Multiple Sclerosis Clinical Trials

109 studies are recruiting for multiple sclerosis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Boston, Massachusetts 13 Chicago, Illinois 13 New York, New York 13 Bethesda, Maryland 9 Cleveland, Ohio 7 Baltimore, Maryland 6 St Louis, Missouri 6 Aurora, Colorado 5 Birmingham, Alabama 5 Houston, Texas 5 Kansas City, Kansas 5 San Francisco, California 5 Atlanta, Georgia 4 Austin, Texas 4 Dallas, Texas 4 Seattle, Washington 4 Columbus, Ohio 3 East Hanover, New Jersey 3 Miami, Florida 3 Milwaukee, Wisconsin 3 Palo Alto, California 3 Pittsburgh, Pennsylvania 3 Salt Lake City, Utah 3 Urbana, Illinois 3 Washington D.C., District of Columbia 3

Studies now recruiting

  1. Delivery of a Culturally Tailored Exercise Training Intervention for Hispanics With Multiple Sclerosis

    The purpose of this study is to establish differences in the primary outcome of walking dysfunction using the 12-Item Multiple Sclerosis Walking Scale (MSWS-12) and to establish differences in the secondary outcome of HRQoL using the 29-Item Multiple Sclerosis Walking Scale (MSWS-29) between the ex…

    Stage
    Not phased
    Ages
    18 and older
    Site
    The University of Texas Health Science Center at Houston, Houston, Texas
    Run by
    The University of Texas Health Science Center, Houston

    See if you can join NCT07606742 on ClinicalTrials.gov

  2. Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

    Studies performed under 89-N-0045 are designed to examine the natural history of multiple sclerosis (MS) using MRI and immunological measures. In addition to studying the natural history of untreated patients, the natural history of patients receiving approved disease-modifying therapies of MS will…

    Stage
    Not phased
    Ages
    18 to 120
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT00001248 on ClinicalTrials.gov

  3. Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

    Inflammatory or degenerative diseases of the brain and spinal cord, such as multiple sclerosis, may be related to problems with an individual s immune system. However, more information is needed on the ways in which the cells of the immune system interact with the central nervous system (CNS). This…

    Stage
    Not phased
    Ages
    0 to 99
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Allergy and Infectious Diseases (NIAID)

    See if you can join NCT00794352 on ClinicalTrials.gov

  4. Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

    Background: Multiple sclerosis (MS) affects the brain, spinal cord, and optic nerves. MS lesions can appear on the MRI (magnetic resonance imaging) scans in many ways. Sometimes they light up from the outer edge and fill inward. This is called ring enhancement. Researchers think this type of lesion…

    Stage
    Phase 2
    Ages
    18 to 120
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT02784210 on ClinicalTrials.gov

  5. Clinical Applications of Advanced Ophthalmic Imaging

    The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased eyes and normal controls. There are two phases in this study. The firs…

    Stage
    Not phased
    Ages
    18 to 99
    Site
    Bascom Palmer Eye Institute, Miami, Florida
    Run by
    University of Miami

    See if you can join NCT03135327 on ClinicalTrials.gov

  6. Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

    This phase Ib trial studies the side effects of nivolumab and to see how well it works alone and in combination with other treatments, such as ipilimumab, cabozantinib, platinum containing therapy, and fluoropyrimidine, in treating patients with autoimmune disorders and cancer that has spread from …

    Stage
    Phase 1
    Ages
    18 and older
    Site
    University of California Davis Comprehensive Cancer Center, Sacramento, California
    Locations
    52 in total
    Run by
    National Cancer Institute (NCI)

    See if you can join NCT03816345 on ClinicalTrials.gov

  7. Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis

    This is a randomized, open-label, parallel, Phase 3 study with 2-arms for treatment. The purpose of this study is to evaluate SC administration of frexalimab every 4 weeks (q4w) compared to IV administration of frexalimab q4w in male and female participants with RMS and nrSPMS (aged 18 to 60 years …

    Stage
    Phase 3
    Ages
    18 to 60
    Site
    North Central Neurology Associates- Site Number : 8401100, Cullman, Alabama
    Locations
    40 in total
    Run by
    Sanofi

    See if you can join NCT07325292 on ClinicalTrials.gov

  8. A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy

    The purpose of this study is to assess the imaging biomarkers, patient outcomes, safety, tolerability, and treatment satisfaction of ocrelizumab (OCR) combined with recombinant human hyaluronidase (rHuPH20) administered subcutaneously (SC) in participants with relapsing multiple sclerosis (RMS) or …

    Stage
    Phase 4
    Ages
    18 to 65
    Site
    Atlanta Neuroscience Institute, Atlanta, Georgia
    Locations
    3 in total
    Run by
    Genentech, Inc.

