Mild Cognitive Impairment Clinical Trials

86 studies are recruiting for mild cognitive impairment in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)

   The purpose of this study is to evaluate the effect of atorvastatin on brain vessel reactivity and with it on blood flow in people with mild cognitive impairment.

   Stage

   Phase 2

   Ages

   60 to 95

   Site

   Johns Hopkins University, Bayview Medical Center, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT04765137 on ClinicalTrials.gov

2. Dual Task Perturbation Training for OAwMCI

   Studies have determined that compared to cognitively intact older adults (CIOA), older adults with mild cognitive impairment (OAwMCI) exhibit more pronounced balance and gait impairments which lead to an increased risk of falls and mobility decline. Such impairments are evident during dual-tasking …

   Stage

   Not phased

   Ages

   55 and older

   Site

   University of Illinois at Chicago, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT04938349 on ClinicalTrials.gov

3. Digital Tools to Support Healthcare Decision Making

   The goal for this project is to support the cognitive components of older adults' health-management activities through development of digital assistant technology tools tailored to three exemplar healthcare management task activities: accessing support services, managing healthcare finances, and us…

   Stage

   Not phased

   Ages

   60 and older

   Site

   University of Illinois Urbana-Champaign, Champaign, Illinois

   Locations

   3 in total

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT07485725 on ClinicalTrials.gov

4. Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive Decline

   The investigators aim to conduct a randomized controlled trial to compare two symptom-management programs for Black older adults with early cognitive decline (self-reported confirmed by testing) and chronic pain. The programs are Mindfulness-Based Cognitive Therapy with Walking (MBCT+w) and Active …

   Stage

   Not phased

   Ages

   50 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06246929 on ClinicalTrials.gov

5. Voice Technology-Based Self-Management Intervention

   This study aims to test a new technology-based program designed to help improve the ability to manage chronic conditions. This program includes daily smart speaker use for managing different tasks and technology learning. Proper self-management of chronic conditions is critical to the maintenance o…

   Stage

   Not phased

   Ages

   55 and older

   Site

   Emory University, Atlanta, Georgia

   Run by

   Emory University

   See if you can join NCT06982261 on ClinicalTrials.gov

6. Feasibility of Implementing Time-restricted Eating in Women With Mild Cognitive Impairment

   This study will investigate the feasibility of implementing a time-restricted eating intervention in females with mild cognitive impairment. Targeted therapeutic interventions that improve cognitive impairment and delay onset of ADRD are particularly important for females, who have twice the lifeti…

   Stage

   Not phased

   Ages

   45 to 95

   Site

   University of Kentucky, Lexington, Kentucky

   Run by

   Julie Pendergast

   See if you can join NCT05858008 on ClinicalTrials.gov

7. CBD for Individuals at Risk for Alzheimer's Disease

   This is a double-blind, randomized controlled trial designed to test the effects of cannabidiol (CBD) on validated biomarkers of Alzheimer's disease (AD) progression, and behavioral, neurocognitive, and clinical measures, with putative mechanisms of action.

   Stage

   Phase 2

   Ages

   55 to 85

   Site

   University of Colorado - Anschutz Medical Campus, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT05822362 on ClinicalTrials.gov

8. Music for Pain and Dementia

   This study aims to provide mechanistic insights into how group drumming as a music-based intervention (MBI) affects pain responses and nociceptive function in individuals with Alzheimer's Disease (AD), mild dementia or mild cognitive impairment (MCI). Heart rate (HR), heart rate variability (HRV), …

   Stage

   Not phased

   Ages

   50 to 80

   Site

   Connecticut Mental Health Clinic, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT07602283 on ClinicalTrials.gov

9. Telehealth-Adapted Compensatory Training and Intervention for Cognition

   The goal of this clinical trial is to develop a five-week virtual cognitive training intervention for people with Mild Cognitive Impairment (MCI) based off an existing eight-week intervention. The main question it aims to answer is: • Is five weeks of training as good as eight weeks in improving co…

   Stage

   Not phased

   Ages

   65 to 84

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT07366346 on ClinicalTrials.gov

10. Phase 2 - Rhythmic Light Therapy for Alzheimer's Disease Patients

    Participants will randomly be placed into one of four groups and experience one of the four following conditions: (1) a placebo light that provides a 40 hertz (Hz) flicker (rhythmic light [RL]); (2) a placebo light with a random flicker (placebo condition for rhythmic light); (3) a light source tha…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Light and Health Research Center, Menands, New York

    Locations

    2 in total

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT05016219 on ClinicalTrials.gov

11. Human Mesenchymal Stem Cells & Monoclonal Antibodies in the Treatment for Mild Cognitive Impairment or Early Alzheimer's Disease.

    The purpose of this study is to test if adding one infusion of (Human Mesenchymal Stem Cells) hMSCs to the treatment with standard of care (SOC) monoclonal antibodies (mAb) will stabilize the rate of cognitive and functional decline associated with mild Alzheimer's Disease.

