Multiple Sclerosis Clinical Trials

109 studies are recruiting for multiple sclerosis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. HOBSCOTCH-MS-Efficacy Trial

   The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-MS to improve the quality of life and cognitive function in Service Members, Veterans and civilians who have multiple sclerosis with cognitive and memory problems (MS participants). This study will also ass…

   Stage

   Not phased

   Ages

   20 to 75

   Site

   Dartmouth-Health Lebanon, Lebanon, New Hampshire

   Run by

   Dartmouth-Hitchcock Medical Center

   See if you can join NCT06951919 on ClinicalTrials.gov

2. Understanding and Enhancing Human Health and Movement

   By doing this study, investigators hope to learn how electrical stimulation can improve human movement, biomechanics, and function and to gather information on the safety and effectiveness of an implanted electrical stimulation system after paralysis from spinal cord injury, stroke, multiple sclero…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio

   Run by

   Louis Stokes VA Medical Center

   See if you can join NCT07738978 on ClinicalTrials.gov

3. A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

   The purpose of this study is to evaluate safety, effiectiveness, and to gain insight into the treatment experience of participants prescribed BRIUMVI® (ublituximab-xiiy) in the real-world setting

   Stage

   Not phased

   Ages

   18 and older

   Site

   TG Therapeutics Investigational Trial Site, Birmingham, Alabama

   Locations

   113 in total

   Run by

   TG Therapeutics, Inc.

   See if you can join NCT06433752 on ClinicalTrials.gov

4. A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy

   The purpose of this study is to assess the imaging biomarkers, patient outcomes, safety, tolerability, and treatment satisfaction of ocrelizumab (OCR) combined with recombinant human hyaluronidase (rHuPH20) administered subcutaneously (SC) in participants with relapsing multiple sclerosis (RMS) or …

   Stage

   Phase 4

   Ages

   18 to 65

   Site

   Alabama Neurology Associates, Birmingham, Alabama

   Locations

   8 in total

   Run by

   Genentech, Inc.

   See if you can join NCT07609719 on ClinicalTrials.gov

5. A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)

   The primary objective of the study is to compare the prevalence rate of major congenital malformations (MCM) between 2 cohorts of pregnant participants with MS who are exposed to BRIUMVI® and who are unexposed to BRIUMVI®.

   Stage

   Not phased

   Ages

   15 to 50

   Site

   BRIUMVI® Pregnancy Registry Virtual Research Coordination Center, Wilmington, North Carolina

   Run by

   TG Therapeutics, Inc.

   See if you can join NCT06433765 on ClinicalTrials.gov

6. Dry Needling in Multiple Sclerosis

   This study is being conducted at the Human Functional Performance Laboratory in the School of Physical Therapy and Rehabilitation Sciences (MDT Building) at the University of South Florida. The study is supported by the Consortium of Multiple Sclerosis Centers. The investigators are conducting this…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   University of South Florida, Tampa, Florida

   Run by

   University of South Florida

   See if you can join NCT07615725 on ClinicalTrials.gov

7. iConquerMS™ - A Patient-Powered Research Network for Multiple Sclerosis

   iConquerMS™ is a research initiative developed by and for people with multiple sclerosis (MS) to contribute their health data and ideas to advance and accelerate research into MS. iConquerMS welcomes adults with MS and others interested in advancing MS research, children and teens with MS and their…

   Stage

   Not phased

   Ages

   Any age

   Site

   Accelerated Cure Project, Waltham, Massachusetts

   Run by

   Accelerated Cure Project for Multiple Sclerosis

   See if you can join NCT02486562 on ClinicalTrials.gov

8. Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

   Studies performed under 89-N-0045 are designed to examine the natural history of multiple sclerosis (MS) using MRI and immunological measures. In addition to studying the natural history of untreated patients, the natural history of patients receiving approved disease-modifying therapies of MS will…

   Stage

   Not phased

   Ages

   18 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT00001248 on ClinicalTrials.gov

9. Care in Multiple Sclerosis (MS)

   This study is structured around three main aims. In Aim 1, investigators will conduct community-based participatory research (CBPR) to develop culturally tailored methods to assess childhood adversity in multiple sclerosis (MS). Aim 2 will investigate the impact of childhood adversity on MS outcome…

   Stage

   Not phased

   Ages

   18 to 29

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   6 in total

   Run by

   NYU Langone Health

   See if you can join NCT07011914 on ClinicalTrials.gov

10. Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis

    The study aims to study the effects of a novel treatment for vestibular symptoms in people with multiple sclerosis. The main objective is to determine whether daily personalized gaze stabilization training is more beneficial than intermittent gaze stability training in people with multiple sclerosi…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Emory Univeristy, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT06495138 on ClinicalTrials.gov

11. Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

    Background: In people with multiple sclerosis (MS), brain and cerebrospinal fluid (CSF) biomarkers indicate inflammation or disease. Researchers want to see if 4 drugs given alone or combined affect MS biomarkers. They want to see if a change in biomarker levels can predict which drugs a person wit…

    Stage

    Phase 1

    Ages

    18 to 120

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Allergy and Infectious Diseases (NIAID)

    See if you can join NCT03109288 on ClinicalTrials.gov

12. Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for MS

    This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of multiple sclerosis

    Stage

    Phase 1

    Ages

    Any age

    Site

    Prodromos Stem Cell Institute, Naples, Florida

    Locations

    2 in total

    Run by

    The Foundation for Orthopaedics and Regenerative Medicine

    See if you can join NCT05003388 on ClinicalTrials.gov

13. Study of KITE-363 in Participants With Autoimmune Neurologic Diseases That Did Not Respond to Usual Treatment

    This study will have two Phases: Phase 1a and Phase 1b. The goals of this clinical study are to learn more about the study drug KITE-363, by evaluating its safety, tolerability and efficacy in participants with relapsed/refractory autoimmune neurologic diseases. The primary objectives of this study…