    See if you can join NCT07609719 on ClinicalTrials.gov

  9. A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

    The purpose of this study is to evaluate safety, effiectiveness, and to gain insight into the treatment experience of participants prescribed BRIUMVI® (ublituximab-xiiy) in the real-world setting

    Stage
    Not phased
    Ages
    18 and older
    Site
    TG Therapeutics Investigational Trial Site, Birmingham, Alabama
    Locations
    109 in total
    Run by
    TG Therapeutics, Inc.

    See if you can join NCT06433752 on ClinicalTrials.gov

  10. Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain

    The purpose of this study is to to explore the safety and efficacy of the EXOPULSE Mollii suit, a full-body electrostimulation suit, for individuals with neurological or neuromuscular conditions that cause spasticity, hyperreflexia, and/or pain.

    Stage
    Not phased
    Ages
    18 to 75
    Site
    Shirley Ryan AbilityLab, Chicago, Illinois
    Run by
    Shirley Ryan AbilityLab

    See if you can join NCT07132775 on ClinicalTrials.gov

  11. Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

    Background: In people with multiple sclerosis (MS), brain and cerebrospinal fluid (CSF) biomarkers indicate inflammation or disease. Researchers want to see if 4 drugs given alone or combined affect MS biomarkers. They want to see if a change in biomarker levels can predict which drugs a person wit…

    Stage
    Phase 1
    Ages
    18 to 120
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Allergy and Infectious Diseases (NIAID)

    See if you can join NCT03109288 on ClinicalTrials.gov

  12. Identifying and Characterizing Preclinical MS

    The purpose of this research study is to try and identify risk factors and biologic changes that suggest that someone may go on to develop multiple sclerosis before a person has shown any symptoms of the disease.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Yale University, North Haven, Connecticut
    Run by
    Yale University

    See if you can join NCT05787795 on ClinicalTrials.gov

  13. An Open-label Study of AZD0120 in Adults With Multiple Sclerosis

    This trial is a Phase 1b, open-label, multi-center, clinical study of AZD0120, a BCMA/CD19 dual targeting CAR+ T-cell therapy, to evaluate the safety and tolerability in adult participants with Multiple Sclerosis.

    Stage
    Phase 1
    Ages
    18 to 60
    Site
    Research Site, Washington D.C., District of Columbia
    Locations
    19 in total
    Run by
    AstraZeneca

    See if you can join NCT07224373 on ClinicalTrials.gov

  14. A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)

    The primary objective of the study is to compare the prevalence rate of major congenital malformations (MCM) between 2 cohorts of pregnant participants with MS who are exposed to BRIUMVI® and who are unexposed to BRIUMVI®.

    Stage
    Not phased
    Ages
    15 to 50
    Site
    BRIUMVI® Pregnancy Registry Virtual Research Coordination Center, Wilmington, North Carolina
    Run by
    TG Therapeutics, Inc.

    See if you can join NCT06433765 on ClinicalTrials.gov

  15. A Study Comparing Effectiveness of Kesimpta® (Ofatumumab) Versus Ocrevus® (Ocrelizumab) in Real-world Practice

    This study aims to generate real-world evidence on the clinical effectiveness and economic burden of ofatumumab (OMB) versus ocrelizumab (OCR) in patients diagnosed with multiple sclerosis (MS) in the United States (US). Clinical effectiveness will be assessed using annualized relapse rate (ARR), w…

    Stage
    Not phased
    Ages
    18 to 100
    Site
    Novartis, East Hanover, New Jersey
    Run by
    Novartis Pharmaceuticals

    See if you can join NCT07779460 on ClinicalTrials.gov

  16. Music-4-MS to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study

    Multiple sclerosis (MS) rates in the U.S. have nearly doubled over the past decade, making it a leading cause of nontraumatic functional impairment in young adults and significantly affecting cognitive function in up to 70% of people with MS. While traditional cognitive rehabilitation methods are l…

    Stage
    Not phased
    Ages
    18 to 80
    Site
    University of Texas at Austin, Austin, Texas
    Run by
    University of Texas at Austin

