Mild Cognitive Impairment Clinical Trials

86 studies are recruiting for mild cognitive impairment in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. BID LTM Digital Intervention in Aging

   Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM). The decline in these faculties is accelerated and becomes significant deficits in LTM and cognitive control functions at the level or a diagnosis of Mild Cognitive Imp…

   Stage

   Not phased

   Ages

   60 to 85

   Site

   University of California, San Francsico, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT06916221 on ClinicalTrials.gov

2. Wake Forest Alzheimer's Disease Clinical Core

   Efforts to find treatments for AD have yielded only modest benefits, likely because longstanding AD pathological processes induce irreversible neurological compromise. These processes begin years before the onset of clinical symptoms. This possibility has been incorporated into a model describing s…

   Stage

   Not phased

   Ages

   55 and older

   Site

   Wake Forest Baptist Health, Winston-Salem, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT03140865 on ClinicalTrials.gov

3. Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Memory Abilities

   This is a pilot study of non-invasive transcranial magnetic stimulation (TMS) to improve memory in healthy adults. It will also examine treating memory deficits in older adults with amnestic mild cognitive impairment (aMCI), a condition that frequently precedes Alzheimer's disease (AD). The study w…

   Stage

   Not phased

   Ages

   19 and older

   Site

   University of Nebraska Medical Center, Omaha, Nebraska

   Run by

   University of Nebraska

   See if you can join NCT03574207 on ClinicalTrials.gov

4. Sense4Safety Intervention

   Falls and fall-related injuries are significant public health issues for adults 65 years of age and older. Over a third of older adults (OA) fall each year and 10-20% of falls result in serious injuries such as fractures and head trauma. The annual direct medical costs in the US as a result of fall…

   Stage

   Phase 1

   Ages

   65 and older

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT07220668 on ClinicalTrials.gov

5. Multimodal Investigation of Neural Plasticity

   This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in cognitively intact older adults (healthy controls, HC) and in those with mild cognitive impairment (MCI).

   Stage

   Not phased

   Ages

   60 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT06453980 on ClinicalTrials.gov

6. Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

   The goal of this study is to objectively test one's sense of smell, called olfaction, in participants with Subjective Cognitive Concerns (SCC), Mild Cognitive Impairment, Mild Behavioral Impairment (MBI), and age-matched controls. The main question it aims to answer is whether the AROMHA Brain Heal…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT05881239 on ClinicalTrials.gov

7. Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's

   The goal of this clinical trial is to test the effectiveness of a computerized anxiety sensitivity treatment (CAST) compared to a health education control (HEC) in older adults with mild cognitive impairment (MCI) or mild Alzheimer's Disease and related dementias (ADRD) and their care partners. The…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Anxiety and Behavioral Health Clinic, Tallahassee, Florida

   Locations

   3 in total

   Run by

   Florida State University

   See if you can join NCT05748613 on ClinicalTrials.gov

8. Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease

   In people with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), reduced capacity for locomotor adaptation is a fundamental but poorly understood mechanism that can be a sensitive biomarker of cognitive-motor impairments. It is also an important therapeutic target for exercise-based int…

   Stage

   Not phased

   Ages

   50 to 90

   Site

   Emory Rehabilitation Hospital, Atlanta, Georgia

   Run by

   Emory University

   See if you can join NCT06484244 on ClinicalTrials.gov

9. Tau PET in Imaging and Cognition: Healthy Adults From 55-90

   The investigators aim to use the new PET radioligand, 18F-MK-6240, to detect tau pathology in cognitive healthy and mild cognitive impairment (MCI) elders. The investigators will then examine the interactions between differential tau burden and performance on cognitive tasks, functional magnetic re…

   Stage

   Not phased

   Ages

   55 to 90

   Site

   Columbia University Medical Center, New York, New York

   Run by

   Yaakov Stern

   See if you can join NCT03372317 on ClinicalTrials.gov

10. Tennessee Alzheimer's Project

    The primary objective of the Vanderbilt Alzheimer's Disease Research Center (VADRC) is to provide local and national researchers with access to a well-characterized and diverse clinical cohort, including participant referrals, biosamples, clinical data, and neuroimaging data. The VADRC Clinical Cor…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05372172 on ClinicalTrials.gov

11. Retinal Imaging in Neurodegenerative Disease

    This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Duke University Medical Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT03233646 on ClinicalTrials.gov

12. Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease

    The goal of this clinical trial is to learn about how genetics and the response to stress predicts cognitive decline in individuals with mild cognitive impairment. The main question[s] it aims to answer are: * Does the hormone response to acute stress predict the degree of cognitive impairment foll…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05795634 on ClinicalTrials.gov

13. Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance

    This randomized, double-blind, placebo-controlled, 8-week clinical trial is designed to evaluate the effects of Sabroxy®, a standardized extract of Oroxylum indicum bark, on insulin resistance and cognitive function in adults with mild cognitive impairment and insulin resistance. A total of 120 par…

    Stage

    Not phased

    Ages

    40 to 80

    Site

    San Francisco Research Institute, San Francisco, California

    Run by

    SF Research Institute, Inc.