    Stage

    Phase 2

    Ages

    55 to 90

    Site

    University of Miami Department of Neurology, Miami, Florida

    Run by

    Bernard (Barry) Baumel

    See if you can join NCT07512362 on ClinicalTrials.gov

12. TREAD: Time Restricted Eating Intervention for Alzheimer's Disease

    The goal of this clinical trial is to learn if restricting the time of eating to allow for prolonged fasting at night may reduce sleep disturbances, cognitive decay, and pathology in patients diagnosed with Mild Cognitive Impairment (MCI) or early to moderate Alzheimer's disease (AD). It will also …

    Stage

    Phase 1

    Ages

    60 and older

    Site

    Shiley Marcos Alzheimer's Disease Center, San Diego, California

    Run by

    University of California, San Diego

    See if you can join NCT06548191 on ClinicalTrials.gov

13. Working Memory and Physical Exercise Training in Patients With Mild Cognitive Impairment

    The prevalence of dementia will double in the next three decades in the U.S.; effective treatment or prevention for dementia is urgently needed. The current exploratory project aims to evaluate and understand how the brain and cognition may improve after a 12-week intervention that combines brain t…

    Stage

    Not phased

    Ages

    50 to 80

    Site

    University of Maryland Baltimore, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT05948930 on ClinicalTrials.gov

14. Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment

    This is a single-arm feasibility study employing a pre-post design with a 12-week intervention period. The study utilizes a telehealth-assisted home-based resistance exercise program, with a structured progression from supervised to unsupervised sessions over 12 weeks.

    Stage

    Not phased

    Ages

    55 to 80

    Site

    University of Texas Medical Branch, Galveston, Galveston, Texas

    Run by

    The University of Texas Medical Branch, Galveston

    See if you can join NCT07416799 on ClinicalTrials.gov

15. Wayfinding Intervention and Long-Term Memory

    Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment. Cognitive training with an immersive video game promises to drive hippocampal-cortical plasticity and associated gains that…

    Stage

    Not phased

    Ages

    60 to 85

    Site

    UCSF Mission Bay, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT05625425 on ClinicalTrials.gov

16. Music Therapy for Patients With Alzheimer's Disease

    This study is designed to assess the feasibility that individualized reminiscence-based virtual music therapy sessions can enhance autobiographical memory, mood, and cognition in patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD). 60 patients with MCI or …

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Johns Hopkins School of Medicine, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05151562 on ClinicalTrials.gov

17. Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

    In this research study we want to learn more about the effects of non-invasive brain stimulation on memory and brain-network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation c…

    Stage

    EARLY_Phase 1

    Ages

    40 to 99

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06538311 on ClinicalTrials.gov

18. Multi-modal Large Language Model-Empowered Talk Therapy for Older Adults With ADRD

    The purpose of this study is to test the usefulness and the effect of Smart Virtual Reminiscence (SVR) therapy intervention on the Behavioral and Psychological Symptoms of Dementia (BPSD) of patients with Alzheimer's Disease and Related Dementias (ADRD). SVR is designed to help older adults improve…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Sidney & Lois Eskenazi Hospital, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT07499570 on ClinicalTrials.gov

19. A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses

    The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitne…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Arizona State University, Phoenix, Arizona

    Run by

    Arizona State University

    See if you can join NCT05877196 on ClinicalTrials.gov

20. IHT for Mild Cognitive Impairment

    This phase I clinical trial will examine the safety and efficacy of intermittent hypoxia training (IHT) for up to 12 weeks to treat subjects with mild cognitive impairment (MCI).

    Stage

    Not phased

    Ages

    55 to 79

    Site

    University of North Texas Health Science Center, Fort Worth, Texas

    Run by

    University of North Texas Health Science Center

    See if you can join NCT05495087 on ClinicalTrials.gov

21. Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

    The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS). By comparing brain activity across different groups and relating it to symptom severity…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06897670 on ClinicalTrials.gov

22. rTMS to Improve Cognition in Parkinson's

    The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease or atypical parkinsonism and mild impairments in their thinking. The hypothesis i…

    Stage

    Phase 1

    Ages

    50 and older

    Site

    Edward Hines Jr. VA Hospital, Hines, IL, Hines, Illinois

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT03836950 on ClinicalTrials.gov

23. Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia

    Bio-Hermes-002 is a 120-day cross-sectional study that will result in a blood, CSF, retinal, digital, MRI, and PET brain imaging biomarker database that can be used to determine the primary objective. Digital biomarkers and blood-based biomarkers will be tested to determine whether a meaningful rel…

    Stage

    Not phased

    Ages

    60 to 90

    Site

    JEM Research Institute, Atlantis, Florida

    Locations

    26 in total

    Run by

    GAP Innovations, PBC

    See if you can join NCT06584357 on ClinicalTrials.gov

24. Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol

    The goal of this clinical trial is to evaluate an investigational ultralow dose Positron Emission Tomography (PET) imaging technique for Alzheimer's disease, mild cognitive impairment, other forms of dementia detection and monitoring. The main question it aims to answer is: Can the investigators op…

    Stage

    Phase 2

    Ages

    18 to 120

    Site

    Nuclear Imaging Institute, Englewood, New Jersey

    Run by

    Akiva Mintz

    See if you can join NCT07012993 on ClinicalTrials.gov

25. Transcranial Magnetic Stimulation for MCI

    The goal of this phase II study is to establish the dose-response curves of a safe and clinically feasible non-invasive brain stimulation technique (accelerated Transcranial Magnetic Stimulation (TMS)) to improve both depression and cognitive function in Mild Cognitive Impairment (MCI) patients wit…

    Stage

    Not phased

    Ages

    60 to 85

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05992831 on ClinicalTrials.gov