    Stage

    Phase 1

    Ages

    18 to 75

    Site

    Hoag Memorial Hospital Presbyterian, Newport Beach, California

    Locations

    10 in total

    Run by

    Kite, A Gilead Company

    See if you can join NCT07304154 on ClinicalTrials.gov

14. Comparing Telehealth-Delivered CBT-I to Web-Based CBT-I to Enhance Sleep, Reduce Fatigue, and Promote Neuroprotection

    The objective of this RCT is to assess the efficacy of one-on-one telehealth CBT-I (tCBT-I) compared to web-based CBT-I (wCBT-I) and treatment as usual (TAU) to improve sleep outcomes (Aim 1), fatigue and quality of life (Aim 2), and promote neuroprotection (Exploratory Aim 3), and to explore the c…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    University of Kansas Medical Center- Sleep, Health and Wellness Laboratory, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT06434571 on ClinicalTrials.gov

15. Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis

    This is a randomized, open-label, parallel, Phase 3 study with 2-arms for treatment. The purpose of this study is to evaluate SC administration of frexalimab every 4 weeks (q4w) compared to IV administration of frexalimab q4w in male and female participants with RMS and nrSPMS (aged 18 to 60 years …

    Stage

    Phase 3

    Ages

    18 to 60

    Site

    North Central Neurology Associates- Site Number : 8401100, Cullman, Alabama

    Locations

    68 in total

    Run by

    Sanofi

    See if you can join NCT07325292 on ClinicalTrials.gov

16. Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

    Inflammatory or degenerative diseases of the brain and spinal cord, such as multiple sclerosis, may be related to problems with an individual s immune system. However, more information is needed on the ways in which the cells of the immune system interact with the central nervous system (CNS). This…

    Stage

    Not phased

    Ages

    0 to 99

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Allergy and Infectious Diseases (NIAID)

    See if you can join NCT00794352 on ClinicalTrials.gov

17. Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects

    Our overall objective is to obtain an initial assessment of the potential value of using [18F]3F4AP for imaging demyelinating diseases such as multiple sclerosis: * Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and subjects with multiple sclerosis (MS). Hypothesis 1: Administration o…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04699747 on ClinicalTrials.gov

18. Entire-body PET Scans for Multiple Sclerosis

    To evaluate whether an entire-body positron emission tomography (PET) scanner can be exploited to improve evaluation, monitoring and measurement of both peripheral and central demyelination in multiple sclerosis (MS) patients.

    Stage

    EARLY_Phase 1

    Ages

    25 to 55

    Site

    Brain Health Alliance, Ladera Ranch, California

    Run by

    Brain Health Alliance

    See if you can join NCT04390009 on ClinicalTrials.gov

19. The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis

    Objectives Objective 1: To determine the effects of a 16-week remotely delivered Pilates intervention on walking endurance, walking speed, balance, fatigue, and pain compared to a waitlist control group in individuals with MS. Objective 2: To examine the impact of a 16-week remotely delivered Pilat…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Illinois Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT07504120 on ClinicalTrials.gov

20. Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

    Background: Multiple sclerosis (MS) affects the brain, spinal cord, and optic nerves. MS lesions can appear on the MRI (magnetic resonance imaging) scans in many ways. Sometimes they light up from the outer edge and fill inward. This is called ring enhancement. Researchers think this type of lesion…

    Stage

    Phase 2

    Ages

    18 to 120

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT02784210 on ClinicalTrials.gov

21. Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

    This phase Ib trial studies the side effects of nivolumab and to see how well it works alone and in combination with other treatments, such as ipilimumab, cabozantinib, platinum containing therapy, and fluoropyrimidine, in treating patients with autoimmune disorders and cancer that has spread from …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of California Davis Comprehensive Cancer Center, Sacramento, California

    Locations

    52 in total

    Run by

    National Cancer Institute (NCI)

    See if you can join NCT03816345 on ClinicalTrials.gov

22. A Study of the MIND Diet for Persons With Multiple Sclerosis

    This study will assess the impact of a MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet on brain health and MS symptoms. Participants will be randomly assigned to one of two arms: the diet intervention arm or the "continue current diet"/control arm. Participants randomized to…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Mount Sinai Hospital, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06992115 on ClinicalTrials.gov

23. Vancomycin Study in Multiple Sclerosis (MS)

    The overall goal of this study is to elucidate a mechanism by which vancomycin modulates the gut-brain axis in multiple sclerosis (MS). The gut microbiome plays an important role in autoimmunity, including MS. However, the identity of gut microbes modulating neuroinflammation in MS and their mechan…

    Stage

    Phase 1

    Ages

    18 to 50

    Site

    Corinne Goldsmith Dickinson Center for Multiple Sclerosis at Mount Sinai, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT05539729 on ClinicalTrials.gov

24. Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis

    The goal of this clinical trial is to learn if the time an individual eats each day impacts neurological health in people with multiple sclerosis. The main questions the investigators are asking are: 1. Does meal timing affect biomarkers of neuronal health (neurofilament light chain [NfL] and BDNF)…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT07475377 on ClinicalTrials.gov

25. Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis

    The goal of this clinical trial is to treat male and female participants with two types of Multiple Sclerosis (MS) called primary progressive or secondary progressive MS. The main questions the trial aims to answer are the following: * Is TRX319 safe when administered to patients with progressive f…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    UC San Diego, La Jolla, California

    Locations

    8 in total

    Run by

    Tr1X, Inc.

    See if you can join NCT07477639 on ClinicalTrials.gov