    See if you can join NCT07220694 on ClinicalTrials.gov

14. Innate Immunity Stimulation Via TLR9 in Early AD

    This single-center, double-blind, placebo-controlled study will recruit in total 39 participants with either Mild Cognitive Impairment due to Alzheimer's disease (MCI) or Mild Alzheimer's disease dementia (mild AD). There will be 3 Dose levels. An initial cohort of 13 subjects will be randomized to…

    Stage

    Phase 1

    Ages

    60 to 85

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT05606341 on ClinicalTrials.gov

15. GAMES Intervention in MCI (Mild Cognitive Impairment)

    The objective of the present study is to evaluate whether online, remote gameplay can facilitate social engagement and reduce feelings of loneliness and isolation in adults with and without mild cognitive impairment (MCI).

    Stage

    Not phased

    Ages

    50 to 85

    Site

    Emory University, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT07296133 on ClinicalTrials.gov

16. A Study of Dual-task Exercise Training to Prevent Falls Among Older Adults With Mild Cognitive Impairment

    To determine the efficacy of a dual-task tai ji quan training therapy in reducing the incidence of falls in older adults with mild cognitive impairment.

    Stage

    Not phased

    Ages

    65 to 95

    Site

    Oregon Research Institute, Springfield, Oregon

    Run by

    Oregon Research Institute

    See if you can join NCT05725668 on ClinicalTrials.gov

17. The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia

    Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulat…

    Stage

    Not phased

    Ages

    55 to 89

    Site

    University of California San Francisco, San Francisco, California

    Locations

    6 in total

    Run by

    University of Alabama at Birmingham

    See if you can join NCT04171323 on ClinicalTrials.gov

18. Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)

    The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called "Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training" (RS-tDCS+) which has shown promise for improving complex attention in both he…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Naval Medical Center San Diego, San Diego, California

    Locations

    2 in total

    Run by

    United States Naval Medical Center, San Diego

    See if you can join NCT06413173 on ClinicalTrials.gov

19. Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside

    This project's main goal is to use state-of-the-art passive sensing techniques to identify digital biomarkers that relate to bioenergetic changes in the brain due to nicotinamide riboside supplementation in those with mild cognitive impairment and mild Alzheimer's dementia.

    Stage

    Not phased

    Ages

    18 to 89

    Site

    McLean Hospital, Belmont, Massachusetts

    Run by

    Mclean Hospital

    See if you can join NCT05245903 on ClinicalTrials.gov

20. TabCAT Brain Health Assessment in Primary Care

    Efficient and user-friendly paradigms to detect cognitive impairment, including dementia are needed in primary care. The TabCAT Brain Health Assessment accurately detects cognitive impairment via an appealing tablet interface with automated scoring and EMR integration. This study will evaluate the …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Kaiser Permanente Southern California Department of Research & Evaluation, Pasadena, California

    Run by

    University of California, San Francisco

    See if you can join NCT06090578 on ClinicalTrials.gov

21. bpMedManage: Digital Technology to Support Adherence to Hypertension Medications

    The purpose of the bpMedManage study is to rigorously test the efficacy of a smartphone technology to help improve high blood pressure medication adherence among older adults with mild cognitive impairment (MCI) in a 16-week randomized controlled trial. A total of 100 older adults will be recruited…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of Arizona, Tucson, Arizona

    Locations

    2 in total

    Run by

    University of Arizona

    See if you can join NCT06307574 on ClinicalTrials.gov

22. OCT Angiography and NRAI in Dementia

    The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. Detect retinal blood vessel and blood flow changes in participants with dementia. 2. Detect amyloid protein deposits in the retinas of participants with dementia.

    Stage

    Not phased

    Ages

    55 and older

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT03761381 on ClinicalTrials.gov

23. Race-Based Stress and Cognitive Training for MCI

    This a two phase project that aims to pilot a new adaptation (Phase 1) of Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT; an originally VA-based cognitive rehabilitation manualized intervention for older adults with MCI, with a focus on the impact of s…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Rosalind Franklin University of Medicine and Science, Chicago, Illinois

    Run by

    Rosalind Franklin University of Medicine and Science

    See if you can join NCT06330844 on ClinicalTrials.gov

24. Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease

    The goal of this clinical trial is to evaluate the safety and tolerability of a novel deep brain stimulation (DBS) of the Subthalamic Nucleus (STN) and Nucleus Basalis of Meynert (NBM) to treat cognitive and cognitive-motor symptoms in individuals with Parkinson's disease. The main question it aims…

    Stage

    Not phased

    Ages

    21 to 80

    Site

    Stanford Neuroscience Health Center, Stanford, California

    Run by

    Helen M. Bronte-Stewart

    See if you can join NCT05968703 on ClinicalTrials.gov

25. Safety and Target Engagement of Centella Asiatica in Cognitive Impairment

    This clinical trial is focused on determining whether biological signatures of target engagement by a Centella asiatica water extract product administered orally for 6 weeks can be measured in comparison to placebo. This study will also assess the safety and tolerability of the Centella asiatica wa…

    Stage

    Phase 1

    Ages

    60 to 85

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT05591027 on ClinicalTrials.gov