    See if you can join NCT07759115 on ClinicalTrials.gov

  17. Electrical Stimulation Exercise for Individuals With Lower Limb Paralysis

    The purpose of this research study is to evaluate the effectiveness of an exercise training intervention (24-36 sessions) to improve muscle strength and endurance in the lower limbs of individuals with paralysis. Specifically, surface electrical stimulation or previously implanted stimulator will b…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio
    Run by
    Louis Stokes VA Medical Center

    See if you can join NCT07768761 on ClinicalTrials.gov

  18. A Study Evaluating the Safety and Efficacy of KITE-363 in Relapsed/Refractory Autoimmune Neurologic Diseases

    This study will have two Phases: Phase 1a and Phase 1b. The goals of this clinical study are to learn more about the study drug KITE-363, by evaluating its safety, tolerability and efficacy in participants with relapsed/refractory autoimmune neurologic diseases. The primary objectives of this study…

    Stage
    Phase 1
    Ages
    18 to 75
    Site
    Hoag Memorial Hospital Presbyterian, Newport Beach, California
    Locations
    8 in total
    Run by
    Kite, A Gilead Company

    See if you can join NCT07304154 on ClinicalTrials.gov

  19. Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)

    The primary objectives of the study are to estimate the risk of major congenital malformations (MCMs) in infants born to women with multiple sclerosis (MS) who were exposed to diroximel fumarate (DRF) at any time from 2 weeks after the first day of their last menstrual period (LMP) up through the f…

    Stage
    Not phased
    Ages
    Any age
    Site
    University of Colorado Anschutz Medical Campus, Aurora, Colorado
    Locations
    8 in total
    Run by
    Biogen

    See if you can join NCT05658497 on ClinicalTrials.gov

  20. Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)

    PRISMA, is a pregnancy registry study, focused on comprehensively collecting information about pregnancy in women with chronic neurological conditions from across the United States and internationally. Depending on their specific condition (MS, CIS, NMOSD, or other) and their specific treatment, pa…

    Stage
    Not phased
    Ages
    18 to 64
    Site
    University of California-San Francisco, San Francisco, California
    Run by
    University of California, San Francisco

    See if you can join NCT06940323 on ClinicalTrials.gov

  21. A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis

    The goal of this novel study is to compare the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory (NLM) in persons with multiple sclerosis (pwMS) and mobility disability.

    Stage
    Not phased
    Ages
    18 to 70
    Site
    Kessler Foundation, East Hanover, New Jersey
    Run by
    Kessler Foundation

    See if you can join NCT06197685 on ClinicalTrials.gov

  22. This Study Involves a Positron Emission Tomography (PET) Scan Using a New Investigational Radioactive Tracer, [18F]-FZTA, to Detect Inflammation in the Brain. The Tracer Will be Tested in Healthy Younger Adults and Individuals With Multiple Sclerosis.

    This study involves a Positron Emission Tomography (PET) scan using a new investigational radioactive tracer, [18F]-FZTA, to detect inflammation in the brain. The tracer will be tested in healthy younger adults and individuals with Multiple Sclerosis.

    Stage
    Not phased
    Ages
    18 and older
    Site
    Washington University in St. Louis, St Louis, Missouri
    Run by
    Washington University School of Medicine

    See if you can join NCT07115017 on ClinicalTrials.gov

  23. Understanding and Enhancing Human Health and Movement

    By doing this study, investigators hope to learn how electrical stimulation can improve human movement, biomechanics, and function and to gather information on the safety and effectiveness of an implanted electrical stimulation system after paralysis from spinal cord injury, stroke, multiple sclero…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio
    Run by
    Louis Stokes VA Medical Center

    See if you can join NCT07738978 on ClinicalTrials.gov

  24. Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia

    This study will evaluate the risk of progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by John Cunningham virus (JCV), among people with multiple sclerosis who have been treated with ozanimod. The study will collect and review reported cases of PML to describe patient …

    Stage
    Not phased
    Ages
    Any age
    Site
    Bristol Myers Squibb, Lawrenceville, New Jersey
    Run by
    Bristol-Myers Squibb

    See if you can join NCT07732907 on ClinicalTrials.gov

  25. Single Arm Trial Identifying Barriers and Facilitators to Mindfulness Practice

    This observational study will examine what emotional, physical, and environmental factors make it easier or harder for people with multiple sclerosis (MS) and chronic pain to practice mindfulness daily while participating in a group-based Mindfulness-Based Cognitive Therapy (MBCT) program.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Washington, Seattle, Washington
    Run by
    University of Washington

    See if you can join NCT07573241 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.