Multiple Sclerosis Clinical Trials

109 studies are recruiting for multiple sclerosis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis

   The goal of this clinical trial is to evaluate if combining a medication that can help improve walking in people with multiple sclerosis (MS) with a physical therapy program is better for improving walking than either treatment alone. The main questions this study will answer are: * Does combining …

   Stage

   Phase 3

   Ages

   25 to 75

   Site

   MGH Institute of Health Professions, Boston, Massachusetts

   Run by

   MGH Institute of Health Professions

   See if you can join NCT06136728 on ClinicalTrials.gov

2. Ocrevus Zunovo for MS: Mixed Methods

   Ocrevus Zunovo implementation, feasibility, acceptability, patient satisfaction, treatment persistence, and impact on MS disease outcomes will be analyzed in this mixed methods study. This study will incorporate clinical data and questionnaire results from MS patients who take Ocrevus Zunovo as wel…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Northwestern Memorial Hospital, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT07710105 on ClinicalTrials.gov

3. Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype

   The purpose of this research study is to compare the effects of cannabidiol (CBD), tetrahydrocannabinol (THC), or both, on sleep and pain in persons with multiple sclerosis (MS). Little is known about how CBD and/or THC may help sleep, reduce pain, or perhaps even treat pain through better sleep.

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   Tiffany J. Braley, MD, MS

   See if you can join NCT05269628 on ClinicalTrials.gov

4. Targeting Agonists of Glucagon-like Peptide-1 Receptor for Multiple Sclerosis

   The goal of this clinical trial is to evaluate if the study drug will reduce brain and retinal atrophy by reducing inflammation and subsequently slowing neurodegeneration in people with Multiple Sclerosis. The main outcome for the trial is change in normalized brain parenchymal volume (nBPV), measu…

   Stage

   Phase 2

   Ages

   18 to 60

   Site

   Johns Hopkins University, Baltimore, Maryland

   Locations

   2 in total

   Run by

   Johns Hopkins University

   See if you can join NCT07497399 on ClinicalTrials.gov

5. Exercise Rehabilitation Program in MS Who Use Wheelchairs as a Primary Mobility Device

   Approximately 50% of people with multiple sclerosis (MS) use a wheelchair within 30 years of the initial diagnosis. Wheelchair use in MS is often associated with fatigue as a consequence of muscle weakness. Indeed, fatigue, a prevalent consequence of MS, often becomes debilitating and exhausts ener…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Illinois at Chicago, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT06410261 on ClinicalTrials.gov

6. Functional Balance Intervention in Multiple Sclerosis

   This project involves two sub-parts: Study 1: Effect of lab-based Functional Balance Intervention (FBI) for physical and cognitive symptoms of Multiple Sclerosis. Study 2: Feasibility of home-based FBI for physical and cognitive symptoms of Multiple Sclerosis. Each study involves a 2-arm, Phase-1, …

   Stage

   Not phased

   Ages

   18 to 90

   Site

   University of Illinois at Chicago, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT06341023 on ClinicalTrials.gov

7. Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS)

   This project is a double-blind, sham-controlled, parallel-arm, randomized controlled trial. We will recruit n=170 people living with MS, who are experiencing an episode of depression in the context of a major depressive episode (MDE). Using our remotely supervised (RS) tDCS protocol, enrolled parti…

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT06901687 on ClinicalTrials.gov

8. Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders

   In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be used to understand the natural history, underlying immunologic mechanisms, and clinical implications of central nervous system (CNS) lesions, in particular lesions in the cerebral cortex, in multiple scler…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mount Sinai Hospital, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT05982925 on ClinicalTrials.gov

9. A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years

   The primary objective of this trial is to evaluate the safety and reactogenicity of mRNA-1195 in participants with multiple sclerosis.

   Stage

   Phase 2

   Ages

   18 to 55

   Site

   Quest Research Institute, Farmington Hills, Michigan

   Locations

   17 in total

   Run by

   ModernaTX, Inc.

   See if you can join NCT06735248 on ClinicalTrials.gov

10. Efficacy of Cognitive Behavioral Therapy for Insomnia to Treat Insomnia Symptoms in Individuals With Multiple Sclerosis

    The incidence of insomnia is estimated to be as high as 90% in individuals with MS due to insomnia being underdiagnosed. Sleep disturbances in people with MS have been associated with reduced cognitive performance, physical function, psychological well-being, quality of life, and occupational funct…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT06428006 on ClinicalTrials.gov

11. Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

    This clinical trial studies the effect of respiratory training for enhancing brain and mental health among patients with multiple sclerosis (MS) and cancer (along with their caregivers). The relationship between respiration, cardiovascular effects in the brain, mental health, and neurophysiological…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Mayo Clinic in Rochester, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06788886 on ClinicalTrials.gov

12. Solriamfetol for the Treatment of Multiple Sclerosis Fatigue

    Fatigue is a prevalent and disabling symptom in Multiple Sclerosis (MS), affecting up to 90% of patients. Current treatments, including off-label prescriptions of wake-promoting agents, have shown limited effectiveness. Previous research indicates that these agents may be beneficial specifically fo…

