseases and symp…

   Stage

   Not phased

   Ages

   18 to 60

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Center for Complementary and Integrative Health (NCCIH)

   See if you can join NCT03258580 on ClinicalTrials.gov

9. Morphine or Ketamine for Analgesia

   Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences. Morphine is the standard treatment for children with moderate to severe acute pain, but its use is associated with serious side effects and caregiver …

   Stage

   Phase 3

   Ages

   6 to 17

   Site

   UC Davis Children's Hospital, Sacramento, California

   Locations

   8 in total

   Run by

   Columbia University

   See if you can join NCT06835504 on ClinicalTrials.gov

10. Impact of the NeuroCuple Device on Pain Management After Cesarean Delivery

    This will be a single-center, sham-controlled, 3 arms, randomized (1:1:1) prospective study in females undergoing cesarean delivery to investigate the impact of NeuroCuple™ non-pharmacological analgesic device for management of postoperative pain. The investigators hypothesize that women treated wi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Inova Fairfax Medical Campus, Falls Church, Virginia

    Run by

    Inova Health Care Services

    See if you can join NCT07185425 on ClinicalTrials.gov

11. Anesthetics and Analgesics in Children

    The purpose of this study is to characterize the pharmacokinetic (PK) and safety profile of anesthetics and analgesics in children and adolescents.

    Stage

    Not phased

    Ages

    0 to 17

    Site

    Lucile Packard Children's Hospital, Stanford, California

    Locations

    13 in total

    Run by

    Chi Dang Hornik

    See if you can join NCT03427736 on ClinicalTrials.gov

12. Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI

    The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involve…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05492188 on ClinicalTrials.gov

13. Options for Pain Management Using Nonpharmacological Strategies

    The purpose of this study is to help Veterans learn about different ways they can manage chronic pain that do not involve medications. Veterans will work with a coach to explore the Veterans' values and goals and how different non-medication approaches may fit into these values and goals.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Richard L. Roudebush VA Medical Center, Indianapolis, IN, Indianapolis, Indiana

    Run by

    VA Office of Research and Development

    See if you can join NCT05563792 on ClinicalTrials.gov

14. Exploring the Acute and Dynamic Relationships Between Movement and Pain in Older Adults With Musculoskeletal Pain

    The purpose of this research study is to evaluate the effect of brief bouts of intermittent walking on bodily pain, pain during movement, and how the body adapts to musculoskeletal pain in older adults.

    Stage

    Not phased

    Ages

    55 to 85

    Site

    250 University Blvd, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT06886906 on ClinicalTrials.gov

15. RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain

    To compile characteristics of real-world clinical outcomes for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable Instructions for Use - and - To evaluate the economic value and technical performance of Bosto…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Denver Back Pain Specialists, Greenwood Village, Colorado

    Locations

    118 in total

    Run by

    Boston Scientific Corporation

    See if you can join NCT01719055 on ClinicalTrials.gov

16. Clinical and Scientific Assessment of Pain and Painful Disorders

    Background: Researchers want to better understand pain by studying people with and without different kinds of pain. To do this, researchers will expose people to pleasant and unpleasant sensations. They will ask them questions about their pain. Researchers also want to see if these people are eligi…

    Stage

    Not phased

    Ages

    12 to 120

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Center for Complementary and Integrative Health (NCCIH)

    See if you can join NCT02707029 on ClinicalTrials.gov

17. Integrated Smartphone Technology to Alleviate Malignant Pain (I-STAMP) Testing

    The purpose of the study is to evaluate if the smartphone app, I-STAMP (Integrated Smartphone Technology to Alleviate Malignant Pain), helps participants with cancer pain manage symptoms and keep track of medications.

    Stage

    Not phased

    Ages

    21 and older

    Site

    Dana Farber Cancer Institute, Boston, Massachusetts

    Run by

    Dana-Farber Cancer Institute

    See if you can join NCT06117709 on ClinicalTrials.gov

18. Suzetrigine in TKA

    Total knee replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery. Despite widespread use of multimodal regimens, many patients still rely on opioids, which can cause sedation, nausea…

    Stage

    Phase 3

    Ages

    18 to 80

    Site

    Hospital for Special Surgery, New York, New York

    Run by

    Hospital for Special Surgery, New York

    See if you can join NCT07864896 on ClinicalTrials.gov

19. Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

    The study, known as the Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE), aims to determine the effectiveness of digital CBT in reducing pain, opioid use, and healthcare utilization among AYAs with SCD. It also s…

    Stage

    Not phased

    Ages

    16 to 39

    Site

    University of South Alabama Medical Center, Mobile, Alabama

    Locations

    14 in total

    Run by

    University of Pittsburgh

    See if you can join NCT06374238 on ClinicalTrials.gov

20. State-dependent Interoception, Value-based Decision-making, and Introspection

    Background: Negative emotional states can affect a person s behavior as they make decisions. For example, hunger may make people more impatient; they may then make riskier choices. Other negative emotional states that can change behavior include stress, pain, and sadness. By learning more about how…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Mental Health (NIMH)

    See if you can join NCT05666726 on ClinicalTrials.gov

21. Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery

    The purpose of this study is to identify pharmacokinetics of postpartum ketamine infusion. This study will assess ketamine kinetics and metabolism in this setting. Ketamine is expected to exert different kinetics during the physiologic state of post-pregnancy. The goal in conducting this study is t…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of Utah, Salt Lake City, Utah

    Locations

    2 in total

    Run by

    University of Utah

    See if you can join NCT06767566 on ClinicalTrials.gov

22. Pain and Smoking Study 2.0: A Randomized Clinical Trial of Smoking Cessation Among Veterans With Chronic Pain

    PASS2 aims to expand upon the recently completed study (PASS intervention), which tested the telephone delivery of a cognitive behavioral intervention (CBI). This study will use nightly surveys to optimize the intervention's effectiveness for smoking cessation among Veteran smokers with chronic pai…

    Stage

    Not phased

    Ages

    18 and older

    Site

    VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven, Connecticut

    Run by

    VA Office of Research and Development

    See if you can join NCT06442514 on ClinicalTrials.gov

23. Transcutaneous Electrical Nerve Stimulation for Pain Mitigation During Intrauterine Device Placement

    Investigators are conducting a study to determine whether high frequency transcutaneous electrical nerve stimulation (hfTENS) is effective at reducing pain in women having an IUD inserted.

    Stage

    Not phased

    Ages

    18 and older

    Site

    MUSC Women's Health- Cannon Street, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06991075 on ClinicalTrials.gov

24. Impact of Art Therapy on Self-Reported Pain and Anxiety Scores of Patients Waiting to Be Seen in the Emergency Department

    The objective of this research is to assess the effects of engaging in coloring activities on patients' self-reported pain and anxiety scores while they wait to be seen by a physician in an emergency department (ED). The current literature on patient visits in the ED highlights the significance of …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Stony Brook University Hospital, Stony Brook, New York

    Run by

    Stony Brook University

    See if you can join NCT05540106 on ClinicalTrials.gov

25. Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children

    Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies. This clinical trial aims to see how well pre-recorded guided imagery therapy sessions help …

    Stage

    Not phased

    Ages

    7 to 12

    Site

    Baylor College of Medicine/Texas Children's Hospital, Austin, Texas

    Locations

    2 in total

    Run by

    Baylor College of Medicine

    See if you can join NCT07222943 on ClinicalTrials.gov