    Stage

    Phase 2

    Ages

    18 to 60

    Site

    Johns Hopkins University, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06170970 on ClinicalTrials.gov

13. Hyperpolarized Carbon Metabolic Imaging in Multiple Sclerosis

    The main purpose of this study is to assess whether hyperpolarized carbon imaging in relapsing remitting multiple sclerosis (MS) patients can be used to predict response to anti-CD20 disease modifying therapy. Study procedures will include magnetic resonance imaging (MRI) assessments with a hyperpo…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Byers Hall, San Francisco, California

    Run by

    Ari Green

    See if you can join NCT07510607 on ClinicalTrials.gov

14. Pathological Basis of MRI Signal Changes in Multiple Sclerosis

    Background: Multiple sclerosis (MS) is a disease that damages the central nervous system (brain and spinal cord). This leads to increased physical disability over time. The disease is lifelong once it begins. Researchers want to learn more about MS s stages and follow them until a person s death. O…

    Stage

    Not phased

    Ages

    18 to 120

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT02659956 on ClinicalTrials.gov

15. Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy

    Background: Multiple sclerosis (MS) and progressive multifocal leukoencephalopathy (PML) are disorders that affect the central nervous system (CNS). The CNS includes the brain, spinal cord, and optic nerves. Both diseases can cause muscle weakness and impair vision, speech, and coordination. Resear…

    Stage

    Phase 1

    Ages

    18 to 120

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT05849467 on ClinicalTrials.gov

16. Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

    The purpose of this research is to examine the effects of two different exercise training regimens for managing depression and improving other health indicators among persons with multiple sclerosis (MS). The project will enroll persons with MS and major depressive disorder (MDD) between 18 and 64 …

    Stage

    Not phased

    Ages

    18 to 64

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT05051618 on ClinicalTrials.gov

17. Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

    The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical [F-18]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tr…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    University of Alabama at Birmingham Medical Center, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT03759522 on ClinicalTrials.gov

18. Silodosin for Urinary Symptoms in Female Patients With Multiple Sclerosis

    The goal of this clinical trial is to learn if silodosin works to treat lower urinary tract symptoms (LUTS) in female patients with multiple sclerosis (MS). It will also learn about the effect of the drug on voiding parameters. The main questions it aims to answer are: Does silodosin improve lower …

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Atlantic Health, Morristown, New Jersey

    Run by

    Atlantic Health System

    See if you can join NCT07614321 on ClinicalTrials.gov

19. Dry Needling in Multiple Sclerosis

    This study is placed at the Human Functional Performance Laboratory in the School of physical therapy and Rehabilitation Sciences (MDT building) at University of South Florida. The study is supported by Consortium of Multiple Sclerosis Centers. We are doing this study to see if a treatment called d…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of South Florida, Tampa, Florida

    Run by

    University of South Florida

    See if you can join NCT07615725 on ClinicalTrials.gov

20. Deciphering Preserved Autonomic Function After Multiple Sclerosis

    This study looks to characterize gradients of dysfunction in the autonomic nervous system in patients with clinically diagnosed multiple sclerosis. The autonomic nervous system plays key roles in regulation of blood pressure, skin blood flow, and bladder health- all issues that individuals with mul…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07012135 on ClinicalTrials.gov

21. Intestinal Immunity in Neurologic Disease

    The purpose of this study is to ascertain the functional profiles of the immune cells within the gastrointestinal tract and to determine how these cells contribute to autoimmune and neurologic diseases.

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Yale MS Clinic, North Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06329453 on ClinicalTrials.gov

22. Genes and Environment in Multiple Sclerosis

    The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfu…

    Stage

    Not phased

    Ages

    18 and older

    Site

    National Institute of Neurological Disorders and Stroke, Bethesda, Maryland

    Locations

    5 in total

    Run by

    Columbia University

    See if you can join NCT01353547 on ClinicalTrials.gov

23. Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

    This study will evaluate the influence of sleep apnea on clinical and radiological features of MS. Sleep apnea is associated with hypoxemia during sleep, which is likely detrimental to MS. Clinical data (MRI, lab results, medical history, labs, and sleep studies) of MS patients will be collected an…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT04603196 on ClinicalTrials.gov

24. Nomad P-KAFO Study

    The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk. The main questions it aims to answer are to quantify the effectiveness of the Nomad in improving mobilit…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Shirley Ryan AbilityLab, Chicago, Illinois

    Run by

    Shirley Ryan AbilityLab

    See if you can join NCT05644522 on ClinicalTrials.gov

25. Fall Prevention Among People With Spinal Cord Injury and Multiple Sclerosis Who Use Wheelchairs and Scooters

    The research team is conducting a study to determine if a fall prevention program designed specifically for people who use wheelchairs and scooters can help people better prevent and manage falls compared to the standard of care. This study will compare two groups of participants: 1. One group will…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Disability Participation and Quality of Life (DPQOL) Laboratory, Urbana, Illinois

    Run by

    University of Illinois at Urbana-Champaign

    See if you can join NCT07167680 on ClinicalTrials.gov